Aliases for ARHGAP21 Gene
External Ids for ARHGAP21 Gene
Previous GeneCards Identifiers for ARHGAP21 Gene
ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al., 2005 [PubMed 15793564]).[supplied by OMIM, Mar 2008]
GeneCards Summary for ARHGAP21 Gene
ARHGAP21 (Rho GTPase Activating Protein 21) is a Protein Coding gene. Diseases associated with ARHGAP21 include Ciliary Dyskinesia, Primary, 13 and Aarskog-Scott Syndrome. Among its related pathways are p75 NTR receptor-mediated signalling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP23.
UniProtKB/Swiss-Prot Summary for ARHGAP21 Gene
Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions.