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Aliases for ARHGAP22 Gene

Aliases for ARHGAP22 Gene

  • Rho GTPase Activating Protein 22 2 3 5
  • Rho-Type GTPase-Activating Protein 22 3 4
  • Rho GTPase-Activating Protein 22 3
  • RhoGap22 3
  • RhoGAP2 3
  • RHOGAP2 4

External Ids for ARHGAP22 Gene

Previous GeneCards Identifiers for ARHGAP22 Gene

  • GC10M048998
  • GC10M049324
  • GC10M049654
  • GC10M043918
  • GC10M048446

Summaries for ARHGAP22 Gene

Entrez Gene Summary for ARHGAP22 Gene

  • This gene encodes a member of the GTPase activating protein family which activates a GTPase belonging to the RAS superfamily of small GTP-binding proteins. The encoded protein is insulin-responsive, is dependent on the kinase Akt and requires the Akt-dependent 14-3-3 binding protein which binds sequentially to two serine residues. The result of these interactions is regulation of cell motility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for ARHGAP22 Gene

ARHGAP22 (Rho GTPase Activating Protein 22) is a Protein Coding gene. Among its related pathways are p75 NTR receptor-mediated signalling and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP24.

UniProtKB/Swiss-Prot for ARHGAP22 Gene

  • Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity).

Additional gene information for ARHGAP22 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP22 Gene

Genomics for ARHGAP22 Gene

GeneHancer (GH) Regulatory Elements for ARHGAP22 Gene

Promoters and enhancers for ARHGAP22 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J048603 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 671.2 +50.1 50124 5.3 RB1 RAD21 ZNF335 SCRT2 ZNF143 FOS SMARCA5 ZNF654 USF2 CEBPB ARHGAP22 PTPN20CP GC10M048611 GC10M048584
GH10J048655 Promoter/Enhancer 1.5 Ensembl ENCODE 660.3 +0.1 115 1.7 SMAD1 ATF1 ARNT ARID4B SIN3A ZNF2 IRF4 ZNF48 GLIS2 CBX5 ARHGAP22 ENSG00000251413 GC10M048627
GH10J048451 Promoter/Enhancer 0.7 EPDnew dbSUPER 650.1 +204.6 204598 0.1 ARHGAP22 ENSG00000279822 ARHGAP22-IT1
GH10J048656 Enhancer 0.5 ENCODE 650.7 +1.1 1074 0.2 MTA1 GMEB1 HDAC2 ZBTB2 ZNF512 ARHGAP22 ENSG00000251413 GC10M048627
GH10J048633 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 38.8 +21.7 21672 1.8 MAX EBF1 RELA ZNF316 POLR2A ZNF157 ATF7 IKZF2 RUNX3 MAFK ARHGAP22 ENSG00000251413 GC10M048627
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ARHGAP22 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARHGAP22 gene promoter:

Genomic Locations for ARHGAP22 Gene

Genomic Locations for ARHGAP22 Gene
chr10:48,430,318-48,656,265
(GRCh38/hg38)
Size:
225,948 bases
Orientation:
Minus strand
chr10:49,654,077-49,864,310
(GRCh37/hg19)

Genomic View for ARHGAP22 Gene

Genes around ARHGAP22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP22 Gene

Proteins for ARHGAP22 Gene

  • Protein details for ARHGAP22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z5H3-RHG22_HUMAN
    Recommended name:
    Rho GTPase-activating protein 22
    Protein Accession:
    Q7Z5H3
    Secondary Accessions:
    • A0AVP7
    • A5YM75
    • B4DED8
    • B9EGA0
    • C9JDM2
    • O00152
    • Q6ZSB0

    Protein attributes for ARHGAP22 Gene

    Size:
    698 amino acids
    Molecular mass:
    76779 Da
    Quaternary structure:
    • Interacts with VEZF1.

    Alternative splice isoforms for ARHGAP22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGAP22 Gene

Post-translational modifications for ARHGAP22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARHGAP22 Gene

Domains & Families for ARHGAP22 Gene

Gene Families for ARHGAP22 Gene

Protein Domains for ARHGAP22 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARHGAP22: view

No data available for UniProtKB/Swiss-Prot for ARHGAP22 Gene

Function for ARHGAP22 Gene

Molecular function for ARHGAP22 Gene

UniProtKB/Swiss-Prot Function:
Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity).

Phenotypes From GWAS Catalog for ARHGAP22 Gene

Gene Ontology (GO) - Molecular Function for ARHGAP22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA,TAS --
GO:0005515 protein binding IPI 21078624
genes like me logo Genes that share ontologies with ARHGAP22: view
genes like me logo Genes that share phenotypes with ARHGAP22: view

Animal Models for ARHGAP22 Gene

MGI Knock Outs for ARHGAP22:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARHGAP22 Gene

Localization for ARHGAP22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP22 Gene

Cytoplasm. Nucleus. Note=Mainly cytoplasmic. Some fraction is nuclear (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGAP22 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARHGAP22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005925 focal adhesion HDA 21423176
genes like me logo Genes that share ontologies with ARHGAP22: view

Pathways & Interactions for ARHGAP22 Gene

genes like me logo Genes that share pathways with ARHGAP22: view

Pathways by source for ARHGAP22 Gene

3 Reactome pathways for ARHGAP22 Gene
1 GeneGo (Thomson Reuters) pathway for ARHGAP22 Gene

Gene Ontology (GO) - Biological Process for ARHGAP22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007165 signal transduction IEA --
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with ARHGAP22: view

No data available for SIGNOR curated interactions for ARHGAP22 Gene

Drugs & Compounds for ARHGAP22 Gene

No Compound Related Data Available

Transcripts for ARHGAP22 Gene

Unigene Clusters for ARHGAP22 Gene

Rho GTPase activating protein 22:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP22 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - - - - - - - - - -
SP6: - -
SP7: - - - - - - - - -
SP8:
SP9:
SP10:

Relevant External Links for ARHGAP22 Gene

GeneLoc Exon Structure for
ARHGAP22
ECgene alternative splicing isoforms for
ARHGAP22

Expression for ARHGAP22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARHGAP22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGAP22 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.8) and Brain - Substantia nigra (x4.3).

Protein differential expression in normal tissues from HIPED for ARHGAP22 Gene

This gene is overexpressed in Heart (66.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARHGAP22 Gene



Protein tissue co-expression partners for ARHGAP22 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARHGAP22 Gene:

ARHGAP22

SOURCE GeneReport for Unigene cluster for ARHGAP22 Gene:

Hs.655672

Evidence on tissue expression from TISSUES for ARHGAP22 Gene

  • Nervous system(4.5)
  • Lung(4.1)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with ARHGAP22: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGAP22 Gene

Orthologs for ARHGAP22 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP22 34 33
  • 99.01 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ARHGAP22 34 33
  • 87.53 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ARHGAP22 34 33
  • 83.64 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgap22 16 34 33
  • 81.98 (n)
rat
(Rattus norvegicus)
Mammalia Arhgap22 33
  • 77.7 (n)
oppossum
(Monodelphis domestica)
Mammalia ARHGAP22 34
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGAP22 34
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARHGAP22 34 33
  • 68.6 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap22 33
  • 57.91 (n)
zebrafish
(Danio rerio)
Actinopterygii arhgap22 34
  • 59 (a)
OneToMany
ARHGAP22 (2 of 2) 34
  • 56 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta RhoGAPp190 34
  • 5 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rga-5 34
  • 5 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 49 (a)
OneToMany
Species where no ortholog for ARHGAP22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP22 Gene

ENSEMBL:
Gene Tree for ARHGAP22 (if available)
TreeFam:
Gene Tree for ARHGAP22 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ARHGAP22: view image

Paralogs for ARHGAP22 Gene

(9) SIMAP similar genes for ARHGAP22 Gene using alignment to 5 proteins:

  • RHG22_HUMAN
  • A6NHM7_HUMAN
  • A6NJ38_HUMAN
  • D6R9V6_HUMAN
  • D6RBJ8_HUMAN
genes like me logo Genes that share paralogs with ARHGAP22: view

Variants for ARHGAP22 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP22 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs796052167 likely-benign, Long QT syndrome 48,604,783(-) T/G 5_prime_UTR_variant, coding_sequence_variant, genic_upstream_transcript_variant, intron_variant, missense_variant, non_coding_transcript_variant
rs1000010300 -- 48,436,574(-) C/A genic_downstream_transcript_variant, intron_variant
rs1000011995 -- 48,645,350(-) A/C genic_upstream_transcript_variant, intron_variant
rs1000022301 -- 48,521,711(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000056463 -- 48,521,378(-) C/A/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP22 Gene

Variant ID Type Subtype PubMed ID
esv1005947 CNV loss 20482838
esv25392 CNV loss 19812545
esv26659 CNV loss 19812545
esv3623157 CNV loss 21293372
nsv1039508 CNV gain 25217958
nsv1042677 CNV loss 25217958
nsv1046588 CNV gain 25217958
nsv1127109 CNV deletion 24896259
nsv1143637 CNV deletion 24896259
nsv473834 CNV novel sequence insertion 20440878
nsv516006 CNV loss 19592680
nsv550813 CNV loss 21841781
nsv550814 CNV loss 21841781
nsv550815 CNV loss 21841781
nsv550816 CNV loss 21841781
nsv6598 CNV insertion 18451855
nsv6609 CNV deletion 18451855
nsv950952 CNV deletion 24416366

Variation tolerance for ARHGAP22 Gene

Residual Variation Intolerance Score: 81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.95; 49.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARHGAP22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARHGAP22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP22 Gene

Disorders for ARHGAP22 Gene

Additional Disease Information for ARHGAP22

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ARHGAP22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGAP22 Gene

Publications for ARHGAP22 Gene

  1. Genome-wide association study of conduct disorder symptomatology. (PMID: 20585324) Dick DM … Bierut L (Molecular psychiatry 2011) 3 44 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 44 58
  4. Identification and characterization of ARHGAP24 and ARHGAP25 genes in silico. (PMID: 15254788) Katoh M … Katoh M (International journal of molecular medicine 2004) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for ARHGAP22 Gene

Sources for ARHGAP22 Gene

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