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Rho GTPases alternate between an inactive GDP-bound state and an active GTP-bound state, and GEFs facilitate GDP/GTP exchange. This gene encodes a guanine nucleotide exchange factor (GEF) which interacts with Rho GTPases involved in contraction of vascular smooth muscles, regulation of responses to angiotensin II and lens cell differentiation. Multiple transcript variants encod... See more...
Aliases for ARHGEF25 Gene
Aliases for ARHGEF25 Gene
External Ids for ARHGEF25 Gene
- HGNC: 30275
- Entrez Gene: 115557
- Ensembl: ENSG00000240771
- OMIM: 610215
- UniProtKB: Q86VW2
Previous GeneCards Identifiers for ARHGEF25 Gene
- GC12P055041
- GC12P058004
Summaries for ARHGEF25 Gene
-
Rho GTPases alternate between an inactive GDP-bound state and an active GTP-bound state, and GEFs facilitate GDP/GTP exchange. This gene encodes a guanine nucleotide exchange factor (GEF) which interacts with Rho GTPases involved in contraction of vascular smooth muscles, regulation of responses to angiotensin II and lens cell differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
GeneCards Summary for ARHGEF25 Gene
ARHGEF25 (Rho Guanine Nucleotide Exchange Factor 25) is a Protein Coding gene. Diseases associated with ARHGEF25 include Atrophic Rhinitis. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is TRIO.
UniProtKB/Swiss-Prot Summary for ARHGEF25 Gene
-
May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis (By similarity).
Additional gene information for ARHGEF25 Gene
- HGNC(30275)
- Entrez Gene(115557)
- Ensembl(ENSG00000240771)
- OMIM(610215)
- UniProtKB(Q86VW2)
- Open Targets Platform(ENSG00000240771)
- Search for ARHGEF25 at DataMed
- Search for ARHGEF25 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARHGEF25 Gene
Genomics for ARHGEF25 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ARHGEF25 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ARHGEF25 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ARHGEF25
Genomic Locations for ARHGEF25 Gene
Genomic Locations for ARHGEF25 Gene
- chr12:57,610,116-57,617,245
- (GRCh38/hg38)
- Size:
- 7,130 bases
- Orientation:
- Plus strand
- chr12:58,003,963-58,013,162
- (GRCh37/hg19)
- Size:
- 9,200 bases
- Orientation:
- Plus strand
Genomic View for ARHGEF25 Gene
Genes around ARHGEF25 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.3 by HGNC
- 12q13.3 by Entrez Gene
- 12q13.3 by Ensembl
ARHGEF25 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ARHGEF25 Gene
Proteins for ARHGEF25 Gene
-
Protein details for ARHGEF25 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86VW2-ARHGP_HUMAN
- Recommended name:
- Rho guanine nucleotide exchange factor 25
- Protein Accession:
- Q86VW2
- A6NJH5
- A9CQZ6
- F8W7Z4
- Q8WV84
- Q96E63
Protein attributes for ARHGEF25 Gene
- Size:
- 580 amino acids
- Molecular mass:
- 63843 Da
- Quaternary structure:
-
- Interacts (via the DH domain) with BVES (via the C-terminus cytoplasmic tail) (By similarity). Interacts with activated GNAQ and GNA11. Interacts with RHOA, CDC42 and RAC1.
Protein Expression for ARHGEF25 Gene
Post-translational modifications for ARHGEF25 Gene
Other Protein References for ARHGEF25 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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-
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- antibodies-online: Show 3 available GEFT / P63RhoGEF Antibodies ranked by validation data
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No data available for DME Specific Peptides for ARHGEF25 Gene
Domains & Families for ARHGEF25 Gene
Gene Families for ARHGEF25 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for ARHGEF25 Gene
- InterPro:
- Blocks:
-
- Pleckstrin-like
- DH domain
- ProtoNet:
Suggested Antigen Peptide Sequences for ARHGEF25 Gene
- GenScript: Design optimal peptide antigens:
-
- RAC/CDC42/Rho exchange factor (A9CQZ6_HUMAN)
- p63RhoGEF (ARHGP_HUMAN)
- cDNA FLJ32854 fis, clone TESTI2003498, moderately similar to TRIPLE FUNCTIONAL DOMAIN PROTEIN (Q96M35_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q86VW2UniProtKB/Swiss-Prot:
ARHGP_HUMAN :- The guanine nucleotide exchange activity is autoinhibited by the PH domain.
- Domain:
-
- The guanine nucleotide exchange activity is autoinhibited by the PH domain.
Function for ARHGEF25 Gene
Molecular function for ARHGEF25 Gene
- UniProtKB/Swiss-Prot Function:
- May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis (By similarity).
Phenotypes From GWAS Catalog for ARHGEF25 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005085 | guanyl-nucleotide exchange factor activity | IEA | -- |
| GO:0005089 | Rho guanyl-nucleotide exchange factor activity | IEA | -- |
Phenotypes for ARHGEF25 Gene
- MGI mutant phenotypes for ARHGEF25:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ARHGEF25:
-
- no effect
- shRNA abundance <= 25%
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Increased ionizing radiation sensitivity
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Decreased viability
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Synthetic lethal with c-Myc after tamoxifen stimulation
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miRNA for ARHGEF25 Gene
- miRTarBase miRNAs that target ARHGEF25
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARHGEF25 Gene
Localization for ARHGEF25 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ARHGEF25 Gene
- Cell membrane. Cytoplasm, myofibril, sarcomere. Note=Highly colocalizes with actin regions.
