Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ARHGAP5 Gene

Aliases for ARHGAP5 Gene

  • Rho GTPase Activating Protein 5 2 3 5
  • Rho-Type GTPase-Activating Protein 5 3 4
  • Growth Factor Independent 2 2 3
  • P190-B 3 4
  • P100 RasGAP-Associated P105 Protein 3
  • Rho GTPase-Activating Protein 5 3
  • P105 RhoGAP 3
  • P190BRhoGAP 3
  • RhoGAP5 3
  • RHOGAP5 4
  • GFI2 3

External Ids for ARHGAP5 Gene

Previous HGNC Symbols for ARHGAP5 Gene

  • GFI2

Previous GeneCards Identifiers for ARHGAP5 Gene

  • GC14P030000
  • GC14P026333
  • GC14P030536
  • GC14P031615
  • GC14P032546
  • GC14P012663

Summaries for ARHGAP5 Gene

Entrez Gene Summary for ARHGAP5 Gene

  • Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family which may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARHGAP5 Gene

ARHGAP5 (Rho GTPase Activating Protein 5) is a Protein Coding gene. Diseases associated with ARHGAP5 include Capillary Disease. Among its related pathways are Focal Adhesion and Cytoskeletal Signaling. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activator activity. An important paralog of this gene is ARHGAP35.

UniProtKB/Swiss-Prot for ARHGAP5 Gene

  • GTPase-activating protein for Rho family members (PubMed:8537347).

Gene Wiki entry for ARHGAP5 Gene

Additional gene information for ARHGAP5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP5 Gene

Genomics for ARHGAP5 Gene

GeneHancer (GH) Regulatory Elements for ARHGAP5 Gene

Promoters and enhancers for ARHGAP5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J032074 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +1.0 1040 5.9 HDGF PKNOX1 CLOCK FOXA2 ARNT ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ARHGAP5-AS1 ARHGAP5 RNU6-8 RNU6-7 RPL21P5 LOC101927124 GC14P032154
GH14J032134 Enhancer 1 ENCODE 22.8 +58.7 58746 0.1 PKNOX1 CLOCK ARNT ZNF133 NEUROD1 FEZF1 GLI4 ZNF2 YY1 ZNF121 ARHGAP5 RNU6-8 NPAS3 LOC100533787 ENSG00000257472 ENSG00000257155 ENSG00000258196 RNU6-7 HECTD1 DTD2
GH14J031204 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 9.7 -868.8 -868823 5.1 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 HECTD1 RPL21P5 G2E3 SCFD1 ARHGAP5 HEATR5A DTD2 RNU6-541P
GH14J032251 Enhancer 1.1 Ensembl ENCODE 12.1 +176.0 176012 0.9 FOXA2 ARID4B ZNF2 ZNF48 SLC30A9 ARID2 ZNF143 RUNX3 DEK MXD4 ARHGAP5 LOC100533787 LOC644295
GH14J032101 Enhancer 0.9 Ensembl ENCODE 12.4 +26.4 26364 1 PKNOX1 PAX8 FEZF1 ZNF121 GATA3 ZNF316 ZNF213 ZSCAN5C IKZF2 RUNX3 ARHGAP5 RNU6-7 RNU6-8 ARHGAP5-AS1 GC14P032154
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARHGAP5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARHGAP5 gene promoter:
  • STAT1
  • CREB
  • deltaCREB
  • Evi-1
  • Nkx2-2
  • Pax-4a
  • LHX3b

Genomic Locations for ARHGAP5 Gene

Genomic Locations for ARHGAP5 Gene
83,615 bases
Plus strand
83,615 bases
Plus strand

Genomic View for ARHGAP5 Gene

Genes around ARHGAP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP5 Gene

Proteins for ARHGAP5 Gene

  • Protein details for ARHGAP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho GTPase-activating protein 5
    Protein Accession:
    Secondary Accessions:
    • A1L375
    • A1L376
    • A8KAA1
    • D3DS89
    • D3DS90
    • Q05BE8
    • Q05BU8
    • Q59ER0
    • Q6DHZ3

    Protein attributes for ARHGAP5 Gene

    1502 amino acids
    Molecular mass:
    172460 Da
    Quaternary structure:
    • May interact with RASA1/p120GAP.
    • Sequence=AAA95963.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAH32723.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARHGAP5 Gene

    Alternative splice isoforms for ARHGAP5 Gene


neXtProt entry for ARHGAP5 Gene

Post-translational modifications for ARHGAP5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for ARHGAP5

No data available for DME Specific Peptides for ARHGAP5 Gene

Domains & Families for ARHGAP5 Gene

Gene Families for ARHGAP5 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ARHGAP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The pG1 pseudoGTPase domain does not bind GTP.
  • The pG1 pseudoGTPase domain does not bind GTP.
genes like me logo Genes that share domains with ARHGAP5: view

Function for ARHGAP5 Gene

Molecular function for ARHGAP5 Gene

UniProtKB/Swiss-Prot Function:
GTPase-activating protein for Rho family members (PubMed:8537347).
GENATLAS Biochemistry:
Rho/GTPase activating protein 5,expressed in a variety of cells,located diffusely in the cytoplasm

Phenotypes From GWAS Catalog for ARHGAP5 Gene

Gene Ontology (GO) - Molecular Function for ARHGAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005096 GTPase activator activity TAS --
GO:0005515 protein binding IPI 23622247
GO:0005525 GTP binding IEA --
GO:0042169 SH2 domain binding IPI 1689011
genes like me logo Genes that share ontologies with ARHGAP5: view
genes like me logo Genes that share phenotypes with ARHGAP5: view

Animal Models for ARHGAP5 Gene

MGI Knock Outs for ARHGAP5:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARHGAP5 Gene

Localization for ARHGAP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP5 Gene

