Aliases for ARHGDIB Gene
External Ids for ARHGDIB Gene
Previous HGNC Symbols for ARHGDIB Gene
Previous GeneCards Identifiers for ARHGDIB Gene
Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).[supplied by OMIM, Dec 2010]
GeneCards Summary for ARHGDIB Gene
ARHGDIB (Rho GDP Dissociation Inhibitor Beta) is a Protein Coding gene. Diseases associated with ARHGDIB include Severe Congenital Neutropenia. Among its related pathways are p75 NTR receptor-mediated signalling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include GTPase activity and Rho GDP-dissociation inhibitor activity. An important paralog of this gene is ARHGDIG.
UniProtKB/Swiss-Prot Summary for ARHGDIB Gene
Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (PubMed:8356058, PubMed:7512369). Regulates reorganization of the actin cytoskeleton mediated by Rho family members (PubMed:8262133).