Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ARHGAP23 Gene

Aliases for ARHGAP23 Gene

  • Rho GTPase Activating Protein 23 2 3 5
  • Rho-Type GTPase-Activating Protein 23 4
  • KIAA1501 4

External Ids for ARHGAP23 Gene

Previous GeneCards Identifiers for ARHGAP23 Gene

  • GC17P036984
  • GC17P033825
  • GC17P036584
  • GC17P032409

Summaries for ARHGAP23 Gene

Entrez Gene Summary for ARHGAP23 Gene

  • The RHO (see ARHA; MIM 165390) family of small GTPases are involved in signal transduction through transmembrane receptors, and they are inactive in the GDP-bound form and active in the GTP-bound form. GTPase-activating proteins, such as ARHGAP23, inactivate RHO family proteins by stimulating their hydrolysis of GTP (Katoh and Katoh, 2004 [PubMed 15254754]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ARHGAP23 Gene

ARHGAP23 (Rho GTPase Activating Protein 23) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP21.

UniProtKB/Swiss-Prot for ARHGAP23 Gene

  • GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Additional gene information for ARHGAP23 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP23 Gene

Genomics for ARHGAP23 Gene

GeneHancer (GH) Regulatory Elements for ARHGAP23 Gene

Promoters and enhancers for ARHGAP23 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I038425 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 554.8 +8.5 8547 6 BCOR JUN MAX SIN3A ZMYM3 EBF1 ZIC2 ZNF48 ZFHX2 GATA3 ARHGAP23 GC17M038426 GC17P038497 PIR59659 GC17P038495
GH17I038420 Promoter/Enhancer 1.1 Ensembl dbSUPER 550.8 +0.0 21 0.2 MXI1 MAZ SP3 ZBTB8A ZNF335 ZFHX2 GLIS2 POLR2A GLIS1 PATZ1 ARHGAP23 GC17M038410 GC17M038423 PIR51176
GH17I038416 Enhancer 0.9 dbSUPER 550.8 -1.3 -1277 2.4 HDAC1 ZSCAN4 ZNF48 TCF12 ZNF766 GLIS2 ZNF143 RUNX3 EGR2 SP3 ARHGAP23 GC17M038410 GC17M038417 GC17M038418 PIR32801 MRPL45
GH17I038350 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.6 -67.3 -67331 2.7 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 PIR56504 SOCS7 GPR179 ARHGAP23
GH17I038447 Promoter/Enhancer 1.6 Ensembl ENCODE dbSUPER 8 +32.9 32867 9.4 SIN3A ZNF2 ETS1 ZNF121 GLIS2 ZNF143 FOS SP5 REST PPARG ENSG00000276170 GC17M038463 LOC101929494 PIR47370 PIR56037 LOC105371762 MED1 SNORA21 ARHGAP23 GC17M038495
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ARHGAP23 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARHGAP23 gene promoter:

Genomic Locations for ARHGAP23 Gene

Genomic Locations for ARHGAP23 Gene
93,113 bases
Plus strand

Genomic View for ARHGAP23 Gene

Genes around ARHGAP23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP23 Gene

Proteins for ARHGAP23 Gene

  • Protein details for ARHGAP23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho GTPase-activating protein 23
    Protein Accession:

    Protein attributes for ARHGAP23 Gene

    1491 amino acids
    Molecular mass:
    162192 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ARHGAP23 Gene


neXtProt entry for ARHGAP23 Gene

Post-translational modifications for ARHGAP23 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARHGAP23 Gene

Domains & Families for ARHGAP23 Gene

Suggested Antigen Peptide Sequences for ARHGAP23 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARHGAP23: view

No data available for UniProtKB/Swiss-Prot for ARHGAP23 Gene

Function for ARHGAP23 Gene

Molecular function for ARHGAP23 Gene

UniProtKB/Swiss-Prot Function:
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Phenotypes From GWAS Catalog for ARHGAP23 Gene

Gene Ontology (GO) - Molecular Function for ARHGAP23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS --
genes like me logo Genes that share ontologies with ARHGAP23: view
genes like me logo Genes that share phenotypes with ARHGAP23: view

Animal Models for ARHGAP23 Gene

MGI Knock Outs for ARHGAP23:

Animal Model Products

miRNA for ARHGAP23 Gene

miRTarBase miRNAs that target ARHGAP23

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARHGAP23 Gene

Localization for ARHGAP23 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGAP23 gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 4
plasma membrane 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARHGAP23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome HDA,IDA 19199708
genes like me logo Genes that share ontologies with ARHGAP23: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP23 Gene

Pathways & Interactions for ARHGAP23 Gene

genes like me logo Genes that share pathways with ARHGAP23: view

Pathways by source for ARHGAP23 Gene

3 Reactome pathways for ARHGAP23 Gene

Interacting Proteins for ARHGAP23 Gene

Selected Interacting proteins: Q9P227-RHG23_HUMAN for ARHGAP23 Gene via IID

Gene Ontology (GO) - Biological Process for ARHGAP23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IBA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP23: view

No data available for SIGNOR curated interactions for ARHGAP23 Gene

Drugs & Compounds for ARHGAP23 Gene

No Compound Related Data Available

Transcripts for ARHGAP23 Gene

mRNA/cDNA for ARHGAP23 Gene

(12) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARHGAP23 Gene

Rho GTPase activating protein 23:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP23 Gene

No ASD Table

Relevant External Links for ARHGAP23 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARHGAP23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARHGAP23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARHGAP23 Gene

This gene is overexpressed in Frontal cortex (15.1), Testis (10.5), Retina (10.2), and Fetal testis (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARHGAP23 Gene

Protein tissue co-expression partners for ARHGAP23 Gene

NURSA nuclear receptor signaling pathways regulating expression of ARHGAP23 Gene:


SOURCE GeneReport for Unigene cluster for ARHGAP23 Gene:


mRNA Expression by UniProt/SwissProt for ARHGAP23 Gene:

Tissue specificity: Expressed in placenta, prostate, hippocampus and brain medulla. Also expressed in brain tumor, salivary gland tumor, head and neck tumor.

Evidence on tissue expression from TISSUES for ARHGAP23 Gene

  • Nervous system(4.6)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with ARHGAP23: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGAP23 Gene

Orthologs for ARHGAP23 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ARHGAP23 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARHGAP23 33
  • 97.32 (n)
(Canis familiaris)
Mammalia ARHGAP23 33
  • 91.92 (n)
(Bos Taurus)
Mammalia ARHGAP23 33
  • 91.69 (n)
(Mus musculus)
Mammalia Arhgap23 33 16
  • 88.78 (n)
(Rattus norvegicus)
Mammalia Arhgap23 33
  • 88.44 (n)
(Gallus gallus)
Aves LOC101750894 33
  • 78.79 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap23 33
  • 64.11 (n)
(Danio rerio)
Actinopterygii LOC100006233 33
  • 60.29 (n)
Species where no ortholog for ARHGAP23 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARHGAP23 Gene

Gene Tree for ARHGAP23 (if available)
Gene Tree for ARHGAP23 (if available)

Paralogs for ARHGAP23 Gene

Variants for ARHGAP23 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP23 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000003840 -- 38,446,317(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000035807 -- 38,428,991(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000119538 -- 38,485,790(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000131812 -- 38,480,941(+) T/C intron_variant
rs1000176129 -- 38,419,556(+) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP23 Gene

Variant ID Type Subtype PubMed ID
esv23483 CNV gain+loss 19812545
esv2758688 CNV gain+loss 17122850
esv27695 CNV gain 19812545
nsv1118072 CNV deletion 24896259
nsv1126455 CNV deletion 24896259
nsv1146669 OTHER inversion 26484159
nsv428341 CNV gain+loss 18775914
nsv469701 CNV loss 16826518
nsv833436 CNV loss 17160897
nsv953892 CNV deletion 24416366
nsv9549 CNV gain 18304495
nsv960483 CNV duplication 23825009

Variation tolerance for ARHGAP23 Gene

Gene Damage Index Score: 4.87; 67.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARHGAP23 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP23 Gene

Disorders for ARHGAP23 Gene

Additional Disease Information for ARHGAP23

No disorders were found for ARHGAP23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGAP23 Gene

Publications for ARHGAP23 Gene

  1. Identification and characterization of human ARHGAP23 gene in silico. (PMID: 15254754) Katoh M … Katoh M (International journal of oncology 2004) 2 3 4 22 58
  2. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58

Products for ARHGAP23 Gene

Sources for ARHGAP23 Gene

Loading form....