Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family which may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] See more...

Aliases for ARHGAP5 Gene

Aliases for ARHGAP5 Gene

  • Rho GTPase Activating Protein 5 2 3 5
  • P190-B 2 3 4
  • Rho-Type GTPase-Activating Protein 5 3 4
  • Rho GTPase-Activating Protein 5 3 4
  • Growth Factor Independent 2 2 3
  • P190BRhoGAP 2 3
  • RhoGAP5 2 3
  • P100 RasGAP-Associated P105 Protein 3
  • P105 RhoGAP 3
  • ARHGAP5 5
  • RHOGAP5 4
  • GFI2 3

External Ids for ARHGAP5 Gene

Previous HGNC Symbols for ARHGAP5 Gene

  • GFI2

Previous GeneCards Identifiers for ARHGAP5 Gene

  • GC14P030000
  • GC14P026333
  • GC14P030536
  • GC14P031615
  • GC14P032546
  • GC14P012663

Summaries for ARHGAP5 Gene

Entrez Gene Summary for ARHGAP5 Gene

  • Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family which may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARHGAP5 Gene

ARHGAP5 (Rho GTPase Activating Protein 5) is a Protein Coding gene. Diseases associated with ARHGAP5 include Lung Cancer. Among its related pathways are Signaling by GPCR and Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activator activity. An important paralog of this gene is TCERG1.

UniProtKB/Swiss-Prot Summary for ARHGAP5 Gene

Gene Wiki entry for ARHGAP5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARHGAP5 Gene

Genomics for ARHGAP5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ARHGAP5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARHGAP5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ARHGAP5

Top Transcription factor binding sites by QIAGEN in the ARHGAP5 gene promoter:
  • CREB
  • deltaCREB
  • Evi-1
  • LHX3b
  • Nkx2-2
  • Pax-4a
  • STAT1

Genomic Locations for ARHGAP5 Gene

Genomic Locations for ARHGAP5 Gene
chr14:32,072,588-32,159,728
(GRCh38/hg38)
Size:
87,141 bases
Orientation:
Plus strand
chr14:32,545,320-32,628,934
(GRCh37/hg19)
Size:
83,615 bases
Orientation:
Plus strand

Genomic View for ARHGAP5 Gene

Genes around ARHGAP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP5 Gene

Proteins for ARHGAP5 Gene

  • Protein details for ARHGAP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13017-RHG05_HUMAN
    Recommended name:
    Rho GTPase-activating protein 5
    Protein Accession:
    Q13017
    Secondary Accessions:
    • A1L375
    • A1L376
    • A8KAA1
    • D3DS89
    • D3DS90
    • Q05BE8
    • Q05BU8
    • Q59ER0
    • Q6DHZ3

    Protein attributes for ARHGAP5 Gene

    Size:
    1502 amino acids
    Molecular mass:
    172460 Da
    Quaternary structure:
    • May interact with RASA1/p120GAP.
    SequenceCaution:
    • Sequence=AAA95963.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAH32723.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARHGAP5 Gene

    Alternative splice isoforms for ARHGAP5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGAP5 Gene

Post-translational modifications for ARHGAP5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARHGAP5 Gene

Domains & Families for ARHGAP5 Gene

Gene Families for ARHGAP5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ARHGAP5 Gene

Suggested Antigen Peptide Sequences for ARHGAP5 Gene

GenScript: Design optimal peptide antigens:
  • p190-B (RHG05_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13017

UniProtKB/Swiss-Prot:

RHG05_HUMAN :
  • The pG1 pseudoGTPase domain does not bind GTP.
Domain:
  • The pG1 pseudoGTPase domain does not bind GTP.
genes like me logo Genes that share domains with ARHGAP5: view

Function for ARHGAP5 Gene

Molecular function for ARHGAP5 Gene

UniProtKB/Swiss-Prot Function:
GTPase-activating protein for Rho family members (PubMed:8537347).
GENATLAS Biochemistry:
Rho/GTPase activating protein 5,expressed in a variety of cells,located diffusely in the cytoplasm

Phenotypes From GWAS Catalog for ARHGAP5 Gene

Gene Ontology (GO) - Molecular Function for ARHGAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005096 GTPase activator activity TAS,IEA --
GO:0005515 protein binding IPI 23622247
GO:0005525 GTP binding IEA --
GO:0042169 SH2 domain binding IBA,IPI 1689011
genes like me logo Genes that share ontologies with ARHGAP5: view
genes like me logo Genes that share phenotypes with ARHGAP5: view

Animal Models for ARHGAP5 Gene

MGI Knock Outs for ARHGAP5:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARHGAP5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARHGAP5 Gene

Localization for ARHGAP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP5 Gene

Cytoplasm. Cell membrane. Peripheral membrane protein. Note=Also membrane-associated in a fibrillar pattern that colocalizes with the alpha5-beta1 integrin receptor (ITGA5/ITGB1) for fibronectin. {ECO:0000269 PubMed:8537347}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGAP5 gene
Compartment Confidence
cytosol 5
plasma membrane 4
endoplasmic reticulum 4
cytoskeleton 2
nucleus 2
extracellular 1
mitochondrion 1
endosome 1
lysosome 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARHGAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 8537347
GO:0005783 endoplasmic reticulum IBA,IDA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ARHGAP5: view

