Aliases for ARHGEF10 Gene
External Ids for ARHGEF10 Gene
Previous GeneCards Identifiers for ARHGEF10 Gene
This gene encodes a Rho guanine nucleotide exchange factor (GEF). Rho GEFs regulate the activity of small Rho GTPases by stimulating the exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and may play a role in neural morphogenesis. Mutations in this gene are associated with slowed nerve conduction velocity (SNCV). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
GeneCards Summary for ARHGEF10 Gene
ARHGEF10 (Rho Guanine Nucleotide Exchange Factor 10) is a Protein Coding gene. Diseases associated with ARHGEF10 include Slowed Nerve Conduction Velocity, Autosomal Dominant and Ulnar Neuropathy. Among its related pathways are Signaling by GPCR and Signaling by Slit. Gene Ontology (GO) annotations related to this gene include Rho guanyl-nucleotide exchange factor activity and kinesin binding. An important paralog of this gene is ARHGEF10L.
UniProtKB/Swiss-Prot Summary for ARHGEF10 Gene
May play a role in developmental myelination of peripheral nerves.