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The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in ... See more...
Aliases for ARHGAP35 Gene
Aliases for ARHGAP35 Gene
External Ids for ARHGAP35 Gene
- HGNC: 4591
- Entrez Gene: 2909
- Ensembl: ENSG00000160007
- OMIM: 605277
- UniProtKB: Q9NRY4
Previous HGNC Symbols for ARHGAP35 Gene
- GRLF1
Previous GeneCards Identifiers for ARHGAP35 Gene
- GC19P047422
- GC19P046918
Summaries for ARHGAP35 Gene
-
The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids. [provided by RefSeq, Jul 2008]
GeneCards Summary for ARHGAP35 Gene
ARHGAP35 (Rho GTPase Activating Protein 35) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling. Gene Ontology (GO) annotations related to this gene include GTP binding and transcription corepressor activity. An important paralog of this gene is SYDE2.
UniProtKB/Swiss-Prot Summary for ARHGAP35 Gene
-
Rho GTPase-activating protein (GAP) (PubMed:19673492, PubMed:28894085). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity (PubMed:19673492). This binding is inhibited by phosphorylation by PRKCA (PubMed:19673492). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (By similarity). Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (By similarity). During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth (By similarity). Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; this function is however unclear and would need additional experimental evidences (PubMed:1894621).
Additional gene information for ARHGAP35 Gene
- HGNC(4591)
- Entrez Gene(2909)
- Ensembl(ENSG00000160007)
- OMIM(605277)
- UniProtKB(Q9NRY4)
- Open Targets Platform(ENSG00000160007)
- Monarch Initiative
- Search for ARHGAP35 at DataMed
- Search for ARHGAP35 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARHGAP35 Gene
Genomics for ARHGAP35 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ARHGAP35 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ARHGAP35 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ARHGAP35
Genomic Locations for ARHGAP35 Gene
Genomic Locations for ARHGAP35 Gene
- chr19:46,860,997-47,005,077
- (GRCh38/hg38)
- Size:
- 144,081 bases
- Orientation:
- Plus strand
- chr19:47,421,933-47,508,334
- (GRCh37/hg19)
- Size:
- 86,402 bases
- Orientation:
- Plus strand
Genomic View for ARHGAP35 Gene
Genes around ARHGAP35 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.32 by HGNC
- 19q13.32 by Entrez Gene
- 19q13.32 by Ensembl
ARHGAP35 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ARHGAP35 Gene
Proteins for ARHGAP35 Gene
-
Protein details for ARHGAP35 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NRY4-RHG35_HUMAN
- Recommended name:
- Rho GTPase-activating protein 35
- Protein Accession:
- Q9NRY4
- A7E2A4
- Q14452
- Q9C0E1
Protein attributes for ARHGAP35 Gene
- Size:
- 1499 amino acids
- Molecular mass:
- 170514 Da
- Quaternary structure:
-
- Interacts with RASA1 (By similarity). Interacts with the general transcription factor GTF2I, the interaction sequesters GTF2I in the cytoplasm (PubMed:19393245).
- SequenceCaution:
-
- Sequence=AAA58618.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAF80386.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAF80386.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305};
Protein Expression for ARHGAP35 Gene
Post-translational modifications for ARHGAP35 Gene
- Phosphorylation of Tyr-1105 by PTK6 promotes the association with RASA1, inactivating RHOA while activating RAS. Phosphorylation at Tyr-308 by PDGFRA inhibits binding to GTF2I (PubMed:18829532, PubMed:19393245). Phosphorylated by PRKCA at Ser-1221 and Thr-1226, induces relocalization from the cytoplasm to regions of plasma membrane ruffling and prevents the binding and substrate specificity regulation by phospholipids (PubMed:19673492). In brain, phosphorylated by FYN and SRC (By similarity). During focal adhesion formation, phosphorylated by MAPK1 and MAPK3 at the C-terminal region, probably at Ser-1451, Ser-1476, Thr-1480 and Ser-1483. Phosphorylation by MAPK1 and MAPK3 inhibits GAP function and localizes ARGHAP35 away from newly forming focal adhesions and stress fibers in cells spreading on fibronectin (By similarity). Phosphorylation at Ser-1476 and Thr-1480 by GSK3B requires priming by MAPK and inhibits RhoGAP activity and modulates polarized cell migration (By similarity).
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for ARHGAP35 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ GRF-1 Antibody and Immunotag™ Phospho-GRF-1 (Tyr1105) Antibody
- Novus Biologicals Antibodies for ARHGAP35
-
Abcam antibodies for ARHGAP35
- Invitrogen Antibodies for ARHGAP35 (AFLGC-ARHGAP35)
- antibodies-online: Show 19 available GRLF1 Antibodies ranked by validation data
- Compare Top GRLF1 Antibodies
-
Recommended
- 40 WB Antibodies (anti-human)
- 6 IHC (p) Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 1 DB Antibody (anti-human)
- 32 WB Antibodies (anti-mouse)
- 5 IHC (p) Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 31 WB Antibodies (anti-rat)
- 5 IHC (p) Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
-
Boster Bio Antibodies for ARHGAP35
-
Santa Cruz Biotechnology (SCBT) Antibodies for ARHGAP35
Protein Products
-
OriGene Purified Proteins for ARHGAP35
- Search Origene for MassSpec and Protein Over-expression Lysates for ARHGAP35
- Origene Custom Protein Services for ARHGAP35
- Novus Biologicals proteins for ARHGAP35
-
Abcam proteins for ARHGAP35
Assay Products
- antibodies-online: Show 7 available GRLF1 Elisa Kits ranked by validation data
- Compare Top GRLF1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for ARHGAP35 Gene
Domains & Families for ARHGAP35 Gene
Gene Families for ARHGAP35 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
Protein Domains for ARHGAP35 Gene
- InterPro:
- Blocks:
-
- RhoGAP domain
- FF domain
- ProtoNet:
Suggested Antigen Peptide Sequences for ARHGAP35 Gene
- GenScript: Design optimal peptide antigens:
-
- Rho GAP p190A (RHG35_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9NRY4UniProtKB/Swiss-Prot:
RHG35_HUMAN :- N-terminal part (1-266) has GTPase activity. Required for proper cellular localization.
- Domain:
-
- N-terminal part (1-266) has GTPase activity. Required for proper cellular localization.
- The pG1 pseudoGTPase domain does not bind GTP.
Function for ARHGAP35 Gene
Molecular function for ARHGAP35 Gene
- UniProtKB/Swiss-Prot Function:
- Rho GTPase-activating protein (GAP) (PubMed:19673492, PubMed:28894085). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity (PubMed:19673492). This binding is inhibited by phosphorylation by PRKCA (PubMed:19673492). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (By similarity). Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (By similarity). During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth (By similarity). Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; this function is however unclear and would need additional experimental evidences (PubMed:1894621).
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Binding of acidic phospholipids inhibits the Rho GAP activity and promotes the Rac GAP activity.
Phenotypes From GWAS Catalog for ARHGAP35 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003924 | GTPase activity | IEA | -- |
| GO:0005096 | GTPase activator activity | TAS | -- |
| GO:0005525 | GTP binding | IEA | -- |
Phenotypes for ARHGAP35 Gene
- MGI mutant phenotypes for ARHGAP35:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for ARHGAP35:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased vaccinia virus (VACV) infection
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- shRNA abundance <= 25%
- Strongly decreased CFP-tsO45G cell surface transport
- Downregulation of RLR pathway after Sendai virus (SeV) infection
Animal Models for ARHGAP35 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ARHGAP35 - Select products 50% OFF >
- * ARHGAP35 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ARHGAP35
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ARHGAP35
-
Santa Cruz Biotechnology (SCBT) CRISPR for ARHGAP35
miRNA for ARHGAP35 Gene
- miRTarBase miRNAs that target ARHGAP35
-
- hsa-miR-296-3p (MIRT038489)
- hsa-miR-181b-5p (MIRT047266)
- hsa-miR-17-5p (MIRT151852)
- hsa-miR-20a-5p (MIRT151853)
- hsa-miR-93-5p (MIRT151854)
- hsa-miR-106b-5p (MIRT151857)
- hsa-miR-20b-5p (MIRT151863)
- hsa-miR-519d-3p (MIRT151867)
- hsa-miR-574-5p (MIRT539135)
- hsa-miR-5010-3p (MIRT539136)
- hsa-miR-2113 (MIRT539137)
- hsa-miR-147a (MIRT539138)
- hsa-miR-3611 (MIRT539139)
- hsa-miR-6818-5p (MIRT539140)
- hsa-miR-6867-5p (MIRT539141)
- hsa-miR-4670-3p (MIRT539142)
- hsa-miR-6749-3p (MIRT613630)
- hsa-miR-6763-3p (MIRT613631)
- hsa-miR-660-3p (MIRT613632)
- hsa-miR-5193 (MIRT613633)
- hsa-miR-5587-3p (MIRT613634)
- hsa-miR-4707-5p (MIRT613635)
- hsa-miR-5196-3p (MIRT613636)
- hsa-miR-6501-3p (MIRT613637)
- hsa-miR-6768-3p (MIRT613638)
- hsa-miR-1827 (MIRT738079)
- hsa-miR-3612 (MIRT741545)
- hsa-miR-4443 (MIRT744579)
- hsa-miR-4524a-3p (MIRT745834)
- hsa-miR-4722-5p (MIRT747580)
- hsa-miR-4768-3p (MIRT748608)
- hsa-miR-5091 (MIRT749658)
- hsa-miR-548aa (MIRT750475)
- hsa-miR-548ap-3p (MIRT750560)
- hsa-miR-548t-3p (MIRT750794)
- hsa-miR-650 (MIRT752993)
- hsa-miR-6786-3p (MIRT755910)
- hsa-miR-6808-5p (MIRT756549)
- hsa-miR-6880-5p (MIRT758292)
- hsa-miR-6893-5p (MIRT758693)
- hsa-miR-7847-3p (MIRT759825)
- hsa-miR-940 (MIRT760790)
- hsa-miR-198 (MIRT784076)
- hsa-miR-210-3p (MIRT784196)
- hsa-miR-6774-3p (MIRT788657)
- hsa-miR-4330 (MIRT790435)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ARHGAP35
- Browse OriGene Inhibitory RNA Products For ARHGAP35
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARHGAP35
Clone Products
- Applied Biological Materials (abm): Clones for ARHGAP35 - Select products 50% OFF >
- * ARHGAP35 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ARHGAP35
- Addgene plasmids for ARHGAP35
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ARHGAP35
Cell Line Products
-
Horizon Cell Lines for ARHGAP35
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARHGAP35 Gene
Localization for ARHGAP35 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP35 Gene
- Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm. Nucleus. Cell membrane. Note=In response to integrins and SDC4 and upon phosphorylation by PKC, relocalizes from the cytoplasm to regions of plasma membrane ruffling where it colocalizes with polymerized actin. {ECO:0000250 UniProtKB:Q91YM2}.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| cytosol | 5 |
| plasma membrane | 4 |
| nucleus | 4 |
| extracellular | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nuclear bodies (3)
- Aggresome (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
| GO:0005886 | plasma membrane | IEA | -- |
Pathways & Interactions for ARHGAP35 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Semaphorin interactions | ||
| 2 | Regulation of actin cytoskeleton | ||
| 3 | Developmental Biology |
.51
|
|
| 4 | Signaling by PTK6 | ||
| 5 | Cytoskeletal Signaling | ||
Pathways by source for ARHGAP35 Gene
4 BioSystems pathways for ARHGAP35 Gene
10 Reactome pathways for ARHGAP35 Gene
4 KEGG pathways for ARHGAP35 Gene
3 GeneGo (Thomson Reuters) pathways for ARHGAP35 Gene
- Cell adhesion Integrin-mediated cell adhesion and migration
- Cytoskeleton remodeling FAK signaling
- Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
1 Cell Signaling Technology pathway for ARHGAP35 Gene
Interacting Proteins for ARHGAP35 Gene
GPS-Prot Interaction Network for ARHGAP35
SIGNOR curated interactions for ARHGAP35 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001843 | neural tube closure | IEA | -- |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007411 | axon guidance | ISS | -- |
| GO:0007413 | axonal fasciculation | ISS | -- |
| GO:0008064 | regulation of actin polymerization or depolymerization | ISS | -- |
Transcripts for ARHGAP35 Gene
mRNA/cDNA for ARHGAP35 Gene
- 2 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000672722 9290 nts (view in UCSC)
- ENST00000595822 2977 nts (view in UCSC)
- ENST00000596593 346 nts (view in UCSC)
- ENST00000598548 572 nts (view in UCSC)
- ENST00000599284 931 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ARHGAP35 - Select products 50% OFF >
- * ARHGAP35 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ARHGAP35
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ARHGAP35
-
Santa Cruz Biotechnology (SCBT) CRISPR for ARHGAP35
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ARHGAP35
- Browse OriGene Inhibitory RNA Products For ARHGAP35
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARHGAP35
Clone Products
- Applied Biological Materials (abm): Clones for ARHGAP35 - Select products 50% OFF >
- * ARHGAP35 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ARHGAP35
- Addgene plasmids for ARHGAP35
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ARHGAP35
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||
| SP4: |
Relevant External Links for ARHGAP35 Gene
- GeneLoc Exon Structure for
- ARHGAP35
Expression for ARHGAP35 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
This gene is overexpressed in Brain (13.1), Fetal Brain (11.6), Plasma (8.0), and Frontal cortex (7.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARHGAP35 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ARHGAP35
SOURCE GeneReport for Unigene cluster for ARHGAP35 Gene:
Hs.509447mRNA Expression by UniProt/SwissProt for ARHGAP35 Gene:
Q9NRY4-RHG35_HUMAN
Tissue specificity:
Detected in neutrophils (at protein level).
Evidence on tissue expression from TISSUES for ARHGAP35 Gene
- Nervous system(4.9)
- Liver(4.5)
- Blood(4.4)
- Lung(3.6)
- Skin(3)
- Eye(2.7)
- Heart(2.7)
- Kidney(2.7)
- Muscle(2.5)
- Intestine(2.2)
- Adrenal gland(2.1)
Primer Products
-
OriGene qPCR primer pairs for ARHGAP35
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGAP35 Gene
Orthologs for ARHGAP35 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ARHGAP35 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | ARHGAP35 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ARHGAP35 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ARHGAP35 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Grlf1 30 31 |
|
OneToOne | |
| Arhgap35 17 |
|
||||
| Rat (Rattus norvegicus) |
Mammalia | Arhgap35 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ARHGAP35 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ARHGAP35 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | ARHGAP35 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | arhgap35 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | arhgap35a 31 |
|
OneToMany | |
| LOC100004299 30 |
|
||||
| arhgap35 31 |
|
OneToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000870 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | RhoGAPp190 30 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | rga-5 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany |
- Species where no ortholog for ARHGAP35 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for ARHGAP35 Gene
- ENSEMBL:
- Gene Tree for ARHGAP35 (if available)
- TreeFam:
- Gene Tree for ARHGAP35 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ARHGAP35: view image
Paralogs for ARHGAP35 Gene
Variants for ARHGAP35 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ARHGAP35 Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 774356 | Benign: not provided | 46,919,050(+) | T/C | SYNONYMOUS_VARIANT | |
| 774357 | Benign: not provided | 46,922,167(+) | G/T | SYNONYMOUS_VARIANT | |
| 782652 | Benign: not provided | 46,920,418(+) | G/A | SYNONYMOUS_VARIANT | |
| rs1555757156 | Uncertain Significance: not provided | 46,919,973(+) | GA/G | FRAMESHIFT_VARIANT | |
| rs869312173 | Uncertain Significance: Ductal breast carcinoma | 46,920,634(+) | GC/AA | MISSENSE_VARIANT |
Residual Variation Intolerance Score:
0.892% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.90;
35.47% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ARHGAP35 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ARHGAP35
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP35 Gene
Disorders for ARHGAP35 Gene
Additional Disease Information for ARHGAP35
No disorders were found for ARHGAP35 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGAP35 Gene
Publications for ARHGAP35 Gene
- Molecular cloning and characterization of a factor that binds the human glucocorticoid receptor gene and represses its expression. (PMID: 1894621) LeClerc S … Govindan MV (The Journal of biological chemistry 1991) 2 3 4 23
- Neutrophil functions and autoimmune arthritis in the absence of p190RhoGAP: generation and analysis of a novel null mutation in mice. (PMID: 20675588) Németh T … Mócsai A (Journal of immunology (Baltimore, Md. : 1950) 2010) 2 3 4
- Regulation of the substrate preference of p190RhoGAP by protein kinase C-mediated phosphorylation of a phospholipid binding site. (PMID: 19673492) Lévay M … Ligeti E (Biochemistry 2009) 3 4 23
- p190-A, a human tumor suppressor gene, maps to the chromosomal region 19q13.3 that is reportedly deleted in some gliomas. (PMID: 11054565) Tikoo A … Maruta H (Gene 2000) 3 4 23
- NMR structural studies on human p190-A RhoGAPFF1 revealed that domain phosphorylation by the PDGF-receptor alpha requires its previous unfolding. (PMID: 19393245) Bonet R … Macias MJ (Journal of molecular biology 2009) 3 4
ExternalLinks
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Sources for ARHGAP35 Gene
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