Pathways & Interactions for ARHGAP5 Gene

genes like me logo Genes that share pathways with ARHGAP5: view

Pathways by source for ARHGAP5 Gene

3 BioSystems pathways for ARHGAP5 Gene
3 Reactome pathways for ARHGAP5 Gene
2 KEGG pathways for ARHGAP5 Gene
2 GeneGo (Thomson Reuters) pathways for ARHGAP5 Gene
  • G-protein signaling_Cross-talk between Ras-family GTPases
  • G-protein signaling_Regulation of CDC42 activity
5 Qiagen pathways for ARHGAP5 Gene
  • G12-G13 in Cellular Signaling
  • Ras Pathway
  • RhoA Pathway
  • RhoGDI Pathway
  • Transendothelial Migration of Leukocytes
1 Cell Signaling Technology pathway for ARHGAP5 Gene
1 GeneTex pathway for ARHGAP5 Gene

SIGNOR curated interactions for ARHGAP5 Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for ARHGAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS 8537347
GO:0007165 signal transduction IEA --
GO:0007266 Rho protein signal transduction TAS 8537347
GO:0030879 mammary gland development IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with ARHGAP5: view

Drugs & Compounds for ARHGAP5 Gene

No Compound Related Data Available

Transcripts for ARHGAP5 Gene

mRNA/cDNA for ARHGAP5 Gene

2 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARHGAP5

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c
SP1:
SP2: - -
SP3: - - - - - - - -
SP4:
SP5: - -
SP6:

Relevant External Links for ARHGAP5 Gene

GeneLoc Exon Structure for
ARHGAP5

Expression for ARHGAP5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARHGAP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARHGAP5 Gene

This gene is overexpressed in Serum (29.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARHGAP5 Gene



Protein tissue co-expression partners for ARHGAP5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ARHGAP5

SOURCE GeneReport for Unigene cluster for ARHGAP5 Gene:

Hs.592313

mRNA Expression by UniProt/SwissProt for ARHGAP5 Gene:

Q13017-RHG05_HUMAN
Tissue specificity: Detected in skin fibroblasts (at protein level) (PubMed:8537347).

Evidence on tissue expression from TISSUES for ARHGAP5 Gene

  • Nervous system(4.9)
  • Kidney(4.5)
  • Liver(4.5)
  • Heart(2.7)
  • Lung(2.4)
  • Skin(2.3)
  • Muscle(2.3)
  • Intestine(2.1)
  • Spleen(2)
genes like me logo Genes that share expression patterns with ARHGAP5: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGAP5 Gene

Orthologs for ARHGAP5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ARHGAP5 30 31
  • 99.8 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ARHGAP5 30 31
  • 95.25 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ARHGAP5 31
  • 95 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia ARHGAP5 30 31
  • 93.75 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Arhgap5 30 17 31
  • 93.54 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Arhgap5 30
  • 93.21 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia ARHGAP5 31
  • 93 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ARHGAP5 30 31
  • 83.98 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ARHGAP5 31
  • 91 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia arhgap5 30
  • 74.97 (n)
Str.9761 30
Zebrafish
(Danio rerio)
Actinopterygii arhgap5 30 31
  • 68.31 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta RhoGAPp190 31 32
  • 28 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea rga-5 31
  • 25 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 53 (a)
ManyToMany
-- 31
  • 39 (a)
ManyToMany
Species where no ortholog for ARHGAP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ARHGAP5 Gene

ENSEMBL:
Gene Tree for ARHGAP5 (if available)
TreeFam:
Gene Tree for ARHGAP5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ARHGAP5: view image

Paralogs for ARHGAP5 Gene

Paralogs for ARHGAP5 Gene

(19) SIMAP similar genes for ARHGAP5 Gene using alignment to 6 proteins:

  • RHG05_HUMAN
  • G3V360_HUMAN
  • G3V444_HUMAN
  • G3V5I7_HUMAN
  • H0YK04_HUMAN
  • L8E796_HUMAN

Pseudogenes.org Pseudogenes for ARHGAP5 Gene

genes like me logo Genes that share paralogs with ARHGAP5: view

Variants for ARHGAP5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ARHGAP5 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
716006 Benign: not provided 32,091,695(+) A/G SYNONYMOUS_VARIANT
781285 Benign: not provided 32,093,527(+) A/G MISSENSE_VARIANT
786247 Benign: not provided 32,091,923(+) A/G SYNONYMOUS_VARIANT
786248 Benign: not provided 32,092,847(+) A/G SYNONYMOUS_VARIANT
786249 Benign: not provided 32,093,582(+) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for ARHGAP5 Gene

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP5 Gene

Variant ID Type Subtype PubMed ID
esv3584226 CNV gain 25503493
nsv1046526 CNV gain 25217958
nsv564182 CNV gain 21841781
nsv832764 CNV gain 17160897
nsv974322 CNV duplication 23825009
nsv974323 CNV duplication 23825009

Variation tolerance for ARHGAP5 Gene

Residual Variation Intolerance Score: 4.01% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.90; 48.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARHGAP5 Gene

Human Gene Mutation Database (HGMD)
ARHGAP5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARHGAP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP5 Gene

Disorders for ARHGAP5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ARHGAP5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lung cancer
  • adenocarcinoma of lung
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ARHGAP5

genes like me logo Genes that share disorders with ARHGAP5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARHGAP5 Gene

Publications for ARHGAP5 Gene

  1. p190-B, a new member of the Rho GAP family, and Rho are induced to cluster after integrin cross-linking. (PMID: 8537347) Burbelo PD … Yamada Y (The Journal of biological chemistry 1995) 2 3 4 23
  2. Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry. (PMID: 16777052) Zhan X … Desiderio DM (Analytical biochemistry 2006) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. P190-B, a Rho-GTPase-activating protein, is differentially expressed in terminal end buds and breast cancer. (PMID: 10939588) Chakravarty G … Rosen JM (Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2000) 3 23
  5. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3

Products for ARHGAP5 Gene

  • Signalway Proteins for ARHGAP5

Sources for ARHGAP5 Gene