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RICS is a neuron-associated GTPase-activating protein that may regulate dendritic spine morphology and strength by modulating Rho GTPase (see RHOA; MIM 165390) activity (Okabe et al., 2003 [PubMed 12531901]).[supplied by OMIM, Mar 2008] See more...
Aliases for ARHGAP32 Gene
Aliases for ARHGAP32 Gene
- Rho GTPase Activating Protein 32 2 3 5
- GC-GAP 2 3 4
- GRIT 2 3 4
- RICS 2 3 4
- RhoGAP Involved In The Beta-Catenin-N-Cadherin And NMDA Receptor Signaling 3 4
- GAB-Associated Cdc42/Rac GTPase-Activating Protein 3 4
- Brain-Specific Rho GTPase-Activating Protein 3 4
- Rho/Cdc42/Rac GTPase-Activating Protein RICS 3 4
- GTPase Regulator Interacting With TrkA 3 4
- Rho-Type GTPase-Activating Protein 32 3 4
- Rho GTPase-Activating Protein 32 3 4
External Ids for ARHGAP32 Gene
- HGNC: 17399
- NCBI Entrez Gene: 9743
- Ensembl: ENSG00000134909
- OMIM®: 608541
- UniProtKB/Swiss-Prot: A7KAX9
Previous GeneCards Identifiers for ARHGAP32 Gene
- GC11M128834
- GC11M124785
Summaries for ARHGAP32 Gene
-
RICS is a neuron-associated GTPase-activating protein that may regulate dendritic spine morphology and strength by modulating Rho GTPase (see RHOA; MIM 165390) activity (Okabe et al., 2003 [PubMed 12531901]).[supplied by OMIM, Mar 2008]
GeneCards Summary for ARHGAP32 Gene
ARHGAP32 (Rho GTPase Activating Protein 32) is a Protein Coding gene. Diseases associated with ARHGAP32 include Bartter Syndrome, Type 2, Antenatal and Borna Disease. Among its related pathways are Signaling by GPCR and p75 NTR receptor-mediated signalling. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and phosphatidylinositol binding. An important paralog of this gene is ARHGAP33.
UniProtKB/Swiss-Prot Summary for ARHGAP32 Gene
-
GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity).
Additional gene information for ARHGAP32 Gene
- HGNC (17399)
- NCBI Entrez Gene (9743)
- Ensembl (ENSG00000134909)
- OMIM® (608541)
- UniProtKB/Swiss-Prot (A7KAX9)
- Open Targets Platform(ENSG00000134909)
- Search for ARHGAP32 at DataMed
- Search for ARHGAP32 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARHGAP32 Gene
Genomics for ARHGAP32 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ARHGAP32 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ARHGAP32 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ARHGAP32
Genomic Locations for ARHGAP32 Gene
Latest Assembly
- chr11:128,965,060-129,279,518
- (GRCh38/hg38)
- Size:
- 314,459 bases
- Orientation:
- Minus strand
Previous Assembly
- chr11:128,834,955-129,149,413
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 314,459 bases
- Orientation:
- Minus strand
- chr11:128,834,955-129,149,219
- (GRCh37/hg19 by Ensembl)
- Size:
- 314,265 bases
- Orientation:
- Minus strand
Genomic View for ARHGAP32 Gene
Genes around ARHGAP32 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q24.3 by HGNC
- 11q24.3 by Entrez Gene
- 11q24.3 by Ensembl
ARHGAP32 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ARHGAP32 Gene
Proteins for ARHGAP32 Gene
-
Protein details for ARHGAP32 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- A7KAX9-RHG32_HUMAN
- Recommended name:
- Rho GTPase-activating protein 32
- Protein Accession:
- A7KAX9
- I7H0B0
- O94820
- Q86YL6
- Q8IUG4
- Q9BWG3
Protein attributes for ARHGAP32 Gene
- Size:
- 2087 amino acids
- Molecular mass:
- 230529 Da
- Quaternary structure:
-
- Interacts with NTRK1 (via cytoplasmic domain); the interaction is independent of the phosphorylation state of NTRK1 (PubMed:12446789). Interacts with SHC3 (via SH2 domain) (PubMed:12446789). Interacts with RASA1 (via SH3 domain); the interaction is necessary for the Ras activation and cell transforming activities of ARHGAP32 (By similarity). Interacts with GAB1 and GAB2 (PubMed:12819203). Interacts with CRK and CRKL (PubMed:12819203, PubMed:12446789). Found in a complex with CRKL and BCAR1; upon EGF stimulation BCAR1 may be replaced by EGFR (PubMed:12446789, PubMed:12819203). Interacts with NCK1 (via SH3 domain); NCK1 recruits phosphorylated BCAR1 to the complex (PubMed:12819203). Isoform 2 interacts with FYN; the interaction appears to be dependent on tyrosine phosphorylation of ARHGAP32 (PubMed:12788081). Interacts with EGFR; the interaction requires EGF stimulation and is increased by SHC3 (PubMed:12446789). Interacts with CDC42; the interaction requires constitutively active CDC42. Interacts with CTNNB1 (PubMed:12531901). Interacts with GRIN2B (PubMed:12857875). Interacts with DLG4 and CDH2 (By similarity). Interacts with GPHN (By similarity).
- SequenceCaution:
-
- Sequence=BAA34432.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Protein Expression for ARHGAP32 Gene
Post-translational modifications for ARHGAP32 Gene
- Isoform 2 is phosphorylated on multiple tyrosine residues by FYN. Phosphorylated tyrosine residues undergo dephosphorylation after stimulation of NMDA receptors (By similarity). Phosphorylated in vitro by CaMK2 in the presence of calmodulin and calcium; which inhibits GAP activity (By similarity).
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for ARHGAP32 Gene
Antibodies for research
- Novus Biologicals Antibodies for ARHGAP32
- Invitrogen Antibodies for ARHGAP32 (AFLGC-ARHGAP32)
-
Biorbyt antibodies for ARHGAP32
Protein products for research
-
OriGene Purified Proteins for ARHGAP32
- Search Origene for MassSpec and Protein Over-expression Lysates for ARHGAP32
- Origene Custom Protein Services for ARHGAP32
- Novus Biologicals proteins for ARHGAP32
-
Abcam proteins for ARHGAP32
Assay products for research
No data available for DME Specific Peptides for ARHGAP32 Gene
Domains & Families for ARHGAP32 Gene
Gene Families for ARHGAP32 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
Protein Domains for ARHGAP32 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ARHGAP32 Gene
- GenScript: Design optimal peptide antigens:
-
- RICS protein (Q86UT2_HUMAN)
- p250GAP (RHG32_HUMAN)
Graphical View of Domain Structure for InterPro Entry
A7KAX9UniProtKB/Swiss-Prot:
RHG32_HUMAN :- The N-terminal PX domain interacts specifically with phosphatidylinositides.
- Domain:
-
- The N-terminal PX domain interacts specifically with phosphatidylinositides.
- Belongs to the PX domain-containing GAP family.
Function for ARHGAP32 Gene
Molecular function for ARHGAP32 Gene
- UniProtKB/Swiss-Prot Function:
- GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity).
