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Aliases for ARHGDIG Gene

Aliases for ARHGDIG Gene

  • Rho GDP Dissociation Inhibitor Gamma 2 3 5
  • Rho GDP Dissociation Inhibitor (GDI) Gamma 2 3
  • Rho-GDI Gamma 3 4
  • RhoGDI Gamma 2 3
  • Rho GDI 3 3 4
  • Rho GDP-Dissociation Inhibitor 3 3
  • RHOGDI-3 3

External Ids for ARHGDIG Gene

Previous GeneCards Identifiers for ARHGDIG Gene

  • GC16P000349
  • GC16P000270
  • GC16P000318
  • GC16P000250
  • GC16P000279
  • GC16P000308
  • GC16P000322
  • GC16P000343
  • GC16P000363
  • GC16P000400
  • GC16P000418
  • GC16P000472

Summaries for ARHGDIG Gene

Entrez Gene Summary for ARHGDIG Gene

  • The GDP-dissociation inhibitors (GDIs) play a primary role in modulating the activation of GTPases by inhibiting the exchange of GDP for GTP. See ARHGDIB (MIM 602843).[supplied by OMIM, Nov 2010]

GeneCards Summary for ARHGDIG Gene

ARHGDIG (Rho GDP Dissociation Inhibitor Gamma) is a Protein Coding gene. Among its related pathways are Development HGF signaling pathway and p75 NTR receptor-mediated signalling. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and Rho GDP-dissociation inhibitor activity. An important paralog of this gene is ARHGDIB.

UniProtKB/Swiss-Prot for ARHGDIG Gene

  • Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post-translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP.

Gene Wiki entry for ARHGDIG Gene

Additional gene information for ARHGDIG Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGDIG Gene

Genomics for ARHGDIG Gene

GeneHancer (GH) Regulatory Elements for ARHGDIG Gene

Promoters and enhancers for ARHGDIG Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J000278 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 650.4 +11.6 11611 3 PKNOX1 KLF14 GLIS2 ZNF350 FOS RUNX3 PHF21A NFYA NFYC REST ARHGDIG AXIN1 WASH4P RHOT2 ENSG00000268836 PDIA2 RGS11 DDX11L10 MRPL28 HBZ
GH16J000268 Promoter/Enhancer 1.2 EPDnew ENCODE dbSUPER 659.6 +0.4 421 1.6 KLF1 NFIA ZNF10 KLF17 ZBTB33 ELF1 ARHGDIG GC16M000274 GC16M000275 RGS11 ENSG00000269881 FAM234A
GH16J000351 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 6.9 +85.2 85178 5.8 ARID4B SIN3A DMAP1 ZBTB7B YY1 TCF12 GLIS2 ZNF143 KLF13 SP3 AXIN1 TMEM8A UBE2I CHTF18 ENSG00000268836 WASH4P WDR24 LUC7L ENSG00000269482 WDR90
GH16J000329 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 7 +62.6 62624 2.9 SOX13 IRF2 KLF1 SAP130 ARID4B RAD21 RARA GATA3 IKZF5 RCOR1 TMEM8A NHLRC4 MRPL28 ARHGDIG NME4 AXIN1 HAGHL PIR38678 GC16P000496
GH16J000337 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 6.9 +70.6 70635 3.4 FOXA2 ARID4B DMAP1 THRB RARA GLIS2 PRPF4 EGR2 ZNF362 CEBPB TMEM8A MRPL28 ARHGDIG RHBDF1 PIR38678 AXIN1 GC16P000496
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARHGDIG on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARHGDIG gene promoter:
  • Lmo2
  • AP-2gamma
  • AP-2beta
  • AP-2alphaA
  • AP-2alpha
  • COMP1
  • Evi-1
  • CBF(2)
  • NF-Y

Genomic Locations for ARHGDIG Gene

Genomic Locations for ARHGDIG Gene
chr16:268,727-283,010
(GRCh38/hg38)
Size:
14,284 bases
Orientation:
Plus strand
chr16:318,726-333,003
(GRCh37/hg19)
Size:
14,278 bases
Orientation:
Plus strand

Genomic View for ARHGDIG Gene

Genes around ARHGDIG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGDIG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGDIG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGDIG Gene

Proteins for ARHGDIG Gene

  • Protein details for ARHGDIG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99819-GDIR3_HUMAN
    Recommended name:
    Rho GDP-dissociation inhibitor 3
    Protein Accession:
    Q99819
    Secondary Accessions:
    • Q4TT69
    • Q96S29

    Protein attributes for ARHGDIG Gene

    Size:
    225 amino acids
    Molecular mass:
    25098 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARHGDIG Gene

Post-translational modifications for ARHGDIG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGDIG Gene

No data available for DME Specific Peptides for ARHGDIG Gene

Domains & Families for ARHGDIG Gene

Gene Families for ARHGDIG Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ARHGDIG Gene

Graphical View of Domain Structure for InterPro Entry

Q99819

UniProtKB/Swiss-Prot:

GDIR3_HUMAN :
  • Belongs to the Rho GDI family.
Family:
  • Belongs to the Rho GDI family.
genes like me logo Genes that share domains with ARHGDIG: view

Function for ARHGDIG Gene

Molecular function for ARHGDIG Gene

UniProtKB/Swiss-Prot Function:
Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post-translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP.
GENATLAS Biochemistry:
Rho GDP-dissociation inhibitor (GDI) gamma,preferentially expressed in brain and pancreas,binding to RHOA and CDC42

Phenotypes From GWAS Catalog for ARHGDIG Gene

Gene Ontology (GO) - Molecular Function for ARHGDIG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005094 Rho GDP-dissociation inhibitor activity IEA --
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0030695 GTPase regulator activity IEA --
genes like me logo Genes that share ontologies with ARHGDIG: view
genes like me logo Genes that share phenotypes with ARHGDIG: view

Animal Models for ARHGDIG Gene

MGI Knock Outs for ARHGDIG:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARHGDIG

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ARHGDIG Gene

Localization for ARHGDIG Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGDIG Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGDIG gene
Compartment Confidence
cytosol 5
extracellular 2
mitochondrion 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARHGDIG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA --
GO:0016020 membrane IEA --
GO:0031410 cytoplasmic vesicle TAS 9113980
genes like me logo Genes that share ontologies with ARHGDIG: view

Pathways & Interactions for ARHGDIG Gene

genes like me logo Genes that share pathways with ARHGDIG: view

Gene Ontology (GO) - Biological Process for ARHGDIG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007162 negative regulation of cell adhesion TAS 9113980
GO:0007266 Rho protein signal transduction TAS 9113980
GO:0032880 regulation of protein localization IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0050790 regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with ARHGDIG: view

No data available for SIGNOR curated interactions for ARHGDIG Gene

Drugs & Compounds for ARHGDIG Gene

(2) Drugs for ARHGDIG Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with ARHGDIG: view

Transcripts for ARHGDIG Gene

mRNA/cDNA for ARHGDIG Gene

Unigene Clusters for ARHGDIG Gene

Rho GDP dissociation inhibitor (GDI) gamma:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARHGDIG

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGDIG Gene

No ASD Table

Relevant External Links for ARHGDIG Gene

GeneLoc Exon Structure for
ARHGDIG
ECgene alternative splicing isoforms for
ARHGDIG

Expression for ARHGDIG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARHGDIG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGDIG Gene

This gene is overexpressed in Brain - Cortex (x6.1), Brain - Cerebellum (x5.8), Brain - Anterior cingulate cortex (BA24) (x5.4), Brain - Frontal Cortex (BA9) (x5.1), and Brain - Cerebellar Hemisphere (x4.7).

Protein differential expression in normal tissues from HIPED for ARHGDIG Gene

This gene is overexpressed in Tlymphocyte (67.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ARHGDIG Gene



Protein tissue co-expression partners for ARHGDIG Gene

NURSA nuclear receptor signaling pathways regulating expression of ARHGDIG Gene:

ARHGDIG

SOURCE GeneReport for Unigene cluster for ARHGDIG Gene:

Hs.647388

mRNA Expression by UniProt/SwissProt for ARHGDIG Gene:

Q99819-GDIR3_HUMAN
Tissue specificity: Primarily expressed in pancreas and brain.

Evidence on tissue expression from TISSUES for ARHGDIG Gene

  • Nervous system(4.4)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with ARHGDIG: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGDIG Gene

Orthologs for ARHGDIG Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGDIG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGDIG 34 33
  • 98.84 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ARHGDIG 34 33
  • 86.76 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ARHGDIG 34 33
  • 83.66 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arhgdig 33
  • 82.67 (n)
mouse
(Mus musculus)
Mammalia Arhgdig 16 34 33
  • 81.93 (n)
oppossum
(Monodelphis domestica)
Mammalia ARHGDIG 34
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGDIG 34
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARHGDIG 34 33
  • 74.96 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgdig 33
  • 61.98 (n)
zebrafish
(Danio rerio)
Actinopterygii arhgdig 34
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta RhoGDI 34
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rhi-1 34
  • 37 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RDI1 34
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 40 (a)
OneToMany
Species where no ortholog for ARHGDIG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGDIG Gene

ENSEMBL:
Gene Tree for ARHGDIG (if available)
TreeFam:
Gene Tree for ARHGDIG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ARHGDIG: view image

Paralogs for ARHGDIG Gene

Paralogs for ARHGDIG Gene

(2) SIMAP similar genes for ARHGDIG Gene using alignment to 9 proteins:

  • GDIR3_HUMAN
  • A2ID99_HUMAN
  • A2IDA0_HUMAN
  • A2IDA1_HUMAN
  • C9J3B5_HUMAN
  • C9J9L9_HUMAN
  • C9JR26_HUMAN
  • F1T0H7_HUMAN
  • Q4TT68_HUMAN
genes like me logo Genes that share paralogs with ARHGDIG: view

Variants for ARHGDIG Gene

Sequence variations from dbSNP and Humsavar for ARHGDIG Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000102468 -- 281,084(+) G/A intron_variant
rs1001017192 -- 282,190(+) G/A intron_variant
rs1001164342 -- 279,171(+) A/G upstream_transcript_variant
rs1001280205 -- 280,136(+) C/A upstream_transcript_variant
rs1001510716 -- 279,350(+) C/G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGDIG Gene

Variant ID Type Subtype PubMed ID
dgv32n68 CNV loss 17160897
dgv4808n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
esv3637563 CNV gain 21293372
nsv1144747 CNV deletion 24896259
nsv570947 CNV loss 21841781
nsv570949 CNV loss 21841781
nsv570951 CNV loss 21841781
nsv570952 CNV loss 21841781
nsv827477 CNV gain 20364138
nsv952896 CNV deletion 24416366

Variation tolerance for ARHGDIG Gene

Residual Variation Intolerance Score: 78.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.76; 15.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARHGDIG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARHGDIG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGDIG Gene

Disorders for ARHGDIG Gene

Additional Disease Information for ARHGDIG

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ARHGDIG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGDIG Gene

Publications for ARHGDIG Gene

  1. RhoGDIgamma: a GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas. (PMID: 9113980) Adra CN … Lim B (Proceedings of the National Academy of Sciences of the United States of America 1997) 2 3 4 58
  2. Application of gene network analysis techniques identifies AXIN1/PDIA2 and endoglin haplotypes associated with bicuspid aortic valve. (PMID: 20098615) Wooten EC … Huggins GS (PloS one 2010) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 3 4 58
  5. RhoGDI-3 regulates RhoG and targets this protein to the Golgi complex through its unique N-terminal domain. (PMID: 11967128) Brunet N … Olofsson B (Traffic (Copenhagen, Denmark) 2002) 2 3 58

Products for ARHGDIG Gene

Sources for ARHGDIG Gene

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