Aliases for ARHGAP9 Gene
External Ids for ARHGAP9 Gene
Previous GeneCards Identifiers for ARHGAP9 Gene
This gene encodes a member of the Rho-GAP family of GTPase activating proteins. The protein has substantial GAP activity towards several Rho-family GTPases in vitro, converting them to an inactive GDP-bound state. It is implicated in regulating adhesion of hematopoietic cells to the extracellular matrix. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for ARHGAP9 Gene
ARHGAP9 (Rho GTPase Activating Protein 9) is a Protein Coding gene. Diseases associated with ARHGAP9 include Charcot-Marie-Tooth Disease, Axonal, Type 2U and Interstitial Lung And Liver Disease. Among its related pathways are Signaling by GPCR and G-protein signaling_Regulation of RAC1 activity. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and phosphatidylinositol-3,4,5-trisphosphate binding. An important paralog of this gene is ARHGAP12.
UniProtKB/Swiss-Prot Summary for ARHGAP9 Gene
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix. Binds phosphoinositides, and has the highest affinity for phosphatidylinositol 3,4,5-trisphosphate, followed by phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate.