Aliases for ARHGEF17 Gene
Aliases for ARHGEF17 Gene
External Ids for ARHGEF17 Gene
- HGNC: 21726
- Entrez Gene: 9828
- Ensembl: ENSG00000110237
- OMIM: 617043
- UniProtKB: Q96PE2
Previous GeneCards Identifiers for ARHGEF17 Gene
- GC11P073242
- GC11P072745
- GC11P072697
- GC11P073019
- GC11P069314
Summaries for ARHGEF17 Gene
GeneCards Summary for ARHGEF17 Gene
ARHGEF17 (Rho Guanine Nucleotide Exchange Factor 17) is a Protein Coding gene. Diseases associated with ARHGEF17 include Rectum Adenocarcinoma. Among its related pathways are p75 NTR receptor-mediated signalling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include actin filament binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is SPAG9.
UniProtKB/Swiss-Prot for ARHGEF17 Gene
-
Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases.
Additional gene information for ARHGEF17 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGEF17 Gene
Genomics for ARHGEF17 Gene
GeneHancer (GH) Regulatory Elements for ARHGEF17 Gene
Promoters and enhancers for ARHGEF17 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ARHGEF17 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for ARHGEF17 Gene
Genomic Locations for ARHGEF17 Gene
- chr11:73,305,939-73,369,380
- (GRCh38/hg38)
- Size:
- 63,442 bases
- Orientation:
- Plus strand
- chr11:73,019,334-73,080,425
- (GRCh37/hg19)
Genomic View for ARHGEF17 Gene
Genes around ARHGEF17 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.4 by Ensembl
- 11q13.4 by Entrez Gene
- 11q13.4 by HGNC
ARHGEF17 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ARHGEF17 Gene
Proteins for ARHGEF17 Gene
-
Protein details for ARHGEF17 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96PE2-ARHGH_HUMAN
- Recommended name:
- Rho guanine nucleotide exchange factor 17
- Protein Accession:
- Q96PE2
- B2RP20
- Q86XU2
- Q8N2S0
- Q9Y4G3
Protein attributes for ARHGEF17 Gene
- Size:
- 2063 amino acids
- Molecular mass:
- 221673 Da
- Quaternary structure:
- No Data Available
Protein Expression for ARHGEF17 Gene
Post-translational modifications for ARHGEF17 Gene
Other Protein References for ARHGEF17 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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-
Abcam antibodies for ARHGEF17
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-
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Assay Products
No data available for DME Specific Peptides for ARHGEF17 Gene
Domains & Families for ARHGEF17 Gene
Gene Families for ARHGEF17 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for ARHGEF17 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ARHGEF17 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for ARHGEF17 Gene
Function for ARHGEF17 Gene
Molecular function for ARHGEF17 Gene
- UniProtKB/Swiss-Prot Function:
- Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases.
Phenotypes From GWAS Catalog for ARHGEF17 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005085 | guanyl-nucleotide exchange factor activity | TAS | -- |
| GO:0005089 | Rho guanyl-nucleotide exchange factor activity | TAS | -- |
Phenotypes for ARHGEF17 Gene
- GenomeRNAi human phenotypes for ARHGEF17:
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miRNA for ARHGEF17 Gene
- miRTarBase miRNAs that target ARHGEF17
-
- hsa-mir-452-3p (MIRT539124)
- hsa-mir-4666a-5p (MIRT539125)
- hsa-mir-4320 (MIRT539126)
- hsa-mir-4708-3p (MIRT539127)
- hsa-mir-2276-3p (MIRT539128)
- hsa-mir-4772-3p (MIRT539129)
- hsa-mir-7153-3p (MIRT539130)
- hsa-mir-361-3p (MIRT539131)
- hsa-mir-5685 (MIRT539132)
- hsa-mir-4690-3p (MIRT539133)
- hsa-mir-6834-3p (MIRT539134)
miRNA Products
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-
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- Mammalian expression: PiggyBac
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- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
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-
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARHGEF17 Gene
Localization for ARHGEF17 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 2 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| peroxisome | 1 |
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARHGEF17 Gene
Pathways & Interactions for ARHGEF17 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | p75 NTR receptor-mediated signalling |
.36
|
|
| 2 | Signaling by GPCR | ||
| 3 | Signaling by Rho GTPases | ||
| 4 | RET signaling | ||
| 5 | Regulation of RhoA activity | ||
Pathways by source for ARHGEF17 Gene
1 BioSystems pathway for ARHGEF17 Gene
10 Reactome pathways for ARHGEF17 Gene
Interacting Proteins for ARHGEF17 Gene
Selected Interacting proteins:
Q96PE2-ARHGH_HUMAN
ENSP00000263674
for ARHGEF17 Gene via
IID
STRING
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | -- |
| GO:0030036 | actin cytoskeleton organization | IDA | 12071859 |
| GO:0035023 | regulation of Rho protein signal transduction | IEA | -- |
| GO:0043065 | positive regulation of apoptotic process | TAS | -- |
| GO:0051056 | regulation of small GTPase mediated signal transduction | TAS | -- |
No data available for SIGNOR curated interactions for ARHGEF17 Gene
Transcripts for ARHGEF17 Gene
mRNA/cDNA for ARHGEF17 Gene
- (3) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (179) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ARHGEF17 Gene
- Rho guanine nucleotide exchange factor (GEF) 17:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for ARHGEF17
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Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA Products
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Inhibitory RNA Products
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Clone Products
- VectorBuilder custom plasmid, inducible vectors for ARHGEF17
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ARHGEF17
- genomics-online: cdna clones - Search results for available ARHGEF17 gene related products
- orf clones - Search results for available ARHGEF17 gene related products
- Applied Biological Materials Clones for ARHGEF17
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for ARHGEF17 Gene
This gene is overexpressed in Fetal Brain (15.6), Retina (10.1), Pancreas (9.1), and Placenta (8.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARHGEF17 Gene
NURSA nuclear receptor signaling pathways regulating expression of ARHGEF17 Gene:
ARHGEF17SOURCE GeneReport for Unigene cluster for ARHGEF17 Gene:
Hs.533719mRNA Expression by UniProt/SwissProt for ARHGEF17 Gene:
Q96PE2-ARHGH_HUMAN
Tissue specificity:
Highly expressed in the heart.
Evidence on tissue expression from TISSUES for ARHGEF17 Gene
- Nervous system(4.7)
- Intestine(4.3)
- Liver(4.2)
Primer Products
-
OriGene qPCR primer pairs for ARHGEF17
- genomics-online: primer clones - Search results for available ARHGEF17 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGEF17 Gene
Orthologs for ARHGEF17 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ARHGEF17 33 |
|
||
| dog (Canis familiaris) |
Mammalia | ARHGEF17 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | ARHGEF17 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Arhgef17 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Arhgef17 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | ARHGEF17 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ARHGEF17 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ARHGEF17 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | arhgef17 33 |
|
||
| Str.10835 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | si:ch211-248g20.5 33 |
|
||
| ARHGEF17 (1 of 2) 34 |
|
OneToMany | |||
| ARHGEF17 (2 of 2) 34 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | CG43102 34 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | R02F2.2 34 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.6460 33 |
|
- Species where no ortholog for ARHGEF17 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ARHGEF17 Gene
Variants for ARHGEF17 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000000967 | -- | 73,337,463(+) | A/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000035966 | -- | 73,326,179(+) | A/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000112477 | -- | 73,327,670(+) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000123884 | -- | 73,322,465(+) | T/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000163021 | -- | 73,366,826(+) | G/A | intron_variant |
Residual Variation Intolerance Score:
3.67% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
11.44;
92.82% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ARHGEF17 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGEF17 Gene
Disorders for ARHGEF17 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| rectum adenocarcinoma |
|
|
Search ARHGEF17 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ARHGEF17
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ARHGEF17 Gene
Publications for ARHGEF17 Gene
- A mammalian Rho-specific guanine-nucleotide exchange factor (p164-RhoGEF) without a pleckstrin homology domain. (PMID: 12071859) Rümenapp U … Wieland T (The Biochemical journal 2002) 2 3 4 22 58
- Cell surface tumor endothelial markers are conserved in mice and humans. (PMID: 11559528) Carson-Walter EB … St Croix B (Cancer research 2001) 2 3 4 58
- Mutation of ARHGAP9 in patients with coronary spastic angina. (PMID: 19911011) Takefuji M … Kaibuchi K (Journal of human genetics 2010) 3 44 58
- Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
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- Mammalian expression: PiggyBac
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- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
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Sources for ARHGEF17 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
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