This gene encodes a Rho-GTPase activating protein, which is specific for the small GTPase family member Rac. Binding of the encoded protein by filamin A targets it to sites of membrane protrusion, where it antognizes Rac. This results in suppression of lamellae formation and promotion of retraction to regulate cell polarity. Alternative splicing results in multiple transcript v... See more...

Aliases for ARHGAP24 Gene

Aliases for ARHGAP24 Gene

  • Rho GTPase Activating Protein 24 2 3 5
  • RAC1- And CDC42-Specific GTPase-Activating Protein Of 72 KDa 3 4
  • Rho GTPase-Activating Protein 24 3 4
  • Filamin-A-Associated RhoGAP 3 4
  • Sarcoma Antigen NY-SAR-88 3 4
  • RhoGAP Of 73 KDa 3 4
  • P73RhoGAP 3 4
  • RC-GAP72 3 4
  • FILGAP 3 4
  • FilGAP 2 4
  • Rho-Type GTPase-Activating Protein 24 4
  • DKFZP564B1162 2
  • ARHGAP24 5
  • FLJ33877 2
  • RCGAP72 3
  • P73 3

External Ids for ARHGAP24 Gene

Previous GeneCards Identifiers for ARHGAP24 Gene

  • GC04P086951
  • GC04P086848
  • GC04P086615
  • GC04P086396
  • GC04P082138
  • GC04P085147

Summaries for ARHGAP24 Gene

Entrez Gene Summary for ARHGAP24 Gene

  • This gene encodes a Rho-GTPase activating protein, which is specific for the small GTPase family member Rac. Binding of the encoded protein by filamin A targets it to sites of membrane protrusion, where it antognizes Rac. This results in suppression of lamellae formation and promotion of retraction to regulate cell polarity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

GeneCards Summary for ARHGAP24 Gene

ARHGAP24 (Rho GTPase Activating Protein 24) is a Protein Coding gene. Diseases associated with ARHGAP24 include Genetic Steroid-Resistant Nephrotic Syndrome and Focal Segmental Glomerulosclerosis 1. Among its related pathways are Signaling by GPCR and G-protein signaling_Regulation of RAC1 activity. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP22.

UniProtKB/Swiss-Prot Summary for ARHGAP24 Gene

  • Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis.

Gene Wiki entry for ARHGAP24 Gene

Additional gene information for ARHGAP24 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARHGAP24 Gene

Genomics for ARHGAP24 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ARHGAP24 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J085777 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 622.7 +311.1 311131 17.8 BACH1 TCF12 IKZF2 RCOR1 SP1 TRIM22 FOXJ2 ARNT CEBPB ZSCAN29 ARHGAP24 piR-39904-015 HSALNG0035642 PTPN13
GH04J085473 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 613.3 +1.5 1533 5.5 RNF2 CEBPG GATAD2A PRDM10 TFE3 SOX13 NFKBIZ ZNF692 RCOR2 ZIC2 ARHGAP24 piR-52916-023
GH04J084965 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 600 -509.0 -509049 3.8 GATAD2A PRDM10 ZNF629 SOX13 IKZF1 NFKBIZ ETV6 PRDM1 PHF21A ZIC2 WDFY3-AS2 WDFY3 ARHGAP24 CDS1
GH04J085827 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 605.2 +353.5 353459 2.8 ZNF692 FOXA1 GABPA ZNF776 ZSCAN4 PATZ1 ZNF501 ZNF600 ZNF148 SCRT2 ARHGAP24 MAPK10 WDFY3-AS2 piR-48222-254 piR-39904-015 PTPN13
GH04J085147 Promoter/Enhancer 0.9 EPDnew ENCODE 600.1 -327.5 -327457 0.1 CTCF FOXA1 REST RAD21 TRIM22 SMC3 ZNF654 BHLHE40 TBL1XR1 NFIL3 lnc-ARHGAP24-5 ARHGAP24 RN7SKP48 lnc-ARHGAP24-4 WDFY3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARHGAP24 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ARHGAP24

Top Transcription factor binding sites by QIAGEN in the ARHGAP24 gene promoter:
  • aMEF-2
  • AP-1
  • c-Fos
  • c-Jun
  • E47
  • FOXF2
  • IRF-1
  • MEF-2A
  • STAT5A
  • TBP

