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This gene encodes a protein that plays a key role in the regulation of signaling through Rho GTPases. The encoded protein inhibits the disassociation of Rho family members from GDP (guanine diphosphate), thereby maintaining these factors in an inactive state. Activity of this protein is important in a variety of cellular processes, and expression of this gene may be altered in ... See more...
Aliases for ARHGDIA Gene
Aliases for ARHGDIA Gene
External Ids for ARHGDIA Gene
- HGNC: 678
- NCBI Entrez Gene: 396
- Ensembl: ENSG00000141522
- OMIM®: 601925
- UniProtKB/Swiss-Prot: P52565
Previous HGNC Symbols for ARHGDIA Gene
- GDIA1
Previous GeneCards Identifiers for ARHGDIA Gene
- GC17M079317
- GC17M9I0128
- GC17M080361
- GC17M9I0504
- GC17M9I7418
- GC17M077419
- GC17M079825
- GC17M075227
Summaries for ARHGDIA Gene
-
This gene encodes a protein that plays a key role in the regulation of signaling through Rho GTPases. The encoded protein inhibits the disassociation of Rho family members from GDP (guanine diphosphate), thereby maintaining these factors in an inactive state. Activity of this protein is important in a variety of cellular processes, and expression of this gene may be altered in tumors. Mutations in this gene have been found in individuals with nephrotic syndrome, type 8. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
GeneCards Summary for ARHGDIA Gene
ARHGDIA (Rho GDP Dissociation Inhibitor Alpha) is a Protein Coding gene. Diseases associated with ARHGDIA include Nephrotic Syndrome, Type 8 and Genetic Steroid-Resistant Nephrotic Syndrome. Among its related pathways are p75 NTR receptor-mediated signalling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and Rho GDP-dissociation inhibitor activity. An important paralog of this gene is ARHGDIB.
UniProtKB/Swiss-Prot Summary for ARHGDIA Gene
-
Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1.
Additional gene information for ARHGDIA Gene
- HGNC (678)
- NCBI Entrez Gene (396)
- Ensembl (ENSG00000141522)
- OMIM® (601925)
- UniProtKB/Swiss-Prot (P52565)
- Open Targets Platform(ENSG00000141522)
- Monarch Initiative
- Alliance of Genome Resources
- Search for ARHGDIA at DataMed
- Search for ARHGDIA at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARHGDIA Gene
Genomics for ARHGDIA Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ARHGDIA Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ARHGDIA on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ARHGDIA
- Top Transcription factor binding sites by QIAGEN in the ARHGDIA gene promoter:
-
- AP-1
- C/EBPalpha
- CUTL1
- MyoD
Genomic Locations for ARHGDIA Gene
Latest Assembly
- chr17:81,867,719-81,871,378
- (GRCh38/hg38)
- Size:
- 3,660 bases
- Orientation:
- Minus strand
Previous Assembly
- chr17:79,825,597-79,829,213
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 3,617 bases
- Orientation:
- Minus strand
Genomic View for ARHGDIA Gene
Genes around ARHGDIA on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.3 by HGNC
- 17q25.3 by Entrez Gene
- 17q25.3 by Ensembl
ARHGDIA Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ARHGDIA Gene
Proteins for ARHGDIA Gene
-
Protein details for ARHGDIA Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P52565-GDIR1_HUMAN
- Recommended name:
- Rho GDP-dissociation inhibitor 1
- Protein Accession:
- P52565
- A8MXW0
- B2R5X1
- B4DDD3
- B4DUV9
- Q6IBM5
Protein attributes for ARHGDIA Gene
- Size:
- 204 amino acids
- Molecular mass:
- 23207 Da
- Quaternary structure:
-
- Monomer (By similarity). Interacts with FER (PubMed:21122136). Interacts with PLXNB3 (By similarity). Forms a heterodimer with RAC1 (PubMed:23434736). Interacts with RHOA, the affinity is increased by three orders of magnitude when RHOA is prenylated (PubMed:20628200, PubMed:20400958, PubMed:26646181, PubMed:23434736). Interacts with PSMD10; the interaction increases ARHGDIA association with RHOA, leading to ARHGDIA-mediated inactivation of RHOA and ROCK and prolonged AKT activation (PubMed:20628200). Interacts with KANK2; the interaction is direct and may regulate the interaction of ARHGDIA with RHOA, RAC1 and CDC42 (PubMed:25961457). Interacts with RHOC (PubMed:20400958). Interacts with CDC42 (PubMed:23434736). Interacts with NGFR (via death domain); NGFR binding decreases the affinity for RHOA (PubMed:26646181).
