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The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids. [provided by RefSeq, Jul 2008]
ARHGAP35 (Rho GTPase Activating Protein 35) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling. Gene Ontology (GO) annotations related to this gene include GTP binding and transcription corepressor activity. An important paralog of this gene is SYDE2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0003677 | DNA binding | IEA | -- |
GO:0003924 | GTPase activity | IEA | -- |
GO:0005096 | GTPase activator activity | TAS | -- |
GO:0005525 | GTP binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0005856 | cytoskeleton | IEA | -- |
GO:0005886 | plasma membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Semaphorin interactions | ||
2 | Regulation of actin cytoskeleton | ||
3 | Developmental Biology |
.51
|
|
4 | Signaling by PTK6 | ||
5 | Cytoskeletal Signaling |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001843 | neural tube closure | IEA | -- |
GO:0007165 | signal transduction | IEA | -- |
GO:0007411 | axon guidance | ISS | -- |
GO:0007413 | axonal fasciculation | ISS | -- |
GO:0008064 | regulation of actin polymerization or depolymerization | ISS | -- |
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||
SP2: | - | - | - | - | |||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||
SP4: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ARHGAP35 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | ARHGAP35 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ARHGAP35 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ARHGAP35 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Grlf1 30 31 |
|
OneToOne | |
Arhgap35 17 |
|
||||
Rat (Rattus norvegicus) |
Mammalia | Arhgap35 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | ARHGAP35 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | ARHGAP35 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ARHGAP35 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | arhgap35 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | arhgap35a 31 |
|
OneToMany | |
LOC100004299 30 |
|
||||
arhgap35 31 |
|
OneToMany | |||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000870 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | RhoGAPp190 30 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | rga-5 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
774356 | Benign: not provided | 46,919,050(+) | T/C | SYNONYMOUS_VARIANT | |
774357 | Benign: not provided | 46,922,167(+) | G/T | SYNONYMOUS_VARIANT | |
782652 | Benign: not provided | 46,920,418(+) | G/A | SYNONYMOUS_VARIANT | |
rs1555757156 | Uncertain Significance: not provided | 46,919,973(+) | GA/G | FRAMESHIFT_VARIANT | |
rs869312173 | Uncertain Significance: Ductal breast carcinoma | 46,920,634(+) | GC/AA | MISSENSE_VARIANT |
No disorders were found for ARHGAP35 Gene.