Phenotypes From GWAS Catalog for ARHGAP32 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005096 | GTPase activator activity | IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 12788081 |
| GO:0035091 | phosphatidylinositol binding | IEA | -- |
| GO:1901981 | phosphatidylinositol phosphate binding | IEA | -- |
Phenotypes for ARHGAP32 Gene
- MGI mutant phenotypes for ARHGAP32:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ARHGAP32:
-
- no effect
- Decreased p24 protein expression
- Decreased NF-kappaB reporter expression
- Increased viability after borna disease (rVSVΔG*/BDVG) virus infection
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased viability in ovarian lineage
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Strongly decreased CFP-tsO45G cell surface transport
- Decreased shRNA abundance
Animal Models for ARHGAP32 Gene
- MGI Knock Outs for ARHGAP32:
-
- Arhgap32 Arhgap32<tm1Taki>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ARHGAP32 - Starting at $85 >
- * ARHGAP32 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ARHGAP32
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ARHGAP32
-
Santa Cruz Biotechnology (SCBT) CRISPR for ARHGAP32
miRNA for ARHGAP32 Gene
- miRTarBase miRNAs that target ARHGAP32
-
- hsa-miR-132-3p (MIRT003926)
- rno-miR-132-3p (MIRT004784)
- rno-miR-1-3p (MIRT005654)
- mmu-miR-132-3p (MIRT006729)
- hsa-miR-423-5p (MIRT038109)
- hsa-miR-183-5p (MIRT047063)
- hsa-miR-93-5p (MIRT048798)
- hsa-miR-6082 (MIRT562662)
- hsa-miR-139-5p (MIRT562663)
- mmu-miR-466i-3p (MIRT590637)
- mmu-miR-3076-5p (MIRT590638)
- hsa-miR-4799-5p (MIRT714434)
- hsa-miR-6501-3p (MIRT714435)
- hsa-miR-6838-5p (MIRT714436)
- hsa-miR-497-5p (MIRT714437)
- hsa-miR-424-5p (MIRT714438)
- hsa-miR-195-5p (MIRT714439)
- hsa-miR-16-5p (MIRT714440)
- hsa-miR-15b-5p (MIRT714441)
- hsa-miR-15a-5p (MIRT714442)
- hsa-miR-2278 (MIRT714443)
- hsa-miR-3119 (MIRT784559)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ARHGAP32
- Browse OriGene Inhibitory RNA Products For ARHGAP32
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARHGAP32
Clone products for research
- Applied Biological Materials (abm): Clones for ARHGAP32 - Starting at $45 >
- * ARHGAP32 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for ARHGAP32
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ARHGAP32
Cell Lines for research
-
Horizon Cell Lines for ARHGAP32
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARHGAP32 Gene
Localization for ARHGAP32 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP32 Gene
- Cell junction, synapse, postsynaptic density. Cell projection, dendritic spine. Cytoplasm, cell cortex. Endosome membrane. Golgi apparatus membrane. Endoplasmic reticulum membrane. Membrane. Note=Association to membrane via PX domain (PubMed:17663722). Associated with cortical actin in undifferentiated neuroblastoma cells, but localized to dendritic spine and postsynaptic density after differentiation (By similarity). Colocalizes with EGFR at the cell membrane upon EGF treatment (PubMed:12446789). Colocalizes with GAB2 at the cell membrane (PubMed:12819203). {ECO:0000250 UniProtKB:Q811P8, ECO:0000269 PubMed:12446789, ECO:0000269 PubMed:12819203, ECO:0000269 PubMed:17663722}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| cytoskeleton | 4 |
| golgi apparatus | 4 |
| endosome | 3 |
| plasma membrane | 1 |
| extracellular | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
- Golgi apparatus (3)
- Nucleoli fibrillar center (1)
- Nucleoplasm (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA | -- |
