Aliases for ARHGEF16 Gene
External Ids for ARHGEF16 Gene
Previous GeneCards Identifiers for ARHGEF16 Gene
Although the specific function of this protein is not known yet, it is thought to be involved in protein-protein and protein-lipid interactions. [provided by RefSeq, Jul 2008]
GeneCards Summary for ARHGEF16 Gene
ARHGEF16 (Rho Guanine Nucleotide Exchange Factor 16) is a Protein Coding gene. Diseases associated with ARHGEF16 include Locked-In Syndrome and Chromosome 1P36 Deletion Syndrome. Among its related pathways are Guidance Cues and Growth Cone Motility and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include PDZ domain binding and receptor tyrosine kinase binding. An important paralog of this gene is ARHGEF26.
UniProtKB/Swiss-Prot Summary for ARHGEF16 Gene
Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6.