Aliases for ARHGAP23 Gene
External Ids for ARHGAP23 Gene
Previous GeneCards Identifiers for ARHGAP23 Gene
The RHO (see ARHA; MIM 165390) family of small GTPases are involved in signal transduction through transmembrane receptors, and they are inactive in the GDP-bound form and active in the GTP-bound form. GTPase-activating proteins, such as ARHGAP23, inactivate RHO family proteins by stimulating their hydrolysis of GTP (Katoh and Katoh, 2004 [PubMed 15254754]).[supplied by OMIM, Mar 2008]
GeneCards Summary for ARHGAP23 Gene
ARHGAP23 (Rho GTPase Activating Protein 23) is a Protein Coding gene. Diseases associated with ARHGAP23 include Parainfluenza Virus Type 3 and Lymphocytic Choriomeningitis. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP21.
UniProtKB/Swiss-Prot Summary for ARHGAP23 Gene
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.