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Aliases for ARHGAP25 Gene

Aliases for ARHGAP25 Gene

  • Rho GTPase Activating Protein 25 2 3 5
  • Rho-Type GTPase-Activating Protein 25 3 4
  • Epididymis Secretory Protein Li 308 3
  • Rho GTPase-Activating Protein 25 3
  • HEL-S-308 3
  • KAIA0053 3
  • KIAA0053 4

External Ids for ARHGAP25 Gene

Previous GeneCards Identifiers for ARHGAP25 Gene

  • GC02P068936
  • GC02P068913
  • GC02P068906

Summaries for ARHGAP25 Gene

Entrez Gene Summary for ARHGAP25 Gene

  • ARHGAPs, such as ARHGAP25, encode negative regulators of Rho GTPases (see ARHA; MIM 165390), which are implicated in actin remodeling, cell polarity, and cell migration (Katoh and Katoh, 2004 [PubMed 15254788]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ARHGAP25 Gene

ARHGAP25 (Rho GTPase Activating Protein 25) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP22.

UniProtKB/Swiss-Prot for ARHGAP25 Gene

  • GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Additional gene information for ARHGAP25 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP25 Gene

Genomics for ARHGAP25 Gene

GeneHancer (GH) Regulatory Elements for ARHGAP25 Gene

Promoters and enhancers for ARHGAP25 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I068761 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 576.3 +89.8 89779 16.7 PKNOX1 ATF1 YY1 ZNF766 ATF7 RUNX3 JUNB REST ZNF592 MEF2D ARHGAP25 FBXO48 APLF LINC01888 PLEK LOC105374790
GH02I068732 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 559.8 +58.6 58593 12 CTCF PKNOX1 IRF2 USF1 EBF1 CEBPG IRF9 FOSL1 POLR2A STAT2 ARHGAP25 PLEK LINC01888 FBXO48 APLF LOC105374790
GH02I068679 Enhancer 1.1 Ensembl ENCODE 556.8 0.0 -37 0.5 HDAC1 PKNOX1 ATF1 FOXA2 TAF9B ARNT NFRKB SIN3A CHAMP1 TCF12 ARHGAP25 PROKR1
GH02I068805 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 8.5 +128.5 128533 5 PKNOX1 NFRKB FEZF1 ZBTB40 ZNF766 FOS ATF7 CAVIN1 CEBPB ZNF398 PLEK LINC01888 BMP10 WDR92 ARHGAP25 FBXO48 LINC01890 APLF LOC105374790
GH02I068827 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 5.4 +150.9 150887 5.5 PKNOX1 SMAD1 FEZF1 ZNF2 YY1 FOS SP3 REST ZNF592 MEF2D LINC01888 PLEK LINC01890 FBXO48 ARHGAP25 APLF LOC105374790
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ARHGAP25 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARHGAP25 gene promoter:

Genomic Locations for ARHGAP25 Gene

Genomic Locations for ARHGAP25 Gene
147,233 bases
Plus strand

Genomic View for ARHGAP25 Gene

Genes around ARHGAP25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP25 Gene

Proteins for ARHGAP25 Gene

  • Protein details for ARHGAP25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho GTPase-activating protein 25
    Protein Accession:
    Secondary Accessions:
    • A8K2Y1
    • B7Z498
    • E9PFQ7
    • G5E9G2
    • Q8IXQ2

    Protein attributes for ARHGAP25 Gene

    645 amino acids
    Molecular mass:
    73435 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA06125.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARHGAP25 Gene

    Alternative splice isoforms for ARHGAP25 Gene

neXtProt entry for ARHGAP25 Gene

Post-translational modifications for ARHGAP25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARHGAP25 Gene

Domains & Families for ARHGAP25 Gene

Gene Families for ARHGAP25 Gene

Protein Domains for ARHGAP25 Gene

Suggested Antigen Peptide Sequences for ARHGAP25 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARHGAP25: view

No data available for UniProtKB/Swiss-Prot for ARHGAP25 Gene

Function for ARHGAP25 Gene

Molecular function for ARHGAP25 Gene

UniProtKB/Swiss-Prot Function:
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Phenotypes From GWAS Catalog for ARHGAP25 Gene

Gene Ontology (GO) - Molecular Function for ARHGAP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS --
genes like me logo Genes that share ontologies with ARHGAP25: view
genes like me logo Genes that share phenotypes with ARHGAP25: view

Animal Models for ARHGAP25 Gene

MGI Knock Outs for ARHGAP25:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ARHGAP25 Gene

Localization for ARHGAP25 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGAP25 gene
Compartment Confidence
plasma membrane 5
cytosol 5
extracellular 1
mitochondrion 1
nucleus 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARHGAP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001891 phagocytic cup IDA 26465210
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ARHGAP25: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP25 Gene

Pathways & Interactions for ARHGAP25 Gene

genes like me logo Genes that share pathways with ARHGAP25: view

Pathways by source for ARHGAP25 Gene

3 Reactome pathways for ARHGAP25 Gene

Gene Ontology (GO) - Biological Process for ARHGAP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006911 phagocytosis, engulfment IMP 26465210
GO:0007015 actin filament organization IMP 26465210
GO:0007165 signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP25: view

No data available for SIGNOR curated interactions for ARHGAP25 Gene

Drugs & Compounds for ARHGAP25 Gene

No Compound Related Data Available

Transcripts for ARHGAP25 Gene

Unigene Clusters for ARHGAP25 Gene

Rho GTPase activating protein 25:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP25 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11
SP1: - -
SP2: -
SP3: -
SP4: - -
SP5: -
SP6: - - -

Relevant External Links for ARHGAP25 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARHGAP25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARHGAP25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGAP25 Gene

This gene is overexpressed in Whole Blood (x24.9) and Spleen (x6.0).

Protein differential expression in normal tissues from HIPED for ARHGAP25 Gene

This gene is overexpressed in Serum (26.6), Lymph node (12.4), and Peripheral blood mononuclear cells (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARHGAP25 Gene

Protein tissue co-expression partners for ARHGAP25 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARHGAP25 Gene:


SOURCE GeneReport for Unigene cluster for ARHGAP25 Gene:


Evidence on tissue expression from TISSUES for ARHGAP25 Gene

  • Blood(4.7)
  • Bone marrow(4.2)
genes like me logo Genes that share expression patterns with ARHGAP25: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGAP25 Gene

Orthologs for ARHGAP25 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP25 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARHGAP25 33 34
  • 99.74 (n)
(Bos Taurus)
Mammalia ARHGAP25 33 34
  • 88.65 (n)
(Rattus norvegicus)
Mammalia Arhgap25 33
  • 85.4 (n)
(Mus musculus)
Mammalia Arhgap25 33 16 34
  • 85.04 (n)
(Canis familiaris)
Mammalia ARHGAP25 33 34
  • 82.19 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 77 (a)
-- 34
  • 45 (a)
-- 34
  • 36 (a)
(Monodelphis domestica)
Mammalia ARHGAP25 34
  • 72 (a)
(Gallus gallus)
Aves ARHGAP25 33 34
  • 68.23 (n)
(Anolis carolinensis)
Reptilia ARHGAP25 34
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap25 33
  • 60.71 (n)
(Danio rerio)
Actinopterygii arhgap25 33 34
  • 54.33 (n)
fruit fly
(Drosophila melanogaster)
Insecta RhoGAPp190 34
  • 5 (a)
(Caenorhabditis elegans)
Secernentea rga-5 34
  • 5 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 45 (a)
Species where no ortholog for ARHGAP25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP25 Gene

Gene Tree for ARHGAP25 (if available)
Gene Tree for ARHGAP25 (if available)

Paralogs for ARHGAP25 Gene

(8) SIMAP similar genes for ARHGAP25 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ARHGAP25: view

Variants for ARHGAP25 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP25 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000019210 -- 68,816,926(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000033131 -- 68,818,520(+) G/T genic_downstream_transcript_variant, intron_variant
rs1000054264 -- 68,777,296(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000070232 -- 68,725,642(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000071131 -- 68,734,589(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP25 Gene

Variant ID Type Subtype PubMed ID
dgv3862n100 CNV gain 25217958
nsv476671 CNV novel sequence insertion 20440878
nsv953141 CNV duplication 24416366
nsv997947 CNV gain 25217958

Variation tolerance for ARHGAP25 Gene

Residual Variation Intolerance Score: 78.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.92; 83.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARHGAP25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP25 Gene

Disorders for ARHGAP25 Gene

Additional Disease Information for ARHGAP25

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ARHGAP25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGAP25 Gene

Publications for ARHGAP25 Gene

  1. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7584044) Nomura N … Tabata S (DNA research : an international journal for rapid publication of reports on genes and genomes 1994) 2 3 4 58
  2. Mutation of ARHGAP9 in patients with coronary spastic angina. (PMID: 19911011) Takefuji M … Kaibuchi K (Journal of human genetics 2010) 3 44 58
  3. Identification and characterization of ARHGAP24 and ARHGAP25 genes in silico. (PMID: 15254788) Katoh M … Katoh M (International journal of molecular medicine 2004) 3 22 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ARHGAP25 Gene

Sources for ARHGAP25 Gene

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