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Aliases for ARHGDIB Gene

Aliases for ARHGDIB Gene

  • Rho GDP Dissociation Inhibitor Beta 2 3 5
  • Rho GDP Dissociation Inhibitor (GDI) Beta 2 3
  • Rho-GDI Beta 3 4
  • Rho GDI 2 3 4
  • RAP1GN1 3 4
  • Ly-GDI 3 4
  • GDIA2 3 4
  • GDID4 3 4
  • Rho GDP-Dissociation Inhibitor 2 3
  • RhoGDI2 3
  • LYGDI 3
  • D4 3

External Ids for ARHGDIB Gene

Previous HGNC Symbols for ARHGDIB Gene

  • RAP1GN1
  • GDIA2
  • GDID4

Previous GeneCards Identifiers for ARHGDIB Gene

  • GC12M014834
  • GC12M015239
  • GC12M014995
  • GC12M014986
  • GC12M015094
  • GC12M014864

Summaries for ARHGDIB Gene

Entrez Gene Summary for ARHGDIB Gene

  • Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).[supplied by OMIM, Dec 2010]

GeneCards Summary for ARHGDIB Gene

ARHGDIB (Rho GDP Dissociation Inhibitor Beta) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Actin Nucleation by ARP-WASP Complex. Gene Ontology (GO) annotations related to this gene include GTPase activity and Rho GDP-dissociation inhibitor activity. An important paralog of this gene is ARHGDIA.

UniProtKB/Swiss-Prot for ARHGDIB Gene

  • Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (PubMed:8356058, PubMed:7512369). Regulates reorganization of the actin cytoskeleton mediated by Rho family members (PubMed:8262133).

Gene Wiki entry for ARHGDIB Gene

Additional gene information for ARHGDIB Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGDIB Gene

Genomics for ARHGDIB Gene

GeneHancer (GH) Regulatory Elements for ARHGDIB Gene

Promoters and enhancers for ARHGDIB Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J014945 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 672.6 +6.4 6414 19.1 HDGF PKNOX1 ATF1 FOXA2 SMAD1 YBX1 IRF4 YY1 ZNF766 GATA2 ARHGDIB ERP27 PDE6H WBP11 ART4 H2AFJ HIST4H4 SMCO3 C12orf60 ENSG00000256339
GH12J014883 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 10.4 +76.8 76757 3.2 PKNOX1 SMAD1 NFIB EBF1 CTBP1 GATA3 POLR2A ATF7 RCOR1 IKZF2 MGP ENSG00000256339 ERP27 PDE6H ART4 SMCO3 ARHGDIB HIST4H4 H2AFJ WBP11
GH12J014937 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 11.4 +23.2 23249 2.7 CTCF POLR2A NFATC1 ZNF143 BCL6 SPI1 ERP27 ARHGDIB PDE6H HIST4H4 ENSG00000256339 MGP C12orf60 GC12M014903
GH12J014988 Enhancer 1 FANTOM5 Ensembl dbSUPER 13 -26.7 -26673 0.8 SRF PKNOX1 ATF2 TARDBP IKZF1 NBN ATF7 MLLT1 CREM RUNX3 LOC105369670 ARHGDIB GC12P014973 GC12P014974
GH12J014989 Enhancer 0.8 Ensembl dbSUPER 13.7 -28.2 -28173 0.6 MEIS2 JUNB CBFA2T3 MEF2B BATF ATF2 MEF2D ZNF217 IKZF1 IKZF2 LOC105369670 ARHGDIB LINC01489
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARHGDIB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARHGDIB gene promoter:
  • Pbx1a
  • AML1a
  • ARP-1
  • Nkx6-1
  • HFH-1
  • STAT5A
  • S8
  • PPAR-gamma2
  • PPAR-gamma1

Genomic Locations for ARHGDIB Gene

Genomic Locations for ARHGDIB Gene
19,714 bases
Minus strand
19,713 bases
Minus strand

Genomic View for ARHGDIB Gene

Genes around ARHGDIB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGDIB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGDIB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGDIB Gene

Proteins for ARHGDIB Gene

  • Protein details for ARHGDIB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho GDP-dissociation inhibitor 2
    Protein Accession:
    Secondary Accessions:
    • B5BU79

    Protein attributes for ARHGDIB Gene

    201 amino acids
    Molecular mass:
    22988 Da
    Quaternary structure:
    • Interacts with RHOA (PubMed:20400958). Interacts with RAC1 (PubMed:7512369). Interacts with RAC2 (PubMed:10655614). Interacts with CDC42 (PubMed:7512369).

    Three dimensional structures from OCA and Proteopedia for ARHGDIB Gene

neXtProt entry for ARHGDIB Gene

Post-translational modifications for ARHGDIB Gene

  • Ubiquitination at posLast=175175, posLast=164164, Lys138, posLast=124124, Lys102, posLast=6363, Lys50, and Lys33
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ARHGDIB Gene

Domains & Families for ARHGDIB Gene

Gene Families for ARHGDIB Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ARHGDIB Gene

Suggested Antigen Peptide Sequences for ARHGDIB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Rho GDI family.
  • Belongs to the Rho GDI family.
genes like me logo Genes that share domains with ARHGDIB: view

Function for ARHGDIB Gene

Molecular function for ARHGDIB Gene

UniProtKB/Swiss-Prot Function:
Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (PubMed:8356058, PubMed:7512369). Regulates reorganization of the actin cytoskeleton mediated by Rho family members (PubMed:8262133).
GENATLAS Biochemistry:
Rho GDP-dissociation inhibitor (GDI) beta,aplysia related,preferentially expressed in hematopoietic cells (signal transduction)

Gene Ontology (GO) - Molecular Function for ARHGDIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IMP 24554735
GO:0005094 Rho GDP-dissociation inhibitor activity IDA,IEA 7512369
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IPI 7512369
GO:0048365 Rac GTPase binding IDA 7512369
genes like me logo Genes that share ontologies with ARHGDIB: view
genes like me logo Genes that share phenotypes with ARHGDIB: view

Animal Models for ARHGDIB Gene

MGI Knock Outs for ARHGDIB:

Animal Model Products

miRNA for ARHGDIB Gene

miRTarBase miRNAs that target ARHGDIB

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARHGDIB Gene

Localization for ARHGDIB Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGDIB Gene

Cytoplasm, cytosol.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGDIB gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 5
nucleus 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ARHGDIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS,IEA 16130169
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton TAS 16130169
GO:0016020 membrane IEA --
GO:0031410 cytoplasmic vesicle TAS 9113980
genes like me logo Genes that share ontologies with ARHGDIB: view

Pathways & Interactions for ARHGDIB Gene

genes like me logo Genes that share pathways with ARHGDIB: view

SIGNOR curated interactions for ARHGDIB Gene

Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for ARHGDIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007162 negative regulation of cell adhesion TAS 9113980
GO:0007275 multicellular organism development TAS 8434008
GO:0035023 regulation of Rho protein signal transduction IMP 8262133
GO:0043547 positive regulation of GTPase activity IEA --
GO:0050790 regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with ARHGDIB: view

Drugs & Compounds for ARHGDIB Gene

(3) Drugs for ARHGDIB Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(2) Additional Compounds for ARHGDIB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ARHGDIB: view

Transcripts for ARHGDIB Gene

Unigene Clusters for ARHGDIB Gene

Rho GDP dissociation inhibitor (GDI) beta:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGDIB Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c · 11d · 11e
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - -
SP7: -
SP8: -
SP9: - - - - - -
SP10: - - - - -

Relevant External Links for ARHGDIB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARHGDIB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARHGDIB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGDIB Gene

This gene is overexpressed in Whole Blood (x27.8).

Protein differential expression in normal tissues from HIPED for ARHGDIB Gene

This gene is overexpressed in Lavage (22.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARHGDIB Gene

Protein tissue co-expression partners for ARHGDIB Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARHGDIB Gene:


SOURCE GeneReport for Unigene cluster for ARHGDIB Gene:


mRNA Expression by UniProt/SwissProt for ARHGDIB Gene:

Tissue specificity: Detected in bone marrow, thymus and spleen.

Evidence on tissue expression from TISSUES for ARHGDIB Gene

  • Blood(4.9)
  • Nervous system(4.7)
  • Liver(4.4)
  • Lung(3.8)
  • Pancreas(3.6)
  • Spleen(3.1)
  • Lymph node(3)
  • Bone marrow(2.9)
  • Intestine(2.6)
  • Heart(2.3)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with ARHGDIB: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGDIB Gene

Orthologs for ARHGDIB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGDIB Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARHGDIB 34 33
  • 99 (n)
(Canis familiaris)
Mammalia ARHGDIB 34 33
  • 90.33 (n)
(Bos Taurus)
Mammalia ARHGDIB 34 33
  • 89.17 (n)
(Monodelphis domestica)
Mammalia ARHGDIB 34
  • 84 (a)
(Rattus norvegicus)
Mammalia Arhgdib 33
  • 83.67 (n)
(Mus musculus)
Mammalia Arhgdib 16 34 33
  • 83.5 (n)
(Ornithorhynchus anatinus)
Mammalia ARHGDIB 34
  • 75 (a)
(Gallus gallus)
Aves ARHGDIB 34 33
  • 81.5 (n)
(Anolis carolinensis)
Reptilia ARHGDIB 34
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgdib 33
  • 73.67 (n)
Str.5653 33
African clawed frog
(Xenopus laevis)
Amphibia arhgdib-prov 33
(Danio rerio)
Actinopterygii arhgdig 33
  • 71.91 (n)
zgc65966 33
fruit fly
(Drosophila melanogaster)
Insecta RhoGDI 34 35
  • 45 (a)
(Caenorhabditis elegans)
Secernentea rhi-1 34 35
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RDI1 34
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 44 (a)
Species where no ortholog for ARHGDIB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGDIB Gene

Gene Tree for ARHGDIB (if available)
Gene Tree for ARHGDIB (if available)
Evolutionary constrained regions (ECRs) for ARHGDIB: view image

Paralogs for ARHGDIB Gene

Paralogs for ARHGDIB Gene

(2) SIMAP similar genes for ARHGDIB Gene using alignment to 5 proteins:

  • F5H2R5_HUMAN
  • F5H3P3_HUMAN
  • F5H6Q0_HUMAN
genes like me logo Genes that share paralogs with ARHGDIB: view

Variants for ARHGDIB Gene

Sequence variations from dbSNP and Humsavar for ARHGDIB Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000092671 -- 14,952,305(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000177338 -- 14,942,060(-) G/C 3_prime_UTR_variant, non_coding_transcript_variant
rs1000681706 -- 14,952,362(-) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000922005 -- 14,952,578(-) G/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000980259 -- 14,951,911(-) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGDIB Gene

Variant ID Type Subtype PubMed ID
dgv1394n100 CNV gain 25217958
esv3580158 CNV loss 25503493
nsv469120 CNV gain 19166990
nsv557613 CNV gain 21841781
nsv951333 CNV duplication 24416366

Variation tolerance for ARHGDIB Gene

Residual Variation Intolerance Score: 22.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.61; 13.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARHGDIB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGDIB Gene

Disorders for ARHGDIB Gene

Additional Disease Information for ARHGDIB

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ARHGDIB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGDIB Gene

Publications for ARHGDIB Gene

  1. Ly-GDI, a GDP-dissociation inhibitor of the RhoA GTP-binding protein, is expressed preferentially in lymphocytes. (PMID: 8356058) Scherle P … Staudt LM (Proceedings of the National Academy of Sciences of the United States of America 1993) 2 3 4 22 58
  2. cDNA cloning of a human mRNA preferentially expressed in hematopoietic cells and with homology to a GDP-dissociation inhibitor for the rho GTP-binding proteins. (PMID: 8434008) Lelias JM … Lim B (Proceedings of the National Academy of Sciences of the United States of America 1993) 2 3 4 22 58
  3. Identification of a novel protein with GDP dissociation inhibitor activity for the ras-like proteins CDC42Hs and rac I. (PMID: 7512369) Adra CN … Lim B (Genes, chromosomes & cancer 1993) 3 4 22 58
  4. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 44 58
  5. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PMID: 19170196) Shen M … Lan Q (Environmental and molecular mutagenesis 2009) 3 44 58

Products for ARHGDIB Gene

Sources for ARHGDIB Gene

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