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Aliases for ARHGEF26 Gene

Aliases for ARHGEF26 Gene

  • Rho Guanine Nucleotide Exchange Factor 26 2 3 5
  • Src Homology 3 Domain-Containing Guanine Nucleotide Exchange Factor 2 3
  • Rho Guanine Nucleotide Exchange Factor (GEF) 26 2 3
  • SH3 Domain-Containing Guanine Exchange Factor 3 4
  • SGEF 3 4
  • Testicular Tissue Protein Li 171 3
  • HMFN1864 3
  • CSGEF 3

External Ids for ARHGEF26 Gene

Previous GeneCards Identifiers for ARHGEF26 Gene

  • GC03P153839
  • GC03P151230

Summaries for ARHGEF26 Gene

Entrez Gene Summary for ARHGEF26 Gene

  • This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays a role in the promotion of macropinocytosis. Underexpression of the encoded protein may be a predictive marker of chemoresistant disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for ARHGEF26 Gene

ARHGEF26 (Rho Guanine Nucleotide Exchange Factor 26) is a Protein Coding gene. Among its related pathways are p75 NTR receptor-mediated signalling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF16.

UniProtKB/Swiss-Prot for ARHGEF26 Gene

  • Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry.

Additional gene information for ARHGEF26 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGEF26 Gene

Genomics for ARHGEF26 Gene

GeneHancer (GH) Regulatory Elements for ARHGEF26 Gene

Promoters and enhancers for ARHGEF26 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I154120 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 566.2 +1.2 1184 2.8 ARID4B SIN3A BMI1 RAD21 YY1 ZNF335 GLIS2 EGR1 ZNF366 EGR2 ARHGEF26 ARHGEF26-AS1 LOC105374167
GH03I154059 Enhancer 0.9 Ensembl ENCODE 20.2 -60.5 -60542 2 NCOA3 PKNOX1 ESRRA CLOCK E2F1 CTBP1 GATA3 RCOR1 SMARCE1 HLF ARHGEF26-AS1 ARHGEF26 GC03P154024
GH03I154089 Enhancer 0.6 ENCODE 25.6 -31.3 -31254 0.9 SMARCE1 PKNOX1 ESRRA CLOCK DPF2 ZBTB40 ZNF217 CTBP1 GATA3 JUND ARHGEF26-AS1 ARHGEF26 GC03P154024
GH03I154132 Enhancer 1.1 FANTOM5 ENCODE 11.1 +12.3 12296 1 PKNOX1 INSM2 KLF17 FEZF1 ZNF2 ZNF366 ZSCAN5C SCRT2 CEBPB OVOL3 ARHGEF26-AS1 ARHGEF26 LOC105374167
GH03I154322 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 4.5 +203.0 203005 3 PKNOX1 SMAD1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 DHX36 ARHGEF26-AS1 ARHGEF26 LOC105374167
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ARHGEF26 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ARHGEF26 Gene

Genomic Locations for ARHGEF26 Gene
chr3:154,121,003-154,257,827
(GRCh38/hg38)
Size:
136,825 bases
Orientation:
Plus strand
chr3:153,838,792-153,975,616
(GRCh37/hg19)

Genomic View for ARHGEF26 Gene

Genes around ARHGEF26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGEF26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGEF26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGEF26 Gene

Proteins for ARHGEF26 Gene

  • Protein details for ARHGEF26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DR7-ARHGQ_HUMAN
    Recommended name:
    Rho guanine nucleotide exchange factor 26
    Protein Accession:
    Q96DR7
    Secondary Accessions:
    • B3KVP8
    • E9PBD0
    • Q68CL1
    • Q6AZ96
    • Q6Q8Q8
    • Q96AW8
    • Q96DR6
    • Q9H9D7
    • Q9H9R2
    • Q9UFW5

    Protein attributes for ARHGEF26 Gene

    Size:
    871 amino acids
    Molecular mass:
    97346 Da
    Quaternary structure:
    • Interacts with ICAM1 and RHOG.
    SequenceCaution:
    • Sequence=AAH16628.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAL27002.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=BAB14159.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14292.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ARHGEF26 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGEF26 Gene

Post-translational modifications for ARHGEF26 Gene

No Post-translational modifications

Other Protein References for ARHGEF26 Gene

No data available for DME Specific Peptides for ARHGEF26 Gene

Domains & Families for ARHGEF26 Gene

Gene Families for ARHGEF26 Gene

Suggested Antigen Peptide Sequences for ARHGEF26 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARHGEF26: view

No data available for UniProtKB/Swiss-Prot for ARHGEF26 Gene

Function for ARHGEF26 Gene

Molecular function for ARHGEF26 Gene

UniProtKB/Swiss-Prot Function:
Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry.
UniProtKB/Swiss-Prot Induction:
Certain mRNA species appear to be up-regulated by androgens in prostate cancer cells.

Phenotypes From GWAS Catalog for ARHGEF26 Gene

Gene Ontology (GO) - Molecular Function for ARHGEF26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity TAS --
GO:0005089 Rho guanyl-nucleotide exchange factor activity TAS --
genes like me logo Genes that share ontologies with ARHGEF26: view
genes like me logo Genes that share phenotypes with ARHGEF26: view

Animal Models for ARHGEF26 Gene

MGI Knock Outs for ARHGEF26:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARHGEF26 Gene

Localization for ARHGEF26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGEF26 Gene

Cell projection, ruffle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGEF26 gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARHGEF26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IEA --
GO:0005829 cytosol TAS --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with ARHGEF26: view

Pathways & Interactions for ARHGEF26 Gene

genes like me logo Genes that share pathways with ARHGEF26: view

Gene Ontology (GO) - Biological Process for ARHGEF26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001886 endothelial cell morphogenesis IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0035023 regulation of Rho protein signal transduction IEA --
GO:0043065 positive regulation of apoptotic process TAS --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGEF26: view

No data available for SIGNOR curated interactions for ARHGEF26 Gene

Drugs & Compounds for ARHGEF26 Gene

(1) Drugs for ARHGEF26 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with ARHGEF26: view

Transcripts for ARHGEF26 Gene

Unigene Clusters for ARHGEF26 Gene

Rho guanine nucleotide exchange factor (GEF) 26:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF26 Gene

No ASD Table

Relevant External Links for ARHGEF26 Gene

GeneLoc Exon Structure for
ARHGEF26
ECgene alternative splicing isoforms for
ARHGEF26

Expression for ARHGEF26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARHGEF26 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARHGEF26 Gene

This gene is overexpressed in Plasma (66.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARHGEF26 Gene



Protein tissue co-expression partners for ARHGEF26 Gene

NURSA nuclear receptor signaling pathways regulating expression of ARHGEF26 Gene:

ARHGEF26

SOURCE GeneReport for Unigene cluster for ARHGEF26 Gene:

Hs.240845

mRNA Expression by UniProt/SwissProt for ARHGEF26 Gene:

Q96DR7-ARHGQ_HUMAN
Tissue specificity: Isoform 1 is broadly expressed, with highest levels in liver (at protein level). Certain mRNA species appear to be specifically expressed in prostate and liver.

Evidence on tissue expression from TISSUES for ARHGEF26 Gene

  • Nervous system(4.5)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with ARHGEF26: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGEF26 Gene

Orthologs for ARHGEF26 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGEF26 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGEF26 33 34
  • 99.45 (n)
cow
(Bos Taurus)
Mammalia ARHGEF26 33 34
  • 89 (n)
dog
(Canis familiaris)
Mammalia ARHGEF26 33 34
  • 87.73 (n)
rat
(Rattus norvegicus)
Mammalia Arhgef26 33
  • 84.51 (n)
mouse
(Mus musculus)
Mammalia Arhgef26 33 16 34
  • 84.45 (n)
oppossum
(Monodelphis domestica)
Mammalia ARHGEF26 34
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 64 (a)
OneToMany
-- 34
  • 60 (a)
OneToMany
chicken
(Gallus gallus)
Aves ARHGEF26 33 34
  • 76.58 (n)
lizard
(Anolis carolinensis)
Reptilia ARHGEF26 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgef26 33
  • 65.41 (n)
zebrafish
(Danio rerio)
Actinopterygii BX957353.1 34
  • 33 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Exn 34
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ephx-1 34
  • 22 (a)
OneToMany
Species where no ortholog for ARHGEF26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGEF26 Gene

ENSEMBL:
Gene Tree for ARHGEF26 (if available)
TreeFam:
Gene Tree for ARHGEF26 (if available)

Paralogs for ARHGEF26 Gene

Paralogs for ARHGEF26 Gene

(3) SIMAP similar genes for ARHGEF26 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARHGEF26: view

Variants for ARHGEF26 Gene

Sequence variations from dbSNP and Humsavar for ARHGEF26 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000024094 -- 154,230,741(+) G/T intron_variant
rs1000025926 -- 154,164,325(+) A/G intron_variant
rs1000053449 -- 154,230,340(+) C/A intron_variant
rs1000054707 -- 154,236,317(+) A/G intron_variant
rs1000110302 -- 154,182,175(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGEF26 Gene

Variant ID Type Subtype PubMed ID
nsv508962 CNV insertion 20534489
nsv481083 CNV novel sequence insertion 20440878
nsv480100 CNV novel sequence insertion 20440878
nsv4072 CNV insertion 18451855
nsv1139170 CNV deletion 24896259
nsv1131740 CNV deletion 24896259
nsv1117034 CNV deletion 24896259
esv3598250 CNV gain 21293372
esv3598249 CNV loss 21293372
esv3412820 CNV duplication 20981092
esv2763308 CNV loss 21179565
esv1286199 CNV insertion 17803354
esv1003556 CNV insertion 20482838

Variation tolerance for ARHGEF26 Gene

Residual Variation Intolerance Score: 76.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.25; 85.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARHGEF26 Gene

Human Gene Mutation Database (HGMD)
ARHGEF26
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARHGEF26

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGEF26 Gene

Disorders for ARHGEF26 Gene

Additional Disease Information for ARHGEF26

No disorders were found for ARHGEF26 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGEF26 Gene

Publications for ARHGEF26 Gene

  1. Isolation of the novel human guanine nucleotide exchange factor Src homology 3 domain-containing guanine nucleotide exchange factor (SGEF) and of C-terminal SGEF, an N-terminally truncated form of SGEF, the expression of which is regulated by androgen in prostate cancer cells. (PMID: 12697679) Qi H … Labrie C (Endocrinology 2003) 2 3 4 22 58
  2. SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis. (PMID: 15133129) Ellerbroek SM … Burridge K (Molecular biology of the cell 2004) 2 3 4 58
  3. Differential activation and function of Rho GTPases during Salmonella-host cell interactions. (PMID: 17074883) Patel JC … Galán JE (The Journal of cell biology 2006) 4 22 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PMID: 15221005) Yamada S … Nakagawara A (Oncogene 2004) 3 4 58

Products for ARHGEF26 Gene

Sources for ARHGEF26 Gene

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