Aliases for ARHGDIA Gene
Aliases for ARHGDIA Gene
External Ids for ARHGDIA Gene
- HGNC: 678
- Entrez Gene: 396
- Ensembl: ENSG00000141522
- OMIM: 601925
- UniProtKB: P52565
Previous HGNC Symbols for ARHGDIA Gene
- GDIA1
Previous GeneCards Identifiers for ARHGDIA Gene
- GC17M079317
- GC17M9I0128
- GC17M080361
- GC17M9I0504
- GC17M9I7418
- GC17M077419
- GC17M079825
- GC17M075227
Summaries for ARHGDIA Gene
-
This gene encodes a protein that plays a key role in the regulation of signaling through Rho GTPases. The encoded protein inhibits the disassociation of Rho family members from GDP (guanine diphosphate), thereby maintaining these factors in an inactive state. Activity of this protein is important in a variety of cellular processes, and expression of this gene may be altered in tumors. Mutations in this gene have been found in individuals with nephrotic syndrome, type 8. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
GeneCards Summary for ARHGDIA Gene
ARHGDIA (Rho GDP Dissociation Inhibitor Alpha) is a Protein Coding gene. Diseases associated with ARHGDIA include Nephrotic Syndrome, Type 8 and Familial Idiopathic Steroid-Resistant Nephrotic Syndrome With Diffuse Mesangial Sclerosis. Among its related pathways are Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and Rho GDP-dissociation inhibitor activity. An important paralog of this gene is ARHGDIB.
UniProtKB/Swiss-Prot for ARHGDIA Gene
-
Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1.
Additional gene information for ARHGDIA Gene
- Monarch Initiative
- Search for ARHGDIA at DataMed
- Search for ARHGDIA at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGDIA Gene
Genomics for ARHGDIA Gene
GeneHancer (GH) Regulatory Elements for ARHGDIA Gene
Promoters and enhancers for ARHGDIA Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around ARHGDIA on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ARHGDIA gene promoter:
-
- AP-1
- CUTL1
- C/EBPalpha
- MyoD
Regulatory Element Products
Genomic Locations for ARHGDIA Gene
Genomic Locations for ARHGDIA Gene
- chr17:81,867,719-81,871,406
- (GRCh38/hg38)
- Size:
- 3,688 bases
- Orientation:
- Minus strand
- chr17:79,825,597-79,829,282
- (GRCh37/hg19)
- Size:
- 3,686 bases
- Orientation:
- Minus strand
Genomic View for ARHGDIA Gene
Genes around ARHGDIA on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.3 by Entrez Gene
- 17q25.3 by HGNC
- 17q25.3 by Ensembl
ARHGDIA Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ARHGDIA Gene
Proteins for ARHGDIA Gene
-
Protein details for ARHGDIA Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P52565-GDIR1_HUMAN
- Recommended name:
- Rho GDP-dissociation inhibitor 1
- Protein Accession:
- P52565
- A8MXW0
- B2R5X1
- B4DDD3
- B4DUV9
- Q6IBM5
Protein attributes for ARHGDIA Gene
- Size:
- 204 amino acids
- Molecular mass:
- 23207 Da
- Quaternary structure:
-
- Monomer. Interacts with FER. Interacts with PLXNB3 (By similarity). Forms a heterodimer with RAC1. Interacts with RHOA, the affinity is increased by three orders of magnitude when RHOA is prenylated. Interacts with PSMD10; the interaction increases ARHGDIA association with RHOA, leading to ARHGDIA-mediated inactivation of RHOA and ROCK and prolonged AKT activation. Interacts with RHOC and CDC42.
Three dimensional structures from OCA and Proteopedia for ARHGDIA Gene
Protein Expression for ARHGDIA Gene
Post-translational modifications for ARHGDIA Gene
Other Protein References for ARHGDIA Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ARHGDIA
-
Abcam antibodies for ARHGDIA
- Invitrogen Antibodies for ARHGDIA (AFLGC-ARHGDIA)
- antibodies-online: Search results for 160 available ARHGDIA Antibodies ranked by validation data
- Compare Top ARHGDIA Antibodies
-
Recommended
- 113 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 FACS Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 26 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 50 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 FACS Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 1 IF Antibody (anti-mouse)
- GeneTex ARHGDIA Antibody for ARHGDIA
-
Santa Cruz Biotechnology (SCBT) Antibodies for ARHGDIA
Protein Products
-
OriGene Purified Proteins for ARHGDIA
- Search Origene for MassSpec and Protein Over-expression Lysates for ARHGDIA
- Origene Custom Protein Services for ARHGDIA
- ProSpec Recombinant Proteins for ARHGDIA
- Search GeneTex for Proteins for ARHGDIA
-
Abcam proteins for ARHGDIA
No data available for DME Specific Peptides for ARHGDIA Gene
Domains & Families for ARHGDIA Gene
Gene Families for ARHGDIA Gene
- Human Protein Atlas (HPA):
-
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for ARHGDIA Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ARHGDIA Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P52565- Family:
-
- Belongs to the Rho GDI family.
Function for ARHGDIA Gene
Molecular function for ARHGDIA Gene
- UniProtKB/Swiss-Prot Function:
- Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1.
- GENATLAS Biochemistry:
- Rho GDP-dissociation factor inhibitor (GDI) alpha,aplysia related
Phenotypes From GWAS Catalog for ARHGDIA Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005094 | Rho GDP-dissociation inhibitor activity | IEA | -- |
| GO:0005096 | GTPase activator activity | IEA | -- |
| GO:0005504 | fatty acid binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 9681826 |
| GO:0017048 | Rho GTPase binding | IEA | -- |
Phenotypes for ARHGDIA Gene
- MGI mutant phenotypes for ARHGDIA:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ARHGDIA:
-
- Decreased viability ratio
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Increased cell death HMECs cells
- Decreased ionizing radiation sensitivity
- Decreased viability
- no effect
- Decreased hepcidin::fluc mRNA expression
- shRNA abundance <= 50%
Animal Models for ARHGDIA Gene
- MGI Knock Outs for ARHGDIA:
-
- Arhgdia Arhgdia<tm1Ytk>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ARHGDIA
-
CRISPR Products
-
OriGene CRISPR knockouts for ARHGDIA
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ARHGDIA
- genomics-online: gRNA clones - Search results for available ARHGDIA gene related products
- Applied Biological Materials CRISPR for ARHGDIA
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ARHGDIA
miRNA for ARHGDIA Gene
- miRTarBase miRNAs that target ARHGDIA
-
- hsa-mir-16-5p (MIRT001479)
- hsa-mir-151a-5p (MIRT004486)
- hsa-mir-877-3p (MIRT036932)
- hsa-mir-744-5p (MIRT037531)
- hsa-mir-423-5p (MIRT038106)
- hsa-mir-484 (MIRT042136)
- hsa-mir-183-5p (MIRT047092)
- hsa-mir-92a-3p (MIRT049570)
- hsa-mir-4745-3p (MIRT490654)
- hsa-mir-1538 (MIRT490655)
- hsa-mir-6894-5p (MIRT490656)
- hsa-mir-765 (MIRT490657)
- hsa-mir-7154-3p (MIRT490658)
- hsa-mir-766-5p (MIRT490659)
- hsa-mir-891a-5p (MIRT512270)
- hsa-mir-4524a-3p (MIRT512271)
- hsa-mir-7110-3p (MIRT512272)
- hsa-mir-6845-3p (MIRT512273)
- hsa-mir-6769b-3p (MIRT512274)
- hsa-mir-4723-3p (MIRT512275)
- hsa-mir-3183 (MIRT512276)
- hsa-mir-361-3p (MIRT512277)
- hsa-mir-4692 (MIRT512278)
- hsa-mir-4514 (MIRT512279)
- hsa-mir-4768-3p (MIRT512280)
- hsa-mir-6511a-5p (MIRT512281)
- hsa-mir-1910-3p (MIRT512282)
- hsa-mir-4524b-3p (MIRT512283)
- hsa-mir-195-5p (MIRT512284)
- hsa-mir-424-5p (MIRT512285)
- hsa-mir-497-5p (MIRT512286)
- hsa-mir-6838-5p (MIRT512287)
- hsa-mir-15a-5p (MIRT512288)
- hsa-mir-15b-5p (MIRT512289)
- hsa-mir-6744-3p (MIRT524873)
- hsa-mir-4757-5p (MIRT524874)
- hsa-mir-151b (MIRT524875)
- hsa-mir-330-5p (MIRT559516)
- hsa-mir-5787 (MIRT559517)
- hsa-mir-4505 (MIRT559518)
- hsa-mir-6884-5p (MIRT559519)
- hsa-mir-485-5p (MIRT559520)
- hsa-mir-4695-5p (MIRT559521)
- hsa-mir-6801-5p (MIRT562657)
- hsa-mir-298 (MIRT562658)
- hsa-mir-4783-3p (MIRT562659)
- hsa-mir-4729 (MIRT562660)
- hsa-mir-6510-5p (MIRT562661)
- hsa-mir-1273h-3p (MIRT568487)
- hsa-mir-6866-5p (MIRT568488)
- hsa-mir-877-5p (MIRT568489)
- hsa-mir-4653-3p (MIRT568490)
- hsa-mir-6847-3p (MIRT568491)
- hsa-mir-4771 (MIRT568492)
- hsa-mir-3166 (MIRT568493)
- hsa-mir-3975 (MIRT568494)
- hsa-mir-6754-5p (MIRT568495)
- hsa-mir-4441 (MIRT568496)
- hsa-mir-4270 (MIRT568497)
- hsa-mir-6768-5p (MIRT568498)
- hsa-mir-6743-5p (MIRT572239)
- hsa-mir-4688 (MIRT572240)
- mmu-mir-200b-5p (MIRT734485)
- hsa-mir-1236-5p (MIRT736285)
- hsa-mir-1275 (MIRT736914)
- hsa-mir-1293 (MIRT737144)
- hsa-mir-1343-3p (MIRT737425)
- hsa-mir-181a-3p (MIRT738022)
- hsa-mir-184 (MIRT738185)
- hsa-mir-1908-5p (MIRT738313)
- hsa-mir-200b-3p (MIRT738763)
- hsa-mir-200c-3p (MIRT738775)
- hsa-mir-211-3p (MIRT738923)
- hsa-mir-221-5p (MIRT739072)
- hsa-mir-2467-5p (MIRT739329)
- hsa-mir-3064-5p (MIRT739690)
- hsa-mir-3188 (MIRT740934)
- hsa-mir-328-5p (MIRT741279)
- hsa-mir-3612 (MIRT741546)
- hsa-mir-3652 (MIRT741882)
- hsa-mir-3677-3p (MIRT742146)
- hsa-mir-375 (MIRT742636)
- hsa-mir-3912-5p (MIRT742853)
- hsa-mir-3937 (MIRT743121)
- hsa-mir-4265 (MIRT743498)
- hsa-mir-4283 (MIRT743708)
- hsa-mir-4296 (MIRT743793)
- hsa-mir-429 (MIRT743823)
- hsa-mir-4316 (MIRT743989)
- hsa-mir-4322 (MIRT744031)
- hsa-mir-4326 (MIRT744093)
- hsa-mir-4417 (MIRT744138)
- hsa-mir-4430 (MIRT744320)
- hsa-mir-4435 (MIRT744419)
- hsa-mir-4437 (MIRT744489)
- hsa-mir-4455 (MIRT744717)
- hsa-mir-4483 (MIRT745141)
- hsa-mir-4493 (MIRT745309)
- hsa-mir-4508 (MIRT745555)
- hsa-mir-4525 (MIRT745905)
- hsa-mir-4651 (MIRT746527)
- hsa-mir-4665-5p (MIRT746752)
- hsa-mir-4674 (MIRT746866)
- hsa-mir-4721 (MIRT747543)
- hsa-mir-4747-5p (MIRT748224)
- hsa-mir-4755-3p (MIRT748356)
- hsa-mir-4763-5p (MIRT748583)
- hsa-mir-4765 (MIRT748593)
- hsa-mir-4787-5p (MIRT748884)
- hsa-mir-5010-5p (MIRT749487)
- hsa-mir-5088-5p (MIRT749633)
- hsa-mir-5196-5p (MIRT750008)
- hsa-mir-5589-5p (MIRT751022)
- hsa-mir-608 (MIRT751965)
- hsa-mir-625-5p (MIRT752579)
- hsa-mir-635 (MIRT752673)
- hsa-mir-637 (MIRT752680)
- hsa-mir-6504-5p (MIRT752927)
- hsa-mir-650 (MIRT752994)
- hsa-mir-661 (MIRT753545)
- hsa-mir-663a (MIRT753574)
- hsa-mir-6739-3p (MIRT754292)
- hsa-mir-6747-5p (MIRT754508)
- hsa-mir-6751-5p (MIRT754585)
- hsa-mir-6752-5p (MIRT754615)
- hsa-mir-6761-5p (MIRT754955)
- hsa-mir-6774-5p (MIRT755340)
- hsa-mir-6783-3p (MIRT755722)
- hsa-mir-6787-5p (MIRT755934)
- hsa-mir-6795-5p (MIRT756121)
- hsa-mir-6803-5p (MIRT756391)
- hsa-mir-6842-3p (MIRT757337)
- hsa-mir-6842-5p (MIRT757349)
- hsa-mir-6852-5p (MIRT757634)
- hsa-mir-6885-5p (MIRT758530)
- hsa-mir-6887-5p (MIRT758579)
- hsa-mir-7109-5p (MIRT758936)
- hsa-mir-7110-5p (MIRT758975)
- hsa-mir-8068 (MIRT760075)
- hsa-mir-8073 (MIRT760120)
- hsa-mir-891a-3p (MIRT760433)
- hsa-mir-9500 (MIRT760871)
- hsa-mir-95-5p (MIRT760916)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ARHGDIA
- Browse OriGene Inhibitory RNA Products For ARHGDIA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARHGDIA
- genomics-online: shRNA clones - Search results for available ARHGDIA gene related products
Clone Products
-
OriGene ORF clones in human for ARHGDIA
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ARHGDIA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ARHGDIA
- genomics-online: cdna clones - Search results for available ARHGDIA gene related products
- orf clones - Search results for available ARHGDIA gene related products
- Applied Biological Materials Clones for ARHGDIA
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ARHGDIA
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ARHGDIA Gene
Localization for ARHGDIA Gene
Subcellular locations from UniProtKB/Swiss-Prot for ARHGDIA Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytoskeleton | 5 |
| cytosol | 5 |
| nucleus | 3 |
| plasma membrane | 2 |
- Cytosol (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | IEA | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005856 | cytoskeleton | TAS | 16130169 |
Pathways & Interactions for ARHGDIA Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | p75 NTR receptor-mediated signalling |
.36
|
|
| 2 | Actin Nucleation by ARP-WASP Complex |
.35
|
|
| 3 | G-protein signaling RAC1 in cellular process | ||
| 4 | Development HGF signaling pathway | ||
| 5 | Vasopressin-regulated water reabsorption | ||
Pathways by source for ARHGDIA Gene
6 BioSystems pathways for ARHGDIA Gene
8 Reactome pathways for ARHGDIA Gene
2 KEGG pathways for ARHGDIA Gene
7 GeneGo (Thomson Reuters) pathways for ARHGDIA Gene
6 Qiagen pathways for ARHGDIA Gene
1 Cell Signaling Technology pathway for ARHGDIA Gene
Interacting Proteins for ARHGDIA Gene
Selected Interacting proteins:
P52565-GDIR1_HUMAN
ENSP00000269321
for ARHGDIA Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for ARHGDIA
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007162 | negative regulation of cell adhesion | TAS | 8262133 |
| GO:0007266 | Rho protein signal transduction | IEA | -- |
| GO:0008360 | regulation of cell shape | IEA | -- |
| GO:0030336 | negative regulation of cell migration | IEA | -- |
| GO:0032880 | regulation of protein localization | IEA | -- |
Transcripts for ARHGDIA Gene
mRNA/cDNA for ARHGDIA Gene
- (8) REFSEQ mRNAs :
- (22) Additional mRNA sequences :
- (367) Selected AceView cDNA sequences:
- (17) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000582520 245 bps (uc060lov.1)
- ENST00000269321 1906 bps (uc002kbq.3)
- ENST00000400721 1568 bps (uc021ufg.2)
- ENST00000584461 886 bps (uc060lox.1)
- ENST00000541078 1517 bps (uc021uff.2)
Unigene Clusters for ARHGDIA Gene
- Rho GDP dissociation inhibitor (GDI) alpha:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for ARHGDIA
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ARHGDIA
- genomics-online: gRNA clones - Search results for available ARHGDIA gene related products
- Applied Biological Materials CRISPR for ARHGDIA
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ARHGDIA
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ARHGDIA
- Browse OriGene Inhibitory RNA Products For ARHGDIA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARHGDIA
- genomics-online: shRNA clones - Search results for available ARHGDIA gene related products
Clone Products
-
OriGene ORF clones in human for ARHGDIA
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ARHGDIA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ARHGDIA
- genomics-online: cdna clones - Search results for available ARHGDIA gene related products
- orf clones - Search results for available ARHGDIA gene related products
- Applied Biological Materials Clones for ARHGDIA
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | · | 7f | · | 7g | · | 7h | ^ | 8a | · | 8b | ^ | 9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP11: | - |
