Aliases for ARHGEF11 Gene
External Ids for ARHGEF11 Gene
Previous GeneCards Identifiers for ARHGEF11 Gene
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for ARHGEF11 Gene
ARHGEF11 (Rho Guanine Nucleotide Exchange Factor 11) is a Protein Coding gene. Diseases associated with ARHGEF11 include Fetal Macrosomia and Malignant Breast Melanoma. Among its related pathways are Guidance Cues and Growth Cone Motility and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and G protein-coupled receptor binding. An important paralog of this gene is ARHGEF12.
UniProtKB/Swiss-Prot Summary for ARHGEF11 Gene
May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth.