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Aliases for ARHGEF16 Gene

Aliases for ARHGEF16 Gene

  • Rho Guanine Nucleotide Exchange Factor 16 2 3 3 4 5
  • Rho Guanine Nucleotide Exchange Factor (GEF) 16 2 3
  • Ephexin-4 3 4
  • Ephexin4 2 3
  • NBR 3 4
  • Rho Guanine Exchange Factor (GEF) 16 3
  • Putative Neuroblastoma Protein 2
  • EPHEXIN4 4
  • GEF16 3

External Ids for ARHGEF16 Gene

Previous GeneCards Identifiers for ARHGEF16 Gene

  • GC01P002818
  • GC01P003328
  • GC01P002945
  • GC01P003154
  • GC01P003163
  • GC01P003394
  • GC01P002663
  • GC01P003370

Summaries for ARHGEF16 Gene

Entrez Gene Summary for ARHGEF16 Gene

  • Although the specific function of this protein is not known yet, it is thought to be involved in protein-protein and protein-lipid interactions. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARHGEF16 Gene

ARHGEF16 (Rho Guanine Nucleotide Exchange Factor 16) is a Protein Coding gene. Diseases associated with ARHGEF16 include Frontal Sinusitis. Among its related pathways are Signaling by Rho GTPases and GPCR Pathway. Gene Ontology (GO) annotations related to this gene include PDZ domain binding and receptor tyrosine kinase binding. An important paralog of this gene is ARHGEF26.

UniProtKB/Swiss-Prot for ARHGEF16 Gene

  • Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6.

Additional gene information for ARHGEF16 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGEF16 Gene

Genomics for ARHGEF16 Gene

GeneHancer (GH) Regulatory Elements for ARHGEF16 Gene

Promoters and enhancers for ARHGEF16 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J003470 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 608.2 +17.0 16987 1.9 SP1 CTCF ZNF148 POLR2A AHR TFE3 HNF1A PPARG SP5 KLF14 ARHGEF16 MEGF6 ENSG00000272088 GC01M003454 GC01P003264
GH01J003453 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 21.6 +3.1 3050 8.8 ELF3 CTCF ZNF148 ZNF121 AHR TFE3 SP7 SP1 PPARG SP5 ARHGEF16 WRAP73 TP73-AS1 ENSG00000272153 C1orf174 GC01M003454 ENSG00000272088 GC01P003264
GH01J003479 Enhancer 1.2 Ensembl ENCODE dbSUPER 17.2 +26.8 26822 4.4 NCOA3 SP1 CREB1 RXRA ZIC2 CTCF CTBP1 MNT CEBPB JUN ARHGEF16 MEGF6 TPRG1L ENSG00000238260 TP73 WRAP73 ENSG00000272088 GC01M003454
GH01J003483 Enhancer 1.1 Ensembl ENCODE dbSUPER 13.8 +29.4 29418 0.4 CTCF KAT8 ZNF600 GATAD2A REST KLF7 PATZ1 POLR2A TRIM22 ZBTB26 ARHGEF16 MEGF6 TPRG1L ENSG00000238260 TP73 WRAP73 ENSG00000272088 GC01M003454
GH01J003393 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 6 -60.8 -60782 1.2 SP7 MZF1 GLIS2 PKNOX1 ZBTB8A ZNF600 PRDM10 ZIC2 KLF7 ZNF692 GC01P003395 ARHGEF16 PRDM16 GC01M003384 GC01P003264
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARHGEF16 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARHGEF16 gene promoter:
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma

Genomic Locations for ARHGEF16 Gene

Genomic Locations for ARHGEF16 Gene
chr1:3,454,583-3,481,115
(GRCh38/hg38)
Size:
26,533 bases
Orientation:
Plus strand
chr1:3,370,990-3,397,677
(GRCh37/hg19)
Size:
26,688 bases
Orientation:
Plus strand

Genomic View for ARHGEF16 Gene

Genes around ARHGEF16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGEF16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGEF16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGEF16 Gene

Proteins for ARHGEF16 Gene

  • Protein details for ARHGEF16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VV41-ARHGG_HUMAN
    Recommended name:
    Rho guanine nucleotide exchange factor 16
    Protein Accession:
    Q5VV41
    Secondary Accessions:
    • Q86TF0
    • Q99434

    Protein attributes for ARHGEF16 Gene

    Size:
    709 amino acids
    Molecular mass:
    80105 Da
    Quaternary structure:
    • Interacts with ELMO2, EPHA2, RAC1 and RHOG; mediates activation of RAC1 by EPHA2. Interacts with TAX1BP3 (via PDZ domain). May interact with CDC42; stimulated by HPV16 E6.
    SequenceCaution:
    • Sequence=AAH02681.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARHGEF16 Gene

    Alternative splice isoforms for ARHGEF16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGEF16 Gene

Post-translational modifications for ARHGEF16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARHGEF16 Gene

Domains & Families for ARHGEF16 Gene

Gene Families for ARHGEF16 Gene

Protein Domains for ARHGEF16 Gene

Suggested Antigen Peptide Sequences for ARHGEF16 Gene

GenScript: Design optimal peptide antigens:
  • Ephexin-4 (ARHGG_HUMAN)
  • cDNA FLJ52867, highly similar to Rho guanine nucleotide exchange factor 16 (B4DJM7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5VV41

UniProtKB/Swiss-Prot:

ARHGG_HUMAN :
  • The PDZ-binding motif mediates interaction with TAX1BP3.
Domain:
  • The PDZ-binding motif mediates interaction with TAX1BP3.
genes like me logo Genes that share domains with ARHGEF16: view

Function for ARHGEF16 Gene

Molecular function for ARHGEF16 Gene

UniProtKB/Swiss-Prot Function:
Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6.
UniProtKB/Swiss-Prot Induction:
Up-regulated by HPV16 E6 (at protein level).

Phenotypes From GWAS Catalog for ARHGEF16 Gene

Gene Ontology (GO) - Molecular Function for ARHGEF16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA,IDA 20679435
GO:0005515 protein binding IPI 20679435
GO:0017048 Rho GTPase binding IPI 20679435
GO:0030165 PDZ domain binding IPI 21139582
GO:0030971 receptor tyrosine kinase binding IPI 20679435
genes like me logo Genes that share ontologies with ARHGEF16: view
genes like me logo Genes that share phenotypes with ARHGEF16: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARHGEF16

Clone Products

  • Applied Biological Materials (abm): Clones for ARHGEF16 - Now 50% OFF >
  • * ARHGEF16 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ARHGEF16 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ARHGEF16 Gene

Localization for ARHGEF16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGEF16 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGEF16 gene
Compartment Confidence
cytosol 4
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for ARHGEF16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ARHGEF16: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ARHGEF16 Gene

Pathways & Interactions for ARHGEF16 Gene

genes like me logo Genes that share pathways with ARHGEF16: view

Gene Ontology (GO) - Biological Process for ARHGEF16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0035023 regulation of Rho protein signal transduction IEA --
GO:0043065 positive regulation of apoptotic process TAS --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
GO:0060326 cell chemotaxis IMP 20679435
genes like me logo Genes that share ontologies with ARHGEF16: view

No data available for SIGNOR curated interactions for ARHGEF16 Gene

Drugs & Compounds for ARHGEF16 Gene

No Compound Related Data Available

Transcripts for ARHGEF16 Gene

mRNA/cDNA for ARHGEF16 Gene

Unigene Clusters for ARHGEF16 Gene

Rho guanine nucleotide exchange factor (GEF) 16:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARHGEF16

Clone Products

  • Applied Biological Materials (abm): Clones for ARHGEF16 - Now 50% OFF >
  • * ARHGEF16 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ARHGEF16 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF16 Gene

No ASD Table

Relevant External Links for ARHGEF16 Gene

GeneLoc Exon Structure for
ARHGEF16
ECgene alternative splicing isoforms for
ARHGEF16

Expression for ARHGEF16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARHGEF16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGEF16 Gene

This gene is overexpressed in Colon - Transverse (x6.4) and Kidney - Cortex (x4.4).

Protein differential expression in normal tissues from HIPED for ARHGEF16 Gene

This gene is overexpressed in Stomach (18.9), Colon (18.4), and Pancreas (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARHGEF16 Gene



NURSA nuclear receptor signaling pathways regulating expression of ARHGEF16 Gene:

ARHGEF16

SOURCE GeneReport for Unigene cluster for ARHGEF16 Gene:

Hs.87435

Evidence on tissue expression from TISSUES for ARHGEF16 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ARHGEF16: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGEF16 Gene

Orthologs for ARHGEF16 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGEF16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGEF16 35 34
  • 98.03 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ARHGEF16 35 34
  • 86.24 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ARHGEF16 35 34
  • 84.18 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARHGEF16 35
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgef16 17 34 35
  • 80.96 (n)
rat
(Rattus norvegicus)
Mammalia Arhgef16 34
  • 80.91 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGEF16 35
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARHGEF16 35 34
  • 69.57 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARHGEF16 35
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16153 34
zebrafish
(Danio rerio)
Actinopterygii arhgef16 34 35
  • 61.51 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5334 34
fruit fly
(Drosophila melanogaster)
Insecta BcDNA:GH03693 36
  • 33 (a)
Exn 35
  • 10 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-218 34
  • 49.28 (n)
K07D4.7a 36
  • 39 (a)
K07D4.7b 36
  • 39 (a)
ephx-1 35
  • 20 (a)
OneToMany
Species where no ortholog for ARHGEF16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGEF16 Gene

ENSEMBL:
Gene Tree for ARHGEF16 (if available)
TreeFam:
Gene Tree for ARHGEF16 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ARHGEF16: view image

Paralogs for ARHGEF16 Gene

Paralogs for ARHGEF16 Gene

(11) SIMAP similar genes for ARHGEF16 Gene using alignment to 5 proteins:

  • ARHGG_HUMAN
  • B0QZD3_HUMAN
  • B0QZD4_HUMAN
  • B4DJM7_HUMAN
  • L8EAP0_HUMAN
genes like me logo Genes that share paralogs with ARHGEF16: view

Variants for ARHGEF16 Gene

Sequence variations from dbSNP and Humsavar for ARHGEF16 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000041823 -- 3,453,371(+) G/C upstream_transcript_variant
rs1000097390 -- 3,458,164(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000113947 -- 3,471,006(+) G/T intron_variant
rs1000114696 -- 3,478,820(+) C/G intron_variant
rs1000153481 -- 3,466,789(+) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGEF16 Gene

Variant ID Type Subtype PubMed ID
esv1571906 CNV deletion 17803354
esv2758915 CNV gain 17122850
esv3355688 CNV duplication 20981092
esv3449417 CNV duplication 20981092
esv3563426 CNV deletion 23714750
esv3893545 CNV loss 25118596
nsv1012423 CNV gain 25217958
nsv299 CNV insertion 18451855
nsv470687 CNV loss 18288195
nsv475972 CNV novel sequence insertion 20440878
nsv476024 CNV novel sequence insertion 20440878
nsv545124 CNV loss 21841781
nsv830092 CNV gain+loss 17160897
nsv830203 CNV loss 17160897
nsv951959 CNV deletion 24416366

Variation tolerance for ARHGEF16 Gene

Residual Variation Intolerance Score: 85.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.90; 59.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARHGEF16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARHGEF16
Human Gene Mutation Database (HGMD)
ARHGEF16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGEF16 Gene

Disorders for ARHGEF16 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ARHGEF16 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
frontal sinusitis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ARHGEF16

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ARHGEF16: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARHGEF16 Gene

Publications for ARHGEF16 Gene

  1. The HPV16 E6 binding protein Tip-1 interacts with ARHGEF16, which activates Cdc42. (PMID: 21139582) Oliver AW … Hampson IN (British journal of cancer 2011) 3 4 58
  2. Mutation of ARHGAP9 in patients with coronary spastic angina. (PMID: 19911011) Takefuji M … Kaibuchi K (Journal of human genetics 2010) 3 45 58
  3. Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism. (PMID: 20679435) Hiramoto-Yamaki N … Katoh H (The Journal of cell biology 2010) 3 4 58
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for ARHGEF16 Gene

Sources for ARHGEF16 Gene

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