Three dimensional structures from OCA and Proteopedia for ARHGDIA Gene
Protein Expression for ARHGDIA Gene
Post-translational modifications for ARHGDIA Gene
Other Protein References for ARHGDIA Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences ARHGDIA / RHOGDI Antibody
- G Biosciences Immunotag™ ARHGDIA Antibody
- Novus Biologicals Antibodies for ARHGDIA
-
Abcam antibodies for ARHGDIA
- Invitrogen Antibodies for ARHGDIA (AFLGC-ARHGDIA)
- antibodies-online: Show 40 available ARHGDIA Antibodies ranked by validation data
- Compare Top ARHGDIA Antibodies
-
Recommended
- 117 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 36 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
- 47 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
-
Boster Bio Antibodies for ARHGDIA
-
Santa Cruz Biotechnology (SCBT) Antibodies for ARHGDIA
- Sino Biological Antibodies for ARHGDIA
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for ARHGDIA
- Origene Custom Protein Services for ARHGDIA
- ProSpec Recombinant Proteins for ARHGDIA
-
Abcam proteins for ARHGDIA
No data available for DME Specific Peptides for ARHGDIA Gene
Domains & Families for ARHGDIA Gene
Gene Families for ARHGDIA Gene
- Human Protein Atlas (HPA):
-
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for ARHGDIA Gene
- InterPro:
- Blocks:
-
- RHO protein GDP dissociation inhibitor signature
Suggested Antigen Peptide Sequences for ARHGDIA Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ50748, highly similar to Rho GDP-dissociation inhibitor 1 (A8MXW0_HUMAN)
- Rho-GDI alpha (GDIR1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P52565- Family:
-
- Belongs to the Rho GDI family.
Function for ARHGDIA Gene
Molecular function for ARHGDIA Gene
- UniProtKB/Swiss-Prot Function:
- Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1.
- GENATLAS Biochemistry:
- Rho GDP-dissociation factor inhibitor (GDI) alpha,aplysia related
Phenotypes From GWAS Catalog for ARHGDIA Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005094 | Rho GDP-dissociation inhibitor activity | IEA,IBA | 21873635 |
| GO:0005096 | GTPase activator activity | IEA | -- |
| GO:0005504 | fatty acid binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 10489445 |
| GO:0019901 | protein kinase binding | IEA | -- |
Phenotypes for ARHGDIA Gene
- MGI mutant phenotypes for ARHGDIA:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ARHGDIA:
Animal Models for ARHGDIA Gene
- MGI Knock Outs for ARHGDIA:
-
- Arhgdia Arhgdia<tm1Ytk>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ARHGDIA - Starting at $85 >
- * ARHGDIA CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ARHGDIA
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ARHGDIA
-
Santa Cruz Biotechnology (SCBT) CRISPR for ARHGDIA
miRNA for ARHGDIA Gene
- miRTarBase miRNAs that target ARHGDIA
-
- hsa-miR-16-5p (MIRT001479)
- hsa-miR-151a-5p (MIRT004486)
- mmu-miR-7b-5p (MIRT009249)
- mmu-miR-324-3p (MIRT010890)
- mmu-miR-15a-5p (MIRT011870)
- mmu-miR-9-5p (MIRT015373)
- hsa-miR-877-3p (MIRT036932)
- hsa-miR-744-5p (MIRT037531)
- hsa-miR-423-5p (MIRT038106)
- hsa-miR-484 (MIRT042136)
- hsa-miR-183-5p (MIRT047092)
- hsa-miR-92a-3p (MIRT049570)
- hsa-miR-4745-3p (MIRT490654)
- hsa-miR-1538 (MIRT490655)
- hsa-miR-6894-5p (MIRT490656)
- hsa-miR-765 (MIRT490657)
- hsa-miR-7154-3p (MIRT490658)
- hsa-miR-766-5p (MIRT490659)
- hsa-miR-891a-5p (MIRT512270)
- hsa-miR-4524a-3p (MIRT512271)
- hsa-miR-7110-3p (MIRT512272)
- hsa-miR-6845-3p (MIRT512273)
- hsa-miR-6769b-3p (MIRT512274)
- hsa-miR-4723-3p (MIRT512275)
- hsa-miR-3183 (MIRT512276)
- hsa-miR-361-3p (MIRT512277)
- hsa-miR-4692 (MIRT512278)
- hsa-miR-4514 (MIRT512279)
- hsa-miR-4768-3p (MIRT512280)
- hsa-miR-6511a-5p (MIRT512281)
- hsa-miR-1910-3p (MIRT512282)
- hsa-miR-4524b-3p (MIRT512283)
- hsa-miR-195-5p (MIRT512284)
- hsa-miR-424-5p (MIRT512285)
- hsa-miR-497-5p (MIRT512286)
- hsa-miR-6838-5p (MIRT512287)
- hsa-miR-15a-5p (MIRT512288)
- hsa-miR-15b-5p (MIRT512289)
- hsa-miR-6744-3p (MIRT524873)
- hsa-miR-4757-5p (MIRT524874)
- hsa-miR-151b (MIRT524875)
- hsa-miR-330-5p (MIRT559516)
- hsa-miR-5787 (MIRT559517)
- hsa-miR-4505 (MIRT559518)
- hsa-miR-6884-5p (MIRT559519)
- hsa-miR-485-5p (MIRT559520)
- hsa-miR-4695-5p (MIRT559521)
- hsa-miR-6801-5p (MIRT562657)
- hsa-miR-298 (MIRT562658)
- hsa-miR-4783-3p (MIRT562659)
- hsa-miR-4729 (MIRT562660)
- hsa-miR-6510-5p (MIRT562661)
- hsa-miR-1273h-3p (MIRT568487)
- hsa-miR-6866-5p (MIRT568488)
- hsa-miR-877-5p (MIRT568489)
- hsa-miR-4653-3p (MIRT568490)
- hsa-miR-6847-3p (MIRT568491)
- hsa-miR-4771 (MIRT568492)
- hsa-miR-3166 (MIRT568493)
- hsa-miR-3975 (MIRT568494)
- hsa-miR-6754-5p (MIRT568495)
- hsa-miR-4441 (MIRT568496)
- hsa-miR-4270 (MIRT568497)
- hsa-miR-6768-5p (MIRT568498)
- hsa-miR-6743-5p (MIRT572239)
- hsa-miR-4688 (MIRT572240)
- mmu-miR-200b-5p (MIRT734485)
- hsa-miR-1236-5p (MIRT736285)
- hsa-miR-1275 (MIRT736914)
- hsa-miR-1293 (MIRT737144)
- hsa-miR-1343-3p (MIRT737425)
- hsa-miR-181a-3p (MIRT738022)
- hsa-miR-184 (MIRT738185)
- hsa-miR-1908-5p (MIRT738313)
- hsa-miR-200b-3p (MIRT738763)
- hsa-miR-200c-3p (MIRT738775)
- hsa-miR-211-3p (MIRT738923)
- hsa-miR-221-5p (MIRT739072)
- hsa-miR-2467-5p (MIRT739329)
- hsa-miR-3064-5p (MIRT739690)
- hsa-miR-3188 (MIRT740934)
- hsa-miR-328-5p (MIRT741279)
- hsa-miR-3612 (MIRT741546)
- hsa-miR-3652 (MIRT741882)
- hsa-miR-3677-3p (MIRT742146)
- hsa-miR-375 (MIRT742636)
- hsa-miR-3912-5p (MIRT742853)
- hsa-miR-3937 (MIRT743121)
- hsa-miR-4265 (MIRT743498)
- hsa-miR-4283 (MIRT743708)
- hsa-miR-4296 (MIRT743793)
- hsa-miR-429 (MIRT743823)
- hsa-miR-4316 (MIRT743989)
- hsa-miR-4322 (MIRT744031)
- hsa-miR-4326 (MIRT744093)
- hsa-miR-4417 (MIRT744138)
- hsa-miR-4430 (MIRT744320)
- hsa-miR-4435 (MIRT744419)
- hsa-miR-4437 (MIRT744489)
- hsa-miR-4455 (MIRT744717)
- hsa-miR-4483 (MIRT745141)
- hsa-miR-4493 (MIRT745309)
- hsa-miR-4508 (MIRT745555)
- hsa-miR-4525 (MIRT745905)
- hsa-miR-4651 (MIRT746527)
- hsa-miR-4665-5p (MIRT746752)
- hsa-miR-4674 (MIRT746866)
- hsa-miR-4721 (MIRT747543)
- hsa-miR-4747-5p (MIRT748224)
- hsa-miR-4755-3p (MIRT748356)
- hsa-miR-4763-5p (MIRT748583)
- hsa-miR-4765 (MIRT748593)
- hsa-miR-4787-5p (MIRT748884)
- hsa-miR-5010-5p (MIRT749487)
- hsa-miR-5088-5p (MIRT749633)
- hsa-miR-5196-5p (MIRT750008)
- hsa-miR-5589-5p (MIRT751022)
- hsa-miR-608 (MIRT751965)
- hsa-miR-625-5p (MIRT752579)
- hsa-miR-635 (MIRT752673)
- hsa-miR-637 (MIRT752680)
- hsa-miR-6504-5p (MIRT752927)
- hsa-miR-650 (MIRT752994)
- hsa-miR-661 (MIRT753545)
- hsa-miR-663a (MIRT753574)
- hsa-miR-6739-3p (MIRT754292)
- hsa-miR-6747-5p (MIRT754508)
- hsa-miR-6751-5p (MIRT754585)
- hsa-miR-6752-5p (MIRT754615)
- hsa-miR-6761-5p (MIRT754955)
- hsa-miR-6774-5p (MIRT755340)
- hsa-miR-6783-3p (MIRT755722)
- hsa-miR-6787-5p (MIRT755934)
- hsa-miR-6795-5p (MIRT756121)
- hsa-miR-6803-5p (MIRT756391)
- hsa-miR-6842-3p (MIRT757337)
- hsa-miR-6842-5p (MIRT757349)
- hsa-miR-6852-5p (MIRT757634)
- hsa-miR-6885-5p (MIRT758530)
- hsa-miR-6887-5p (MIRT758579)
- hsa-miR-7109-5p (MIRT758936)
- hsa-miR-7110-5p (MIRT758975)
- hsa-miR-8068 (MIRT760075)
- hsa-miR-8073 (MIRT760120)
- hsa-miR-891a-3p (MIRT760433)
- hsa-miR-9500 (MIRT760871)
- hsa-miR-95-5p (MIRT760916)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ARHGDIA
- Browse OriGene Inhibitory RNA Products For ARHGDIA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARHGDIA
Clone products for research
- Applied Biological Materials (abm): Clones for ARHGDIA - Starting at $45 >
- * ARHGDIA as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG202112
- MR202112
- MR202112L3
- MR202112L4
- RC200902
- RC200902L1
- RC200902L2
- RC200902L3
- RC200902L4
- RC231004
- RC231004L3
- RC231004L4
- RC233427
- RC236789
- RC236790
- RC236918
- RC237549
- RG200902
- RG231004
- RG233427
- RR204316
- RR204316L3
- RR204316L4
- MR202112L3V
- MR202112L4V
- RC200902L1V
- RC200902L2V
- RC200902L3V
- RC200902L4V
- RC231004L3V
- RC231004L4V
- RR204316L3V
- RR204316L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ARHGDIA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ARHGDIA
Cell Lines for research
-
Horizon Cell Lines for ARHGDIA
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ARHGDIA Gene
Localization for ARHGDIA Gene
Subcellular locations from UniProtKB/Swiss-Prot for ARHGDIA Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| cytosol | 5 |
| extracellular | 4 |
| nucleus | 3 |
| plasma membrane | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| peroxisome | 1 |
- Cytosol (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001772 | immunological synapse | IEA | -- |
| GO:0005615 | extracellular space | IEA | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | IEA,TAS | -- |
Pathways & Interactions for ARHGDIA Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | p75 NTR receptor-mediated signalling |
.36
|
|
| 2 | Actin Nucleation by ARP-WASP Complex |
Actin Nucleation by ARP-WASP Complex
.66
|
RhoA Pathway
.35
|
| 3 | G-protein signaling RAC1 in cellular process | ||
| 4 | Cytoskeletal Signaling | ||
| 5 | Development HGF signaling pathway | ||
Pathways by source for ARHGDIA Gene
6 BioSystems pathways for ARHGDIA Gene
8 Reactome pathways for ARHGDIA Gene
2 KEGG pathways for ARHGDIA Gene
7 GeneGo (Thomson Reuters) pathways for ARHGDIA Gene
- Development MAG-dependent inhibition of neurite outgrowth
- G-protein signaling_Rac2 regulation pathway
- G-protein signaling_Regulation of CDC42 activity
- G-protein signaling_Regulation of RAC1 activity
- G-protein signaling_RhoA regulation pathway
6 Qiagen pathways for ARHGDIA Gene
- Actin Nucleation by ARP-WASP Complex
- Actin-Based Motility by Rho Family GTPases
- Crosstalk Between CARM1 and ESRs
- Rho Family GTPases
- RhoA Pathway
1 Cell Signaling Technology pathway for ARHGDIA Gene
Interacting Proteins for ARHGDIA Gene
Selected Interacting proteins:
P52565-GDIR1_HUMAN
ENSP00000269321
for ARHGDIA Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for ARHGDIA
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007162 | negative regulation of cell adhesion | TAS | 8262133 |
| GO:0007266 | Rho protein signal transduction | IEA,IBA | 21873635 |
| GO:0008360 | regulation of cell shape | IEA | -- |
| GO:0030336 | negative regulation of cell migration | IEA | -- |
| GO:0032880 | regulation of protein localization | IEA | -- |
Transcripts for ARHGDIA Gene
mRNA/cDNA for ARHGDIA Gene
- 7 REFSEQ mRNAs :
- 37 NCBI additional mRNA sequence :
- 17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000269321 1837 nts (view in UCSC)
- ENST00000400721 1568 nts (view in UCSC)
- ENST00000541078 1517 nts (view in UCSC)
- ENST00000578351 421 nts (view in UCSC)
- ENST00000579121 637 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ARHGDIA - Starting at $85 >
- * ARHGDIA CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ARHGDIA
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ARHGDIA
-
Santa Cruz Biotechnology (SCBT) CRISPR for ARHGDIA
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ARHGDIA
- Browse OriGene Inhibitory RNA Products For ARHGDIA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARHGDIA
Clone products for research
- Applied Biological Materials (abm): Clones for ARHGDIA - Starting at $45 >
- * ARHGDIA as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG202112
- MR202112
- MR202112L3
- MR202112L4
- RC200902
- RC200902L1
- RC200902L2
- RC200902L3
- RC200902L4
- RC231004
- RC231004L3
- RC231004L4
- RC233427
- RC236789
- RC236790
- RC236918
- RC237549
- RG200902
- RG231004
- RG233427
- RR204316
- RR204316L3
- RR204316L4
- MR202112L3V
- MR202112L4V
- RC200902L1V
- RC200902L2V
- RC200902L3V
- RC200902L4V
- RC231004L3V
- RC231004L4V
- RR204316L3V
- RR204316L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ARHGDIA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ARHGDIA
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | · | 7f | · | 7g | · | 7h | ^ | 8a | · | 8b | ^ | 9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
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| SP11: | - |
Relevant External Links for ARHGDIA Gene
- GeneLoc Exon Structure for
- ARHGDIA
Expression for ARHGDIA Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Thymus (Hematopoietic System)
- Double Negative 2 Thymocytes Thymus
-
Blood (Cardiovascular System)
- Double Negative 2 Thymocytes Thymus
- Brain (Nervous System)
- Intestine (Gastrointestinal Tract)
- Heart (Cardiovascular System)
- Bone (Muscoskeletal System)
- Smooth Muscle (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARHGDIA Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ARHGDIA
SOURCE GeneReport for Unigene cluster for ARHGDIA Gene:
Hs.159161Evidence on tissue expression from TISSUES for ARHGDIA Gene
- Nervous system(5)
- Skin(5)
- Lung(4.9)
- Liver(4.9)
- Intestine(4.8)
- Blood(4.8)
- Muscle(4.6)
- Pancreas(4)
- Kidney(3.7)
- Stomach(3.6)
- Eye(3.4)
- Heart(2.8)
- Spleen(2.8)
- Bone marrow(2.7)
- Lymph node(2.6)
- Adrenal gland(2.6)
- Bone(2.3)
- Thyroid gland(2.3)
Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGDIA Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- integumentary
- respiratory
- urinary
Regions:
Head and neck:
- ear
Thorax:
- heart
- lung
Abdomen:
- kidney
Pelvis:
- urinary bladder
General:
- blood
- blood vessel
- coagulation system
- red blood cell
- skin
Primer products for research
-
OriGene qPCR primer pairs for ARHGDIA
-
OriGene qPCR primer pairs and template standards for ARHGDIA
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARHGDIA Gene
Orthologs for ARHGDIA Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ARHGDIA 29 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | ARHGDIA 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ARHGDIA 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ARHGDIA 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Arhgdia 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Arhgdia 29 |
|
||
| Chicken (Gallus gallus) |
Aves | ARHGDIA 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | ARHGDIA 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | arhgdia 29 |
|
||
| Str.1468 29 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.13978 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | arhgdia 29 30 |
|
OneToOne | |
