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Aliases for ARHGAP30 Gene

Aliases for ARHGAP30 Gene

  • Rho GTPase Activating Protein 30 2 3 5
  • Rho-Type GTPase-Activating Protein 30 4

External Ids for ARHGAP30 Gene

Previous GeneCards Identifiers for ARHGAP30 Gene

  • GC01M157830
  • GC01M159283
  • GC01M132374

Summaries for ARHGAP30 Gene

GeneCards Summary for ARHGAP30 Gene

ARHGAP30 (Rho GTPase Activating Protein 30) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP32.

UniProtKB/Swiss-Prot for ARHGAP30 Gene

  • GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42.

Additional gene information for ARHGAP30 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP30 Gene

Genomics for ARHGAP30 Gene

GeneHancer (GH) Regulatory Elements for ARHGAP30 Gene

Promoters and enhancers for ARHGAP30 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I161066 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 568.4 +1.4 1356 5.1 HDGF PKNOX1 BMI1 ZBTB40 KLF5 IRF4 ZNF207 ZNF143 ATF7 ETV6 ARHGAP30 FCGR2A TSTD1 DUSP12 USP21 PPOX F11R DEDD NECTIN4 ENSG00000232879
GH01I161011 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE dbSUPER 24.2 +52.8 52758 11.7 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 DUSP12 USP21 LOC100287049 DEDD PPOX TSTD1 LOC148430 B4GALT3 ARHGAP30 KLHDC9
GH01I161043 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.3 +23.1 23082 5.8 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 GC01P161046 PIR33280 USF1 DEDD TSTD1 LOC100287049 ARHGAP30 LOC105371471 NECTIN4 KLHDC9
GH01I161037 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 11.1 +31.2 31218 2.2 HDGF PKNOX1 SIN3A ZNF2 YY1 GLIS2 ZNF143 RUNX3 SP3 GLIS1 TSTD1 ENSG00000270149 F11R LOC105371471 ARHGAP30 NECTIN4 ENSG00000232879 USF1
GH01I161539 Enhancer 1.5 Ensembl ENCODE dbSUPER 12.7 -471.8 -471824 4.8 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 SLC30A9 POLR2B GC01P161541 TRN-GTT1-1 DUSP12 FCGR2C USP21 ARHGAP30 FCGR2A FCRLB SLAMF7 LY9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ARHGAP30 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARHGAP30 gene promoter:

Genomic Locations for ARHGAP30 Gene

Genomic Locations for ARHGAP30 Gene
23,030 bases
Minus strand

Genomic View for ARHGAP30 Gene

Genes around ARHGAP30 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP30 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP30 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP30 Gene

Proteins for ARHGAP30 Gene

  • Protein details for ARHGAP30 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho GTPase-activating protein 30
    Protein Accession:
    Secondary Accessions:
    • Q5SY52
    • Q5SY53
    • Q5SY54
    • Q6ZML6
    • Q7Z3J8
    • Q86XI7

    Protein attributes for ARHGAP30 Gene

    1101 amino acids
    Molecular mass:
    118582 Da
    Quaternary structure:
    • Interacts with RHOU in a GTP-independent manner.
    • Sequence=AAH43387.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAD18709.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAI15373.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI15375.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ARHGAP30 Gene


neXtProt entry for ARHGAP30 Gene

Post-translational modifications for ARHGAP30 Gene

  • Ubiquitination at Lys181
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ARHGAP30 Gene

Domains & Families for ARHGAP30 Gene

Gene Families for ARHGAP30 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ARHGAP30 Gene

Suggested Antigen Peptide Sequences for ARHGAP30 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARHGAP30: view

No data available for UniProtKB/Swiss-Prot for ARHGAP30 Gene

Function for ARHGAP30 Gene

Molecular function for ARHGAP30 Gene

UniProtKB/Swiss-Prot Function:
GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42.

Phenotypes From GWAS Catalog for ARHGAP30 Gene

Gene Ontology (GO) - Molecular Function for ARHGAP30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS --
genes like me logo Genes that share ontologies with ARHGAP30: view

Phenotypes for ARHGAP30 Gene

genes like me logo Genes that share phenotypes with ARHGAP30: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ARHGAP30 Gene

Localization for ARHGAP30 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP30 Gene

Cytoplasmic vesicle.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGAP30 gene
Compartment Confidence
cytosol 5
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ARHGAP30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0031410 cytoplasmic vesicle IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with ARHGAP30: view

Pathways & Interactions for ARHGAP30 Gene

genes like me logo Genes that share pathways with ARHGAP30: view

Pathways by source for ARHGAP30 Gene

3 Reactome pathways for ARHGAP30 Gene

Interacting Proteins for ARHGAP30 Gene

Gene Ontology (GO) - Biological Process for ARHGAP30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007264 small GTPase mediated signal transduction IBA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP30: view

No data available for SIGNOR curated interactions for ARHGAP30 Gene

Drugs & Compounds for ARHGAP30 Gene

No Compound Related Data Available

Transcripts for ARHGAP30 Gene

Unigene Clusters for ARHGAP30 Gene

Rho GTPase activating protein 30:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP30 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13
SP2: -
SP5: -
SP6: - - - -
SP7: - -
SP9: - - - - - - - -

Relevant External Links for ARHGAP30 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARHGAP30 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARHGAP30 Gene

mRNA differential expression in normal tissues according to GTEx for ARHGAP30 Gene

This gene is overexpressed in Whole Blood (x24.5) and Spleen (x5.2).

Protein differential expression in normal tissues from HIPED for ARHGAP30 Gene

This gene is overexpressed in Pancreas (22.5), Peripheral blood mononuclear cells (12.8), and Lymph node (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARHGAP30 Gene

Protein tissue co-expression partners for ARHGAP30 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARHGAP30 Gene:


SOURCE GeneReport for Unigene cluster for ARHGAP30 Gene:


Evidence on tissue expression from TISSUES for ARHGAP30 Gene

  • Blood(4.4)
  • Spleen(4.3)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with ARHGAP30: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGAP30 Gene

Orthologs for ARHGAP30 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGAP30 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARHGAP30 33 34
  • 99.63 (n)
(Bos Taurus)
Mammalia ARHGAP30 33 34
  • 85.82 (n)
(Canis familiaris)
Mammalia ARHGAP30 33 34
  • 84.05 (n)
(Mus musculus)
Mammalia Arhgap30 33 16 34
  • 81.01 (n)
(Rattus norvegicus)
Mammalia Arhgap30 33
  • 80.89 (n)
(Monodelphis domestica)
Mammalia ARHGAP30 34
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia ARHGAP30 34
  • 51 (a)
(Gallus gallus)
Aves -- 34
  • 30 (a)
(Danio rerio)
Actinopterygii CU915267.1 34 34
  • 66 (a)
fruit fly
(Drosophila melanogaster)
Insecta CdGAPr 34
  • 12 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RGD1 34
  • 12 (a)
Species where no ortholog for ARHGAP30 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARHGAP30 Gene

Gene Tree for ARHGAP30 (if available)
Gene Tree for ARHGAP30 (if available)

Paralogs for ARHGAP30 Gene

Paralogs for ARHGAP30 Gene

(4) SIMAP similar genes for ARHGAP30 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ARHGAP30: view

Variants for ARHGAP30 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP30 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000081495 -- 161,050,291(-) G/A intron_variant
rs1000122296 -- 161,057,436(-) A/G intron_variant
rs1000201810 -- 161,060,323(-) C/T intron_variant
rs1000337060 -- 161,060,643(-) T/C intron_variant
rs1000396299 -- 161,051,090(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP30 Gene

Variant ID Type Subtype PubMed ID
nsv1129471 CNV tandem duplication 24896259
nsv1149777 CNV insertion 26484159
nsv3221 CNV deletion 18451855
nsv3232 CNV insertion 18451855

Variation tolerance for ARHGAP30 Gene

Residual Variation Intolerance Score: 73.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.79; 89.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARHGAP30 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP30 Gene

Disorders for ARHGAP30 Gene

Additional Disease Information for ARHGAP30

No disorders were found for ARHGAP30 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGAP30 Gene

Publications for ARHGAP30 Gene

  1. ARHGAP30 is a Wrch-1-interacting protein involved in actin dynamics and cell adhesion. (PMID: 21565175) Naji L … Aspenström P (Biochemical and biophysical research communications 2011) 3 4 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  3. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PMID: 15144186) Brill LM … Peters EC (Analytical chemistry 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. ArhGAP30 promotes p53 acetylation and function in colorectal cancer. (PMID: 25156493) Wang J … Fang JY (Nature communications 2014) 3 58

Products for ARHGAP30 Gene

Sources for ARHGAP30 Gene

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