Aliases for ARHGAP36 Gene

Aliases for ARHGAP36 Gene

  • Rho GTPase Activating Protein 36 2 3 5
  • Rho GTPase-Activating Protein 36 3 4

External Ids for ARHGAP36 Gene

Previous GeneCards Identifiers for ARHGAP36 Gene

  • GC0XP130192
  • GC0XP119585

Summaries for ARHGAP36 Gene

GeneCards Summary for ARHGAP36 Gene

ARHGAP36 (Rho GTPase Activating Protein 36) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP6.

UniProtKB/Swiss-Prot Summary for ARHGAP36 Gene

  • GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Additional gene information for ARHGAP36 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARHGAP36 Gene

Genomics for ARHGAP36 Gene

GeneHancer (GH) Regulatory Elements for ARHGAP36 Gene

Promoters and enhancers for ARHGAP36 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ131058 Promoter 0.9 EPDnew Ensembl 750.6 +2.0 2015 0.6 EGR1 EZH2 L3MBTL2 ARHGAP36 LINC01201
GH0XJ131081 Promoter 0.3 EPDnew 763.6 +25.2 25171 0.1 ARHGAP36 LINC01201 piR-45932-118
GH0XJ131078 Promoter 0.3 EPDnew 750.3 +22.2 22212 0.1 ARHGAP36 LINC01201 piR-45932-118
GH0XJ130984 Enhancer 0.4 Ensembl ENCODE 0.2 -71.3 -71312 0.5 TCF7L2 piR-52680-403 ARHGAP36 LINC01201
GH0XJ130988 Enhancer 0.3 Ensembl 0.2 -69.3 -69285 0.4 NFE2 MAFG piR-52680-403 ARHGAP36 LINC01201
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARHGAP36 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ARHGAP36 Gene

Genomic Locations for ARHGAP36 Gene
33,400 bases
Plus strand
31,642 bases
Plus strand

Genomic View for ARHGAP36 Gene

Genes around ARHGAP36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP36 Gene

Proteins for ARHGAP36 Gene

  • Protein details for ARHGAP36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho GTPase-activating protein 36
    Protein Accession:
    Secondary Accessions:
    • B7Z234
    • B7Z439
    • Q5JRL9
    • Q5JRM0
    • Q5JRM1
    • Q96NU6

    Protein attributes for ARHGAP36 Gene

    547 amino acids
    Molecular mass:
    61664 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH63790.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ARHGAP36 Gene


neXtProt entry for ARHGAP36 Gene

Post-translational modifications for ARHGAP36 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARHGAP36 Gene

Domains & Families for ARHGAP36 Gene

Gene Families for ARHGAP36 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for ARHGAP36 Gene

Suggested Antigen Peptide Sequences for ARHGAP36 Gene

GenScript: Design optimal peptide antigens:
  • Rho GTPase-activating protein 36 (RHG36_HUMAN)
genes like me logo Genes that share domains with ARHGAP36: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ARHGAP36 Gene

Function for ARHGAP36 Gene

Molecular function for ARHGAP36 Gene

UniProtKB/Swiss-Prot Function:
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Gene Ontology (GO) - Molecular Function for ARHGAP36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
genes like me logo Genes that share ontologies with ARHGAP36: view
genes like me logo Genes that share phenotypes with ARHGAP36: view

Animal Model Products

CRISPR Products

miRNA for ARHGAP36 Gene

miRTarBase miRNAs that target ARHGAP36

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARHGAP36 Gene

Localization for ARHGAP36 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGAP36 gene
Compartment Confidence
cytosol 4
plasma membrane 1
extracellular 1
endoplasmic reticulum 1
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (2)
  • Plasma membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARHGAP36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ARHGAP36: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP36 Gene

Pathways & Interactions for ARHGAP36 Gene

genes like me logo Genes that share pathways with ARHGAP36: view

Pathways by source for ARHGAP36 Gene

3 Reactome pathways for ARHGAP36 Gene

Gene Ontology (GO) - Biological Process for ARHGAP36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP36: view

No data available for SIGNOR curated interactions for ARHGAP36 Gene

Drugs & Compounds for ARHGAP36 Gene

No Compound Related Data Available

Transcripts for ARHGAP36 Gene

mRNA/cDNA for ARHGAP36 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP36 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - - - - -
SP2: - - - -
SP3: - -
SP4: -
SP6: -

Relevant External Links for ARHGAP36 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARHGAP36 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARHGAP36 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGAP36 Gene

This gene is overexpressed in Pituitary (x31.0) and Brain - Hypothalamus (x13.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ARHGAP36 Gene

NURSA nuclear receptor signaling pathways regulating expression of ARHGAP36 Gene:


SOURCE GeneReport for Unigene cluster for ARHGAP36 Gene:


Evidence on tissue expression from TISSUES for ARHGAP36 Gene

  • Adrenal gland(4.4)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ARHGAP36: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGAP36 Gene

Orthologs for ARHGAP36 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGAP36 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARHGAP36 33 32
  • 99.7 (n)
(Canis familiaris)
Mammalia ARHGAP36 33 32
  • 92.08 (n)
(Bos Taurus)
Mammalia ARHGAP36 33 32
  • 89.16 (n)
(Mus musculus)
Mammalia Arhgap36 17 33 32
  • 85.13 (n)
(Rattus norvegicus)
Mammalia Arhgap36 32
  • 83.79 (n)
(Monodelphis domestica)
Mammalia -- 33
  • 34 (a)
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 7 (a)
(Gallus gallus)
Aves -- 33
  • 37 (a)
(Danio rerio)
Actinopterygii zgc:136763 33
  • 25 (a)
fruit fly
(Drosophila melanogaster)
Insecta RhoGAP102A 33
  • 11 (a)
(Caenorhabditis elegans)
Secernentea rga-6 33
  • 13 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LRG1 33
  • 9 (a)
Species where no ortholog for ARHGAP36 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ARHGAP36 Gene

Gene Tree for ARHGAP36 (if available)
Gene Tree for ARHGAP36 (if available)
Evolutionary constrained regions (ECRs) for ARHGAP36: view image

Paralogs for ARHGAP36 Gene

Paralogs for ARHGAP36 Gene

(1) SIMAP similar genes for ARHGAP36 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ARHGAP36: view

Variants for ARHGAP36 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP36 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs140912896 uncertain-significance, not provided 131,084,993(+) A/G coding_sequence_variant, missense_variant
rs1000013918 -- 131,080,593(+) C/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000066382 -- 131,079,901(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000153000 -- 131,068,504(+) A/C genic_upstream_transcript_variant, intron_variant
rs1000328106 -- 131,086,275(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP36 Gene

Variant ID Type Subtype PubMed ID
nsv523130 CNV gain 19592680

Variation tolerance for ARHGAP36 Gene

Residual Variation Intolerance Score: 8.88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.58; 12.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARHGAP36 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP36 Gene

Disorders for ARHGAP36 Gene

Additional Disease Information for ARHGAP36

No disorders were found for ARHGAP36 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGAP36 Gene

Publications for ARHGAP36 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 56
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  5. Cdc42 and Rac1 activity is reduced in human pheochromocytoma and correlates with FARP1 and ARHGEF1 expression. (PMID: 26911374) Croisé P … Gasman S (Endocrine-related cancer 2016) 3 56

Products for ARHGAP36 Gene

Sources for ARHGAP36 Gene