Cytoplasm. Cell membrane; Peripheral membrane protein. Note=Also membrane-associated in a fibrillar pattern that colocalizes with the alpha5-beta1 integrin receptor (ITGA5/ITGB1) for fibronectin. {ECO:0000269 PubMed:8537347}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGAP5 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 4
cytoskeleton 2
nucleus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARHGAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm TAS 8537347
GO:0005783 endoplasmic reticulum IDA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with ARHGAP5: view

Pathways & Interactions for ARHGAP5 Gene

genes like me logo Genes that share pathways with ARHGAP5: view

Pathways by source for ARHGAP5 Gene

1 GeneTex pathway for ARHGAP5 Gene
3 BioSystems pathways for ARHGAP5 Gene
3 Reactome pathways for ARHGAP5 Gene
2 KEGG pathways for ARHGAP5 Gene

SIGNOR curated interactions for ARHGAP5 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ARHGAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS 8537347
GO:0007165 signal transduction IEA --
GO:0007266 Rho protein signal transduction TAS 8537347
GO:0030879 mammary gland development IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with ARHGAP5: view

Drugs & Compounds for ARHGAP5 Gene

No Compound Related Data Available

Transcripts for ARHGAP5 Gene

Unigene Clusters for ARHGAP5 Gene

Rho GTPase activating protein 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c
SP2: - -
SP3: - - - - - - - -
SP5: - -

Relevant External Links for ARHGAP5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARHGAP5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARHGAP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARHGAP5 Gene

This gene is overexpressed in Serum (29.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARHGAP5 Gene

Protein tissue co-expression partners for ARHGAP5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARHGAP5 Gene:


SOURCE GeneReport for Unigene cluster for ARHGAP5 Gene:


mRNA Expression by UniProt/SwissProt for ARHGAP5 Gene:

Tissue specificity: Detected in skin fibroblasts (at protein level) (PubMed:8537347).

Evidence on tissue expression from TISSUES for ARHGAP5 Gene

  • Nervous system(4.8)
  • Kidney(4.3)
  • Liver(4.3)
  • Heart(2)
genes like me logo Genes that share expression patterns with ARHGAP5: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGAP5 Gene

Orthologs for ARHGAP5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARHGAP5 34 33
  • 99.8 (n)
(Canis familiaris)
Mammalia ARHGAP5 34 33
  • 95.25 (n)
(Monodelphis domestica)
Mammalia ARHGAP5 34
  • 95 (a)
(Bos Taurus)
Mammalia ARHGAP5 34 33
  • 93.75 (n)
(Mus musculus)
Mammalia Arhgap5 16 34 33
  • 93.54 (n)
(Rattus norvegicus)
Mammalia Arhgap5 33
  • 93.21 (n)
(Ornithorhynchus anatinus)
Mammalia ARHGAP5 34
  • 93 (a)
(Gallus gallus)
Aves ARHGAP5 34 33
  • 83.98 (n)
(Anolis carolinensis)
Reptilia ARHGAP5 34
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap5 33
  • 74.97 (n)
Str.9761 33
(Danio rerio)
Actinopterygii arhgap5 34 33
  • 68.31 (n)
fruit fly
(Drosophila melanogaster)
Insecta RhoGAPp190 34 35
  • 28 (a)
(Caenorhabditis elegans)
Secernentea rga-5 34
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 53 (a)
-- 34
  • 39 (a)
Species where no ortholog for ARHGAP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP5 Gene

Gene Tree for ARHGAP5 (if available)
Gene Tree for ARHGAP5 (if available)
Evolutionary constrained regions (ECRs) for ARHGAP5: view image

Paralogs for ARHGAP5 Gene

Paralogs for ARHGAP5 Gene

(19) SIMAP similar genes for ARHGAP5 Gene using alignment to 6 proteins:

  • G3V360_HUMAN
  • G3V444_HUMAN
  • G3V5I7_HUMAN
  • H0YK04_HUMAN
  • L8E796_HUMAN Pseudogenes for ARHGAP5 Gene

genes like me logo Genes that share paralogs with ARHGAP5: view

Variants for ARHGAP5 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP5 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000009796 -- 32,151,419(+) T/C intron_variant
rs1000041778 -- 32,108,919(+) A/C intron_variant
rs1000110961 -- 32,088,092(+) T/C intron_variant
rs1000132040 -- 32,128,494(+) C/T intron_variant
rs1000154511 -- 32,160,075(+) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP5 Gene

Variant ID Type Subtype PubMed ID
esv3584226 CNV gain 25503493
nsv1046526 CNV gain 25217958
nsv564182 CNV gain 21841781
nsv832764 CNV gain 17160897
nsv974322 CNV duplication 23825009
nsv974323 CNV duplication 23825009

Variation tolerance for ARHGAP5 Gene

Residual Variation Intolerance Score: 4.01% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.90; 48.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARHGAP5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP5 Gene

Disorders for ARHGAP5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ARHGAP5 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
capillary disease
  • disease of capillaries
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ARHGAP5

genes like me logo Genes that share disorders with ARHGAP5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARHGAP5 Gene

Publications for ARHGAP5 Gene

  1. p190-B, a new member of the Rho GAP family, and Rho are induced to cluster after integrin cross-linking. (PMID: 8537347) Burbelo PD … Yamada Y (The Journal of biological chemistry 1995) 2 3 4 22 58
  2. Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry. (PMID: 16777052) Zhan X … Desiderio DM (Analytical biochemistry 2006) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. P190-B, a Rho-GTPase-activating protein, is differentially expressed in terminal end buds and breast cancer. (PMID: 10939588) Chakravarty G … Rosen JM (Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2000) 3 22 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ARHGAP5 Gene

Sources for ARHGAP5 Gene

Loading form....