Genomic Locations for ARHGAP24 Gene

Genomic Locations for ARHGAP24 Gene
chr4:85,475,150-86,002,668
(GRCh38/hg38)
Size:
527,519 bases
Orientation:
Plus strand
chr4:86,396,267-86,923,823
(GRCh37/hg19)
Size:
527,557 bases
Orientation:
Plus strand

Genomic View for ARHGAP24 Gene

Genes around ARHGAP24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP24 Gene

Proteins for ARHGAP24 Gene

  • Protein details for ARHGAP24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N264-RHG24_HUMAN
    Recommended name:
    Rho GTPase-activating protein 24
    Protein Accession:
    Q8N264
    Secondary Accessions:
    • Q4KMG1
    • Q6ZNV3
    • Q86TI5
    • Q86WE4
    • Q9H0T6

    Protein attributes for ARHGAP24 Gene

    Size:
    748 amino acids
    Molecular mass:
    84258 Da
    Quaternary structure:
    • Interacts with FLNA.
    SequenceCaution:
    • Sequence=AAO65178.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for ARHGAP24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGAP24 Gene

Post-translational modifications for ARHGAP24 Gene

  • Phosphorylated by ROCK, leading to activate the RacGAP activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARHGAP24 Gene

Domains & Families for ARHGAP24 Gene

Protein Domains for ARHGAP24 Gene

InterPro:
Blocks:
  • RhoGAP domain
  • Pleckstrin-like
ProtoNet:

Suggested Antigen Peptide Sequences for ARHGAP24 Gene

GenScript: Design optimal peptide antigens:
  • p73RhoGAP (RHG24_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N264

UniProtKB/Swiss-Prot:

RHG24_HUMAN :
  • The coiled coil domain mediates the interaction with FLNA leading to its recruitment to lamellae.
Domain:
  • The coiled coil domain mediates the interaction with FLNA leading to its recruitment to lamellae.
genes like me logo Genes that share domains with ARHGAP24: view

Function for ARHGAP24 Gene

Molecular function for ARHGAP24 Gene

UniProtKB/Swiss-Prot Function:
Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis.
UniProtKB/Swiss-Prot Induction:
[Isoform 2]: Up-regulated during capillary tube formation in umbilical vein endothelial cells.

Phenotypes From GWAS Catalog for ARHGAP24 Gene

Gene Ontology (GO) - Molecular Function for ARHGAP24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA,IBA 21873635
GO:0005515 protein binding IPI 16862148
genes like me logo Genes that share ontologies with ARHGAP24: view
genes like me logo Genes that share phenotypes with ARHGAP24: view

Animal Models for ARHGAP24 Gene

MGI Knock Outs for ARHGAP24:

Animal Model Products

CRISPR Products

miRNA for ARHGAP24 Gene

miRTarBase miRNAs that target ARHGAP24

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARHGAP24

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARHGAP24 Gene

Localization for ARHGAP24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP24 Gene

Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell junction, focal adhesion. Cell projection. Note=Localizes to actin stress fibers. In migrating cells, localizes to membrane lamellae and protusions.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGAP24 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
plasma membrane 2
extracellular 2
nucleus 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARHGAP24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005912 adherens junction IEA --
GO:0005925 focal adhesion IEA,IBA 21873635
genes like me logo Genes that share ontologies with ARHGAP24: view

Pathways & Interactions for ARHGAP24 Gene

PathCards logo

SuperPathways for ARHGAP24 Gene

genes like me logo Genes that share pathways with ARHGAP24: view

Pathways by source for ARHGAP24 Gene

3 Reactome pathways for ARHGAP24 Gene
1 GeneGo (Thomson Reuters) pathway for ARHGAP24 Gene
  • G-protein signaling_Regulation of RAC1 activity
1 GeneTex pathway for ARHGAP24 Gene

SIGNOR curated interactions for ARHGAP24 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ARHGAP24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0007165 signal transduction IEA --
GO:0007275 multicellular organism development IEA --
GO:0030154 cell differentiation IEA --
GO:0035021 negative regulation of Rac protein signal transduction IBA 21873635
genes like me logo Genes that share ontologies with ARHGAP24: view

Drugs & Compounds for ARHGAP24 Gene

No Compound Related Data Available

Transcripts for ARHGAP24 Gene

mRNA/cDNA for ARHGAP24 Gene

5 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARHGAP24

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP24 Gene

No ASD Table

Relevant External Links for ARHGAP24 Gene

GeneLoc Exon Structure for
ARHGAP24

Expression for ARHGAP24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARHGAP24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARHGAP24 Gene

This gene is overexpressed in Pancreatic juice (24.3), Blymphocyte (23.9), and Adipocyte (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ARHGAP24 Gene



Protein tissue co-expression partners for ARHGAP24 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ARHGAP24

SOURCE GeneReport for Unigene cluster for ARHGAP24 Gene:

Hs.444229

mRNA Expression by UniProt/SwissProt for ARHGAP24 Gene:

Q8N264-RHG24_HUMAN
Tissue specificity: Isoform 1 is widely expressed with a higher level in kidney. Isoform 2 is mainly expressed in endothelial cells.

Evidence on tissue expression from TISSUES for ARHGAP24 Gene

  • Nervous system(4.4)
  • Spleen(4.4)
  • Kidney(3.3)
  • Blood(2.6)
  • Heart(2.5)
  • Muscle(2.4)
genes like me logo Genes that share expression patterns with ARHGAP24: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGAP24 Gene

Orthologs for ARHGAP24 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP24 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ARHGAP24 30 31
  • 99.38 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ARHGAP24 30 31
  • 92.02 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ARHGAP24 30 31
  • 89.33 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Arhgap24 30 17 31
  • 86.42 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Arhgap24 30
  • 84.14 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia ARHGAP24 31
  • 80 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ARHGAP24 30 31
  • 77.79 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ARHGAP24 31
  • 82 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia arhgap24 30
  • 73.13 (n)
Zebrafish
(Danio rerio)
Actinopterygii arhgap24 30 31
  • 69.03 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta RhoGAPp190 31
  • 4 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea rga-5 31
  • 5 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 52 (a)
OneToMany
Species where no ortholog for ARHGAP24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ARHGAP24 Gene

ENSEMBL:
Gene Tree for ARHGAP24 (if available)
TreeFam:
Gene Tree for ARHGAP24 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ARHGAP24: view image

Paralogs for ARHGAP24 Gene

Paralogs for ARHGAP24 Gene

(29) SIMAP similar genes for ARHGAP24 Gene using alignment to 4 proteins:

  • RHG24_HUMAN
  • D6RBC2_HUMAN
  • D6RCP5_HUMAN
  • D6RHH1_HUMAN
genes like me logo Genes that share paralogs with ARHGAP24: view

Variants for ARHGAP24 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ARHGAP24 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
723157 Benign: not provided 86,000,528(+) G/A MISSENSE_VARIANT
780484 Benign: not provided 85,995,269(+) T/C MISSENSE_VARIANT
809638 Uncertain Significance: not provided 85,994,618(+) A/G MISSENSE_VARIANT
rs112475438 Uncertain Significance: not provided 85,942,147(+) A/G MISSENSE_VARIANT,INTRON_VARIANT
rs143423680 Uncertain Significance: Focal segmental glomerulosclerosis 1 85,977,655(+) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for ARHGAP24 Gene

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP24 Gene

Variant ID Type Subtype PubMed ID
dgv2843n106 CNV deletion 24896259
esv1208111 CNV insertion 17803354
esv1340531 CNV deletion 17803354
esv1939576 CNV deletion 18987734
esv1993171 CNV deletion 18987734
esv2106659 CNV deletion 18987734
esv2228589 CNV deletion 18987734
esv2234618 CNV deletion 18987734
esv2425088 CNV deletion 19546169
esv24400 CNV loss 19812545
esv2509163 CNV deletion 19546169
esv2515650 CNV deletion 19546169
esv2565886 CNV deletion 19546169
esv2592051 CNV deletion 19546169
esv2597045 CNV deletion 19546169
esv2660474 CNV deletion 23128226
esv2665029 CNV deletion 23128226
esv2670543 CNV deletion 23128226
esv2676122 CNV deletion 23128226
esv2727921 CNV deletion 23290073
esv2727922 CNV deletion 23290073
esv2727923 CNV deletion 23290073
esv2727924 CNV deletion 23290073
esv2727925 CNV deletion 23290073
esv2727926 CNV deletion 23290073
esv2727927 CNV deletion 23290073
esv2727928 CNV deletion 23290073
esv2742711 CNV deletion 23290073
esv274900 CNV gain+loss 21479260
esv2763373 CNV gain 21179565
esv3300162 CNV deletion 24192839
esv3305527 CNV mobile element insertion 20981092
esv3309462 CNV mobile element insertion 20981092
esv3327662 CNV insertion 20981092
esv3341775 CNV insertion 20981092
esv3388062 CNV insertion 20981092
esv3393597 CNV insertion 20981092
esv3420600 CNV insertion 20981092
esv3564178 CNV deletion 23714750
esv3564180 CNV deletion 23714750
esv3564182 CNV deletion 23714750
esv3564183 CNV deletion 23714750
esv3601243 CNV loss 21293372
esv3601244 CNV loss 21293372
esv3601245 CNV loss 21293372
esv3601249 CNV loss 21293372
esv3601251 CNV loss 21293372
esv3601252 CNV loss 21293372
esv3893974 CNV loss 25118596
esv3989 CNV loss 18987735
esv4911 CNV loss 18987735
esv5098 CNV loss 18987735
esv7427 CNV loss 19470904
esv8014 CNV loss 19470904
nsv1005257 CNV gain 25217958
nsv1073780 CNV deletion 25765185
nsv1073781 CNV deletion 25765185
nsv1074195 CNV deletion 25765185
nsv1074732 CNV deletion 25765185
nsv1074733 CNV deletion 25765185
nsv1111278 CNV tandem duplication 24896259
nsv1136884 CNV deletion 24896259
nsv1139279 CNV deletion 24896259
nsv1143290 CNV deletion 24896259
nsv1145829 CNV deletion 26484159
nsv1150414 CNV deletion 26484159
nsv289665 CNV deletion 16902084
nsv290889 CNV deletion 16902084
nsv291712 CNV deletion 16902084
nsv461566 CNV gain 19166990
nsv461567 CNV loss 19166990
nsv470048 CNV gain 18288195
nsv470049 CNV loss 18288195
nsv477347 CNV novel sequence insertion 20440878
nsv509910 OTHER sequence alteration 20534489
nsv519588 CNV gain 19592680
nsv526211 CNV loss 19592680
nsv594747 CNV gain 21841781
nsv594755 CNV loss 21841781
nsv594756 CNV loss 21841781
nsv829999 CNV gain 17160897
nsv830000 CNV loss 17160897
nsv950350 CNV duplication 24416366
nsv956377 CNV deletion 24416366
nsv956400 CNV deletion 24416366
nsv956422 CNV deletion 24416366

Variation tolerance for ARHGAP24 Gene

Residual Variation Intolerance Score: 81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.36; 53.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARHGAP24 Gene

Human Gene Mutation Database (HGMD)
ARHGAP24
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARHGAP24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP24 Gene

Disorders for ARHGAP24 Gene

MalaCards: The human disease database

(5) MalaCards diseases for ARHGAP24 Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
genetic steroid-resistant nephrotic syndrome
  • nephrotic syndrome, steroid-resistant, autosomal recessive
focal segmental glomerulosclerosis 1
  • fsgs1
focal segmental glomerulosclerosis
  • fgs
focal segmental glomerulosclerosis 6
  • fsgs6
periventricular nodular heterotopia
  • periventricular heterotopia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ARHGAP24

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ARHGAP24: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARHGAP24 Gene

Publications for ARHGAP24 Gene

  1. Identification and characterization of ARHGAP24 and ARHGAP25 genes in silico. (PMID: 15254788) Katoh M … Katoh M (International journal of molecular medicine 2004) 2 3 4 23
  2. Characterization of a novel GTPase-activating protein associated with focal adhesions and the actin cytoskeleton. (PMID: 15611138) Lavelin I … Geiger B (The Journal of biological chemistry 2005) 3 4 23
  3. A vascular cell-restricted RhoGAP, p73RhoGAP, is a key regulator of angiogenesis. (PMID: 15302923) Su ZJ … Gamble JR (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 23
  4. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4
  5. Genome-wide association study of PR interval. (PMID: 20062060) Pfeufer A … Heckbert SR (Nature genetics 2010) 3 41

Products for ARHGAP24 Gene

Sources for ARHGAP24 Gene