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| cytosol | 4 |
| cytoskeleton | 2 |
| extracellular | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| golgi apparatus | 1 |
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | ISS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0030016 | myofibril | ISS | -- |
Pathways & Interactions for ARHGEF25 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by GPCR | ||
| 2 | RET signaling | ||
| 3 | Regulation of CDC42 activity | ||
| 4 | Regulation of RAC1 activity | ||
| 5 | Regulation of RhoA activity | ||
Pathways by source for ARHGEF25 Gene
3 BioSystems pathways for ARHGEF25 Gene
5 Reactome pathways for ARHGEF25 Gene
Interacting Proteins for ARHGEF25 Gene
GPS-Prot Interaction Network for ARHGEF25
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007186 | G protein-coupled receptor signaling pathway | TAS | -- |
| GO:0035023 | regulation of Rho protein signal transduction | IEA | -- |
Transcripts for ARHGEF25 Gene
mRNA/cDNA for ARHGEF25 Gene
- 4 REFSEQ mRNAs :
- 7 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000333972 2246 nts (view in UCSC)
- ENST00000286494 2554 nts (view in UCSC)
- ENST00000471370 1945 nts (view in UCSC)
- ENST00000469072 668 nts (view in UCSC)
- ENST00000466399 593 nts (view in UCSC)
CRISPR Products
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- MG204889
- MG216788
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- MR216788L4
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Relevant External Links for ARHGEF25 Gene
- GeneLoc Exon Structure for
- ARHGEF25
Expression for ARHGEF25 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
- Testicular Interstitial Cells Testis Interstitium
- Eye (Sensory Organs)
This gene is overexpressed in Colon (20.8), Urinary Bladder (19.2), Cervix (7.6), and Ovary (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ARHGEF25 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ARHGEF25
SOURCE GeneReport for Unigene cluster for ARHGEF25 Gene:
Hs.61581mRNA Expression by UniProt/SwissProt for ARHGEF25 Gene:
Q86VW2-ARHGP_HUMAN
Tissue specificity:
Isoform 1 and isoform 2 are highly expressed in excitable tissues, such as brain, heart and muscle. Also detected in kidney and liver.
Evidence on tissue expression from TISSUES for ARHGEF25 Gene
- Nervous system(4.7)
- Muscle(2.4)
- Heart(2.3)
- Kidney(2.2)
Primer Products
-
OriGene qPCR primer pairs for ARHGEF25
-
OriGene qPCR primer pairs and template standards for ARHGEF25
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGEF25 Gene
Orthologs for ARHGEF25 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ARHGEF25 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | GEFT 31 |
|
OneToOne | |
| ARHGEF25 30 |
|
||||
| Dog (Canis familiaris) |
Mammalia | ARHGEF25 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Arhgef25 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Arhgef25 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ARHGEF25 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| Zebrafish (Danio rerio) |
Actinopterygii | ARHGEF25 (2 of 2) 31 |
|
OneToMany | |
| arhgef25b 31 |
|
OneToMany | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | trio 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for ARHGEF25 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for ARHGEF25 Gene
- ENSEMBL:
- Gene Tree for ARHGEF25 (if available)
- TreeFam:
- Gene Tree for ARHGEF25 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ARHGEF25: view image
Paralogs for ARHGEF25 Gene
Paralogs for ARHGEF25 Gene
(3) SIMAP similar genes for ARHGEF25 Gene using alignment to 1 proteins:
- ARHGP_HUMAN
Variants for ARHGEF25 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ARHGEF25 Gene
| SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 768558 | Benign: not provided | 57,616,380(+) | A/. | NON_CODING_TRANSCRIPT_VARIANT,NO_SEQUENCE_ALTERATION | |
| rs193921117 | Uncertain Significance: Malignant tumor of prostate | 57,614,324(+) | C/A | INTRON_VARIANT | |
| rs1564374 | - | p.Gln506Arg | |||
| rs17854492 | - | p.Gly397Arg | |||
| rs17857333 | - | p.Cys253Tyr |
Residual Variation Intolerance Score:
44% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.00;
49.87% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ARHGEF25 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ARHGEF25
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGEF25 Gene
Disorders for ARHGEF25 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| atrophic rhinitis |
|
|
Search ARHGEF25 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ARHGEF25
No data available for UniProtKB/Swiss-Prot and Genatlas for ARHGEF25 Gene
Publications for ARHGEF25 Gene
- A Rac/Cdc42-specific exchange factor, GEFT, induces cell proliferation, transformation, and migration. (PMID: 12547822) Guo X … Liu M (The Journal of biological chemistry 2003) 2 3 4 23
- p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene. (PMID: 15069594) Lutz S … Wieland T (Naunyn-Schmiedeberg's archives of pharmacology 2004) 3 4 23
- Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs. (PMID: 18096806) Lutz S … Tesmer JJ (Science (New York, N.Y.) 2007) 3 4
- Modulation of muscle regeneration, myogenesis, and adipogenesis by the Rho family guanine nucleotide exchange factor GEFT. (PMID: 16314529) Bryan BA … Liu M (Molecular and cellular biology 2005) 3 4
- The guanine nucleotide exchange factor p63RhoGEF, a specific link between Gq/11-coupled receptor signaling and RhoA. (PMID: 15632174) Lutz S … Wieland T (The Journal of biological chemistry 2005) 3 4
ExternalLinks
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- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ARHGEF25
- Search GeneCopoeia for miRNA 3'UTR Target clone products for ARHGEF25
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARHGEF25
Sources for ARHGEF25 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB