Aliases for ARHGDIG Gene
External Ids for ARHGDIG Gene
Previous GeneCards Identifiers for ARHGDIG Gene
The GDP-dissociation inhibitors (GDIs) play a primary role in modulating the activation of GTPases by inhibiting the exchange of GDP for GTP. See ARHGDIB (MIM 602843).[supplied by OMIM, Nov 2010]
GeneCards Summary for ARHGDIG Gene
ARHGDIG (Rho GDP Dissociation Inhibitor Gamma) is a Protein Coding gene. Diseases associated with ARHGDIG include Deafness, Autosomal Recessive 104. Among its related pathways are Signaling by GPCR and G13 Signaling Pathway. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and Rho GDP-dissociation inhibitor activity. An important paralog of this gene is ARHGDIB.
UniProtKB/Swiss-Prot Summary for ARHGDIG Gene
Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post-translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP.