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Aliases for ARHGAP26 Gene

Aliases for ARHGAP26 Gene

  • Rho GTPase Activating Protein 26 2 3 5
  • Oligophrenin-1-Like Protein 3 4
  • OPHN1L 3 4
  • GRAF 3 4
  • GTPase Regulator Associated With Focal Adhesion Kinase Pp125(FAK) 3
  • GTPase Regulator Associated With The Focal Adhesion Kinase Pp125 2
  • GTPase Regulator Associated With Focal Adhesion Kinase 4
  • Rho-Type GTPase-Activating Protein 26 4
  • Rho GTPase-Activating Protein 26 3
  • KIAA0621 4
  • OPHN1L1 3
  • GRAF1 3

External Ids for ARHGAP26 Gene

Previous GeneCards Identifiers for ARHGAP26 Gene

  • GC05P142179
  • GC05P142130
  • GC05P137297

Summaries for ARHGAP26 Gene

Entrez Gene Summary for ARHGAP26 Gene

  • Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017]

GeneCards Summary for ARHGAP26 Gene

ARHGAP26 (Rho GTPase Activating Protein 26) is a Protein Coding gene. Diseases associated with ARHGAP26 include Juvenile Myelomonocytic Leukemia and Myelodysplastic Syndrome. Among its related pathways are Signaling events mediated by focal adhesion kinase and p75 NTR receptor-mediated signalling. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and phospholipid binding. An important paralog of this gene is ARHGAP10.

UniProtKB/Swiss-Prot for ARHGAP26 Gene

  • GTPase-activating protein for RHOA and CDC42.

Gene Wiki entry for ARHGAP26 Gene

Additional gene information for ARHGAP26 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP26 Gene

Genomics for ARHGAP26 Gene

GeneHancer (GH) Regulatory Elements for ARHGAP26 Gene

Promoters and enhancers for ARHGAP26 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J142769 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.4 418 3 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 KLF13 ARHGAP26 ENSG00000251205 MRPL11P2 GC05P142826 GC05P142827
GH05J143007 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 28.1 +239.1 239145 3.1 PKNOX1 ATF1 SMAD1 STAT5A BMI1 YBX1 BATF KLF5 IRF4 RAD21 ARHGAP26 NR3C1 ENSG00000285366 ARHGAP26-IT1
GH05J143117 Enhancer 1.1 FANTOM5 Ensembl ENCODE 36.4 +348.4 348443 2 CTCF EBF1 FEZF1 ATF2 BCL11B ZFP69B PRDM6 ZNF692 EED ZNF341 ARHGAP26 NR3C1 ARHGAP26-IT1 ENSG00000285366
GH05J142794 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 25.1 +29.7 29691 11 FOXA2 ZSCAN4 SIN3A ZNF121 IKZF2 CREM RUNX3 RXRA REST NR2F2 ARHGAP26 ARHGAP26-AS1 GC05P142827 GC05P142826
GH05J143124 Enhancer 1.2 FANTOM5 ENCODE 29.1 +354.5 354467 0.2 HDGF ATF1 FEZF1 ZNF766 GATA2 ATF7 REST MEF2D SMARCA4 ZSCAN16 ARHGAP26 NR3C1 ARHGAP26-IT1 ENSG00000285366
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARHGAP26 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARHGAP26 gene promoter:
  • Gfi-1
  • NF-kappaB1
  • Arnt
  • AhR
  • TBP
  • Lmo2
  • POU6F1 (c2)
  • GATA-1
  • aMEF-2
  • MEF-2

Genomic Locations for ARHGAP26 Gene

Genomic Locations for ARHGAP26 Gene
458,635 bases
Plus strand
458,628 bases
Plus strand

Genomic View for ARHGAP26 Gene

Genes around ARHGAP26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP26 Gene

Proteins for ARHGAP26 Gene

  • Protein details for ARHGAP26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho GTPase-activating protein 26
    Protein Accession:
    Secondary Accessions:
    • O75117
    • Q5D035
    • Q9BYS6
    • Q9BYS7
    • Q9UJ00

    Protein attributes for ARHGAP26 Gene

    814 amino acids
    Molecular mass:
    92235 Da
    Quaternary structure:
    • Interacts with NYAP1, NYAP2 and MYO16 (By similarity). Binds to the C-terminus of PTK2/FAK1.

    Three dimensional structures from OCA and Proteopedia for ARHGAP26 Gene

    Alternative splice isoforms for ARHGAP26 Gene


neXtProt entry for ARHGAP26 Gene

Post-translational modifications for ARHGAP26 Gene

  • Ubiquitination at posLast=454454
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ARHGAP26 Gene

Domains & Families for ARHGAP26 Gene

Gene Families for ARHGAP26 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for ARHGAP26 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARHGAP26: view

No data available for UniProtKB/Swiss-Prot for ARHGAP26 Gene

Function for ARHGAP26 Gene

Molecular function for ARHGAP26 Gene

UniProtKB/Swiss-Prot Function:
GTPase-activating protein for RHOA and CDC42.

Phenotypes From GWAS Catalog for ARHGAP26 Gene

Gene Ontology (GO) - Molecular Function for ARHGAP26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS --
GO:0005515 protein binding IEA,IPI 11432776
GO:0005543 phospholipid binding IDA 18954304
genes like me logo Genes that share ontologies with ARHGAP26: view
genes like me logo Genes that share phenotypes with ARHGAP26: view

Human Phenotype Ontology for ARHGAP26 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ARHGAP26 Gene

Localization for ARHGAP26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP26 Gene

Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=Colocalizes with actin stress fibers and cortical actin structures. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGAP26 gene
Compartment Confidence
cytosol 5
cytoskeleton 3
plasma membrane 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ARHGAP26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005925 focal adhesion IEA --
genes like me logo Genes that share ontologies with ARHGAP26: view

Pathways & Interactions for ARHGAP26 Gene

genes like me logo Genes that share pathways with ARHGAP26: view

Pathways by source for ARHGAP26 Gene

1 BioSystems pathway for ARHGAP26 Gene
3 Reactome pathways for ARHGAP26 Gene
1 GeneGo (Thomson Reuters) pathway for ARHGAP26 Gene
1 Qiagen pathway for ARHGAP26 Gene
1 Cell Signaling Technology pathway for ARHGAP26 Gene

Gene Ontology (GO) - Biological Process for ARHGAP26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007399 nervous system development NAS 9582072
GO:0030036 actin cytoskeleton organization NAS,IEA 11998687
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction IEA,TAS --
genes like me logo Genes that share ontologies with ARHGAP26: view

No data available for SIGNOR curated interactions for ARHGAP26 Gene

Drugs & Compounds for ARHGAP26 Gene

(1) Drugs for ARHGAP26 Gene - From:

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
HJC 0350 Pharma 0
genes like me logo Genes that share compounds with ARHGAP26: view

Transcripts for ARHGAP26 Gene

mRNA/cDNA for ARHGAP26 Gene

Unigene Clusters for ARHGAP26 Gene

Rho GTPase activating protein 26:
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP26 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ·
SP1: - - - -
SP2: - -

ExUns: 23c ^ 24
SP1: -

Relevant External Links for ARHGAP26 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARHGAP26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARHGAP26 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGAP26 Gene

This gene is overexpressed in Whole Blood (x8.3).

Protein differential expression in normal tissues from HIPED for ARHGAP26 Gene

This gene is overexpressed in Frontal cortex (16.3), Breast (13.8), and Cerebrospinal fluid (13.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARHGAP26 Gene

Protein tissue co-expression partners for ARHGAP26 Gene

NURSA nuclear receptor signaling pathways regulating expression of ARHGAP26 Gene:


SOURCE GeneReport for Unigene cluster for ARHGAP26 Gene:


Evidence on tissue expression from TISSUES for ARHGAP26 Gene

  • Nervous system(4.7)
  • Heart(4.2)
  • Liver(4.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGAP26 Gene

Germ Layers:
  • mesoderm
  • immune
  • lymphatic
  • blood
  • bone marrow
  • white blood cell
genes like me logo Genes that share expression patterns with ARHGAP26: view

No data available for mRNA Expression by UniProt/SwissProt for ARHGAP26 Gene

Orthologs for ARHGAP26 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP26 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARHGAP26 34 33
  • 99.63 (n)
(Canis familiaris)
Mammalia ARHGAP26 34 33
  • 94.31 (n)
(Bos Taurus)
Mammalia ARHGAP26 34 33
  • 93.86 (n)
(Ornithorhynchus anatinus)
Mammalia ARHGAP26 34
  • 93 (a)
(Monodelphis domestica)
Mammalia ARHGAP26 34
  • 91 (a)
(Mus musculus)
Mammalia Arhgap26 16 34 33
  • 90.95 (n)
(Rattus norvegicus)
Mammalia Arhgap26 33
  • 90.65 (n)
(Gallus gallus)
Aves ARHGAP26 34 33
  • 81.14 (n)
(Anolis carolinensis)
Reptilia ARHGAP26 34
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap26 33
  • 73.99 (n)
(Danio rerio)
Actinopterygii arhgap42a 34
  • 48 (a)
fruit fly
(Drosophila melanogaster)
Insecta Graf 34 33
  • 52.74 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013143 33
  • 51.58 (n)
(Caenorhabditis elegans)
Secernentea T04C9.1 34 33
  • 53.57 (n)
Species where no ortholog for ARHGAP26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP26 Gene

Gene Tree for ARHGAP26 (if available)
Gene Tree for ARHGAP26 (if available)
Evolutionary constrained regions (ECRs) for ARHGAP26: view image

Paralogs for ARHGAP26 Gene

(13) SIMAP similar genes for ARHGAP26 Gene using alignment to 11 proteins:

  • C9J6V4_HUMAN
  • F8W8N5_HUMAN
  • H0Y4P9_HUMAN
  • H0Y835_HUMAN
  • H7C1J1_HUMAN
  • H7C205_HUMAN
  • H7C3P8_HUMAN Pseudogenes for ARHGAP26 Gene

genes like me logo Genes that share paralogs with ARHGAP26: view

Variants for ARHGAP26 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP26 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs121918546 pathogenic, Juvenile myelomonocytic leukemia, Leukemia, juvenile myelomonocytic (JMML) [MIM:607785] 143,041,855(+) A/C/G coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant
rs139391817 not-provided, not specified 142,932,125(+) T/C coding_sequence_variant, genic_downstream_transcript_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, synonymous_variant
rs200573018 not-provided, not specified 143,134,097(+) C/T coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant
rs562055157 not-provided, not specified 143,207,377(+) A/G coding_sequence_variant, genic_downstream_transcript_variant, intron_variant, missense_variant, non_coding_transcript_variant
rs587778047 not-provided, not specified 143,041,850(+) T/GTGGGG coding_sequence_variant, frameshift, genic_downstream_transcript_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP26 Gene

Variant ID Type Subtype PubMed ID
esv25431 CNV loss 19812545
esv2673894 CNV deletion 23128226
esv3357911 CNV duplication 20981092
esv3373766 CNV insertion 20981092
esv3419200 CNV duplication 20981092
esv3441979 CNV insertion 20981092
esv3449609 CNV duplication 20981092
esv3570475 CNV loss 25503493
esv3606999 CNV gain 21293372
esv3607005 CNV gain 21293372
esv3607010 CNV loss 21293372
esv3607011 CNV gain 21293372
esv3607012 CNV loss 21293372
esv3607013 CNV gain 21293372
esv3607014 CNV loss 21293372
nsv1025662 CNV loss 25217958
nsv1031126 CNV gain 25217958
nsv1128195 CNV deletion 24896259
nsv1140576 CNV deletion 24896259
nsv473426 CNV novel sequence insertion 20440878
nsv475872 CNV novel sequence insertion 20440878
nsv5040 CNV insertion 18451855
nsv507298 OTHER sequence alteration 20534489
nsv522807 CNV loss 19592680
nsv599925 CNV loss 21841781
nsv830510 CNV gain 17160897
nsv830511 CNV gain 17160897
nsv950419 CNV duplication 24416366
nsv950420 CNV duplication 24416366

Variation tolerance for ARHGAP26 Gene

Residual Variation Intolerance Score: 4.55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.99; 20.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARHGAP26 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP26 Gene

Disorders for ARHGAP26 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ARHGAP26 Gene - From: OMIM, ClinVar, GTR, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
juvenile myelomonocytic leukemia
  • jmml
myelodysplastic syndrome
  • mds
  • thalassemia, alpha-
- elite association - COSMIC cancer census association via MalaCards


  • Leukemia, juvenile myelomonocytic (JMML) [MIM:607785]: An aggressive pediatric myelodysplastic syndrome/myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell compartment with proliferation of differentiated progeny. Patients have splenomegaly, enlarged lymph nodes, rashes, and hemorrhages. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal translocation t(5;11)(q31;q23) with KMT2A/MLL1 has been found in leukemic cells from JMML patients, also carrying inactivating mutations on the second allele (PubMed:10908648). {ECO:0000269 PubMed:10908648}.

Additional Disease Information for ARHGAP26

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ARHGAP26: view

No data available for Genatlas for ARHGAP26 Gene

Publications for ARHGAP26 Gene

  1. The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q. (PMID: 10908648) Borkhardt A … Lampert F (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 4 22 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Association of a common nonsynonymous variant in GLUT9 with serum uric acid levels in old order amish. (PMID: 18759275) McArdle PF … Shuldiner AR (Arthritis and rheumatism 2008) 3 44 58
  4. Cytoskeletal changes induced by GRAF, the GTPase regulator associated with focal adhesion kinase, are mediated by Rho. (PMID: 9858476) Taylor JM … Parsons JT (Journal of cell science 1999) 2 3 58
  5. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 3 4 58

Products for ARHGAP26 Gene

Sources for ARHGAP26 Gene

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