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The RHO (see ARHA; MIM 165390) family of small GTPases are involved in signal transduction through transmembrane receptors, and they are inactive in the GDP-bound form and active in the GTP-bound form. GTPase-activating proteins, such as ARHGAP23, inactivate RHO family proteins by stimulating their hydrolysis of GTP (Katoh and Katoh, 2004 [PubMed 15254754]).[supplied by OMIM, Mar 2008]
ARHGAP23 (Rho GTPase Activating Protein 23) is a Protein Coding gene. Diseases associated with ARHGAP23 include Parainfluenza Virus Type 3 and Lymphocytic Choriomeningitis. Among its related pathways are Signaling by GPCR and p75 NTR receptor-mediated signalling. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP21.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005096 | GTPase activator activity | IEA | -- |
GO:0005515 | protein binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005829 | cytosol | TAS | -- |
GO:0070062 | extracellular exosome | HDA | 19199708 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | p75 NTR receptor-mediated signalling |
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2 | Signaling by GPCR | ||
3 | Signaling by Rho GTPases |
Symbol | External ID(s) | Details |
---|---|---|
CDH1 | ||
ENSG00000272822 | ||
HNRNPA1 | ||
MEPCE | ||
RPAP1 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0043547 | positive regulation of GTPase activity | IEA | -- |
GO:0051056 | regulation of small GTPase mediated signal transduction | TAS | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ARHGAP23 30 |
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Dog (Canis familiaris) |
Mammalia | ARHGAP23 30 |
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Cow (Bos Taurus) |
Mammalia | ARHGAP23 30 |
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Mouse (Mus musculus) |
Mammalia | Arhgap23 30 17 |
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Rat (Rattus norvegicus) |
Mammalia | Arhgap23 30 |
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Chicken (Gallus gallus) |
Aves | LOC101750894 30 |
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Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | arhgap23 30 |
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Zebrafish (Danio rerio) |
Actinopterygii | LOC100006233 30 |
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Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv23483 | CNV | gain+loss | 19812545 |
esv2758688 | CNV | gain+loss | 17122850 |
esv27695 | CNV | gain | 19812545 |
nsv1118072 | CNV | deletion | 24896259 |
nsv1126455 | CNV | deletion | 24896259 |
nsv1146669 | OTHER | inversion | 26484159 |
nsv428341 | CNV | gain+loss | 18775914 |
nsv469701 | CNV | loss | 16826518 |
nsv833436 | CNV | loss | 17160897 |
nsv953892 | CNV | deletion | 24416366 |
nsv9549 | CNV | gain | 18304495 |
nsv960483 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
parainfluenza virus type 3 |
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lymphocytic choriomeningitis |
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