Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ARHGAP21 Gene

Aliases for ARHGAP21 Gene

  • Rho GTPase Activating Protein 21 2 3 5
  • Rho-Type GTPase-Activating Protein 21 3 4
  • Rho GTPase-Activating Protein 10 3 4
  • ARHGAP10 3 4
  • Rho-GTPase Activating Protein 10 3
  • Rho GTPase-Activating Protein 21 3
  • KIAA1424 4

External Ids for ARHGAP21 Gene

Previous GeneCards Identifiers for ARHGAP21 Gene

  • GC10M024876
  • GC10M024912
  • GC10M024873

Summaries for ARHGAP21 Gene

Entrez Gene Summary for ARHGAP21 Gene

  • ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al., 2005 [PubMed 15793564]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ARHGAP21 Gene

ARHGAP21 (Rho GTPase Activating Protein 21) is a Protein Coding gene. Among its related pathways are p75 NTR receptor-mediated signalling and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP23.

UniProtKB/Swiss-Prot for ARHGAP21 Gene

  • Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions.

Additional gene information for ARHGAP21 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP21 Gene

Genomics for ARHGAP21 Gene

GeneHancer (GH) Regulatory Elements for ARHGAP21 Gene

Promoters and enhancers for ARHGAP21 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J024717 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 650.7 +2.0 1956 7.5 HDGF PKNOX1 FOXA2 ARID4B SIN3A YY1 POLR2B ZNF207 FOS SP3 ARHGAP21 COQ10BP1 GC10P024495
GH10J024929 Enhancer 0.9 ENCODE dbSUPER 20.6 -205.7 -205651 0.5 MEIS2 SMAD1 RB1 BACH1 EBF1 BMI1 YBX1 ATF7 IKZF2 RUNX3 ARHGAP21 PRTFDC1 RN7SKP241 GC10M024909 ENSG00000273107
GH10J024900 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -178.3 -178283 3.6 HDGF PKNOX1 ATF1 SMAD1 ARNT SIN3A FEZF1 IRF4 BRCA1 TCF12 PRTFDC1 ARHGAP21 RN7SKP241 GC10M024909 ENSG00000228667
GH10J024920 Enhancer 1.4 Ensembl ENCODE dbSUPER 9.4 -198.2 -198200 2.8 PKNOX1 SMAD1 ARNT IRF4 ZNF766 FOS JUNB REST ZNF592 MEF2D PRTFDC1 ARHGAP21 GC10M024909 RN7SKP241 ENSG00000273107
GH10J024762 Enhancer 0.9 Ensembl ENCODE 11.6 -39.2 -39208 1.4 HDAC1 MEIS2 FOXA2 THRB ETS1 TEAD3 NR2F6 MAFK SOX5 NANOG PRTFDC1 ARHGAP21 LOC105376456 GC10P024495
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARHGAP21 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARHGAP21 gene promoter:
  • GATA-2
  • GATA-1
  • GATA-3
  • Hlf
  • NF-1
  • AML1a
  • S8
  • Lhx3a
  • LHX3b

Genomic Locations for ARHGAP21 Gene

Genomic Locations for ARHGAP21 Gene
140,060 bases
Minus strand
140,060 bases
Minus strand

Genomic View for ARHGAP21 Gene

Genes around ARHGAP21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP21 Gene

Proteins for ARHGAP21 Gene

  • Protein details for ARHGAP21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho GTPase-activating protein 21
    Protein Accession:
    Secondary Accessions:
    • Q0VF98
    • Q7Z3P7
    • Q8N3A2
    • Q8NI19
    • Q8TBV5
    • Q9P2C3

    Protein attributes for ARHGAP21 Gene

    1957 amino acids
    Molecular mass:
    217331 Da
    Quaternary structure:
    • Interacts with GTP-bound ARF1 and ARF6. Interacts with CTNNA1.
    • Depletion of ARHGAP21 induces cell spreading and accumulation of F-actin stress fibers.
    • Required for In1A-dependent entry of Listeria monocytogenes into cells.

    Three dimensional structures from OCA and Proteopedia for ARHGAP21 Gene

    Alternative splice isoforms for ARHGAP21 Gene


neXtProt entry for ARHGAP21 Gene

Post-translational modifications for ARHGAP21 Gene

  • Sumoylated with SUMO2 and SUMO3 in proliferating lymphocytes.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARHGAP21 Gene

Domains & Families for ARHGAP21 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARHGAP21: view

No data available for UniProtKB/Swiss-Prot for ARHGAP21 Gene

Function for ARHGAP21 Gene

Molecular function for ARHGAP21 Gene

UniProtKB/Swiss-Prot Function:
Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions.
UniProtKB/Swiss-Prot Induction:
Up-regulated upon cell differentiation.

Phenotypes From GWAS Catalog for ARHGAP21 Gene

Gene Ontology (GO) - Molecular Function for ARHGAP21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS --
GO:0005515 protein binding IPI 17347647
genes like me logo Genes that share ontologies with ARHGAP21: view
genes like me logo Genes that share phenotypes with ARHGAP21: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARHGAP21 Gene

Localization for ARHGAP21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP21 Gene

Golgi apparatus membrane; Peripheral membrane protein. Cell junction. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Localization to the Golgi is dependent on interaction with GTP-bound ARF1.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGAP21 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
golgi apparatus 5
plasma membrane 4
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (3)
  • Plasma membrane (3)
  • Actin filaments (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARHGAP21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IDA 20525016
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with ARHGAP21: view

Pathways & Interactions for ARHGAP21 Gene

genes like me logo Genes that share pathways with ARHGAP21: view

Pathways by source for ARHGAP21 Gene

3 Reactome pathways for ARHGAP21 Gene

Gene Ontology (GO) - Biological Process for ARHGAP21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007030 Golgi organization IMP 20525016
GO:0007165 signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IBA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
GO:0051645 Golgi localization IBA --
genes like me logo Genes that share ontologies with ARHGAP21: view

No data available for SIGNOR curated interactions for ARHGAP21 Gene

Drugs & Compounds for ARHGAP21 Gene

(2) Drugs for ARHGAP21 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
HJC 0350 Pharma 0
genes like me logo Genes that share compounds with ARHGAP21: view

Transcripts for ARHGAP21 Gene

mRNA/cDNA for ARHGAP21 Gene

Unigene Clusters for ARHGAP21 Gene

Rho GTPase activating protein 21:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP21 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1: - - - - -
SP3: - - - -
SP5: -

ExUns: 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27a · 27b ^ 28 ^ 29
SP1: - -
SP2: - -

Relevant External Links for ARHGAP21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARHGAP21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARHGAP21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARHGAP21 Gene

This gene is overexpressed in Plasma (29.4) and Fetal Brain (20.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARHGAP21 Gene

Protein tissue co-expression partners for ARHGAP21 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARHGAP21 Gene:


SOURCE GeneReport for Unigene cluster for ARHGAP21 Gene:


mRNA Expression by UniProt/SwissProt for ARHGAP21 Gene:

Tissue specificity: Widely expressed with higher expression in brain, heart, skeletal muscle and placenta.

Evidence on tissue expression from TISSUES for ARHGAP21 Gene

  • Nervous system(4.8)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with ARHGAP21: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGAP21 Gene

Orthologs for ARHGAP21 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP21 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARHGAP21 34 33
  • 99.52 (n)
(Canis familiaris)
Mammalia ARHGAP21 34 33
  • 85.65 (n)
(Bos Taurus)
Mammalia ARHGAP21 34 33
  • 84.96 (n)
(Mus musculus)
Mammalia Arhgap21 16 34 33
  • 83.99 (n)
(Rattus norvegicus)
Mammalia Arhgap21 33
  • 83.32 (n)
(Monodelphis domestica)
Mammalia ARHGAP21 34
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia ARHGAP21 34
  • 78 (a)
(Gallus gallus)
Aves ARHGAP21 34 33
  • 75.08 (n)
(Anolis carolinensis)
Reptilia ARHGAP21 34
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap21 33
  • 67.44 (n)
Str.595 33
African clawed frog
(Xenopus laevis)
Amphibia rGAP 33
(Danio rerio)
Actinopterygii arhgap21b 34 33
  • 59.47 (n)
arhgap21a 34
  • 50 (a)
wufe14a09 33
fruit fly
(Drosophila melanogaster)
Insecta RhoGAP19D 34
  • 18 (a)
(Caenorhabditis elegans)
Secernentea pac-1 34
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9299 34
  • 48 (a)
Species where no ortholog for ARHGAP21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP21 Gene

Gene Tree for ARHGAP21 (if available)
Gene Tree for ARHGAP21 (if available)
Evolutionary constrained regions (ECRs) for ARHGAP21: view image

Paralogs for ARHGAP21 Gene

(38) SIMAP similar genes for ARHGAP21 Gene using alignment to 8 proteins:

  • F8W9U9_HUMAN
  • H0Y468_HUMAN
  • H0Y5T2_HUMAN
  • L8EB25_HUMAN
  • Q5JSD8_HUMAN Pseudogenes for ARHGAP21 Gene

genes like me logo Genes that share paralogs with ARHGAP21: view

Variants for ARHGAP21 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP21 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1060499743 likely-pathogenic, Abnormality of brain morphology 24,596,030(-) A/C coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1064795561 uncertain-significance, not specified 24,620,104(-) TCT/T coding_sequence_variant, frameshift, non_coding_transcript_variant
rs1000002525 -- 24,724,156(-) C/A/G 5_prime_UTR_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, upstream_transcript_variant
rs1000048373 -- 24,583,337(-) T/C downstream_transcript_variant
rs1000052583 -- 24,631,369(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP21 Gene

Variant ID Type Subtype PubMed ID
esv2666299 CNV deletion 23128226
esv2734095 CNV deletion 23290073
esv3333243 CNV insertion 20981092
esv3622649 CNV loss 21293372
nsv1037958 CNV gain 25217958
nsv473270 CNV novel sequence insertion 20440878
nsv6099 CNV insertion 18451855
nsv947769 CNV duplication 23825009
nsv947770 CNV duplication 23825009
nsv982895 CNV duplication 23825009

Variation tolerance for ARHGAP21 Gene

Residual Variation Intolerance Score: 3.52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.30; 62.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARHGAP21 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP21 Gene

Disorders for ARHGAP21 Gene

Additional Disease Information for ARHGAP21

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ARHGAP21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGAP21 Gene

Publications for ARHGAP21 Gene

  1. ARHGAP10, a novel human gene coding for a potentially cytoskeletal Rho-GTPase activating protein. (PMID: 12056806) Bassères DS … Saad ST (Biochemical and biophysical research communications 2002) 2 3 4 58
  2. Post-translational modification of the RhoGTPase activating protein 21, ARHGAP21, by SUMO2/3. (PMID: 22922005) Bigarella CL … Archangelo LF (FEBS letters 2012) 3 4 58
  3. Structural basis for ARF1-mediated recruitment of ARHGAP21 to Golgi membranes. (PMID: 17347647) Ménétrey J … Houdusse A (The EMBO journal 2007) 3 4 58
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 44 58
  5. Golgi-localized GAP for Cdc42 functions downstream of ARF1 to control Arp2/3 complex and F-actin dynamics. (PMID: 15793564) Dubois T … Chavrier P (Nature cell biology 2005) 3 4 58

Products for ARHGAP21 Gene

Sources for ARHGAP21 Gene

Loading form....