Expression for ARHGDIA Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Thymus (Hematopoietic System)
- Double Negative 2 Thymocytes Thymus
-
Blood (Cardiovascular System)
- Double Negative 2 Thymocytes Thymus
- Brain (Nervous System)
- Intestine (Gastrointestinal Tract)
- Heart (Cardiovascular System)
- Bone (Muscoskeletal System)
- Smooth Muscle (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARHGDIA Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ARHGDIA Gene:
ARHGDIASOURCE GeneReport for Unigene cluster for ARHGDIA Gene:
Hs.159161Evidence on tissue expression from TISSUES for ARHGDIA Gene
- Nervous system(5)
- Lung(4.9)
- Skin(4.9)
- Intestine(4.8)
- Liver(4.8)
- Blood(4.7)
- Muscle(4.6)
- Pancreas(3.7)
- Kidney(3.4)
- Stomach(3.3)
- Eye(2.9)
- Bone marrow(2.4)
- Heart(2.2)
- Spleen(2.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGDIA Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- integumentary
- respiratory
- urinary
Regions:
Head and neck:
- ear
Thorax:
- heart
- lung
Abdomen:
- kidney
Pelvis:
- urinary bladder
General:
- blood
- blood vessel
- coagulation system
- red blood cell
- skin
Primer Products
-
OriGene qPCR primer pairs for ARHGDIA
-
OriGene qPCR primer pairs and template standards for ARHGDIA
- genomics-online: primer clones - Search results for available ARHGDIA gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARHGDIA Gene
Orthologs for ARHGDIA Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ARHGDIA 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | ARHGDIA 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ARHGDIA 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ARHGDIA 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Arhgdia 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Arhgdia 33 |
|
||
| chicken (Gallus gallus) |
Aves | ARHGDIA 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ARHGDIA 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | arhgdia 33 |
|
||
| Str.1468 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.13978 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | arhgdia 34 33 |
|
OneToOne | |
| wufa96g11 33 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012168 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | RhoGDI 34 35 33 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | rhi-1 34 35 33 |
|
OneToMany | |
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ADR098C 33 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F05313g 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RDI1 36 34 33 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | SCN1 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os06g0318300 33 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU06561 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany | |
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC6F12.06 33 |
|
- Species where no ortholog for ARHGDIA was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for ARHGDIA Gene
- ENSEMBL:
- Gene Tree for ARHGDIA (if available)
- TreeFam:
- Gene Tree for ARHGDIA (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ARHGDIA: view image
Paralogs for ARHGDIA Gene
Variants for ARHGDIA Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs587776969 | pathogenic, Nephrotic syndrome, type 8 | 81,868,936(-) | GTCGTCGTC/GTCGTC | coding_sequence_variant, inframe_deletion, intron_variant, non_coding_transcript_variant, splice_acceptor_variant | |
| rs587777552 | pathogenic, Nephrotic syndrome, type 8 | 81,868,973(-) | C/A | coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant | |
| rs587777553 | pathogenic, Nephrotic syndrome, type 8 | 81,869,230(-) | G/A | coding_sequence_variant, non_coding_transcript_variant, stop_gained | |
