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Aliases for ARHGAP28 Gene

Aliases for ARHGAP28 Gene

  • Rho GTPase Activating Protein 28 2 3 5
  • Rho-Type GTPase-Activating Protein 28 4
  • KIAA1314 4

External Ids for ARHGAP28 Gene

Previous GeneCards Identifiers for ARHGAP28 Gene

  • GC18P006781
  • GC18U900243

Summaries for ARHGAP28 Gene

GeneCards Summary for ARHGAP28 Gene

ARHGAP28 (Rho GTPase Activating Protein 28) is a Protein Coding gene. Diseases associated with ARHGAP28 include Central Nervous System Organ Benign Neoplasm and Substance Dependence. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP18.

UniProtKB/Swiss-Prot for ARHGAP28 Gene

  • GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Additional gene information for ARHGAP28 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP28 Gene

Genomics for ARHGAP28 Gene

GeneHancer (GH) Regulatory Elements for ARHGAP28 Gene

Promoters and enhancers for ARHGAP28 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18I006728 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 550.8 +0.8 800 4.4 ATF1 SIN3A FEZF1 GLI4 ZNF2 ZNF121 ZNF766 GLIS2 ATF7 SP3 LOC101927168 ARHGAP28 GC18M006695 ENSG00000279479
GH18I006834 Promoter 0.5 EPDnew 550.1 +104.7 104748 0.1 ARHGAP28 GC18P006828 ENSG00000263797
GH18I006355 Enhancer 0.8 FANTOM5 39.6 -373.8 -373765 0.1 ZBTB6 INSM2 KLF17 FEZF1 YY1 ZNF335 GLIS2 GLI2 PRDM10 FOS ARHGAP28 L3MBTL4 MIR4317 GC18M006270
GH18I006750 Enhancer 1 Ensembl ENCODE dbSUPER 12.4 +22.5 22533 2.7 JUN CEBPB MAX CEBPG ZIC2 ETS1 SP1 ATF4 POU5F1 SPI1 ARHGAP28 GC18M006695 GC18P006824
GH18I006718 Enhancer 0.6 dbSUPER 18.6 -10.4 -10429 2.4 ZNF335 ATF4 JUND CTBP1 JUN CEBPB CEBPG EP300 LOC101927168 ARHGAP28 ENSG00000279479 GC18M006695 PIR51107
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ARHGAP28 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARHGAP28 gene promoter:

Genomic Locations for ARHGAP28 Gene

Genomic Locations for ARHGAP28 Gene
185,999 bases
Plus strand

Genomic View for ARHGAP28 Gene

Genes around ARHGAP28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP28 Gene

Proteins for ARHGAP28 Gene

  • Protein details for ARHGAP28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho GTPase-activating protein 28
    Protein Accession:
    Secondary Accessions:
    • A8MQB7
    • A8MU88
    • Q6P160
    • Q8N4T3
    • Q9NW53

    Protein attributes for ARHGAP28 Gene

    729 amino acids
    Molecular mass:
    82060 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA91533.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA92552.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ARHGAP28 Gene


neXtProt entry for ARHGAP28 Gene

Post-translational modifications for ARHGAP28 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ARHGAP28 Gene

Domains & Families for ARHGAP28 Gene

Gene Families for ARHGAP28 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ARHGAP28 Gene

Suggested Antigen Peptide Sequences for ARHGAP28 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARHGAP28: view

No data available for UniProtKB/Swiss-Prot for ARHGAP28 Gene

Function for ARHGAP28 Gene

Molecular function for ARHGAP28 Gene

UniProtKB/Swiss-Prot Function:
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Phenotypes From GWAS Catalog for ARHGAP28 Gene

Gene Ontology (GO) - Molecular Function for ARHGAP28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS --
genes like me logo Genes that share ontologies with ARHGAP28: view
genes like me logo Genes that share phenotypes with ARHGAP28: view

Animal Models for ARHGAP28 Gene

MGI Knock Outs for ARHGAP28:

Animal Model Products

miRNA for ARHGAP28 Gene

miRTarBase miRNAs that target ARHGAP28

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARHGAP28 Gene

Localization for ARHGAP28 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGAP28 gene
Compartment Confidence
cytosol 5
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARHGAP28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ARHGAP28: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP28 Gene

Pathways & Interactions for ARHGAP28 Gene

genes like me logo Genes that share pathways with ARHGAP28: view

Pathways by source for ARHGAP28 Gene

3 Reactome pathways for ARHGAP28 Gene

Interacting Proteins for ARHGAP28 Gene

Gene Ontology (GO) - Biological Process for ARHGAP28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
GO:0051497 negative regulation of stress fiber assembly IEA --
GO:1904425 negative regulation of GTP binding IEA --
genes like me logo Genes that share ontologies with ARHGAP28: view

No data available for SIGNOR curated interactions for ARHGAP28 Gene

Drugs & Compounds for ARHGAP28 Gene

No Compound Related Data Available

Transcripts for ARHGAP28 Gene

mRNA/cDNA for ARHGAP28 Gene

(5) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(15) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARHGAP28 Gene

Rho GTPase activating protein 28:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP28 Gene

No ASD Table

Relevant External Links for ARHGAP28 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARHGAP28 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARHGAP28 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGAP28 Gene

This gene is overexpressed in Testis (x12.4).

Protein differential expression in normal tissues from HIPED for ARHGAP28 Gene

This gene is overexpressed in Stomach (60.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARHGAP28 Gene

NURSA nuclear receptor signaling pathways regulating expression of ARHGAP28 Gene:


SOURCE GeneReport for Unigene cluster for ARHGAP28 Gene:


mRNA Expression by UniProt/SwissProt for ARHGAP28 Gene:

Tissue specificity: Expressed in testis. Expressed at moderate level in kidney and ovary, and weakly expressed in spleen and skeletal muscle.

Evidence on tissue expression from TISSUES for ARHGAP28 Gene

  • Nervous system(4.3)
  • Skin(4)
genes like me logo Genes that share expression patterns with ARHGAP28: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGAP28 Gene

Orthologs for ARHGAP28 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP28 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARHGAP28 33 34
  • 99.55 (n)
(Canis familiaris)
Mammalia ARHGAP28 33 34
  • 89.63 (n)
(Bos Taurus)
Mammalia ARHGAP28 33 34
  • 86.82 (n)
(Rattus norvegicus)
Mammalia Arhgap28 33
  • 84.13 (n)
(Mus musculus)
Mammalia Arhgap28 33 16 34
  • 83.42 (n)
(Monodelphis domestica)
Mammalia ARHGAP28 34
  • 47 (a)
(Ornithorhynchus anatinus)
Mammalia ARHGAP28 34
  • 45 (a)
(Gallus gallus)
Aves ARHGAP28 33 34
  • 67.15 (n)
(Anolis carolinensis)
Reptilia ARHGAP28 34
  • 45 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap28 33
  • 64.78 (n)
(Danio rerio)
Actinopterygii arhgap28 33 34
  • 54.88 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG17082 34
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 37 (a)
Species where no ortholog for ARHGAP28 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARHGAP28 Gene

Gene Tree for ARHGAP28 (if available)
Gene Tree for ARHGAP28 (if available)

Paralogs for ARHGAP28 Gene

genes like me logo Genes that share paralogs with ARHGAP28: view

Variants for ARHGAP28 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP28 Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000002158 -- 6,793,780(+) G/C genic_upstream_transcript_variant, intron_variant
rs1000055795 -- 6,852,041(+) T/G intron_variant
rs1000064953 -- 6,893,364(+) G/T intron_variant
rs1000070807 -- 6,841,515(+) T/C intron_variant
rs1000085094 -- 6,760,224(+) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP28 Gene

Variant ID Type Subtype PubMed ID
nsv9605 CNV loss 18304495
nsv9604 CNV loss 18304495
nsv833583 CNV gain 17160897
nsv576397 CNV gain 21841781
nsv132229 CNV insertion 16902084
nsv1064175 CNV gain 25217958
nsv1061995 CNV gain 25217958
nsv1061855 CNV gain 25217958
nsv1059678 CNV gain 25217958
esv3584943 CNV gain 24956385
esv34611 CNV gain 17911159
esv3400638 CNV insertion 20981092
esv3355334 CNV insertion 20981092
esv3307626 CNV mobile element insertion 20981092
esv27738 CNV gain 19812545
esv2758711 CNV gain 17122850
esv2673830 CNV deletion 23128226

Variation tolerance for ARHGAP28 Gene

Residual Variation Intolerance Score: 24.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.64; 65.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARHGAP28 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP28 Gene

Disorders for ARHGAP28 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ARHGAP28 Gene - From: HGMD, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ARHGAP28

genes like me logo Genes that share disorders with ARHGAP28: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARHGAP28 Gene

Publications for ARHGAP28 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  2. DNA sequence and analysis of human chromosome 18. (PMID: 16177791) Nusbaum C … Lander ES (Nature 2005) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Association of substance dependence phenotypes in the COGA sample. (PMID: 24832863) Wetherill L … Foroud T (Addiction biology 2015) 3 58

Products for ARHGAP28 Gene

Sources for ARHGAP28 Gene

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