Aliases for ARHGEF15 Gene
External Ids for ARHGEF15 Gene
Previous GeneCards Identifiers for ARHGEF15 Gene
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. This gene encodes a protein that functions as a specific guanine nucleotide exchange factor for RhoA. It also interacts with ephrin A4 in vascular smooth muscle cells. Two alternatively spliced transcripts variants that encode the same protein have been found for this gene. [provided by RefSeq, Aug 2010]
GeneCards Summary for ARHGEF15 Gene
ARHGEF15 (Rho Guanine Nucleotide Exchange Factor 15) is a Protein Coding gene. Diseases associated with ARHGEF15 include Early Infantile Epileptic Encephalopathy and Ohtahara Syndrome. Among its related pathways are fMLP Pathway and p75 NTR receptor-mediated signalling. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF5.
UniProtKB/Swiss-Prot Summary for ARHGEF15 Gene
Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2.