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This gene encodes a member of the Rho-GAP family of GTPase activating proteins. The protein has substantial GAP activity towards several Rho-family GTPases in vitro, converting them to an inactive GDP-bound state. It is implicated in regulating adhesion of hematopoietic cells to the extracellular matrix. Multiple transcript variants encoding different isoforms have been found f... See more...
Aliases for ARHGAP9 Gene
Aliases for ARHGAP9 Gene
External Ids for ARHGAP9 Gene
- HGNC: 14130
- Entrez Gene: 64333
- Ensembl: ENSG00000123329
- OMIM: 610576
- UniProtKB: Q9BRR9
Previous GeneCards Identifiers for ARHGAP9 Gene
- GC12M059326
- GC12M058009
- GC12M057582
- GC12M056152
- GC12M057866
- GC12M054903
Summaries for ARHGAP9 Gene
-
This gene encodes a member of the Rho-GAP family of GTPase activating proteins. The protein has substantial GAP activity towards several Rho-family GTPases in vitro, converting them to an inactive GDP-bound state. It is implicated in regulating adhesion of hematopoietic cells to the extracellular matrix. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for ARHGAP9 Gene
ARHGAP9 (Rho GTPase Activating Protein 9) is a Protein Coding gene. Diseases associated with ARHGAP9 include Charcot-Marie-Tooth Disease, Axonal, Type 2U and Interstitial Lung And Liver Disease. Among its related pathways are Signaling by GPCR and G-protein signaling_Regulation of RAC1 activity. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and phosphatidylinositol-3,4,5-trisphosphate binding. An important paralog of this gene is ARHGAP12.
UniProtKB/Swiss-Prot Summary for ARHGAP9 Gene
-
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix. Binds phosphoinositides, and has the highest affinity for phosphatidylinositol 3,4,5-trisphosphate, followed by phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate.
Additional gene information for ARHGAP9 Gene
- HGNC(14130)
- Entrez Gene(64333)
- Ensembl(ENSG00000123329)
- OMIM(610576)
- UniProtKB(Q9BRR9)
- Open Targets Platform(ENSG00000123329)
- Monarch Initiative
- Search for ARHGAP9 at DataMed
- Search for ARHGAP9 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARHGAP9 Gene
Genomics for ARHGAP9 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ARHGAP9 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ARHGAP9 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ARHGAP9
- Top Transcription factor binding sites by QIAGEN in the ARHGAP9 gene promoter:
-
- CUTL1
- GATA-2
- HSF2
- NF-1
Genomic Locations for ARHGAP9 Gene
Genomic Locations for ARHGAP9 Gene
- chr12:57,472,262-57,488,824
- (GRCh38/hg38)
- Size:
- 16,563 bases
- Orientation:
- Minus strand
- chr12:57,866,038-57,882,597
- (GRCh37/hg19)
- Size:
- 16,560 bases
- Orientation:
- Minus strand
Genomic View for ARHGAP9 Gene
Genes around ARHGAP9 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.3 by HGNC
- 12q13.3 by Entrez Gene
- 12q13.3 by Ensembl
ARHGAP9 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ARHGAP9 Gene
Proteins for ARHGAP9 Gene
-
Protein details for ARHGAP9 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BRR9-RHG09_HUMAN
- Recommended name:
- Rho GTPase-activating protein 9
- Protein Accession:
- Q9BRR9
- B4DVI3
- E9PDX9
- Q8NAF3
- Q8TCJ3
- Q8WYR0
- Q96EZ2
- Q96S74
Protein attributes for ARHGAP9 Gene
- Size:
- 750 amino acids
- Molecular mass:
- 83260 Da
- Quaternary structure:
-
- Interacts with FASLG.
