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Aliases for ARHGAP32 Gene

Aliases for ARHGAP32 Gene

  • Rho GTPase Activating Protein 32 2 3 5
  • RhoGAP Involved In The Beta-Catenin-N-Cadherin And NMDA Receptor Signaling 3 4
  • GAB-Associated Cdc42/Rac GTPase-Activating Protein 3 4
  • Brain-Specific Rho GTPase-Activating Protein 3 4
  • Rho/Cdc42/Rac GTPase-Activating Protein RICS 3 4
  • GTPase Regulator Interacting With TrkA 3 4
  • Rho-Type GTPase-Activating Protein 32 3 4
  • P200RhoGAP 3 4
  • P250GAP 3 4
  • GC-GAP 3 4
  • GRIT 3 4
  • RICS 3 4
  • RhoGAP Involved In The -Catenin-N-Cadherin And NMDA Receptor Signaling 3
  • Brain-Specific Rho GTP-Ase-Activating Protein 3
  • GTPase-Activating Protein For Cdc42 And Rac1 3
  • Rho GTPase-Activating Protein 32 3
  • Rac GTPase Activating Protein 3
  • GAB-Associated CDC42 3
  • KIAA0712 4
  • PX-RICS 3

External Ids for ARHGAP32 Gene

Previous GeneCards Identifiers for ARHGAP32 Gene

  • GC11M128834
  • GC11M124785

Summaries for ARHGAP32 Gene

Entrez Gene Summary for ARHGAP32 Gene

  • RICS is a neuron-associated GTPase-activating protein that may regulate dendritic spine morphology and strength by modulating Rho GTPase (see RHOA; MIM 165390) activity (Okabe et al., 2003 [PubMed 12531901]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ARHGAP32 Gene

ARHGAP32 (Rho GTPase Activating Protein 32) is a Protein Coding gene. Diseases associated with ARHGAP32 include Neuroblastoma. Among its related pathways are Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases and p75 NTR receptor-mediated signalling. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and phosphatidylinositol binding. An important paralog of this gene is ARHGAP33.

UniProtKB/Swiss-Prot for ARHGAP32 Gene

  • GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity).

Gene Wiki entry for ARHGAP32 Gene

Additional gene information for ARHGAP32 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP32 Gene

Genomics for ARHGAP32 Gene

GeneHancer (GH) Regulatory Elements for ARHGAP32 Gene

Promoters and enhancers for ARHGAP32 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J129278 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 671.5 -0.5 -486 3.2 ARID4B SIN3A RAD21 RARA ZNF335 GLIS2 EGR1 ATF7 EGR2 MXD4 ARHGAP32 GC11M129296
GH11J129023 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 656 +255.3 255252 1.7 JUN DPF2 ELF1 KLF4 ZIC2 ZNF217 JUND GATA3 POLR2A GLIS1 ARHGAP32 KCNJ5 GC11P129031 GC11M128994 RNU6-876P
GH11J129141 Enhancer 1.4 FANTOM5 Ensembl ENCODE 22.8 +135.0 134972 5.3 ARID4B DMAP1 FOS SP5 MIER2 NFIL3 SSRP1 ATF4 RCOR2 KDM1A ARHGAP32 GC11M129150 GC11M129125
GH11J129246 Enhancer 1 Ensembl ENCODE 25.6 +30.6 30552 4.3 ELF3 FOXA2 MLX ARID4B RAD21 FOS CREM ZBTB25 CEBPB MIER2 ARHGAP32 GC11M129217 GC11M129275
GH11J129189 Enhancer 0.7 Ensembl ENCODE 22.3 +88.0 87967 3.2 SMARCE1 ZNF217 CTBP1 JUND GATA3 GATAD2B ARHGAP32 GC11M129197 GC11M129172
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARHGAP32 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ARHGAP32 Gene

Genomic Locations for ARHGAP32 Gene
314,265 bases
Minus strand
314,265 bases
Minus strand

Genomic View for ARHGAP32 Gene

Genes around ARHGAP32 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP32 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP32 Gene

Proteins for ARHGAP32 Gene

  • Protein details for ARHGAP32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho GTPase-activating protein 32
    Protein Accession:
    Secondary Accessions:
    • I7H0B0
    • O94820
    • Q86YL6
    • Q8IUG4
    • Q9BWG3

    Protein attributes for ARHGAP32 Gene

    2087 amino acids
    Molecular mass:
    230529 Da
    Quaternary structure:
    • Interacts with NTRK1 (via cytoplasmic domain); the interaction is independent of the phosphorylation state of NTRK1. Interacts with SHC3 (via SH2 domain). Interacts with RASA1 (via SH3 domain); the interaction is necessary for the Ras activation and cell transforming activities of ARHGAP32 (By similarity). Interacts with GAB1 and GAB2. Interacts with CRK and CRKL. Found in a complex with CRKL and BCAR1; upon EGF stimulation BCAR1 may be replaced by EGFR. Interacts with NCK1 (via SH3 domain); NCK1 recruits phosphorylated BCAR1 to the complex. Isoform 2 interacts with FYN; the interaction appears to be dependent on tyrosine phosphorylation of ARHGAP32. Interacts with EGFR; the interaction requires EGF stimulation and is increased by SHC3. Interacts with CDC42; the interaction requires constitutively active CDC42. Interacts with CTNNB1, DLG4, CDH2 and GRIN2B (By similarity).
    • Sequence=BAA34432.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARHGAP32 Gene

    Alternative splice isoforms for ARHGAP32 Gene


neXtProt entry for ARHGAP32 Gene

Post-translational modifications for ARHGAP32 Gene

  • Isoform 2 is phosphorylated on multiple tyrosine residues by FYN. Phosphorylated tyrosine residues undergo dephosphorylation after stimulation of NMDA receptors (By similarity). Phosphorylated in vitro by CaMK2 in the presence of calmodulin and calcium; which inhibits GAP activity (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARHGAP32 Gene

Domains & Families for ARHGAP32 Gene

Gene Families for ARHGAP32 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for ARHGAP32 Gene

Suggested Antigen Peptide Sequences for ARHGAP32 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The N-terminal PX domain interacts specifically with phosphatidylinositides.
  • The N-terminal PX domain interacts specifically with phosphatidylinositides.
  • Belongs to the PX domain-containing GAP family.
genes like me logo Genes that share domains with ARHGAP32: view

Function for ARHGAP32 Gene

Molecular function for ARHGAP32 Gene

UniProtKB/Swiss-Prot Function:
GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity).

Phenotypes From GWAS Catalog for ARHGAP32 Gene

Gene Ontology (GO) - Molecular Function for ARHGAP32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS --
GO:0005515 protein binding IPI 12788081
GO:0035091 phosphatidylinositol binding IEA --
genes like me logo Genes that share ontologies with ARHGAP32: view
genes like me logo Genes that share phenotypes with ARHGAP32: view

Animal Models for ARHGAP32 Gene

MGI Knock Outs for ARHGAP32:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARHGAP32 Gene

Localization for ARHGAP32 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP32 Gene

Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendritic spine. Cytoplasm, cell cortex. Endosome membrane. Golgi apparatus membrane. Endoplasmic reticulum membrane. Membrane. Note=Association to membrane via PX domain (PubMed:17663722). Associated with cortical actin in undifferentiated neuroblastoma cells, but localized to dendritic spine and postsynaptic density after differentiation (By similarity). Colocalizes with EGFR at the cell membrane upon EGF treatment (PubMed:12446789). Colocalizes with GAB2 at the cell membrane (PubMed:12819203). {ECO:0000250 UniProtKB:Q811P8, ECO:0000269 PubMed:12446789, ECO:0000269 PubMed:12819203, ECO:0000269 PubMed:17663722}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGAP32 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 4
endoplasmic reticulum 4
golgi apparatus 4
plasma membrane 3
endosome 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Nucleoli fibrillar center (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARHGAP32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0001650 fibrillar center IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IEA --
genes like me logo Genes that share ontologies with ARHGAP32: view

Pathways & Interactions for ARHGAP32 Gene

genes like me logo Genes that share pathways with ARHGAP32: view

SIGNOR curated interactions for ARHGAP32 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ARHGAP32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007264 small GTPase mediated signal transduction IBA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP32: view

Drugs & Compounds for ARHGAP32 Gene

(4) Drugs for ARHGAP32 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
Guanosine triphosphate Experimental Pharma 0
HJC 0350 Pharma 0

(2) Additional Compounds for ARHGAP32 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
N-Methyl-D-aspartic acid
  • (R)-2-methylamino-Succinic acid
  • 2-methylamino-Succinic acid
  • Methyl aspartic acid
  • N-Methyl aspartic acid
  • N-Methyl-D-aspartate
genes like me logo Genes that share compounds with ARHGAP32: view

Transcripts for ARHGAP32 Gene

Unigene Clusters for ARHGAP32 Gene

Rho GTPase activating protein 32:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP32 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b · 19c ^ 20a · 20b ^ 21
SP1: - -
SP2: - -
SP4: -

Relevant External Links for ARHGAP32 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARHGAP32 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARHGAP32 Gene

Protein differential expression in normal tissues from HIPED for ARHGAP32 Gene

This gene is overexpressed in Cervix (52.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARHGAP32 Gene

Protein tissue co-expression partners for ARHGAP32 Gene

NURSA nuclear receptor signaling pathways regulating expression of ARHGAP32 Gene:


SOURCE GeneReport for Unigene cluster for ARHGAP32 Gene:


mRNA Expression by UniProt/SwissProt for ARHGAP32 Gene:

Tissue specificity: Isoform 1 and isoform 2 are highly expressed in brain and testis. Isoform 1 is also expressed in other tissues such as lung, liver and spleen.

Evidence on tissue expression from TISSUES for ARHGAP32 Gene

  • Nervous system(4.9)
  • Intestine(4.5)
  • Liver(4.3)
  • Eye(4.2)
genes like me logo Genes that share expression patterns with ARHGAP32: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGAP32 Gene

Orthologs for ARHGAP32 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGAP32 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARHGAP32 34 33
  • 99.54 (n)
(Canis familiaris)
Mammalia ARHGAP32 34 33
  • 87.95 (n)
(Mus musculus)
Mammalia Arhgap32 16 34 33
  • 86.18 (n)
(Rattus norvegicus)
Mammalia Arhgap32 33
  • 85.81 (n)
(Bos Taurus)
Mammalia ARHGAP32 34 33
  • 83.09 (n)
(Monodelphis domestica)
Mammalia ARHGAP32 34
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia ARHGAP32 34
  • 65 (a)
(Gallus gallus)
Aves ARHGAP32 34 33
  • 68.16 (n)
(Anolis carolinensis)
Reptilia ARHGAP32 34
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap32 33
  • 65.17 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.34587 33
(Danio rerio)
Actinopterygii im:7150060 33
  • 60.52 (n)
  • 50 (a)
fruit fly
(Drosophila melanogaster)
Insecta CdGAPr 34
  • 22 (a)
(Caenorhabditis elegans)
Secernentea rrc-1 34
  • 30 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RGD1 34
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 49 (a)
Species where no ortholog for ARHGAP32 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP32 Gene

Gene Tree for ARHGAP32 (if available)
Gene Tree for ARHGAP32 (if available)
Evolutionary constrained regions (ECRs) for ARHGAP32: view image

Paralogs for ARHGAP32 Gene

(9) SIMAP similar genes for ARHGAP32 Gene using alignment to 3 proteins:

  • G3V174_HUMAN
genes like me logo Genes that share paralogs with ARHGAP32: view

Variants for ARHGAP32 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP32 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs749174548 uncertain-significance, Ependymoma 128,970,468(-) G/A/C coding_sequence_variant, genic_downstream_transcript_variant, missense_variant
rs1000001520 -- 129,097,805(-) A/T genic_upstream_transcript_variant, intron_variant
rs1000001892 -- 129,004,919(-) A/C/G intron_variant
rs1000020251 -- 129,232,122(-) G/T genic_upstream_transcript_variant, intron_variant
rs1000029590 -- 129,261,985(-) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP32 Gene

Variant ID Type Subtype PubMed ID
esv2243084 CNV deletion 18987734
esv2287161 CNV deletion 18987734
esv2442229 CNV deletion 19546169
esv2601979 CNV deletion 19546169
esv2661820 CNV deletion 23128226
esv2745247 CNV deletion 23290073
esv3304846 CNV mobile element insertion 20981092
esv3309788 CNV mobile element insertion 20981092
esv3377735 CNV insertion 20981092
esv3394165 CNV insertion 20981092
esv3430662 CNV insertion 20981092
esv3447576 CNV insertion 20981092
esv3548512 CNV deletion 23714750
esv3628054 CNV loss 21293372
esv3628057 CNV loss 21293372
esv3628060 CNV loss 21293372
nsv1125539 CNV tandem duplication 24896259
nsv1138086 CNV deletion 24896259
nsv478140 CNV novel sequence insertion 20440878
nsv525837 CNV loss 19592680
nsv826132 CNV gain 20364138
nsv832291 CNV loss 17160897
nsv983213 CNV duplication 23825009

Variation tolerance for ARHGAP32 Gene

Residual Variation Intolerance Score: 3.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.25; 70.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARHGAP32 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP32 Gene

Disorders for ARHGAP32 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ARHGAP32 Gene - From: GeneCards

Disorder Aliases PubMed IDs
  • neuroblastoma, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ARHGAP32

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ARHGAP32: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARHGAP32 Gene

Publications for ARHGAP32 Gene

  1. Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules. (PMID: 12446789) Nakamura T … Mori N (Molecular and cellular biology 2002) 2 3 4 22 58
  2. PX-RICS, a novel splicing variant of RICS, is a main isoform expressed during neural development. (PMID: 17663722) Hayashi T … Nakamura T (Genes to cells : devoted to molecular & cellular mechanisms 2007) 2 3 4 58
  3. GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2. (PMID: 12819203) Zhao C … Feng GS (The Journal of biological chemistry 2003) 2 3 4 58
  4. p250GAP, a novel brain-enriched GTPase-activating protein for Rho family GTPases, is involved in the N-methyl-d-aspartate receptor signaling. (PMID: 12857875) Nakazawa T … Yamamoto T (Molecular biology of the cell 2003) 3 4 22 58
  5. p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn. (PMID: 12788081) Taniguchi S … Yamamoto T (Biochemical and biophysical research communications 2003) 3 4 22 58

Products for ARHGAP32 Gene

Sources for ARHGAP32 Gene

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