Aliases for ARHGAP27 Gene
External Ids for ARHGAP27 Gene
Previous HGNC Symbols for ARHGAP27 Gene
Previous GeneCards Identifiers for ARHGAP27 Gene
This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may pay a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2013]
GeneCards Summary for ARHGAP27 Gene
ARHGAP27 (Rho GTPase Activating Protein 27) is a Protein Coding gene. Among its related pathways are p75 NTR receptor-mediated signalling and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and SH3 domain binding. An important paralog of this gene is ARHGAP12.
UniProtKB/Swiss-Prot for ARHGAP27 Gene
Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity).