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Aliases for ARHGAP4 Gene

Aliases for ARHGAP4 Gene

  • Rho GTPase Activating Protein 4 2 3 5
  • Rho-GAP Hematopoietic Protein C1 2 3 4
  • Rho-Type GTPase-Activating Protein 4 3 4
  • RGC1 3 4
  • P115 3 4
  • Rho GTPase-Activating Protein 4 3
  • KIAA0131 4
  • RhoGAP4 3
  • RHOGAP4 4
  • SrGAP4 3
  • C1 3

External Ids for ARHGAP4 Gene

Previous GeneCards Identifiers for ARHGAP4 Gene

  • GC0XM147310
  • GC0XM149627
  • GC0XM150758
  • GC0XM151640
  • GC0XM152693
  • GC0XM152826
  • GC0XM153172
  • GC0XM141824

Summaries for ARHGAP4 Gene

Entrez Gene Summary for ARHGAP4 Gene

  • This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins belonging to the RAS superfamily. The protein encoded by the orthologous gene in rat is localized to the Golgi complex and can redistribute to microtubules. The rat protein stimulates the activity of some Rho GTPases in vitro. Genomic deletions of this gene and a neighboring gene have been found in patients with nephrogenic diabetes insipidus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

GeneCards Summary for ARHGAP4 Gene

ARHGAP4 (Rho GTPase Activating Protein 4) is a Protein Coding gene. Diseases associated with ARHGAP4 include Diabetes Insipidus and Diabetes Insipidus, Nephrogenic, Autosomal. Among its related pathways are p75 NTR receptor-mediated signalling and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and Rac GTPase binding. An important paralog of this gene is SRGAP3.

UniProtKB/Swiss-Prot for ARHGAP4 Gene

  • Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells.

Gene Wiki entry for ARHGAP4 Gene

Additional gene information for ARHGAP4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP4 Gene

Genomics for ARHGAP4 Gene

GeneHancer (GH) Regulatory Elements for ARHGAP4 Gene

Promoters and enhancers for ARHGAP4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ153933 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 650.7 +0.2 231 1.9 HDAC1 RB1 SIN3A YY1 ZNF335 GLIS2 ELK1 SMARCA5 SP3 NFYA ARHGAP4 NAA10 TMEM187 RENBP GC0XP153923
GH0XJ153909 Promoter 0.7 EPDnew 650.3 +25.8 25788 0.1 HDGF ZNF687 GLIS2 ENSG00000284987 ARHGAP4 AVPR2
GH0XJ153907 Promoter 0.5 EPDnew 650.3 +27.0 27035 0.1 ENSG00000284987 ARHGAP4 IKBKG AVPR2
GH0XJ153884 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE 12.5 +48.9 48894 3 CTCF KLF1 MAX KLF17 ZIC2 RAD21 HIC1 ZFHX2 GATA3 GLIS2 L1CAM RENBP TMEM187 HCFC1 SNORA70 PDZD4 SSR4 IDH3G SRPK3 PLXNB3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARHGAP4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARHGAP4 gene promoter:
  • Elk-1
  • Ik-3
  • ARP-1
  • Pax-5
  • NF-1/L
  • NF-1
  • AP-1
  • AML1a
  • Tal-1beta
  • E47

Genomic Locations for ARHGAP4 Gene

Genomic Locations for ARHGAP4 Gene
27,633 bases
Minus strand
27,632 bases
Minus strand

Genomic View for ARHGAP4 Gene

Genes around ARHGAP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP4 Gene

Proteins for ARHGAP4 Gene

  • Protein details for ARHGAP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho GTPase-activating protein 4
    Protein Accession:
    Secondary Accessions:
    • Q14144
    • Q86UY3

    Protein attributes for ARHGAP4 Gene

    946 amino acids
    Molecular mass:
    105026 Da
    Quaternary structure:
    • Interacts with NCKAP1L.