| rs1000404602 | -- | 81,867,742(-) | C/T | 3_prime_UTR_variant, non_coding_transcript_variant | |
| rs1000866967 | -- | 81,867,984(-) | G/T | 3_prime_UTR_variant, non_coding_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv21913 | CNV | gain+loss | 19812545 |
| esv3641407 | CNV | gain | 21293372 |
| nsv1071814 | CNV | deletion | 25765185 |
| nsv1126474 | CNV | deletion | 24896259 |
| nsv1136245 | CNV | deletion | 24896259 |
| nsv428351 | CNV | gain | 18775914 |
| nsv470620 | CNV | loss | 18288195 |
| nsv833569 | CNV | loss | 17160897 |
| nsv952391 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
49.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.46;
28.58% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ARHGDIA Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGDIA Gene
Disorders for ARHGDIA Gene
(6) MalaCards diseases for ARHGDIA Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| nephrotic syndrome, type 8 |
|
|
| familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis |
|
|
| nephrotic syndrome |
|
|
| diffuse mesangial sclerosis |
|
|
| retinitis pigmentosa 14 |
|
|
Search ARHGDIA in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
GDIR1_HUMAN- Nephrotic syndrome 8 (NPHS8) [MIM:615244]: A form of nephrotic syndrome, a renal disease clinically characterized by progressive renal failure, severe proteinuria, hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show diffuse mesangial sclerosis, with small glomeruli, hypercellularity, increased extracellular matrix, and contracted/collapsed glomerular tufts surrounded by immature or abnormal podocytes. {ECO:0000269 PubMed:23434736}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for ARHGDIA
No data available for Genatlas for ARHGDIA Gene
Publications for ARHGDIA Gene
- ARHGDIA: a novel gene implicated in nephrotic syndrome. (PMID: 23434736) Gupta IR … Takano T (Journal of medical genetics 2013) 3 4 58
- Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1. (PMID: 20400958) Boulter E … Burridge K (Nature cell biology 2010) 3 4 58
- Gankyrin plays an essential role in Ras-induced tumorigenesis through regulation of the RhoA/ROCK pathway in mammalian cells. (PMID: 20628200) Man JH … Zhang XM (The Journal of clinical investigation 2010) 3 4 58
- The Fer tyrosine kinase regulates interactions of Rho GDP-Dissociation Inhibitor α with the small GTPase Rac. (PMID: 21122136) Fei F … Heisterkamp N (BMC biochemistry 2010) 3 4 58
- Diacylglycerol kinase zeta regulates actin cytoskeleton reorganization through dissociation of Rac1 from RhoGDI. (PMID: 19211846) Abramovici H … Gee SH (Molecular biology of the cell 2009) 3 22 58
Products for ARHGDIA Gene
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- Custom Antibody ServicesOriGene Antibodies for ARHGDIA
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for ARHGDIA
- Search Origene for MassSpec and Protein Over-expression Lysates for ARHGDIA
- Origene Custom Protein Services for ARHGDIA
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ARHGDIA
- Browse OriGene Inhibitory RNA Products For ARHGDIA
- OriGene qPCR primer pairs for ARHGDIA
- OriGene qPCR primer pairs and template standards for ARHGDIA
- OriGene CRISPR knockouts for ARHGDIA
- OriGene ORF clones in human for ARHGDIA
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ARHGDIA
- GenScript: Next-day shipping of latest version cDNA ORF clones for ARHGDIA in any vector
- GenScript Custom Purified and Recombinant Proteins Services for ARHGDIA
- GenScript Custom Assay Services for ARHGDIA
- GenScript Custom overexpressing Cell Line Services for ARHGDIA
- Browse GenScript CRISPR for ARHGDIA
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11