| GO:0001650 | fibrillar center | IBA,IDA | -- |
| GO:0005654 | nucleoplasm | IBA,IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005768 | endosome | IEA | -- |
Pathways & Interactions for ARHGAP32 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | p75 NTR receptor-mediated signalling |
.36
|
|
| 2 | Signaling by GPCR | ||
| 3 | Signaling by Rho GTPases | ||
| 4 | Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases |
Development MAG-dependent inhibition of neurite outgrowth
.42
|
|
| 5 | G-protein signaling_Regulation of CDC42 activity |
G-protein signaling_Regulation of CDC42 activity
-
|
|
Pathways by source for ARHGAP32 Gene
3 Reactome pathways for ARHGAP32 Gene
4 GeneGo (Thomson Reuters) pathways for ARHGAP32 Gene
- Development MAG-dependent inhibition of neurite outgrowth
- G-protein signaling_Regulation of CDC42 activity
- G-protein signaling_Regulation of RAC1 activity
- G-protein signaling_RhoA regulation pathway
1 GeneTex pathway for ARHGAP32 Gene
Interacting Proteins for ARHGAP32 Gene
Selected Interacting proteins:
A7KAX9-RHG32_HUMAN
ENSP00000310561
for ARHGAP32 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for ARHGAP32
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007264 | small GTPase mediated signal transduction | IBA | 21873635 |
| GO:0043547 | positive regulation of GTPase activity | IEA | -- |
| GO:0051056 | regulation of small GTPase mediated signal transduction | TAS | -- |
Drugs & Compounds for ARHGAP32 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| N-Methyl-D-aspartic acid |
|
6384-92-5 |
|
(1) ApexBio Compounds for ARHGAP32 Gene
| Compound | Action | Cas Number |
|---|---|---|
| HJC 0350 | 885434-70-8 |
Transcripts for ARHGAP32 Gene
mRNA/cDNA for ARHGAP32 Gene
- 4 REFSEQ mRNAs :
- 18 NCBI additional mRNA sequence :
- 8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000310343 10111 nts (view in UCSC)
- ENST00000392657 6556 nts (view in UCSC)
- ENST00000524655 8194 nts (view in UCSC)
- ENST00000525234 719 nts (view in UCSC)
- ENST00000526162 6868 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ARHGAP32 - Starting at $85 >
- * ARHGAP32 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ARHGAP32
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ARHGAP32
-
Santa Cruz Biotechnology (SCBT) CRISPR for ARHGAP32
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ARHGAP32
- Browse OriGene Inhibitory RNA Products For ARHGAP32
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARHGAP32
Clone products for research
- Applied Biological Materials (abm): Clones for ARHGAP32 - Starting at $45 >
- * ARHGAP32 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for ARHGAP32
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ARHGAP32
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | · | 19c | ^ | 20a | · | 20b | ^ | 21 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - |
Relevant External Links for ARHGAP32 Gene
- GeneLoc Exon Structure for
- ARHGAP32
Expression for ARHGAP32 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
This gene is overexpressed in Cervix (52.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARHGAP32 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ARHGAP32
SOURCE GeneReport for Unigene cluster for ARHGAP32 Gene:
Hs.440379mRNA Expression by UniProt/SwissProt for ARHGAP32 Gene:
A7KAX9-RHG32_HUMAN
Tissue specificity:
Isoform 1 and isoform 2 are highly expressed in brain and testis. Isoform 1 is also expressed in other tissues such as lung, liver and spleen.