    Three dimensional structures from OCA and Proteopedia for ARHGAP4 Gene

    Alternative splice isoforms for ARHGAP4 Gene


neXtProt entry for ARHGAP4 Gene

Post-translational modifications for ARHGAP4 Gene

  • Ubiquitination at posLast=443443
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ARHGAP4 Gene

Domains & Families for ARHGAP4 Gene

Gene Families for ARHGAP4 Gene

Suggested Antigen Peptide Sequences for ARHGAP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARHGAP4: view

No data available for UniProtKB/Swiss-Prot for ARHGAP4 Gene

Function for ARHGAP4 Gene

Molecular function for ARHGAP4 Gene

UniProtKB/Swiss-Prot Function:
Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells.
GENATLAS Biochemistry:
Rho GTPase activating protein 4,155kDa,aplysia related,involved in signal transduction

Phenotypes From GWAS Catalog for ARHGAP4 Gene

Gene Ontology (GO) - Molecular Function for ARHGAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity TAS 8570618
GO:0005096 GTPase activator activity TAS,IEA --
GO:0005515 protein binding IEA,IPI 16417406
GO:0048365 Rac GTPase binding IBA --
genes like me logo Genes that share ontologies with ARHGAP4: view
genes like me logo Genes that share phenotypes with ARHGAP4: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ARHGAP4 Gene

Localization for ARHGAP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP4 Gene

Cytoplasm. Note=Just below the plasma membrane.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGAP4 gene
Compartment Confidence
cytosol 5
nucleus 4
golgi apparatus 3
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Focal adhesion sites (2)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARHGAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS,IDA --
GO:0005794 Golgi apparatus IEA --
GO:0005829 cytosol TAS --
GO:0005874 microtubule IEA --
GO:0030426 growth cone IEA --
genes like me logo Genes that share ontologies with ARHGAP4: view

Pathways & Interactions for ARHGAP4 Gene

genes like me logo Genes that share pathways with ARHGAP4: view

Pathways by source for ARHGAP4 Gene

1 GeneTex pathway for ARHGAP4 Gene
1 BioSystems pathway for ARHGAP4 Gene
3 Reactome pathways for ARHGAP4 Gene
3 Qiagen pathways for ARHGAP4 Gene

Gene Ontology (GO) - Biological Process for ARHGAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization TAS 8570618
GO:0007165 signal transduction IEA --
GO:0007266 Rho protein signal transduction TAS 8570618
GO:0007399 nervous system development IEA --
GO:0009967 positive regulation of signal transduction IEA --
genes like me logo Genes that share ontologies with ARHGAP4: view

No data available for SIGNOR curated interactions for ARHGAP4 Gene

Drugs & Compounds for ARHGAP4 Gene

(1) Drugs for ARHGAP4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for ARHGAP4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ARHGAP4: view

Transcripts for ARHGAP4 Gene

mRNA/cDNA for ARHGAP4 Gene

Unigene Clusters for ARHGAP4 Gene

Rho GTPase activating protein 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP4 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12 ^ 13a · 13b ^
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP6: - - -
SP9: - - -
SP10: - - - -
SP11: - - - -
SP12: - -
SP16: -

ExUns: 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b
SP1: - - - -
SP2: - - - -
SP3: - - - - - - -
SP5: - - - -
SP7: - - -
SP8: -

Relevant External Links for ARHGAP4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARHGAP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARHGAP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGAP4 Gene

This gene is overexpressed in Whole Blood (x16.4) and Spleen (x7.1).

Protein differential expression in normal tissues from HIPED for ARHGAP4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (19.3), Lymph node (19.3), and Monocytes (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARHGAP4 Gene

Protein tissue co-expression partners for ARHGAP4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARHGAP4 Gene:


SOURCE GeneReport for Unigene cluster for ARHGAP4 Gene:


mRNA Expression by UniProt/SwissProt for ARHGAP4 Gene:

Tissue specificity: Predominantly in hematopoietic cells (spleen, thymus and leukocytes); low levels in placenta, lung and various fetal tissues.

Evidence on tissue expression from TISSUES for ARHGAP4 Gene

  • Bone marrow(4.5)
  • Liver(4.1)
  • Pancreas(4.1)
  • Lymph node(2.7)
  • Spleen(2.7)
genes like me logo Genes that share expression patterns with ARHGAP4: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGAP4 Gene

Orthologs for ARHGAP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARHGAP4 34 33
  • 99.66 (n)
(Canis familiaris)
Mammalia ARHGAP4 34 33
  • 87.92 (n)
(Bos Taurus)
Mammalia ARHGAP4 34 33
  • 85.15 (n)
(Rattus norvegicus)
Mammalia Arhgap4 33
  • 81.34 (n)
(Mus musculus)
Mammalia Arhgap4 16 34 33
  • 80.7 (n)
(Ornithorhynchus anatinus)
Mammalia ARHGAP4 34
  • 66 (a)
(Monodelphis domestica)
Mammalia ARHGAP4 34
  • 66 (a)
(Anolis carolinensis)
Reptilia ARHGAP4 34
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap4 33
  • 57.7 (n)
(Danio rerio)
Actinopterygii arhgap4b 34 33
  • 56.33 (n)
arhgap4a 34
  • 40 (a)
(Caenorhabditis elegans)
Secernentea F12F6.5 35
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 32 (a)
Species where no ortholog for ARHGAP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP4 Gene

Gene Tree for ARHGAP4 (if available)
Gene Tree for ARHGAP4 (if available)
Evolutionary constrained regions (ECRs) for ARHGAP4: view image

Paralogs for ARHGAP4 Gene

(16) SIMAP similar genes for ARHGAP4 Gene using alignment to 14 proteins:

  • C9J5M2_HUMAN
  • H7C120_HUMAN
  • H7C2Z8_HUMAN
  • H7C3G3_HUMAN
  • H7C3K8_HUMAN
  • Q6PJ34_HUMAN
  • S4R314_HUMAN
  • S4R352_HUMAN
genes like me logo Genes that share paralogs with ARHGAP4: view

Variants for ARHGAP4 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP4 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs184401408 likely-benign, Nephrogenic diabetes insipidus 153,906,932(-) C/T downstream_transcript_variant
rs73627263 benign, Nephrogenic diabetes insipidus 153,906,985(-) G/A downstream_transcript_variant
rs782404692 likely-benign, Nephrogenic diabetes insipidus 153,907,010(-) G/A/T downstream_transcript_variant
rs139401482 benign, not specified 153,907,968(-) G/A intron_variant
rs2070097 benign, not specified 153,910,800(-) A/G coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP4 Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV gain+loss 17666407
nsv469867 CNV loss 16826518

Variation tolerance for ARHGAP4 Gene

Residual Variation Intolerance Score: 36.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.88; 59.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARHGAP4 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP4 Gene

Disorders for ARHGAP4 Gene

MalaCards: The human disease database

(4) MalaCards diseases for ARHGAP4 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
diabetes insipidus
diabetes insipidus, nephrogenic, autosomal
  • diabetes insipidus, nephrogenic, type ii
impaired renal function disease
familial hypocalciuric hypercalcemia
  • familial benign hypercalcemia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ARHGAP4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ARHGAP4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARHGAP4 Gene

Publications for ARHGAP4 Gene

  1. An X chromosome-linked gene encoding a protein with characteristics of a rhoGAP predominantly expressed in hematopoietic cells. (PMID: 8570618) Tribioli C … Pelicci P (Proceedings of the National Academy of Sciences of the United States of America 1996) 2 3 4 22 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  3. Immunological profile in a family with nephrogenic diabetes insipidus with a novel 11 kb deletion in AVPR2 and ARHGAP4 genes. (PMID: 18489790) Fujimoto M … Noguchi E (BMC medical genetics 2008) 3 22 58
  4. Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. (PMID: 16417406) Weiner OD … Kirschner MW (PLoS biology 2006) 3 4 58
  5. FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains. (PMID: 12736724) Katoh M … Katoh M (International journal of molecular medicine 2003) 3 22 58

Products for ARHGAP4 Gene

Sources for ARHGAP4 Gene

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