Aliases for ARHGAP30 Gene

Aliases for ARHGAP30 Gene

  • Rho GTPase Activating Protein 30 2 3 5
  • Rho-Type GTPase-Activating Protein 30 3 4
  • Rho GTPase-Activating Protein 30 3 4
  • ARHGAP30 5
  • FLJ00267 2

External Ids for ARHGAP30 Gene

Previous GeneCards Identifiers for ARHGAP30 Gene

  • GC01M157830
  • GC01M159283
  • GC01M161016
  • GC01M132374

Summaries for ARHGAP30 Gene

GeneCards Summary for ARHGAP30 Gene

ARHGAP30 (Rho GTPase Activating Protein 30) is a Protein Coding gene. Among its related pathways are p75 NTR receptor-mediated signalling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP32.

UniProtKB/Swiss-Prot Summary for ARHGAP30 Gene

  • GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARHGAP30 Gene

Genomics for ARHGAP30 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ARHGAP30 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARHGAP30 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ARHGAP30

Top Transcription factor binding sites by QIAGEN in the ARHGAP30 gene promoter:
  • AP-1
  • ATF
  • ATF-2
  • c-Jun
  • Elk-1
  • p53

Genomic Locations for ARHGAP30 Gene

Latest Assembly
23,030 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
22,946 bases
Minus strand

(GRCh37/hg19 by Ensembl)
23,025 bases
Minus strand

Genomic View for ARHGAP30 Gene

Genes around ARHGAP30 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP30 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP30 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP30 Gene

Proteins for ARHGAP30 Gene

  • Protein details for ARHGAP30 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho GTPase-activating protein 30
    Protein Accession:
    Secondary Accessions:
    • Q5SY52
    • Q5SY53
    • Q5SY54
    • Q6ZML6
    • Q7Z3J8
    • Q86XI7

    Protein attributes for ARHGAP30 Gene

    1101 amino acids
    Molecular mass:
    118582 Da
    Quaternary structure:
    • Interacts with RHOU in a GTP-independent manner.
    • Sequence=AAH43387.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAD18709.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for ARHGAP30 Gene


neXtProt entry for ARHGAP30 Gene

Post-translational modifications for ARHGAP30 Gene

  • Ubiquitination at Lys181
  • Modification sites at PhosphoSitePlus

Antibodies for research

  • Biorbyt antibodies for ARHGAP30
  • Boster Bio Antibodies for ARHGAP30

No data available for DME Specific Peptides for ARHGAP30 Gene

Domains & Families for ARHGAP30 Gene

Gene Families for ARHGAP30 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ARHGAP30 Gene

  • RhoGAP domain

Suggested Antigen Peptide Sequences for ARHGAP30 Gene

GenScript: Design optimal peptide antigens:
  • Rho-type GTPase-activating protein 30 (RHG30_HUMAN)
genes like me logo Genes that share domains with ARHGAP30: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ARHGAP30 Gene

Function for ARHGAP30 Gene

Molecular function for ARHGAP30 Gene

UniProtKB/Swiss-Prot Function:
GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42.

Phenotypes From GWAS Catalog for ARHGAP30 Gene

Gene Ontology (GO) - Molecular Function for ARHGAP30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IBA 21873635
genes like me logo Genes that share ontologies with ARHGAP30: view
genes like me logo Genes that share phenotypes with ARHGAP30: view

Animal Models for ARHGAP30 Gene

MGI Knock Outs for ARHGAP30:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARHGAP30

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ARHGAP30 Gene

Localization for ARHGAP30 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP30 Gene

Cytoplasmic vesicle.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGAP30 gene
Compartment Confidence
cytosol 4
nucleus 2
extracellular 1
cytoskeleton 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ARHGAP30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0031410 cytoplasmic vesicle IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with ARHGAP30: view

Pathways & Interactions for ARHGAP30 Gene

genes like me logo Genes that share pathways with ARHGAP30: view

Pathways by source for ARHGAP30 Gene

3 Reactome pathways for ARHGAP30 Gene

Interacting Proteins for ARHGAP30 Gene

SIGNOR curated interactions for ARHGAP30 Gene


Gene Ontology (GO) - Biological Process for ARHGAP30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007264 small GTPase mediated signal transduction IBA 21873635
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP30: view

Drugs & Compounds for ARHGAP30 Gene

No Compound Related Data Available

Transcripts for ARHGAP30 Gene

mRNA/cDNA for ARHGAP30 Gene

11 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARHGAP30

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP30 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13
SP2: -
SP5: -
SP6: - - - -
SP7: - -
SP9: - - - - - - - -

Relevant External Links for ARHGAP30 Gene

GeneLoc Exon Structure for

Expression for ARHGAP30 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARHGAP30 Gene

mRNA differential expression in normal tissues according to GTEx for ARHGAP30 Gene

This gene is overexpressed in Whole Blood (x24.5) and Spleen (x5.2).

Protein differential expression in normal tissues from HIPED for ARHGAP30 Gene

This gene is overexpressed in Pancreas (22.5), Peripheral blood mononuclear cells (12.8), and Lymph node (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARHGAP30 Gene

Protein tissue co-expression partners for ARHGAP30 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ARHGAP30

SOURCE GeneReport for Unigene cluster for ARHGAP30 Gene:


Evidence on tissue expression from TISSUES for ARHGAP30 Gene

  • Blood(4.5)
  • Spleen(4.3)
  • Liver(4.1)
  • Lymph node(2.2)
genes like me logo Genes that share expression patterns with ARHGAP30: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGAP30 Gene

Orthologs for ARHGAP30 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGAP30 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARHGAP30 29 30
  • 99.63 (n)
(Bos Taurus)
Mammalia ARHGAP30 29 30
  • 85.82 (n)
(Canis familiaris)
Mammalia ARHGAP30 29 30
  • 84.05 (n)
(Mus musculus)
Mammalia Arhgap30 29 16 30
  • 81.01 (n)
(Rattus norvegicus)
Mammalia Arhgap30 29
  • 80.89 (n)
(Monodelphis domestica)
Mammalia ARHGAP30 30
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia ARHGAP30 30
  • 51 (a)
(Gallus gallus)
Aves -- 30
  • 30 (a)
(Danio rerio)
Actinopterygii CU915267.1 30 30
  • 66 (a)
Fruit Fly
(Drosophila melanogaster)
Insecta CdGAPr 30
  • 12 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RGD1 30
  • 12 (a)
Species where no ortholog for ARHGAP30 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ARHGAP30 Gene

Gene Tree for ARHGAP30 (if available)
Gene Tree for ARHGAP30 (if available)
Evolutionary constrained regions (ECRs) for ARHGAP30: view image
Alliance of Genome Resources:
Additional Orthologs for ARHGAP30

Paralogs for ARHGAP30 Gene

Paralogs for ARHGAP30 Gene

(4) SIMAP similar genes for ARHGAP30 Gene using alignment to 5 proteins:

  • L0R4U0_HUMAN
genes like me logo Genes that share paralogs with ARHGAP30: view

Variants for ARHGAP30 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ARHGAP30 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs17854839 -- p.Phe70Leu
rs3813609 -- p.Leu591Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ARHGAP30 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP30 Gene

Variant ID Type Subtype PubMed ID
nsv1129471 CNV tandem duplication 24896259
nsv1149777 CNV insertion 26484159
nsv3221 CNV deletion 18451855
nsv3232 CNV insertion 18451855

Variation tolerance for ARHGAP30 Gene

Residual Variation Intolerance Score: 73.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.79; 89.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARHGAP30 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP30 Gene

Disorders for ARHGAP30 Gene

Additional Disease Information for ARHGAP30

No disorders were found for ARHGAP30 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGAP30 Gene

Publications for ARHGAP30 Gene

  1. ARHGAP30 is a Wrch-1-interacting protein involved in actin dynamics and cell adhesion. (PMID: 21565175) Naji L … Aspenström P (Biochemical and biophysical research communications 2011) 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PMID: 15144186) Brill LM … Peters EC (Analytical chemistry 2004) 3 4
  5. Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions. (PMID: 32203420) Müller PM … Rocks O (Nature cell biology 2020) 3

Products for ARHGAP30 Gene

  • Biorbyt antibodies for ARHGAP30

Sources for ARHGAP30 Gene