Aliases for ARHGAP8 Gene
External Ids for ARHGAP8 Gene
Previous GeneCards Identifiers for ARHGAP8 Gene
This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. This family member is a multidomain protein that functions to promote Erk activation and cell motility. Alternative splicing results in multiple transcript variants. Read-through transcripts from the upstream proline rich 5, renal (PRR5) gene into this gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq, Nov 2010]
GeneCards Summary for ARHGAP8 Gene
ARHGAP8 (Rho GTPase Activating Protein 8) is a Protein Coding gene. Diseases associated with ARHGAP8 include Cervix Carcinoma. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is PRR5-ARHGAP8.
UniProtKB/Swiss-Prot for ARHGAP8 Gene
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.