Three dimensional structures from OCA and Proteopedia for ARHGAP9 Gene
Protein Expression for ARHGAP9 Gene
Post-translational modifications for ARHGAP9 Gene
Other Protein References for ARHGAP9 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ ARHGAP9 Polyclonal Antibody and Immunotag™ RHG9 Antibody
-
Custom Antibody ServicesOriGene Antibodies for ARHGAP9
- Novus Biologicals Antibodies for ARHGAP9
- Invitrogen Antibodies for ARHGAP9 (AFLGC-ARHGAP9)
- antibodies-online: Show 5 available ARHGAP9 Antibodies ranked by validation data
- Compare Top ARHGAP9 Antibodies
-
Quality Products:
Protein Products
-
OriGene Purified Proteins for ARHGAP9
- Search Origene for MassSpec and Protein Over-expression Lysates for ARHGAP9
- Origene Custom Protein Services for ARHGAP9
- antibodies-online: Show 3 available ARHGAP9 Proteins ranked by validation data
- Compare Top ARHGAP9 Proteins
-
Quality Products:
-
Abcam proteins for ARHGAP9
No data available for DME Specific Peptides for ARHGAP9 Gene
Domains & Families for ARHGAP9 Gene
Gene Families for ARHGAP9 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for ARHGAP9 Gene
- InterPro:
- Blocks:
-
- RhoGAP domain
- SH3 domain signature
- Pleckstrin-like
- ProtoNet:
Suggested Antigen Peptide Sequences for ARHGAP9 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ55768, highly similar to Rho-GTPase-activating protein 9 (B4DVI3_HUMAN)
- Rho-type GTPase-activating protein 9 (RHG09_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9BRR9UniProtKB/Swiss-Prot:
RHG09_HUMAN :- A region including the PH domain and partially overlapping with the Rho-GAP domain mediates interaction with phosphoinositides.
- Domain:
-
- A region including the PH domain and partially overlapping with the Rho-GAP domain mediates interaction with phosphoinositides.
Function for ARHGAP9 Gene
Molecular function for ARHGAP9 Gene
- UniProtKB/Swiss-Prot Function:
- GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix. Binds phosphoinositides, and has the highest affinity for phosphatidylinositol 3,4,5-trisphosphate, followed by phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate.
Phenotypes From GWAS Catalog for ARHGAP9 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005096 | GTPase activator activity | IDA | 11396949 |
| GO:0005515 | protein binding | IEA,IPI | 25416956 |
| GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding | IDA | 17339315 |
| GO:0008289 | lipid binding | IEA | -- |
Phenotypes for ARHGAP9 Gene
Animal Model Products
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CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ARHGAP9 - Select products 50% OFF >
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-
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miRNA for ARHGAP9 Gene
- miRTarBase miRNAs that target ARHGAP9
miRNA Products
Inhibitory RNA Products
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Clone Products
- Applied Biological Materials (abm): Clones for ARHGAP9 - Select products 50% OFF >
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-
- MG207564
- MR207564
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- MR230784
- RC211794
- RC211794L3
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- RC222813
- RC222813L3
- RC222813L4
- RC223605
- RC223605L3
- RC223605L4
- RG211794
- RG222813
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- RR200052
- RR200052L3
- RR200052L4
- RR200053
- RR200053L3
- RR200053L4
- MR207564L3V
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- RC211794L3V
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- RC222813L3V
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- RC223605L3V
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- RR200052L3V
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- RR200053L3V
- RR200053L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ARHGAP9
- Addgene plasmids for ARHGAP9
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ARHGAP9
Cell Line Products
-
Horizon Cell Lines for ARHGAP9
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARHGAP9 Gene
Localization for ARHGAP9 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| extracellular | 4 |
| mitochondrion | 3 |
| nucleus | 3 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005737 | cytoplasm | IBA | 21873635 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0034774 | secretory granule lumen | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for ARHGAP9 Gene
Pathways & Interactions for ARHGAP9 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
| 2 | p75 NTR receptor-mediated signalling |
.36
|
|
| 3 | Signaling by GPCR | ||
| 4 | Signaling by Rho GTPases | ||
| 5 | G-protein signaling_Regulation of RAC1 activity |
G-protein signaling_Regulation of RAC1 activity
-
|
|
Pathways by source for ARHGAP9 Gene
2 BioSystems pathways for ARHGAP9 Gene
6 Reactome pathways for ARHGAP9 Gene
1 GeneGo (Thomson Reuters) pathway for ARHGAP9 Gene
- G-protein signaling_Regulation of RAC1 activity
Interacting Proteins for ARHGAP9 Gene
Selected Interacting proteins:
Q9BRR9-RHG09_HUMAN
ENSP00000377380
for ARHGAP9 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for ARHGAP9
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | IEA | -- |
| GO:0043087 | regulation of GTPase activity | IBA | 21873635 |
| GO:0043312 | neutrophil degranulation | TAS | -- |
| GO:0043547 | positive regulation of GTPase activity | IEA | -- |
| GO:0051056 | regulation of small GTPase mediated signal transduction | TAS | -- |
Transcripts for ARHGAP9 Gene
mRNA/cDNA for ARHGAP9 Gene
- 11 REFSEQ mRNAs :
- 17 NCBI additional mRNA sequence :
- 24 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000552953 1673 nts (view in UCSC)
- ENST00000424809 2569 nts (view in UCSC)
- ENST00000393797 2912 nts (view in UCSC)
- ENST00000550399 722 nts (view in UCSC)
- ENST00000546200 2256 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ARHGAP9 - Select products 50% OFF >
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-
OriGene CRISPR knockouts for ARHGAP9
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ARHGAP9
-
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miRNA Products
Inhibitory RNA Products
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Clone Products
- Applied Biological Materials (abm): Clones for ARHGAP9 - Select products 50% OFF >
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG207564
- MR207564
- MR207564L3
- MR207564L4
- MR230784
- RC211794
- RC211794L3
- RC211794L4
- RC222813
- RC222813L3
- RC222813L4
- RC223605
- RC223605L3
- RC223605L4
- RG211794
- RG222813
- RG223605
- RR200052
- RR200052L3
- RR200052L4
- RR200053
- RR200053L3
- RR200053L4
- MR207564L3V
- MR207564L4V
- RC211794L3V
- RC211794L4V
- RC222813L3V
- RC222813L4V
- RC223605L3V
- RC223605L4V
- RR200052L3V
- RR200052L4V
- RR200053L3V
- RR200053L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ARHGAP9
- Addgene plasmids for ARHGAP9
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ARHGAP9
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP20: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP21: | - |
| ExUns: | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | · | 16c | ^ | 17 | ^ | 18a | · | 18b | ^ | 19 | ^ | 20 | ^ | 21 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||||||
| SP13: | |||||||||||||||||||||||||||||
| SP14: | |||||||||||||||||||||||||||||
| SP15: | |||||||||||||||||||||||||||||
| SP16: | - | - | |||||||||||||||||||||||||||
| SP17: | |||||||||||||||||||||||||||||
| SP18: | |||||||||||||||||||||||||||||
| SP19: | |||||||||||||||||||||||||||||
| SP20: | |||||||||||||||||||||||||||||
| SP21: |
Relevant External Links for ARHGAP9 Gene
- GeneLoc Exon Structure for
- ARHGAP9
Expression for ARHGAP9 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Skeletal Muscle (Muscoskeletal System)
- Bone (Muscoskeletal System)
-
Spleen (Hematopoietic System)
-
Thymus (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for ARHGAP9 Gene
This gene is overexpressed in Whole Blood (x32.3) and Spleen (x5.3).
This gene is overexpressed in Peripheral blood mononuclear cells (20.3), Monocytes (12.2), CD8 Tcells (11.0), Lymph node (7.1), and Blymphocyte (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARHGAP9 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ARHGAP9
SOURCE GeneReport for Unigene cluster for ARHGAP9 Gene:
Hs.437126mRNA Expression by UniProt/SwissProt for ARHGAP9 Gene:
Q9BRR9-RHG09_HUMAN
Tissue specificity:
Predominantly expressed in peripheral blood leukocytes, spleen, and thymus.
Evidence on tissue expression from TISSUES for ARHGAP9 Gene
- Spleen(4.8)
- Intestine(4.6)
- Lymph node(4.6)
- Muscle(4.5)
- Blood(4.4)
- Nervous system(3)
- Skin(2.8)
- Bone marrow(2.7)
- Lung(2.5)
- Kidney(2.4)
- Heart(2.3)
- Stomach(2.2)
- Liver(2.1)
- Adrenal gland(2.1)
Primer Products
-
OriGene qPCR primer pairs for ARHGAP9
-
OriGene qPCR primer pairs and template standards for ARHGAP9
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGAP9 Gene
Orthologs for ARHGAP9 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ARHGAP9 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
| ARHGAP9 30 |
|
||||
| -- 31 |
|
OneToMany | |||
| Cow (Bos Taurus) |
Mammalia | ARHGAP9 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Arhgap9 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Arhgap9 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ARHGAP9 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | ARHGAP9 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | arhgap9 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | LOC100334461 30 |
|
||
| CABZ01088365.1 31 |
|
OneToOne | |||
| Worm (Caenorhabditis elegans) |
Secernentea | C38D4.5 32 |
|
|
|
| tag-325 31 |
|
OneToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for ARHGAP9 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for ARHGAP9 Gene
- ENSEMBL:
- Gene Tree for ARHGAP9 (if available)
- TreeFam:
- Gene Tree for ARHGAP9 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ARHGAP9: view image
Paralogs for ARHGAP9 Gene
(39) SIMAP similar genes for ARHGAP9 Gene using alignment to 11 proteins:
- RHG09_HUMAN
- F8VQR0_HUMAN
- F8VQY5_HUMAN
- F8VR90_HUMAN
- F8VSD0_HUMAN
- F8VW89_HUMAN
- F8W1N6_HUMAN
- H0YI33_HUMAN
- H0YI36_HUMAN
- J3KPQ4_HUMAN
- R4GN15_HUMAN
- ARHGAP15
- ARHGAP12
- ARHGAP30
- DKFZp451F1115
- ARHGAP32
- RICS
- ARHGAP5
- ARHGAP18
- ARAP3
- ARHGAP27
- CHN1
- BPGAP1
- ARHGAP8
- ARHGAP40
- ARHGAP1
- MYO9A
- FKSG42
- FAM13A
- CHN2
- SNX26
- RALBP1
- BCR
- ARHGAP33
- ARHGAP31
- ARHGAP22
- RACGAP1
- PRR5-ARHGAP8
- LOC553158
- ARHGAP23
- OPHN1
- ARHGAP44
- ARHGAP24
- ARHGAP10
- ARHGAP21
- ABR
- SYDE1
- DKFZp667D142
- ARHGAP35
- ARHGAP26
Variants for ARHGAP9 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ARHGAP9 Gene
| SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 707511 | Likely Benign: not provided | 57,488,136(-) | C/G | MISSENSE_VARIANT,INTRON_VARIANT | |
| 717628 | Likely Benign: not provided | 57,488,117(-) | C/G | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
| 773024 | Benign: not provided | 57,479,200(-) | A/C | SYNONYMOUS_VARIANT | |
| rs1064796198 | Uncertain Significance: not provided | 57,488,107(-) | GTGA/G | INFRAME_DELETION,INTRON_VARIANT | |
| rs11540809 | Uncertain Significance: Charcot-Marie-Tooth disease, axonal, type 2u; Interstitial lung and liver disease | 57,488,185(-) | C/G | MISSENSE_VARIANT,INTRON_VARIANT |
Residual Variation Intolerance Score:
89.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.44;
85.67% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ARHGAP9 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP9 Gene
Disorders for ARHGAP9 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| charcot-marie-tooth disease, axonal, type 2u |
|
|
| interstitial lung and liver disease |
|
|
| ornithosis |
|
|
| myiasis |
|
|
| charcot-marie-tooth disease |
|
|
Search ARHGAP9 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ARHGAP9
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for ARHGAP9 Gene
Publications for ARHGAP9 Gene
- Isolation of a novel human gene, ARHGAP9, encoding a rho-GTPase activating protein. (PMID: 11396949) Furukawa Y … Nakamura Y (Biochemical and biophysical research communications 2001) 2 3 4 23
- Mutation of ARHGAP9 in patients with coronary spastic angina. (PMID: 19911011) Takefuji M … Kaibuchi K (Journal of human genetics 2010) 3 41
- Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PMID: 19807924) Voss M … Janssen O (BMC immunology 2009) 3 4
- Non-canonical interaction of phosphoinositides with pleckstrin homology domains of Tiam1 and ArhGAP9. (PMID: 17339315) Ceccarelli DF … Sicheri F (The Journal of biological chemistry 2007) 3 4
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
ExternalLinks
Products for ARHGAP9 Gene
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Sources for ARHGAP9 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
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- (11) Cell Signaling Technology
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- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
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- (48) IMGT
- (49) Leiden
- (50) miRBase
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- (53) PubMed
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- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
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- (84) COMPARTMENTS
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- (90) CYP
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- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
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- (104) diseasecard
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- (177) snoDB
- (178) MirGeneDB