Aliases for ARHGEF1 Gene
External Ids for ARHGEF1 Gene
Previous GeneCards Identifiers for ARHGEF1 Gene
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]
GeneCards Summary for ARHGEF1 Gene
ARHGEF1 (Rho Guanine Nucleotide Exchange Factor 1) is a Protein Coding gene. Diseases associated with ARHGEF1 include Immunodeficiency 62 and Skin Lipoma. Among its related pathways are Proteoglycans in cancer and fMLP Pathway. Gene Ontology (GO) annotations related to this gene include Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF12.
UniProtKB/Swiss-Prot Summary for ARHGEF1 Gene
Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits (PubMed:9641915, PubMed:9641916). Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase (PubMed:9641915, PubMed:9641916, PubMed:8810315, PubMed:30521495). Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain (PubMed:9641916). This GEF activity is inhibited by binding to activated GNA12 (PubMed:9641916). Mediates angiotensin-2-induced RhoA activation (PubMed:20098430).