Aliases for ARHGAP28 Gene

Aliases for ARHGAP28 Gene

  • Rho GTPase Activating Protein 28 2 3 5
  • Rho-Type GTPase-Activating Protein 28 3 4
  • Rho GTPase-Activating Protein 28 3 4
  • KIAA1314 4

External Ids for ARHGAP28 Gene

Previous GeneCards Identifiers for ARHGAP28 Gene

  • GC18P006781
  • GC18U900243

Summaries for ARHGAP28 Gene

GeneCards Summary for ARHGAP28 Gene

ARHGAP28 (Rho GTPase Activating Protein 28) is a Protein Coding gene. Diseases associated with ARHGAP28 include Meningothelial Meningioma and Hypophosphatasia, Infantile. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP18.

UniProtKB/Swiss-Prot Summary for ARHGAP28 Gene

  • GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Additional gene information for ARHGAP28 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARHGAP28 Gene

Genomics for ARHGAP28 Gene

GeneHancer (GH) Regulatory Elements for ARHGAP28 Gene

Promoters and enhancers for ARHGAP28 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J006728 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 +0.8 784 5 HNRNPK EP300 CTCF ZSCAN5C NRF1 ZNF639 ZIC2 ZBTB11 ZBTB26 TARDBP ENSG00000266441 ARHGAP28 LOC101927168 ENSG00000279479 lnc-ARHGAP28-6 lnc-LRRC30-3
GH18J006834 Promoter 0.3 EPDnew 500.1 +104.7 104748 0.1 ARHGAP28 piR-36393-235 ENSG00000263797
GH18J006355 Enhancer 1 FANTOM5 Ensembl 39.6 -373.6 -373617 0.6 ZNF639 OSR2 BCL11A CREB1 GATA3 KLF8 JUND BATF ZNF335 IKZF3 ARHGAP28 L3MBTL4 lnc-TMEM200C-1 lnc-TMEM200C-2 lnc-ARHGAP28-11
GH18J006718 Enhancer 0.7 Ensembl dbSUPER 18.7 -10.1 -10120 1.6 CTBP1 CEBPG CEBPB JUN JUND ZNF335 EP300 ATF4 ENSG00000266441 ARHGAP28 lnc-ARHGAP28-6 piR-40110-294
GH18J006750 Enhancer 1 ENCODE CraniofacialAtlas dbSUPER 12.4 +22.5 22533 2.7 TEAD4 ZIC2 HDAC2 POLR2A CEBPG YY1 NANOG TCF12 ETS1 ATF4 ARHGAP28 ENSG00000266441 LOC101927168 lnc-LRRC30-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARHGAP28 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ARHGAP28

Top Transcription factor binding sites by QIAGEN in the ARHGAP28 gene promoter:
  • AML1a
  • FOXC1
  • NF-AT
  • NF-AT1
  • Nkx2-5
  • POU2F1
  • POU2F1a
  • STAT5A
  • STAT5B
  • TBP

Genomic Locations for ARHGAP28 Gene

Genomic Locations for ARHGAP28 Gene
185,999 bases
Plus strand
185,999 bases
Plus strand

Genomic View for ARHGAP28 Gene

Genes around ARHGAP28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP28 Gene

Proteins for ARHGAP28 Gene

  • Protein details for ARHGAP28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho GTPase-activating protein 28
    Protein Accession:
    Secondary Accessions:
    • A8MQB7
    • A8MU88
    • Q6P160
    • Q8N4T3
    • Q9NW53

    Protein attributes for ARHGAP28 Gene

    729 amino acids
    Molecular mass:
    82060 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA91533.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAA92552.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for ARHGAP28 Gene


neXtProt entry for ARHGAP28 Gene

Post-translational modifications for ARHGAP28 Gene

  • Glycosylation at Asn534
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • RHG28_HUMAN (2070)

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ARHGAP28

No data available for DME Specific Peptides for ARHGAP28 Gene

Domains & Families for ARHGAP28 Gene

Gene Families for ARHGAP28 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ARHGAP28 Gene

  • RhoGAP domain

Suggested Antigen Peptide Sequences for ARHGAP28 Gene

GenScript: Design optimal peptide antigens:
  • Rho-type GTPase-activating protein 28 (RHG28_HUMAN)
genes like me logo Genes that share domains with ARHGAP28: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ARHGAP28 Gene

Function for ARHGAP28 Gene

Molecular function for ARHGAP28 Gene

UniProtKB/Swiss-Prot Function:
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Phenotypes From GWAS Catalog for ARHGAP28 Gene

Gene Ontology (GO) - Molecular Function for ARHGAP28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IBA 21873635
genes like me logo Genes that share ontologies with ARHGAP28: view
genes like me logo Genes that share phenotypes with ARHGAP28: view

Animal Models for ARHGAP28 Gene

MGI Knock Outs for ARHGAP28:

Animal Model Products

CRISPR Products

miRNA for ARHGAP28 Gene

miRTarBase miRNAs that target ARHGAP28

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARHGAP28 Gene

Localization for ARHGAP28 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGAP28 gene
Compartment Confidence
cytosol 4
nucleus 3
plasma membrane 1
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARHGAP28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ARHGAP28: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP28 Gene

Pathways & Interactions for ARHGAP28 Gene

genes like me logo Genes that share pathways with ARHGAP28: view

Pathways by source for ARHGAP28 Gene

3 Reactome pathways for ARHGAP28 Gene

Interacting Proteins for ARHGAP28 Gene


Gene Ontology (GO) - Biological Process for ARHGAP28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0030833 regulation of actin filament polymerization IBA 21873635
GO:0032956 regulation of actin cytoskeleton organization IBA 21873635
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction IBA,TAS --
genes like me logo Genes that share ontologies with ARHGAP28: view

No data available for SIGNOR curated interactions for ARHGAP28 Gene

Drugs & Compounds for ARHGAP28 Gene

No Compound Related Data Available

Transcripts for ARHGAP28 Gene

mRNA/cDNA for ARHGAP28 Gene

13 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP28 Gene

No ASD Table

Relevant External Links for ARHGAP28 Gene

GeneLoc Exon Structure for

Expression for ARHGAP28 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARHGAP28 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGAP28 Gene

This gene is overexpressed in Testis (x12.4).

Protein differential expression in normal tissues from HIPED for ARHGAP28 Gene

This gene is overexpressed in Stomach (60.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARHGAP28 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ARHGAP28

SOURCE GeneReport for Unigene cluster for ARHGAP28 Gene:


mRNA Expression by UniProt/SwissProt for ARHGAP28 Gene:

Tissue specificity: Expressed in testis. Expressed at moderate level in kidney and ovary, and weakly expressed in spleen and skeletal muscle.

Evidence on tissue expression from TISSUES for ARHGAP28 Gene

  • Nervous system(4.3)
  • Skin(4)
genes like me logo Genes that share expression patterns with ARHGAP28: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGAP28 Gene

Orthologs for ARHGAP28 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP28 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARHGAP28 31 30
  • 99.55 (n)
(Canis familiaris)
Mammalia ARHGAP28 31 30
  • 89.63 (n)
(Bos Taurus)
Mammalia ARHGAP28 31 30
  • 86.82 (n)
(Rattus norvegicus)
Mammalia Arhgap28 30
  • 84.13 (n)
(Mus musculus)
Mammalia Arhgap28 17 31 30
  • 83.42 (n)
(Monodelphis domestica)
Mammalia ARHGAP28 31
  • 47 (a)
(Ornithorhynchus anatinus)
Mammalia ARHGAP28 31
  • 45 (a)
(Gallus gallus)
Aves ARHGAP28 31 30
  • 67.15 (n)
(Anolis carolinensis)
Reptilia ARHGAP28 31
  • 45 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap28 30
  • 64.78 (n)
(Danio rerio)
Actinopterygii arhgap28 31 30
  • 54.88 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG17082 31
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 37 (a)
Species where no ortholog for ARHGAP28 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARHGAP28 Gene

Gene Tree for ARHGAP28 (if available)
Gene Tree for ARHGAP28 (if available)
Evolutionary constrained regions (ECRs) for ARHGAP28: view image

Paralogs for ARHGAP28 Gene

Paralogs for ARHGAP28 Gene

(5) SIMAP similar genes for ARHGAP28 Gene using alignment to 10 proteins:

  • E9PL26_HUMAN
  • J3KT69_HUMAN
genes like me logo Genes that share paralogs with ARHGAP28: view

Variants for ARHGAP28 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ARHGAP28 Gene

SNP ID Clinical significance and condition Chr 18 pos Variation AA Info Type
768928 Benign: not provided 6,908,977(+) G/A MISSENSE_VARIANT
rs1056408 - p.Gln727Pro
rs2303978 - p.Ile168Val
rs6506448 - p.Thr190Ser

Additional dbSNP identifiers (rs#s) for ARHGAP28 Gene

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP28 Gene

Variant ID Type Subtype PubMed ID
esv2673830 CNV deletion 23128226
esv2758711 CNV gain 17122850
esv27738 CNV gain 19812545
esv3307626 CNV mobile element insertion 20981092
esv3355334 CNV insertion 20981092
esv3400638 CNV insertion 20981092
esv34611 CNV gain 17911159
esv3584943 CNV gain 24956385
nsv1059678 CNV gain 25217958
nsv1061855 CNV gain 25217958
nsv1061995 CNV gain 25217958
nsv1064175 CNV gain 25217958
nsv132229 CNV insertion 16902084
nsv576397 CNV gain 21841781
nsv833583 CNV gain 17160897
nsv9604 CNV loss 18304495
nsv9605 CNV loss 18304495

Variation tolerance for ARHGAP28 Gene

Residual Variation Intolerance Score: 24.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.64; 65.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARHGAP28 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP28 Gene

Disorders for ARHGAP28 Gene

MalaCards: The human disease database

(4) MalaCards diseases for ARHGAP28 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
meningothelial meningioma
  • meningotheliomatous meningioma
hypophosphatasia, infantile
  • hops
fibrous meningioma
  • fibroblastic meningioma
substance dependence
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ARHGAP28

genes like me logo Genes that share disorders with ARHGAP28: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARHGAP28 Gene

Publications for ARHGAP28 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 54
  2. DNA sequence and analysis of human chromosome 18. (PMID: 16177791) Nusbaum C … Lander ES (Nature 2005) 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 54

Products for ARHGAP28 Gene

Sources for ARHGAP28 Gene