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Aliases for ARHGAP19-SLIT1 Gene

Subcategory (RNA class) for ARHGAP19-SLIT1 Gene


Quality Score for this RNA gene is


Aliases for ARHGAP19-SLIT1 Gene

  • ARHGAP19-SLIT1 Readthrough (NMD Candidate) 2 3 5

External Ids for ARHGAP19-SLIT1 Gene

Previous GeneCards Identifiers for ARHGAP19-SLIT1 Gene

  • GC10U901525
  • GC10M098757

Summaries for ARHGAP19-SLIT1 Gene

Entrez Gene Summary for ARHGAP19-SLIT1 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring Rho GTPase activating protein 19 (ARHGAP19) and slit homolog 1 (SLIT1) genes on chromosome 10. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is thus unlikely to produce a protein product. [provided by RefSeq, Feb 2011]

GeneCards Summary for ARHGAP19-SLIT1 Gene

ARHGAP19-SLIT1 (ARHGAP19-SLIT1 Readthrough (NMD Candidate)) is an RNA Gene, and is affiliated with the ncRNA class. An important paralog of this gene is ARHGAP19.

Additional gene information for ARHGAP19-SLIT1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP19-SLIT1 Gene

Genomics for ARHGAP19-SLIT1 Gene

GeneHancer (GH) Regulatory Elements for ARHGAP19-SLIT1 Gene

Promoters and enhancers for ARHGAP19-SLIT1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I097291 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.0 42 3.2 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 ZNF2 ZBTB7B YY1 SLC30A9 ARHGAP19 ARHGAP19-SLIT1 R3HCC1L SLIT1 NPM1P26 LOXL4 ENSG00000230928 RPL12P27 ENSG00000231398
GH10I097277 Enhancer 1.1 Ensembl ENCODE 0.4 +13.8 13760 2.5 ELF3 FOXA2 ARID4B RAD21 RARA RFX5 ZNF335 ZNF366 ZNF143 FOS ARHGAP19 SLIT1 ENSG00000231398 ARHGAP19-SLIT1
GH10I097195 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 0.2 +96.0 96042 1.8 RB1 ARID4B MZF1 ZNF76 SIN3A RAD21 ZNF335 GLIS2 ZNF366 ZNF143 PIR51669 C10orf62 SLIT1 ARHGAP19-SLIT1
GH10I097270 Promoter 0.7 EPDnew 0.3 +22.0 21996 0.1 TEAD3 ZBTB17 ARHGAP19 ENSG00000231398 ARHGAP19-SLIT1 LOC105378447
GH10I097280 Enhancer 0.4 ENCODE 0.4 +11.7 11690 1.3 WT1 ZNF7 SLIT1 ARHGAP19 ENSG00000231398 ARHGAP19-SLIT1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ARHGAP19-SLIT1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ARHGAP19-SLIT1 Gene

Genomic Locations for ARHGAP19-SLIT1 Gene
139,632 bases
Minus strand

Genomic View for ARHGAP19-SLIT1 Gene

Genes around ARHGAP19-SLIT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP19-SLIT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP19-SLIT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP19-SLIT1 Gene

Proteins for ARHGAP19-SLIT1 Gene

Protein Expression for ARHGAP19-SLIT1 Gene

Post-translational modifications for ARHGAP19-SLIT1 Gene

No Post-translational modifications

Other Protein References for ARHGAP19-SLIT1 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for ARHGAP19-SLIT1 Gene

Domains & Families for ARHGAP19-SLIT1 Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for ARHGAP19-SLIT1 Gene

Function for ARHGAP19-SLIT1 Gene

Phenotypes From GWAS Catalog for ARHGAP19-SLIT1 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARHGAP19-SLIT1 Gene

Localization for ARHGAP19-SLIT1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ARHGAP19-SLIT1 Gene

Pathways & Interactions for ARHGAP19-SLIT1 Gene

SuperPathways for ARHGAP19-SLIT1 Gene

No Data Available

Interacting Proteins for ARHGAP19-SLIT1 Gene

Gene Ontology (GO) - Biological Process for ARHGAP19-SLIT1 Gene


No data available for Pathways by source and SIGNOR curated interactions for ARHGAP19-SLIT1 Gene

Drugs & Compounds for ARHGAP19-SLIT1 Gene

No Compound Related Data Available

Transcripts for ARHGAP19-SLIT1 Gene


(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP19-SLIT1 Gene

No ASD Table

Relevant External Links for ARHGAP19-SLIT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARHGAP19-SLIT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARHGAP19-SLIT1 Gene

mRNA differential expression in normal tissues according to GTEx for ARHGAP19-SLIT1 Gene

This gene is overexpressed in Pituitary (x13.1), Brain - Hippocampus (x5.7), and Brain - Amygdala (x4.5).

Protein differential expression in normal tissues from HIPED for ARHGAP19-SLIT1 Gene

This gene is overexpressed in Testis (61.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from MaxQB and MOPED for ARHGAP19-SLIT1 Gene

Protein tissue co-expression partners for ARHGAP19-SLIT1 Gene

genes like me logo Genes that share expression patterns with ARHGAP19-SLIT1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGAP19-SLIT1 Gene

Orthologs for ARHGAP19-SLIT1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGAP19-SLIT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 100 (a)
(Canis familiaris)
Mammalia -- 34
  • 92 (a)
(Bos Taurus)
Mammalia -- 34
  • 90 (a)
(Mus musculus)
Mammalia Arhgap19 34
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 80 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 78 (a)
(Gallus gallus)
Aves ARHGAP19 34
  • 74 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 69 (a)
(Danio rerio)
Actinopterygii arhgap19 34
  • 60 (a)
fruit fly
(Drosophila melanogaster)
Insecta RhoGAP54D 34
  • 6 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RGA1 34
  • 5 (a)
RGA2 34
  • 5 (a)
Species where no ortholog for ARHGAP19-SLIT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARHGAP19-SLIT1 Gene

Gene Tree for ARHGAP19-SLIT1 (if available)
Gene Tree for ARHGAP19-SLIT1 (if available)

Paralogs for ARHGAP19-SLIT1 Gene

Paralogs for ARHGAP19-SLIT1 Gene

(3) SIMAP similar genes for ARHGAP19-SLIT1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ARHGAP19-SLIT1: view

Variants for ARHGAP19-SLIT1 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP19-SLIT1 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000017046 -- 97,213,601(-) G/A intron_variant
rs1000062182 -- 97,256,984(-) G/A intron_variant
rs1000090041 -- 97,165,119(-) T/C intron_variant
rs1000111750 -- 97,210,246(-) G/A intron_variant
rs1000124263 -- 97,273,895(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP19-SLIT1 Gene

Variant ID Type Subtype PubMed ID
nsv955563 CNV deletion 24416366
nsv950999 CNV deletion 24416366
nsv950998 CNV deletion 24416366
nsv831952 CNV loss 17160897
nsv7507 CNV deletion 18451855
nsv7506 CNV deletion 18451855
nsv512179 CNV loss 21212237
nsv477981 CNV novel sequence insertion 20440878
nsv473431 CNV novel sequence insertion 20440878
nsv433513 CNV loss 18776910
nsv1150585 CNV deletion 26484159
nsv1143513 CNV deletion 24896259
nsv1127135 CNV deletion 24896259
nsv1110852 OTHER inversion 24896259
nsv1070883 CNV deletion 25765185
nsv1069067 CNV deletion 25765185
nsv1069066 CNV deletion 25765185
nsv1040903 CNV gain 25217958
esv6307 CNV loss 19470904
esv5077 CNV loss 18987735
esv3624311 CNV loss 21293372
esv3624310 CNV loss 21293372
esv3546724 CNV deletion 23714750
esv3546723 CNV deletion 23714750
esv3261163 CNV deletion 24192839
esv2759777 CNV loss 17122850
esv2739862 CNV deletion 23290073
esv2739851 CNV deletion 23290073
esv2739840 CNV deletion 23290073
esv2739829 CNV deletion 23290073
esv2429720 CNV deletion 19546169
esv2304672 CNV deletion 18987734
esv1315028 CNV deletion 17803354
esv1003170 CNV deletion 20482838
esv1001501 CNV deletion 20482838
dgv503n106 CNV deletion 24896259

Variation tolerance for ARHGAP19-SLIT1 Gene

Gene Damage Index Score: 4.64; 65.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARHGAP19-SLIT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP19-SLIT1 Gene

Disorders for ARHGAP19-SLIT1 Gene

Additional Disease Information for ARHGAP19-SLIT1

No disorders were found for ARHGAP19-SLIT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGAP19-SLIT1 Gene

Publications for ARHGAP19-SLIT1 Gene

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 58

Products for ARHGAP19-SLIT1 Gene

Sources for ARHGAP19-SLIT1 Gene

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