Aliases for ARHGAP27 Gene
External Ids for ARHGAP27 Gene
Previous HGNC Symbols for ARHGAP27 Gene
Previous GeneCards Identifiers for ARHGAP27 Gene
This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may pay a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2013]
GeneCards Summary for ARHGAP27 Gene
ARHGAP27 (Rho GTPase Activating Protein 27) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and p75 NTR receptor-mediated signalling. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and SH3 domain binding. An important paralog of this gene is ARHGAP12.
UniProtKB/Swiss-Prot Summary for ARHGAP27 Gene
Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity).