This gene encodes a Rho guanine nucleotide exchange factor (GEF). Rho GEFs regulate the activity of small Rho GTPases by stimulating the exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and may play a role in neural morphogenesis. Mutations in this gene are associated with slowed nerve conduction velocity (SNCV). Alternative splicing results in multiple tran... See more...

Aliases for ARHGEF10 Gene

Aliases for ARHGEF10 Gene

  • Rho Guanine Nucleotide Exchange Factor 10 2 3 3 4 5
  • Rho Guanine Nucleotide Exchange Factor (GEF) 10 2 3
  • KIAA0294 2 4
  • ARHGEF10 5
  • GEF10 3
  • Gef10 2
  • SNCV 3

External Ids for ARHGEF10 Gene

Previous GeneCards Identifiers for ARHGEF10 Gene

  • GC08M001714
  • GC08M002273
  • GC08P001922
  • GC08P001759
  • GC08P001778
  • GC08P001586

Summaries for ARHGEF10 Gene

Entrez Gene Summary for ARHGEF10 Gene

  • This gene encodes a Rho guanine nucleotide exchange factor (GEF). Rho GEFs regulate the activity of small Rho GTPases by stimulating the exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and may play a role in neural morphogenesis. Mutations in this gene are associated with slowed nerve conduction velocity (SNCV). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

GeneCards Summary for ARHGEF10 Gene

ARHGEF10 (Rho Guanine Nucleotide Exchange Factor 10) is a Protein Coding gene. Diseases associated with ARHGEF10 include Slowed Nerve Conduction Velocity, Autosomal Dominant and Ulnar Neuropathy. Among its related pathways are Guidance Cues and Growth Cone Motility and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include Rho guanyl-nucleotide exchange factor activity and kinesin binding. An important paralog of this gene is ARHGEF10L.

UniProtKB/Swiss-Prot Summary for ARHGEF10 Gene

Gene Wiki entry for ARHGEF10 Gene

Additional gene information for ARHGEF10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARHGEF10 Gene

Genomics for ARHGEF10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ARHGEF10 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J001762 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.2 -59.0 -59017 6.2 SP1 PRDM10 TFE3 ZNF692 BACH1 JUND FOXA1 LARP7 PRDM1 MTA2 ENSG00000253982 CLN8 ENSG00000282021 ENSG00000283239 LOC101927752 ARHGEF10 piR-46324
GH08J001822 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +0.8 810 4.1 RNF2 TEAD4 PRDM10 IKZF1 ZIC2 ZSCAN4 PKNOX1 POLR2A PATZ1 REST ARHGEF10 ENSG00000253982 lnc-ERICH1-8 ENSG00000283239 KBTBD11
GH08J001955 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 600.1 +133.5 133453 3.4 JUND SP1 EP300 MGA ZNF766 CEBPB FOXA2 GABPA YY1 MNT ARHGEF10 KBTBD11 ENSG00000285957 LOC100131395 ENSG00000283239
GH08J001927 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE CraniofacialAtlas 600.1 +106.1 106142 6.9 REST ZSCAN4 SP1 POLR2A MNT NRF1 CTCF FOXA2 YY1 ZBTB33 ARHGEF10 piR-32287-100 LOC100131395 KBTBD11 ENSG00000283239
GH08J001951 Promoter/Enhancer 1 EPDnew ENCODE dbSUPER 600.1 +129.1 129053 2.5 SP1 POLR2A YY1 HNF4A MAX ARHGEF10 KBTBD11 ENSG00000253764 ENSG00000285957 LOC100131395 ENSG00000283239
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARHGEF10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ARHGEF10

Top Transcription factor binding sites by QIAGEN in the ARHGEF10 gene promoter:
  • CBF(2)
  • ISGF-3
  • Max
  • MIF-1
  • N-Myc
  • NF-Y
  • Nkx2-2
  • Nkx5-1
  • Pax-4a
  • XBP-1

Genomic Locations for ARHGEF10 Gene

Genomic Locations for ARHGEF10 Gene
134,716 bases
Plus strand
134,666 bases
Plus strand

Genomic View for ARHGEF10 Gene

Genes around ARHGEF10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGEF10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGEF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGEF10 Gene

Proteins for ARHGEF10 Gene

  • Protein details for ARHGEF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho guanine nucleotide exchange factor 10
    Protein Accession:
    Secondary Accessions:
    • O14665
    • Q2KHR8
    • Q68D55
    • Q8IWD9
    • Q8IY77

    Protein attributes for ARHGEF10 Gene

    1369 amino acids
    Molecular mass:
    151612 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH36809.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=AAH40474.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=BAA20754.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=CAH18365.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for ARHGEF10 Gene


neXtProt entry for ARHGEF10 Gene

Post-translational modifications for ARHGEF10 Gene

No data available for DME Specific Peptides for ARHGEF10 Gene

Domains & Families for ARHGEF10 Gene

Gene Families for ARHGEF10 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for ARHGEF10 Gene

Suggested Antigen Peptide Sequences for ARHGEF10 Gene

GenScript: Design optimal peptide antigens:
  • Rho guanine nucleotide exchange factor 10 (ARHGA_HUMAN)
genes like me logo Genes that share domains with ARHGEF10: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ARHGEF10 Gene

Function for ARHGEF10 Gene

Molecular function for ARHGEF10 Gene

UniProtKB/Swiss-Prot Function:
May play a role in developmental myelination of peripheral nerves.

Phenotypes From GWAS Catalog for ARHGEF10 Gene

Gene Ontology (GO) - Molecular Function for ARHGEF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity IEA,IBA 21873635
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA,IDA 16896804
GO:0005515 protein binding IPI 19635168
GO:0019894 kinesin binding IPI 19635168
genes like me logo Genes that share ontologies with ARHGEF10: view
genes like me logo Genes that share phenotypes with ARHGEF10: view

Human Phenotype Ontology for ARHGEF10 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ARHGEF10 Gene

MGI Knock Outs for ARHGEF10:

Animal Model Products

CRISPR Products

miRNA for ARHGEF10 Gene

miRTarBase miRNAs that target ARHGEF10

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARHGEF10

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ARHGEF10 Gene

Localization for ARHGEF10 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGEF10 gene
Compartment Confidence
cytosol 5
cytoskeleton 4
nucleus 3
plasma membrane 2
mitochondrion 2
extracellular 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ARHGEF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IEA,IDA 19635168
GO:0005829 cytosol IEA,NAS 16896804
genes like me logo Genes that share ontologies with ARHGEF10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARHGEF10 Gene

Pathways & Interactions for ARHGEF10 Gene

PathCards logo

SuperPathways for ARHGEF10 Gene

SuperPathway Contained pathways
1 p75 NTR receptor-mediated signalling
2 GPCR Pathway
3 G-AlphaQ Signaling
4 Signaling by GPCR
5 fMLP Pathway
genes like me logo Genes that share pathways with ARHGEF10: view

Pathways by source for ARHGEF10 Gene

21 Qiagen pathways for ARHGEF10 Gene
  • Activation of PKC through GPCR
  • Breast Cancer Regulation by Stathmin1
  • CXCR4 Pathway
  • G-AlphaI Signaling
  • G-AlphaQ Signaling

SIGNOR curated interactions for ARHGEF10 Gene


Gene Ontology (GO) - Biological Process for ARHGEF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022011 myelination in peripheral nervous system IEA,IMP 14508709
GO:0030036 actin cytoskeleton organization IBA 21873635
GO:0035023 regulation of Rho protein signal transduction IEA --
GO:0051298 centrosome duplication IMP 19635168
GO:0051496 positive regulation of stress fiber assembly IBA,IMP 16896804
genes like me logo Genes that share ontologies with ARHGEF10: view

Drugs & Compounds for ARHGEF10 Gene

No Compound Related Data Available

Transcripts for ARHGEF10 Gene

mRNA/cDNA for ARHGEF10 Gene

12 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARHGEF10

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF10 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^ 15 ^ 16 ^ 17 ^
SP5: - -
SP6: -
SP11: -
SP12: - - -
SP13: - - -
SP14: - -
SP15: - - -
SP16: -

ExUns: 18a · 18b ^ 19 ^ 20a · 20b · 20c ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27a · 27b ^ 28 ^ 29

Relevant External Links for ARHGEF10 Gene

GeneLoc Exon Structure for

Expression for ARHGEF10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARHGEF10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGEF10 Gene

This gene is overexpressed in Nerve - Tibial (x4.6).

Protein differential expression in normal tissues from HIPED for ARHGEF10 Gene

This gene is overexpressed in Lung (10.2), Gallbladder (9.6), Placenta (9.1), Testis (8.6), Fetal heart (6.7), and Spinal cord (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARHGEF10 Gene

Protein tissue co-expression partners for ARHGEF10 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ARHGEF10

SOURCE GeneReport for Unigene cluster for ARHGEF10 Gene:


Evidence on tissue expression from TISSUES for ARHGEF10 Gene

  • Nervous system(4.8)
  • Intestine(4.3)
  • Heart(2.3)
  • Muscle(2.3)
  • Skin(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGEF10 Gene

Germ Layers:
  • ectoderm
  • nervous
  • peripheral nerve
  • peripheral nervous system
genes like me logo Genes that share expression patterns with ARHGEF10: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ARHGEF10 Gene

Orthologs for ARHGEF10 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGEF10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARHGEF10 31
  • 97 (a)
(Canis familiaris)
Mammalia ARHGEF10 30 31
  • 80.11 (n)
(Monodelphis domestica)
Mammalia ARHGEF10 31
  • 80 (a)
(Mus musculus)
Mammalia Arhgef10 30 17 31
  • 79.14 (n)
(Ornithorhynchus anatinus)
Mammalia ARHGEF10 31
  • 79 (a)
(Rattus norvegicus)
Mammalia Arhgef10 30
  • 78.65 (n)
(Bos Taurus)
Mammalia ARHGEF10 30 31
  • 78.08 (n)
(Gallus gallus)
Aves ARHGEF10 30 31
  • 72.5 (n)
(Anolis carolinensis)
Reptilia ARHGEF10 31
  • 74 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia arhgef10 30
  • 68.48 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8377 30
(Danio rerio)
Actinopterygii arhgef10 30 31
  • 66.03 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG8557 32
  • 28 (a)
CG43658 31
  • 18 (a)
Species where no ortholog for ARHGEF10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ARHGEF10 Gene

Gene Tree for ARHGEF10 (if available)
Gene Tree for ARHGEF10 (if available)
Evolutionary constrained regions (ECRs) for ARHGEF10: view image

Paralogs for ARHGEF10 Gene

Paralogs for ARHGEF10 Gene

(2) SIMAP similar genes for ARHGEF10 Gene using alignment to 3 proteins:

  • E9PB39_HUMAN
genes like me logo Genes that share paralogs with ARHGEF10: view

Variants for ARHGEF10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ARHGEF10 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
637512 Uncertain Significance: Charcot-Marie-Tooth disease 1,866,584(+) A/C MISSENSE_VARIANT
708484 Likely Benign: not provided 1,898,506(+) A/T MISSENSE_VARIANT
708928 Benign: not provided 1,857,947(+) TTTTTC/T INTRON_VARIANT
709434 Benign: not provided 1,925,295(+) A/G MISSENSE_VARIANT
709435 Likely Benign: not provided 1,952,737(+) G/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for ARHGEF10 Gene

Structural Variations from Database of Genomic Variants (DGV) for ARHGEF10 Gene

Variant ID Type Subtype PubMed ID
dgv1158n67 CNV loss 20364138
dgv1159n67 CNV loss 20364138
dgv1160n67 CNV loss 20364138
dgv11822n54 CNV loss 21841781
dgv11823n54 CNV gain 21841781
dgv11824n54 CNV loss 21841781
dgv11825n54 CNV loss 21841781
dgv11826n54 CNV gain 21841781
dgv11827n54 CNV gain 21841781
dgv11828n54 CNV gain 21841781
dgv1186e201 CNV deletion 23290073
dgv1187e201 CNV deletion 23290073
dgv1260e199 CNV deletion 23128226
dgv3742n106 CNV deletion 24896259
dgv3743n106 CNV deletion 24896259
dgv850n27 CNV loss 19166990
esv1007633 CNV deletion 20482838
esv1011319 CNV deletion 20482838
esv1076332 CNV insertion 17803354
esv1107716 CNV deletion 17803354
esv1138141 CNV deletion 17803354
esv1141021 CNV insertion 17803354
esv1171195 CNV insertion 17803354
esv1208772 CNV insertion 17803354
esv1322301 CNV insertion 17803354
esv1449111 CNV deletion 17803354
esv1484821 CNV insertion 17803354
esv1510196 CNV insertion 17803354
esv1620401 CNV deletion 17803354
esv1651457 CNV deletion 17803354
esv1682354 CNV insertion 17803354
esv1733120 CNV deletion 17803354
esv2052269 CNV deletion 18987734
esv2084774 CNV deletion 18987734
esv2252959 CNV deletion 18987734
esv23451 CNV gain 19812545
esv2415204 CNV deletion 18987734
esv2516234 CNV deletion 19546169
esv2659595 CNV deletion 23128226
esv2660560 CNV deletion 23128226
esv2663389 CNV deletion 23128226
esv2666010 CNV deletion 23128226
esv2667351 CNV deletion 23128226
esv2673010 CNV deletion 23128226
esv2677306 CNV deletion 23128226
esv26851 CNV loss 19812545
esv27054 CNV gain 19812545
esv2736322 CNV deletion 23290073
esv2736323 CNV deletion 23290073
esv2736324 CNV deletion 23290073
esv2736325 CNV deletion 23290073
esv2736326 CNV deletion 23290073
esv2736327 CNV deletion 23290073
esv2736328 CNV deletion 23290073
esv2736330 CNV deletion 23290073
esv2736331 CNV deletion 23290073
esv2736332 CNV deletion 23290073
esv2736333 CNV deletion 23290073
esv2736334 CNV deletion 23290073
esv2736335 CNV deletion 23290073
esv2736336 CNV deletion 23290073
esv2736337 CNV deletion 23290073
esv2736339 CNV deletion 23290073
esv2736341 CNV deletion 23290073
esv2736342 CNV deletion 23290073
esv2736344 CNV deletion 23290073
esv2736345 CNV deletion 23290073
esv2736347 CNV deletion 23290073
esv2736349 CNV deletion 23290073
esv2736352 CNV deletion 23290073
esv2736353 CNV deletion 23290073
esv2736354 CNV deletion 23290073
esv2736355 CNV deletion 23290073
esv2736356 CNV deletion 23290073
esv2736357 CNV deletion 23290073
esv2736358 CNV deletion 23290073
esv2736359 CNV deletion 23290073
esv2736360 CNV deletion 23290073
esv2736361 CNV deletion 23290073
esv2742063 CNV deletion 23290073
esv2743130 CNV deletion 23290073
esv28396 CNV loss 19812545
esv2859235 CNV duplication 24192839
esv3185 CNV loss 18987735
esv3324316 CNV duplication 20981092
esv3542892 CNV deletion 23714750
esv3542894 CNV deletion 23714750
esv3542896 CNV deletion 23714750
esv3542897 CNV deletion 23714750
esv3542898 CNV deletion 23714750
esv3572395 CNV loss 25503493
esv3576504 CNV gain 25503493
esv3615849 CNV gain 21293372
esv3615850 CNV loss 21293372
esv3891267 CNV gain 25118596
esv3957 CNV loss 18987735
esv4225 CNV loss 18987735
esv8802 CNV gain 19470904
esv991834 CNV deletion 20482838
esv993105 CNV loss 20482838
nsv1017511 CNV loss 25217958
nsv1017597 CNV loss 25217958
nsv1019398 CNV loss 25217958
nsv1024325 CNV gain 25217958
nsv1025591 CNV gain 25217958
nsv1075089 CNV deletion 25765185
nsv1075507 CNV deletion 25765185
nsv1076998 CNV deletion 25765185
nsv1109938 CNV deletion 24896259
nsv1109939 CNV deletion 24896259
nsv1115048 CNV deletion 24896259
nsv1115049 CNV deletion 24896259
nsv1117478 CNV tandem duplication 24896259
nsv1117479 CNV tandem duplication 24896259
nsv1117789 CNV deletion 24896259
nsv1117790 CNV deletion 24896259
nsv1118041 CNV deletion 24896259
nsv1118042 CNV deletion 24896259
nsv1118044 CNV deletion 24896259
nsv1119557 CNV insertion 24896259
nsv1125266 CNV insertion 24896259
nsv1143359 CNV deletion 24896259
nsv1148559 CNV deletion 26484159
nsv1150107 CNV deletion 26484159
nsv395839 CNV deletion 16902084
nsv396415 CNV insertion 16902084
nsv397138 CNV deletion 16902084
nsv397172 CNV deletion 16902084
nsv397324 CNV deletion 16902084
nsv398111 CNV insertion 16902084
nsv398112 CNV deletion 16902084
nsv465277 CNV gain 19166990
nsv470167 CNV gain 18288195
nsv475543 CNV novel sequence insertion 20440878
nsv509244 CNV insertion 20534489
nsv511395 CNV loss 21212237
nsv512937 CNV insertion 21212237
nsv517213 CNV loss 19592680
nsv6046 CNV deletion 18451855
nsv609531 CNV gain 21841781
nsv609533 CNV gain 21841781
nsv609534 CNV loss 21841781
nsv609535 CNV loss 21841781
nsv609536 CNV loss 21841781
nsv609537 CNV loss 21841781
nsv609552 CNV loss 21841781
nsv609555 CNV loss 21841781
nsv824454 CNV gain 20364138
nsv824455 CNV gain 20364138
nsv824463 CNV loss 20364138
nsv824472 CNV loss 20364138
nsv831207 CNV loss 17160897
nsv957084 CNV deletion 24416366
nsv957085 CNV deletion 24416366
nsv958481 CNV deletion 24416366

Variation tolerance for ARHGEF10 Gene

Residual Variation Intolerance Score: 75.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.29; 70.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARHGEF10 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGEF10 Gene

Disorders for ARHGEF10 Gene

MalaCards: The human disease database

(22) MalaCards diseases for ARHGEF10 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
slowed nerve conduction velocity, autosomal dominant
  • sncv
ulnar neuropathy
  • ulnar neuropathies
nerve compression syndrome
  • compression neuropathy
radial neuropathy
adie pupil
  • adie syndrome
- elite association - COSMIC cancer census association via MalaCards


  • Slowed nerve conduction velocity (SNCV) [MIM:608236]: Affected individuals present a reduction in nerve conduction velocities without any clinical signs of peripheral or central nervous system dysfunction. SNCV inheritance is autosomal dominant. {ECO:0000269 PubMed:14508709}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for ARHGEF10

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ARHGEF10: view

No data available for Genatlas for ARHGEF10 Gene

Publications for ARHGEF10 Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  3. Functional SNP of ARHGEF10 confers risk of atherothrombotic stroke. (PMID: 20042462) Matsushita T … Kubo M (Human molecular genetics 2010) 3 41
  4. An association screen of myelin-related genes implicates the chromosome 22q11 PIK4CA gene in schizophrenia. (PMID: 17893707) Jungerius BJ … Sinke RJ (Molecular psychiatry 2008) 3 41
  5. Gef10--the third member of a Rho-specific guanine nucleotide exchange factor subfamily with unusual protein architecture. (PMID: 16896804) Mohl M … Lutz S (Naunyn-Schmiedeberg's archives of pharmacology 2006) 2 3

Products for ARHGEF10 Gene

  • Signalway Proteins for ARHGEF10

Sources for ARHGEF10 Gene