Aliases for ARHGAP23 Gene
External Ids for ARHGAP23 Gene
Previous GeneCards Identifiers for ARHGAP23 Gene
The RHO (see ARHA; MIM 165390) family of small GTPases are involved in signal transduction through transmembrane receptors, and they are inactive in the GDP-bound form and active in the GTP-bound form. GTPase-activating proteins, such as ARHGAP23, inactivate RHO family proteins by stimulating their hydrolysis of GTP (Katoh and Katoh, 2004 [PubMed 15254754]).[supplied by OMIM, Mar 2008]
GeneCards Summary for ARHGAP23 Gene
ARHGAP23 (Rho GTPase Activating Protein 23) is a Protein Coding gene. Diseases associated with ARHGAP23 include Parainfluenza Virus Type 3 and Lymphocytic Choriomeningitis. Among its related pathways are Signaling by GPCR and p75 NTR receptor-mediated signalling. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP21.
UniProtKB/Swiss-Prot Summary for ARHGAP23 Gene
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.