Evidence on tissue expression from TISSUES for ARHGAP32 Gene
- Nervous system(4.9)
- Intestine(4.5)
- Eye(4.4)
- Liver(4.2)
Primer products for research
-
OriGene qPCR primer pairs for ARHGAP32
-
OriGene qPCR primer pairs and template standards for ARHGAP32
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGAP32 Gene
Orthologs for ARHGAP32 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ARHGAP32 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ARHGAP32 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Arhgap32 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Arhgap32 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | ARHGAP32 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | ARHGAP32 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ARHGAP32 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ARHGAP32 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | ARHGAP32 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | arhgap32 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.34587 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | im:7150060 30 |
|
||
| ARHGAP32 31 |
|
OneToOne | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CdGAPr 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | rrc-1 31 |
|
ManyToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RGD1 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for ARHGAP32 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for ARHGAP32 Gene
- ENSEMBL:
- Gene Tree for ARHGAP32 (if available)
- TreeFam:
- Gene Tree for ARHGAP32 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ARHGAP32: view image
Paralogs for ARHGAP32 Gene
Variants for ARHGAP32 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ARHGAP32 Gene
| SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs112411848 | Benign: not provided | 128,972,821(-) |
A/G NM_001142685.1(ARHGAP32):c.3643T>C (p.Ser1215Pro) |
MISSENSE | |
| rs113749911 | Likely Benign: not provided | 128,980,714(-) |
G/A NM_001142685.1(ARHGAP32):c.1773C>T (p.Ser591=) |
SYNONYMOUS | |
| rs116064946 | Benign: not provided | 128,972,712(-) |
G/A NM_001142685.1(ARHGAP32):c.3752C>T (p.Ser1251Phe) |
MISSENSE | |
| rs116891747 | Benign: not provided | 128,968,955(-) |
G/A NM_001142685.1(ARHGAP32):c.6216C>T (p.Pro2072=) |
SYNONYMOUS | |
| rs140367157 | Likely Benign: not provided | 128,970,983(-) |
G/C NM_001142685.1(ARHGAP32):c.4188C>G (p.His1396Gln) |
MISSENSE |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2243084 | CNV | deletion | 18987734 |
| esv2287161 | CNV | deletion | 18987734 |
| esv2442229 | CNV | deletion | 19546169 |
| esv2601979 | CNV | deletion | 19546169 |
| esv2661820 | CNV | deletion | 23128226 |
| esv2745247 | CNV | deletion | 23290073 |
| esv3304846 | CNV | mobile element insertion | 20981092 |
| esv3309788 | CNV | mobile element insertion | 20981092 |
| esv3377735 | CNV | insertion | 20981092 |
| esv3394165 | CNV | insertion | 20981092 |
| esv3430662 | CNV | insertion | 20981092 |
| esv3447576 | CNV | insertion | 20981092 |
| esv3548512 | CNV | deletion | 23714750 |
| esv3628054 | CNV | loss | 21293372 |
| esv3628057 | CNV | loss | 21293372 |
| esv3628060 | CNV | loss | 21293372 |
| nsv1125539 | CNV | tandem duplication | 24896259 |
| nsv1138086 | CNV | deletion | 24896259 |
| nsv478140 | CNV | novel sequence insertion | 20440878 |
| nsv525837 | CNV | loss | 19592680 |
| nsv826132 | CNV | gain | 20364138 |
| nsv832291 | CNV | loss | 17160897 |
| nsv983213 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
3.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.25;
70.15% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ARHGAP32 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP32 Gene
Disorders for ARHGAP32 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| bartter syndrome, type 2, antenatal |
|
|
| borna disease |
|
|
| jacobsen syndrome |
|
|
| chromosome 17q23.1-q23.2 deletion syndrome |
|
|
| johanson-blizzard syndrome |
|
|
Search ARHGAP32 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ARHGAP32
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for ARHGAP32 Gene
Publications for ARHGAP32 Gene
- Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules. (PMID: 12446789) Nakamura T … Mori N (Molecular and cellular biology 2002) 2 3 4 23
- PX-RICS, a novel splicing variant of RICS, is a main isoform expressed during neural development. (PMID: 17663722) Hayashi T … Nakamura T (Genes to cells : devoted to molecular & cellular mechanisms 2007) 2 3 4
- GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2. (PMID: 12819203) Zhao C … Feng GS (The Journal of biological chemistry 2003) 2 3 4
- Characterization of a brain-specific Rho GTPase-activating protein, p200RhoGAP. (PMID: 12454018) Moon SY … Zheng Y (The Journal of biological chemistry 2003) 3 4 23
- p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn. (PMID: 12788081) Taniguchi S … Yamamoto T (Biochemical and biophysical research communications 2003) 3 4 23
ExternalLinks
Products for ARHGAP32 Gene
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- Biorbyt antibodies for ARHGAP32
Sources for ARHGAP32 Gene
- (1) GeneCards
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- (4) UniProtKB/Swiss-Prot
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