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Aliases for ARHGAP8 Gene

Aliases for ARHGAP8 Gene

  • Rho GTPase Activating Protein 8 2 3 5
  • Rho-Type GTPase-Activating Protein 8 3 4
  • BNIP-2 And Cdc42GAP Homology Domain-Containing, Proline-Rich And Cdc42GAP-Like Protein Subtype-1 3
  • BCH Domain-Containing Cdc42GAP-Like Protein 3
  • Rho GTPase-Activating Protein 8 3
  • BPGAP1 3
  • PP610 3

External Ids for ARHGAP8 Gene

Previous GeneCards Identifiers for ARHGAP8 Gene

  • GC22P041733
  • GC22P043341
  • GC22P043349
  • GC22P043393
  • GC22P043527
  • GC22P043451
  • GC22P045148
  • GC22P028096
  • GC22P045099

Summaries for ARHGAP8 Gene

Entrez Gene Summary for ARHGAP8 Gene

  • This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. This family member is a multidomain protein that functions to promote Erk activation and cell motility. Alternative splicing results in multiple transcript variants. Read-through transcripts from the upstream proline rich 5, renal (PRR5) gene into this gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for ARHGAP8 Gene

ARHGAP8 (Rho GTPase Activating Protein 8) is a Protein Coding gene. Among its related pathways are p75 NTR receptor-mediated signalling and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is PRR5-ARHGAP8.

UniProtKB/Swiss-Prot for ARHGAP8 Gene

  • GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Gene Wiki entry for ARHGAP8 Gene

Additional gene information for ARHGAP8 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP8 Gene

Genomics for ARHGAP8 Gene

GeneHancer (GH) Regulatory Elements for ARHGAP8 Gene

Promoters and enhancers for ARHGAP8 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J044752 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 668.6 +2.0 1959 4.5 NFIB ZSCAN4 SIN3A ZNF335 GLIS2 EGR2 ZNF398 REST NFIC GLIS1 ARHGAP8 KIAA0930 GC22P044753 PRR5-ARHGAP8 LOC105373062 GC22M044704
GH22J044667 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 650.2 -84.5 -84456 2.2 CTCF KLF1 ZFP64 ZNF335 FOXM1 GLIS2 PATZ1 VEZF1 PRDM10 EZH2 GC22P044669 GC22P044670 PRR5 ARHGAP8 ANP32BP2
GH22J044786 Promoter 0.6 EPDnew 656.3 +33.9 33871 0.1 ZKSCAN1 ARHGAP8 LOC105373062 PRR5-ARHGAP8 GC22M044704
GH22J044848 Promoter 0.5 EPDnew 655 +95.6 95567 0.1 ARHGAP8 LOC105373062 PRR5-ARHGAP8 GC22M044704
GH22J044684 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 12.6 -66.6 -66572 3.4 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF207 ZNF143 ZNF263 SP3 ARHGAP8 ENSG00000273243 SHISAL1 PRR5 PRR5-ARHGAP8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARHGAP8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARHGAP8 gene promoter:
  • Hlf
  • AREB6
  • Roaz
  • HEN1
  • RP58
  • HNF-3beta
  • GR-alpha
  • GR
  • GR-beta
  • ZID

Genomic Locations for ARHGAP8 Gene

Genomic Locations for ARHGAP8 Gene
110,231 bases
Plus strand
160,311 bases
Plus strand

Genomic View for ARHGAP8 Gene

Genes around ARHGAP8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP8 Gene

Proteins for ARHGAP8 Gene

  • Protein details for ARHGAP8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho GTPase-activating protein 8
    Protein Accession:
    Secondary Accessions:
    • A6ZJ79
    • A6ZJ80
    • O75983
    • O95695
    • Q96RW1
    • Q96RW2
    • Q9HA49
    • Q9HC46
    • Q9NSG0
    • Q9NVX8
    • Q9NXL1
    • Q9UH20

    Protein attributes for ARHGAP8 Gene

    464 amino acids
    Molecular mass:
    53484 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ARHGAP8 Gene

neXtProt entry for ARHGAP8 Gene

Post-translational modifications for ARHGAP8 Gene

  • Ubiquitination at Lys95
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ARHGAP8 Gene

Domains & Families for ARHGAP8 Gene

Gene Families for ARHGAP8 Gene

Protein Domains for ARHGAP8 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARHGAP8: view

No data available for UniProtKB/Swiss-Prot for ARHGAP8 Gene

Function for ARHGAP8 Gene

Molecular function for ARHGAP8 Gene

UniProtKB/Swiss-Prot Function:
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
GENATLAS Biochemistry:
Rho GTPase activating protein 8

Phenotypes From GWAS Catalog for ARHGAP8 Gene

Gene Ontology (GO) - Molecular Function for ARHGAP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS --
GO:0005515 protein binding IPI 20179103
genes like me logo Genes that share ontologies with ARHGAP8: view
genes like me logo Genes that share phenotypes with ARHGAP8: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARHGAP8

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ARHGAP8 Gene

Localization for ARHGAP8 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGAP8 gene
Compartment Confidence
cytosol 4
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ARHGAP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ARHGAP8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP8 Gene

Pathways & Interactions for ARHGAP8 Gene

genes like me logo Genes that share pathways with ARHGAP8: view

Pathways by source for ARHGAP8 Gene

1 BioSystems pathway for ARHGAP8 Gene
3 Reactome pathways for ARHGAP8 Gene

Interacting Proteins for ARHGAP8 Gene

Gene Ontology (GO) - Biological Process for ARHGAP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0043087 regulation of GTPase activity IBA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
GO:0070374 positive regulation of ERK1 and ERK2 cascade IDA 20179103
genes like me logo Genes that share ontologies with ARHGAP8: view

No data available for SIGNOR curated interactions for ARHGAP8 Gene

Drugs & Compounds for ARHGAP8 Gene

No Compound Related Data Available

Transcripts for ARHGAP8 Gene

mRNA/cDNA for ARHGAP8 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARHGAP8

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP8 Gene

No ASD Table

Relevant External Links for ARHGAP8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARHGAP8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARHGAP8 Gene

mRNA differential expression in normal tissues according to GTEx for ARHGAP8 Gene

This gene is overexpressed in Spleen (x9.4), Kidney - Cortex (x7.3), and Thyroid (x4.5).

Protein differential expression in normal tissues from HIPED for ARHGAP8 Gene

This gene is overexpressed in Ovary (22.4), Prostate (19.0), and Testis (16.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ARHGAP8 Gene

Protein tissue co-expression partners for ARHGAP8 Gene

NURSA nuclear receptor signaling pathways regulating expression of ARHGAP8 Gene:


mRNA Expression by UniProt/SwissProt for ARHGAP8 Gene:

Tissue specificity: Highly expressed in kidney and placenta. Also expressed in colon, skeletal muscle, small intestine, stomach, and testis. Not detected in brain, liver or spleen. Overexpressed in the majority of colorectal tumors examined.
genes like me logo Genes that share expression patterns with ARHGAP8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGAP8 Gene

Orthologs for ARHGAP8 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARHGAP8 33
  • 92.99 (n)
(Canis familiaris)
Mammalia ARHGAP8 34 33
  • 85.28 (n)
(Rattus norvegicus)
Mammalia Arhgap8 33
  • 84.19 (n)
(Mus musculus)
Mammalia Arhgap8 34 33
  • 84.1 (n)
(Bos Taurus)
Mammalia -- 34
  • 77 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 35 (a)
(Gallus gallus)
Aves ARHGAP8 34 33
  • 69.26 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap8 33
  • 68.39 (n)
Str.17718 33
African clawed frog
(Xenopus laevis)
Amphibia arhgap8-prov 33
fruit fly
(Drosophila melanogaster)
Insecta RhoGAP68F 34 35
  • 30 (a)
(Caenorhabditis elegans)
Secernentea W02B12.8 35
  • 36 (a)
rga-1 34
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 45 (a)
Species where no ortholog for ARHGAP8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ARHGAP8 Gene

Gene Tree for ARHGAP8 (if available)
Gene Tree for ARHGAP8 (if available)
Evolutionary constrained regions (ECRs) for ARHGAP8: view image

Paralogs for ARHGAP8 Gene

Paralogs for ARHGAP8 Gene

(12) SIMAP similar genes for ARHGAP8 Gene using alignment to 12 proteins:

  • A6ZJ79_HUMAN
  • F8W6F3_HUMAN
  • F8W6F4_HUMAN
  • Q52M44_HUMAN
  • Q86XV6_HUMAN
genes like me logo Genes that share paralogs with ARHGAP8: view

Variants for ARHGAP8 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP8 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000040038 -- 44,800,153(+) G/C intron_variant
rs1000045915 -- 44,829,815(+) C/G intron_variant
rs1000056432 -- 44,759,921(+) C/T intron_variant
rs1000104123 -- 44,830,223(+) C/T intron_variant
rs1000116038 -- 44,828,885(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP8 Gene

Variant ID Type Subtype PubMed ID
dgv1326e212 CNV loss 25503493
dgv2466n106 CNV deletion 24896259
dgv2467n106 CNV deletion 24896259
dgv4586n100 CNV loss 25217958
esv1192293 CNV deletion 17803354
esv2259848 CNV deletion 18987734
esv2512679 CNV deletion 19546169
esv2658024 CNV deletion 23128226
esv2663583 CNV deletion 23128226
esv2667102 CNV deletion 23128226
esv2673983 CNV deletion 23128226
esv2674450 CNV deletion 23128226
esv2724370 CNV deletion 23290073
esv2724371 CNV deletion 23290073
esv2724372 CNV deletion 23290073
esv2724374 CNV deletion 23290073
esv2758842 CNV loss 17122850
esv3558231 CNV deletion 23714750
esv3568441 CNV loss 25503493
esv3647906 CNV loss 21293372
esv3647907 CNV loss 21293372
esv3647909 CNV loss 21293372
esv3647910 CNV loss 21293372
nsv1056293 CNV loss 25217958
nsv1059020 CNV loss 25217958
nsv1123602 CNV deletion 24896259
nsv459901 CNV gain 19166990
nsv459902 CNV loss 19166990
nsv471208 CNV gain 18288195
nsv589108 CNV loss 21841781
nsv589121 CNV gain 21841781
nsv589122 CNV loss 21841781
nsv829268 CNV gain 20364138

Variation tolerance for ARHGAP8 Gene

Residual Variation Intolerance Score: 99.6% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARHGAP8 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP8 Gene

Disorders for ARHGAP8 Gene

Additional Disease Information for ARHGAP8

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ARHGAP8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGAP8 Gene

Publications for ARHGAP8 Gene

  1. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 2 3 4 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  3. Active Mek2 as a regulatory scaffold that promotes Pin1 binding to BPGAP1 to suppress BPGAP1-induced acute Erk activation and cell migration. (PMID: 20179103) Pan CQ … Low BC (Journal of cell science 2010) 3 22 58
  4. Activation of EGF receptor endocytosis and ERK1/2 signaling by BPGAP1 requires direct interaction with EEN/endophilin II and a functional RhoGAP domain. (PMID: 15944398) Lua BL … Low BC (Journal of cell science 2005) 3 22 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for ARHGAP8 Gene

Sources for ARHGAP8 Gene

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