Aliases for ARHGEF12 Gene
External Ids for ARHGEF12 Gene
Previous GeneCards Identifiers for ARHGEF12 Gene
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
GeneCards Summary for ARHGEF12 Gene
ARHGEF12 (Rho Guanine Nucleotide Exchange Factor 12) is a Protein Coding gene. Diseases associated with ARHGEF12 include Giant Axonal Neuropathy and Acalculous Cholecystitis. Among its related pathways are Oxytocin signaling pathway and RET signaling. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and G protein-coupled receptor binding. An important paralog of this gene is ARHGEF11.
UniProtKB/Swiss-Prot Summary for ARHGEF12 Gene
May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.