This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays a role in the promotion of macropinocytosis. Underexpression of the encoded protein may be a predictive marker of chemoresistant disease. Alternatively ... See more...

Aliases for ARHGEF26 Gene

Aliases for ARHGEF26 Gene

  • Rho Guanine Nucleotide Exchange Factor 26 2 3 3 4 5
  • Src Homology 3 Domain-Containing Guanine Nucleotide Exchange Factor 2 3
  • Rho Guanine Nucleotide Exchange Factor (GEF) 26 2 3
  • SH3 Domain-Containing Guanine Exchange Factor 3 4
  • SGEF 3 4
  • Testicular Tissue Protein Li 171 3
  • HMFN1864 3
  • CSGEF 3

External Ids for ARHGEF26 Gene

Previous GeneCards Identifiers for ARHGEF26 Gene

  • GC03P153839
  • GC03P151230

Summaries for ARHGEF26 Gene

Entrez Gene Summary for ARHGEF26 Gene

  • This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays a role in the promotion of macropinocytosis. Underexpression of the encoded protein may be a predictive marker of chemoresistant disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for ARHGEF26 Gene

ARHGEF26 (Rho Guanine Nucleotide Exchange Factor 26) is a Protein Coding gene. Diseases associated with ARHGEF26 include Rett Syndrome. Among its related pathways are Signaling by GPCR and p75 NTR receptor-mediated signalling. Gene Ontology (GO) annotations related to this gene include Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF16.

UniProtKB/Swiss-Prot Summary for ARHGEF26 Gene

  • Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry.

Additional gene information for ARHGEF26 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARHGEF26 Gene

Genomics for ARHGEF26 Gene

GeneHancer (GH) Regulatory Elements for ARHGEF26 Gene

Promoters and enhancers for ARHGEF26 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J154120 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 516.1 +1.6 1598 4.4 ZNF217 PHF8 ZFX CLOCK ZBTB26 SAP30 RFX1 ZNF341 POLR2A OSR2 ARHGEF26 ARHGEF26-AS1 LOC105374167
GH03J154089 Enhancer 0.8 Ensembl ENCODE 25.6 -31.1 -31143 1.1 ZNF217 CLOCK CTBP1 ESRRA JUND USF1 GATA3 MYC PKNOX1 DPF2 piR-53063-152 piR-39098-158 piR-47162-089 ARHGEF26-AS1 ARHGEF26 lnc-ARHGEF26-3
GH03J154320 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 8.2 +202.2 202248 4.5 ZBTB40 ZNF217 EP300 SIN3A TCF12 POLR2G SP1 GTF2E2 PHF8 JUND DHX36 lnc-ARHGEF26-2 lnc-ARHGEF26-8 ARHGEF26 ARHGEF26-AS1
GH03J154059 Enhancer 0.7 ENCODE 20.2 -60.5 -60542 2 ZNF217 CTBP1 ESRRA JUND ELF1 GATA3 FOXA1 PKNOX1 DPF2 RCOR1 ARHGEF26-AS1 ARHGEF26 piR-39098-158 lnc-ARHGEF26-3
GH03J154131 Enhancer 1.2 FANTOM5 Ensembl ENCODE 11.3 +11.1 11091 3.4 ZSCAN5C ZNF639 ZNF10 TRIM28 ATF2 OSR2 WT1 SP2 ZBTB17 TCF7L2 ARHGEF26-AS1 ARHGEF26 LOC105374167
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARHGEF26 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ARHGEF26

Genomic Locations for ARHGEF26 Gene

Genomic Locations for ARHGEF26 Gene
chr3:154,121,003-154,257,827
(GRCh38/hg38)
Size:
136,825 bases
Orientation:
Plus strand
chr3:153,838,792-153,975,616
(GRCh37/hg19)
Size:
136,825 bases
Orientation:
Plus strand

Genomic View for ARHGEF26 Gene

Genes around ARHGEF26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGEF26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGEF26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGEF26 Gene

Proteins for ARHGEF26 Gene

  • Protein details for ARHGEF26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DR7-ARHGQ_HUMAN
    Recommended name:
    Rho guanine nucleotide exchange factor 26
    Protein Accession:
    Q96DR7
    Secondary Accessions:
    • B3KVP8
    • E9PBD0
    • Q68CL1
    • Q6AZ96
    • Q6Q8Q8
    • Q96AW8
    • Q96DR6
    • Q9H9D7
    • Q9H9R2
    • Q9UFW5

    Protein attributes for ARHGEF26 Gene

    Size:
    871 amino acids
    Molecular mass:
    97346 Da
    Quaternary structure:
    • Interacts with ICAM1 and RHOG.
    SequenceCaution:
    • Sequence=AAH16628.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAL27002.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=BAB14159.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAB14292.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARHGEF26 Gene

    Alternative splice isoforms for ARHGEF26 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGEF26 Gene

Post-translational modifications for ARHGEF26 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGEF26 Gene

Antibody Products

  • Abcam antibodies for ARHGEF26
  • Santa Cruz Biotechnology (SCBT) Antibodies for ARHGEF26

No data available for DME Specific Peptides for ARHGEF26 Gene

Domains & Families for ARHGEF26 Gene

Gene Families for ARHGEF26 Gene

Protein Domains for ARHGEF26 Gene

Blocks:
  • DH domain
  • Pleckstrin-like
  • SH3 domain signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ARHGEF26 Gene

GenScript: Design optimal peptide antigens:
  • SH3 domain-containing guanine exchange factor (ARHGQ_HUMAN)
genes like me logo Genes that share domains with ARHGEF26: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ARHGEF26 Gene

Function for ARHGEF26 Gene

Molecular function for ARHGEF26 Gene

UniProtKB/Swiss-Prot Function:
Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry.
UniProtKB/Swiss-Prot Induction:
Certain mRNA species appear to be up-regulated by androgens in prostate cancer cells.

Phenotypes From GWAS Catalog for ARHGEF26 Gene

Gene Ontology (GO) - Molecular Function for ARHGEF26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with ARHGEF26: view
genes like me logo Genes that share phenotypes with ARHGEF26: view

Animal Models for ARHGEF26 Gene

MGI Knock Outs for ARHGEF26:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARHGEF26

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARHGEF26 Gene

Localization for ARHGEF26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGEF26 Gene

Cell projection, ruffle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGEF26 gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 3
cytoskeleton 2
extracellular 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARHGEF26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IEA --
GO:0005829 cytosol TAS --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with ARHGEF26: view

Pathways & Interactions for ARHGEF26 Gene

genes like me logo Genes that share pathways with ARHGEF26: view

Gene Ontology (GO) - Biological Process for ARHGEF26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001886 endothelial cell morphogenesis IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0035023 regulation of Rho protein signal transduction IEA --
GO:0043065 positive regulation of apoptotic process TAS --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGEF26: view

No data available for SIGNOR curated interactions for ARHGEF26 Gene

Drugs & Compounds for ARHGEF26 Gene

(1) Drugs for ARHGEF26 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with ARHGEF26: view

Transcripts for ARHGEF26 Gene

mRNA/cDNA for ARHGEF26 Gene

3 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARHGEF26

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF26 Gene

No ASD Table

Relevant External Links for ARHGEF26 Gene

GeneLoc Exon Structure for
ARHGEF26

Expression for ARHGEF26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARHGEF26 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARHGEF26 Gene

This gene is overexpressed in Plasma (66.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARHGEF26 Gene



Protein tissue co-expression partners for ARHGEF26 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ARHGEF26

SOURCE GeneReport for Unigene cluster for ARHGEF26 Gene:

Hs.240845

mRNA Expression by UniProt/SwissProt for ARHGEF26 Gene:

Q96DR7-ARHGQ_HUMAN
Tissue specificity: Isoform 1 is broadly expressed, with highest levels in liver (at protein level). Certain mRNA species appear to be specifically expressed in prostate and liver.

Evidence on tissue expression from TISSUES for ARHGEF26 Gene

  • Nervous system(4.5)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with ARHGEF26: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGEF26 Gene

Orthologs for ARHGEF26 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGEF26 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGEF26 31 30
  • 99.45 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ARHGEF26 31 30
  • 89 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ARHGEF26 31 30
  • 87.73 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arhgef26 30
  • 84.51 (n)
mouse
(Mus musculus)
Mammalia Arhgef26 17 31 30
  • 84.45 (n)
oppossum
(Monodelphis domestica)
Mammalia ARHGEF26 31
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 64 (a)
OneToMany
-- 31
  • 60 (a)
OneToMany
chicken
(Gallus gallus)
Aves ARHGEF26 31 30
  • 76.58 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARHGEF26 31
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgef26 30
  • 65.41 (n)
zebrafish
(Danio rerio)
Actinopterygii BX957353.1 31
  • 33 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Exn 31
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ephx-1 31
  • 22 (a)
OneToMany
Species where no ortholog for ARHGEF26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGEF26 Gene

ENSEMBL:
Gene Tree for ARHGEF26 (if available)
TreeFam:
Gene Tree for ARHGEF26 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ARHGEF26: view image

Paralogs for ARHGEF26 Gene

Paralogs for ARHGEF26 Gene

(3) SIMAP similar genes for ARHGEF26 Gene using alignment to 1 proteins:

  • ARHGQ_HUMAN
genes like me logo Genes that share paralogs with ARHGEF26: view

Variants for ARHGEF26 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ARHGEF26 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
689707 Uncertain Significance: Marfanoid habitus and intellectual disability 154,122,990(+) CGAA/C INFRAME_DELETION
rs12493885 - p.Val29Leu
rs12497267 - p.Leu60Pro
rs13096373 - p.Phe203Ser

Additional dbSNP identifiers (rs#s) for ARHGEF26 Gene

Structural Variations from Database of Genomic Variants (DGV) for ARHGEF26 Gene

Variant ID Type Subtype PubMed ID
esv1003556 CNV insertion 20482838
esv1286199 CNV insertion 17803354
esv2763308 CNV loss 21179565
esv3412820 CNV duplication 20981092
esv3598249 CNV loss 21293372
esv3598250 CNV gain 21293372
nsv1117034 CNV deletion 24896259
nsv1131740 CNV deletion 24896259
nsv1139170 CNV deletion 24896259
nsv4072 CNV insertion 18451855
nsv480100 CNV novel sequence insertion 20440878
nsv481083 CNV novel sequence insertion 20440878
nsv508962 CNV insertion 20534489

Variation tolerance for ARHGEF26 Gene

Residual Variation Intolerance Score: 76.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.25; 85.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARHGEF26 Gene

Human Gene Mutation Database (HGMD)
ARHGEF26
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARHGEF26

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGEF26 Gene

Disorders for ARHGEF26 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ARHGEF26 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
rett syndrome
  • rtt
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ARHGEF26

genes like me logo Genes that share disorders with ARHGEF26: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARHGEF26 Gene

Publications for ARHGEF26 Gene

  1. Isolation of the novel human guanine nucleotide exchange factor Src homology 3 domain-containing guanine nucleotide exchange factor (SGEF) and of C-terminal SGEF, an N-terminally truncated form of SGEF, the expression of which is regulated by androgen in prostate cancer cells. (PMID: 12697679) Qi H … Labrie C (Endocrinology 2003) 2 3 4 23 54
  2. SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis. (PMID: 15133129) Ellerbroek SM … Burridge K (Molecular biology of the cell 2004) 2 3 4 54
  3. Differential activation and function of Rho GTPases during Salmonella-host cell interactions. (PMID: 17074883) Patel JC … Galán JE (The Journal of cell biology 2006) 4 23 54
  4. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PMID: 15221005) Yamada S … Nakagawara A (Oncogene 2004) 3 4 54
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54

Products for ARHGEF26 Gene

Sources for ARHGEF26 Gene