Aliases for ARHGAP42 Gene
External Ids for ARHGAP42 Gene
Previous HGNC Symbols for ARHGAP42 Gene
Previous GeneCards Identifiers for ARHGAP42 Gene
This gene encodes a Rho GTPase-activating protein (RhoGAP), and member of the GRAF or BAR-PH family of proteins. Expression of this gene is enriched in vascular smooth muscle cells and the encoded protein inhibits RhoA activity to regulate vascular tone and control blood pressure. A mutation in the first intron of this gene modulates its expression and is associated with reduced blood pressure in human patients with borderline hypertension. [provided by RefSeq, Jul 2017]
GeneCards Summary for ARHGAP42 Gene
ARHGAP42 (Rho GTPase Activating Protein 42) is a Protein Coding gene. Among its related pathways are Cytoskeletal Signaling and p75 NTR receptor-mediated signalling. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP26.
UniProtKB/Swiss-Prot for ARHGAP42 Gene
May influence blood pressure by functioning as a GTPase-activating protein for RHOA in vascular smooth muscle.