Aliases for ARHGAP29 Gene
External Ids for ARHGAP29 Gene
Previous GeneCards Identifiers for ARHGAP29 Gene
Rap1 is a small GTPase that, through effectors, regulates Rho GTPase signaling. These effectors- Rasip1, Radil, and the protein encoded by this gene- translocate to the cell membrane, where they form a multiprotein complex. This complex is necessary for Rap1-induced inhibition of Rho signaling. Defects in this gene may be a cause of nonsyndromic cleft lip with or without cleft palate. [provided by RefSeq, Jun 2016]
GeneCards Summary for ARHGAP29 Gene
ARHGAP29 (Rho GTPase Activating Protein 29) is a Protein Coding gene. Diseases associated with ARHGAP29 include Cleft Lip With Or Without Cleft Palate and Cleft Lip. Among its related pathways are Hypothetical Craniofacial Development Pathway and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and PDZ domain binding. An important paralog of this gene is ARHGAP45.
UniProtKB/Swiss-Prot Summary for ARHGAP29 Gene
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis.