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Aliases for ARHGEF19 Gene

Aliases for ARHGEF19 Gene

  • Rho Guanine Nucleotide Exchange Factor 19 2 3 3 4 5
  • Rho Guanine Nucleotide Exchange Factor (GEF) 19 2 3
  • Ephexin-2 3 4
  • Ephexin2 2 3
  • Weakly Similar To Rho GEF 3
  • WGEF 3

External Ids for ARHGEF19 Gene

Previous GeneCards Identifiers for ARHGEF19 Gene

  • GC01M015908
  • GC01M016273
  • GC01M016397
  • GC01M016524
  • GC01M015042

Summaries for ARHGEF19 Gene

Entrez Gene Summary for ARHGEF19 Gene

  • Guanine nucleotide exchange factors (GEFs) such as ARHGEF19 accelerate the GTPase activity of Rho GTPases (see RHOA, MIM 165390).[supplied by OMIM, Dec 2008]

GeneCards Summary for ARHGEF19 Gene

ARHGEF19 (Rho Guanine Nucleotide Exchange Factor 19) is a Protein Coding gene. Among its related pathways are Signaling by Rho GTPases and p75 NTR receptor-mediated signalling. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF5.

UniProtKB/Swiss-Prot for ARHGEF19 Gene

Additional gene information for ARHGEF19 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGEF19 Gene

Genomics for ARHGEF19 Gene

GeneHancer (GH) Regulatory Elements for ARHGEF19 Gene

Promoters and enhancers for ARHGEF19 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARHGEF19 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARHGEF19 gene promoter:
  • AhR
  • AP-2alpha
  • AP-2beta
  • AREB6
  • GATA-1
  • MyoD
  • MZF-1
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2

Genomic Locations for ARHGEF19 Gene

Genomic Locations for ARHGEF19 Gene
chr1:16,197,854-16,212,671
(GRCh38/hg38)
Size:
14,818 bases
Orientation:
Minus strand
chr1:16,524,349-16,539,104
(GRCh37/hg19)
Size:
14,756 bases
Orientation:
Minus strand

Genomic View for ARHGEF19 Gene

Genes around ARHGEF19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGEF19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGEF19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGEF19 Gene

Proteins for ARHGEF19 Gene

  • Protein details for ARHGEF19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IW93-ARHGJ_HUMAN
    Recommended name:
    Rho guanine nucleotide exchange factor 19
    Protein Accession:
    Q8IW93
    Secondary Accessions:
    • A6NJ04
    • Q5TEV2
    • Q6PJQ4
    • Q8N244

    Protein attributes for ARHGEF19 Gene

    Size:
    802 amino acids
    Molecular mass:
    89197 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ARHGEF19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGEF19 Gene

Post-translational modifications for ARHGEF19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGEF19 Gene

No data available for DME Specific Peptides for ARHGEF19 Gene

Domains & Families for ARHGEF19 Gene

Gene Families for ARHGEF19 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ARHGEF19 Gene

GenScript: Design optimal peptide antigens:
  • Ephexin-2 (ARHGJ_HUMAN)
  • cDNA FLJ60716, highly similar to Homo sapiens Rho guanine nucleotide exchange factor (GEF) 19 (ARHGEF19), mRNA (B4DN02_HUMAN)
  • Rho guanine nucleotide exchange factor (GEF) 19 (Q5TEV0_HUMAN)
  • Rho guanine nucleotide exchange factor (GEF) 19 (Q5TEV1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARHGEF19: view

No data available for UniProtKB/Swiss-Prot for ARHGEF19 Gene

Function for ARHGEF19 Gene

Molecular function for ARHGEF19 Gene

UniProtKB/Swiss-Prot Function:
Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase.

Phenotypes From GWAS Catalog for ARHGEF19 Gene

Gene Ontology (GO) - Molecular Function for ARHGEF19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA --
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IPI 18256687
genes like me logo Genes that share ontologies with ARHGEF19: view
genes like me logo Genes that share phenotypes with ARHGEF19: view

Animal Model Products

CRISPR Products

miRNA for ARHGEF19 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARHGEF19

Clone Products

  • Applied Biological Materials (abm): Clones for ARHGEF19 - Now 50% OFF >
  • * ARHGEF19 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ARHGEF19 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARHGEF19 Gene

Localization for ARHGEF19 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGEF19 gene
Compartment Confidence
cytosol 4
nucleus 3
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARHGEF19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ARHGEF19: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARHGEF19 Gene

Pathways & Interactions for ARHGEF19 Gene

genes like me logo Genes that share pathways with ARHGEF19: view

Gene Ontology (GO) - Biological Process for ARHGEF19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0032956 regulation of actin cytoskeleton organization IGI 20643356
GO:0035023 regulation of Rho protein signal transduction IEA --
GO:0042060 wound healing IEA --
GO:0043065 positive regulation of apoptotic process TAS --
genes like me logo Genes that share ontologies with ARHGEF19: view

No data available for SIGNOR curated interactions for ARHGEF19 Gene

Drugs & Compounds for ARHGEF19 Gene

No Compound Related Data Available

Transcripts for ARHGEF19 Gene

mRNA/cDNA for ARHGEF19 Gene

Unigene Clusters for ARHGEF19 Gene

Rho guanine nucleotide exchange factor (GEF) 19:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARHGEF19

Clone Products

  • Applied Biological Materials (abm): Clones for ARHGEF19 - Now 50% OFF >
  • * ARHGEF19 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ARHGEF19 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF19 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ·
SP1: - - -
SP2: - - -
SP3: - - - -
SP4: -
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10: - -
SP11: - - -
SP12:
SP13: - -
SP14:

ExUns: 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for ARHGEF19 Gene

GeneLoc Exon Structure for
ARHGEF19
ECgene alternative splicing isoforms for
ARHGEF19

Expression for ARHGEF19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARHGEF19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGEF19 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x5.2) and Skin - Sun Exposed (Lower leg) (x4.1).

Protein differential expression in normal tissues from HIPED for ARHGEF19 Gene

This gene is overexpressed in Prostate (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ARHGEF19 Gene



Protein tissue co-expression partners for ARHGEF19 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARHGEF19 Gene:

ARHGEF19

SOURCE GeneReport for Unigene cluster for ARHGEF19 Gene:

Hs.591532

Evidence on tissue expression from TISSUES for ARHGEF19 Gene

  • Intestine(4.1)
  • Pancreas(4.1)
genes like me logo Genes that share expression patterns with ARHGEF19: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGEF19 Gene

Orthologs for ARHGEF19 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGEF19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGEF19 35 34
  • 99.63 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ARHGEF19 35 34
  • 88.15 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ARHGEF19 35 34
  • 87.97 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgef19 17 35 34
  • 83.06 (n)
rat
(Rattus norvegicus)
Mammalia Arhgef19 34
  • 82.67 (n)
oppossum
(Monodelphis domestica)
Mammalia ARHGEF19 35
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGEF19 35
  • 50 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398522 34
zebrafish
(Danio rerio)
Actinopterygii arhgef19 35 34
  • 63.94 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Exn 35
  • 10 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ephx-1 35
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 33 (a)
OneToMany
Species where no ortholog for ARHGEF19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ARHGEF19 Gene

ENSEMBL:
Gene Tree for ARHGEF19 (if available)
TreeFam:
Gene Tree for ARHGEF19 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ARHGEF19: view image

Paralogs for ARHGEF19 Gene

Paralogs for ARHGEF19 Gene

(6) SIMAP similar genes for ARHGEF19 Gene using alignment to 3 proteins:

  • ARHGJ_HUMAN
  • H0Y4D8_HUMAN
  • Q5TEV0_HUMAN
genes like me logo Genes that share paralogs with ARHGEF19: view

Variants for ARHGEF19 Gene

Sequence variations from dbSNP and Humsavar for ARHGEF19 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000318516 -- 16,197,731(-) C/T downstream_transcript_variant
rs1000517280 -- 16,210,494(-) A/T intron_variant
rs1000763281 -- 16,204,212(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000780016 -- 16,197,487(-) T/C downstream_transcript_variant
rs1000982603 -- 16,204,018(-) T/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGEF19 Gene

Variant ID Type Subtype PubMed ID
esv3585332 CNV loss 21293372
nsv470699 CNV loss 18288195
nsv524045 CNV loss 19592680
nsv545641 CNV loss 21841781
nsv833869 CNV loss 17160897

Variation tolerance for ARHGEF19 Gene

Residual Variation Intolerance Score: 74.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.02; 92.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARHGEF19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARHGEF19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGEF19 Gene

Disorders for ARHGEF19 Gene

Additional Disease Information for ARHGEF19

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ARHGEF19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGEF19 Gene

Publications for ARHGEF19 Gene

  1. Epigenetic regulation of adipocyte differentiation by a Rho guanine nucleotide exchange factor, WGEF. (PMID: 19503838) Horii T … Hatada I (PloS one 2009) 2 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. ARHGEF19 interacts with BRAF to activate MAPK signaling during the tumorigenesis of non-small cell lung cancer. (PMID: 29164615) Li Y … Huang W (International journal of cancer 2018) 3 58
  4. miR-503 regulates metastatic function through Rho guanine nucleotide exchanger factor 19 in hepatocellular carcinoma. (PMID: 24405610) Zhou J … Wang W (The Journal of surgical research 2014) 3 58
  5. Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease. (PMID: 24431302) Arenas E (Journal of molecular cell biology 2014) 3 58

Products for ARHGEF19 Gene

Sources for ARHGEF19 Gene

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