Aliases for ARHGAP26 Gene
External Ids for ARHGAP26 Gene
Previous GeneCards Identifiers for ARHGAP26 Gene
Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017]
GeneCards Summary for ARHGAP26 Gene
ARHGAP26 (Rho GTPase Activating Protein 26) is a Protein Coding gene. Diseases associated with ARHGAP26 include Juvenile Myelomonocytic Leukemia and Myelodysplastic Syndrome. Among its related pathways are Signaling events mediated by focal adhesion kinase and p75 NTR receptor-mediated signalling. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and phospholipid binding. An important paralog of this gene is ARHGAP10.
UniProtKB/Swiss-Prot for ARHGAP26 Gene
GTPase-activating protein for RHOA and CDC42.