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This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may pay a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2013]
ARHGAP27 (Rho GTPase Activating Protein 27) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and p75 NTR receptor-mediated signalling. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and SH3 domain binding. An important paralog of this gene is ARHGAP12.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005096 | GTPase activator activity | ISS | -- |
GO:0005515 | protein binding | IEA | -- |
GO:0017124 | SH3 domain binding | ISS | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0016020 | membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | p75 NTR receptor-mediated signalling |
.36
|
|
2 | Signaling by GPCR | ||
3 | Signaling by Rho GTPases |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006897 | endocytosis | IEA | -- |
GO:0006898 | receptor-mediated endocytosis | ISS | -- |
GO:0007165 | signal transduction | IEA | -- |
GO:0043087 | regulation of GTPase activity | IBA | 21873635 |
GO:0043547 | positive regulation of GTPase activity | ISS | -- |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ARHGAP27 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Arhgap27 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Arhgap27 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Cow (Bos Taurus) |
Mammalia | ARHGAP27 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | ARHGAP27 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ARHGAP27 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | arhgap27 30 |
|
||
Str.11931 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.15274 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | LOC566523 30 |
|
||
arhgap27l 31 |
|
OneToMany | |||
arhgap27 31 |
|
OneToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | tag-325 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | BEM2 33 |
|
|
|
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs117139057 | - | p.His889Gln |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv123e55 | CNV | loss | 17911159 |
dgv1472n106 | CNV | deletion | 24896259 |
esv1009543 | CNV | insertion | 20482838 |
esv22600 | CNV | loss | 19812545 |
esv2676260 | CNV | deletion | 23128226 |
esv2758691 | CNV | gain+loss | 17122850 |
esv3640663 | CNV | loss | 21293372 |
esv3640664 | CNV | loss | 21293372 |
nsv1070831 | CNV | deletion | 25765185 |
nsv1146669 | OTHER | inversion | 26484159 |
nsv428342 | CNV | gain | 18775914 |
nsv511056 | OTHER | complex | 20534489 |
nsv575103 | CNV | loss | 21841781 |
nsv9562 | CNV | gain | 18304495 |
No disorders were found for ARHGAP27 Gene.