Aliases for ARHGEF25 Gene
External Ids for ARHGEF25 Gene
Previous GeneCards Identifiers for ARHGEF25 Gene
Rho GTPases alternate between an inactive GDP-bound state and an active GTP-bound state, and GEFs facilitate GDP/GTP exchange. This gene encodes a guanine nucleotide exchange factor (GEF) which interacts with Rho GTPases involved in contraction of vascular smooth muscles, regulation of responses to angiotensin II and lens cell differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
GeneCards Summary for ARHGEF25 Gene
ARHGEF25 (Rho Guanine Nucleotide Exchange Factor 25) is a Protein Coding gene. Diseases associated with ARHGEF25 include Moyamoya Angiopathy and Atrophic Rhinitis. Among its related pathways are Signaling by GPCR and Regulation of RAC1 activity. Gene Ontology (GO) annotations related to this gene include Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is TRIO.
UniProtKB/Swiss-Prot Summary for ARHGEF25 Gene
May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis (By similarity).