| wufa96g11 29 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012168 29 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | RhoGDI 29 30 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | rhi-1 29 30 31 |
|
OneToMany | |
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ADR098C 29 |
|
||
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F05313g 29 |
|
||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RDI1 29 30 32 |
|
OneToMany | |
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | SCN1 29 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os06g0318300 29 |
|
||
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU06561 29 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 30 |
|
OneToMany | |
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC6F12.06 29 |
|
- Species where no ortholog for ARHGDIA was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for ARHGDIA Gene
- ENSEMBL:
- Gene Tree for ARHGDIA (if available)
- TreeFam:
- Gene Tree for ARHGDIA (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ARHGDIA: view image
- Alliance of Genome Resources:
- Additional Orthologs for ARHGDIA
Paralogs for ARHGDIA Gene
Variants for ARHGDIA Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ARHGDIA Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 1030364 | Uncertain Significance: Nephrotic syndrome, type 8 | 81,868,835(-) |
T/C NM_004309.6(ARHGDIA):c.*41A>G |
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR_VARIANT,INTRON | |
| 1030365 | Uncertain Significance: Nephrotic syndrome, type 8 | 81,869,426(-) |
C/A NM_004309.6(ARHGDIA):c.275-20G>T |
MISSENSE_VARIANT,INTRON | |
| 1033777 | Pathogenic: Nephrotic syndrome, type 8 | 81,868,844(-) |
CGTCA/C NM_004309.6(ARHGDIA):c.*28_*31del |
FRAMESHIFT_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR_VARIANT,INTRON | |
| 915863 | Uncertain Significance: Chronic kidney disease | 81,868,633(-) |
C/T NM_004309.6(ARHGDIA):c.*243G>A |
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR_VARIANT,INTRON | |
| rs111331642 | Benign: not provided | 81,869,059(-) |
G/A NM_004309.6(ARHGDIA):c.432C>T (p.Tyr144=) |
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,INTRON |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv21913 | CNV | gain+loss | 19812545 |
| esv3641407 | CNV | gain | 21293372 |
| nsv1071814 | CNV | deletion | 25765185 |
| nsv1126474 | CNV | deletion | 24896259 |
| nsv1136245 | CNV | deletion | 24896259 |
| nsv428351 | CNV | gain | 18775914 |
| nsv470620 | CNV | loss | 18288195 |
| nsv833569 | CNV | loss | 17160897 |
| nsv952391 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
49.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.46;
28.58% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ARHGDIA Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGDIA Gene
Disorders for ARHGDIA Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| nephrotic syndrome, type 8 |
|
|
| genetic steroid-resistant nephrotic syndrome |
|
|
| nephrotic syndrome |
|
|
| diffuse mesangial sclerosis |
|
|
| articulation disorder |
|
|
Search ARHGDIA in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
GDIR1_HUMAN- Nephrotic syndrome 8 (NPHS8) [MIM:615244]: A form of nephrotic syndrome, a renal disease clinically characterized by progressive renal failure, severe proteinuria, hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show diffuse mesangial sclerosis, with small glomeruli, hypercellularity, increased extracellular matrix, and contracted/collapsed glomerular tufts surrounded by immature or abnormal podocytes. {ECO:0000269 PubMed:23434736}. Note=The disease is caused by variants affecting the gene represented in this entry.
Additional Disease Information for ARHGDIA
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for Genatlas for ARHGDIA Gene
Publications for ARHGDIA Gene
- ARHGDIA: a novel gene implicated in nephrotic syndrome. (PMID: 23434736) Gupta IR … Takano T (Journal of medical genetics 2013) 3 4 72
- KANK deficiency leads to podocyte dysfunction and nephrotic syndrome. (PMID: 25961457) Gee HY … Hildebrandt F (The Journal of clinical investigation 2015) 3 4
- Structural basis of death domain signaling in the p75 neurotrophin receptor. (PMID: 26646181) Lin Z … Ibanez CF (eLife 2015) 3 4
- ARHGDIA mutations cause nephrotic syndrome via defective RHO GTPase signaling. (PMID: 23867502) Gee HY … Hildebrandt F (The Journal of clinical investigation 2013) 3 72
- The Fer tyrosine kinase regulates interactions of Rho GDP-Dissociation Inhibitor α with the small GTPase Rac. (PMID: 21122136) Fei F … Heisterkamp N (BMC biochemistry 2010) 3 4
ExternalLinks
Products for ARHGDIA Gene
- Custom Antibody ServicesOriGene Antibodies for ARHGDIA
- Browse OriGene ELISA Kits
- Custom Assay Services
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- OriGene qPCR primer pairs for ARHGDIA
- OriGene qPCR primer pairs and template standards for ARHGDIA
- OriGene CRISPR knockouts for ARHGDIA
- MG202112
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- RC231004L3V
- RC231004L4V
- RR204316L3V
- RR204316L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Browse Sino Biological Assays
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals proteins and lysates for ARHGDIA
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- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
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- Abcam antibodies for ARHGDIA
- Abcam proteins for ARHGDIA
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- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
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- Browse ELISA Kits
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- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for ARHGDIA (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for ARHGDIA (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for ARHGDIA (ie. knockout, knockin, CRISPRa, CRISPRi)
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- VectorBuilder Stable cell line generation for ARHGDIA
- antibodies-online: Show 40 available ARHGDIA Antibodies ranked by validation data
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- 117 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 36 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
- 47 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- antibodies-online: Show 29 available ARHGDIA Elisa Kits ranked by validation data
- Compare Top ARHGDIA Elisa Kits
- antibodies-online: Show 17 available ARHGDIA Proteins ranked by validation data
- Compare Top ARHGDIA Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for ARHGDIA
- Search Santa Cruz Biotechnology (SCBT) for ARHGDIA siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ARHGDIA
- Custom Antibody ServicesProSci Antibodies for ARHGDIA
- Search for ARHGDIA Proteins at ProSci
- Horizon Cell Lines for ARHGDIA
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ARHGDIA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ARHGDIA
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- Boster Bio Antibodies for ARHGDIA
- Browse Boster Bio ELISA Kits
Sources for ARHGDIA Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc<