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Aliases for ARHGAP19 Gene

Aliases for ARHGAP19 Gene

  • Rho GTPase Activating Protein 19 2 3 5
  • Rho-Type GTPase-Activating Protein 19 3 4
  • Rho GTPase-Activating Protein 19 3
  • Putative RhoGAP Protein 3

External Ids for ARHGAP19 Gene

Previous GeneCards Identifiers for ARHGAP19 Gene

  • GC10M098646
  • GC10M098971
  • GC10M098748
  • GC10M092610

Summaries for ARHGAP19 Gene

Entrez Gene Summary for ARHGAP19 Gene

  • Members of the ARHGAP family, such as ARHGAP19, encode negative regulators of Rho GTPases (see RHOA; MIM 165390), which are involved in cell migration, proliferation, and differentiation, actin remodeling, and G1 cell cycle progression (Lv et al., 2007 [PubMed 17454002]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ARHGAP19 Gene

ARHGAP19 (Rho GTPase Activating Protein 19) is a Protein Coding gene. Among its related pathways are p75 NTR receptor-mediated signalling and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP19-SLIT1.

UniProtKB/Swiss-Prot for ARHGAP19 Gene

  • GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Gene Wiki entry for ARHGAP19 Gene

Additional gene information for ARHGAP19 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP19 Gene

Genomics for ARHGAP19 Gene

GeneHancer (GH) Regulatory Elements for ARHGAP19 Gene

Promoters and enhancers for ARHGAP19 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J097291 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 664.7 +0.0 42 3.2 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 ZNF2 ZBTB7B YY1 SLC30A9 ARHGAP19 ARHGAP19-SLIT1 R3HCC1L SLIT1 NPM1P26 LOXL4 ENSG00000230928 RPL12P27 ENSG00000231398
GH10J097222 Promoter/Enhancer 1.1 EPDnew ENCODE 674.6 +70.2 70184 0.2 SMARCE1 HDAC1 RFX1 SMAD5 TEAD4 MAX SIN3A ZEB2 CTBP1 SMARCA4 ARHGAP19 SLIT1 SLIT1-AS1 LOC105378447 ENSG00000231398 ARHGAP19-SLIT1
GH10J097270 Promoter 0.7 EPDnew 662.7 +22.0 21996 0.1 TEAD3 ZBTB17 ARHGAP19 ENSG00000231398 ARHGAP19-SLIT1 LOC105378447
GH10J097265 Promoter 0.5 EPDnew 662.7 +26.7 26716 0.1 ARHGAP19 ENSG00000231398 ARHGAP19-SLIT1 LOC105378447
GH10J097405 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 21 -114.8 -114815 3.8 HDGF MLX ARID4B SIN3A ZNF2 ZNF143 DEK MXD4 REST ZNF592 FRAT2 RRP12 FRAT1 ARHGAP19 EXOSC1 ZDHHC16 MMS19 UBTD1 ENSG00000249967 HOGA1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARHGAP19 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARHGAP19 gene promoter:
  • Bach2
  • E2F-1
  • E2F
  • HTF
  • RFX1
  • Gfi-1
  • GR-beta
  • GR-alpha
  • GR
  • HNF-4alpha2

Genomic Locations for ARHGAP19 Gene

Genomic Locations for ARHGAP19 Gene
70,501 bases
Minus strand
73,435 bases
Minus strand

Genomic View for ARHGAP19 Gene

Genes around ARHGAP19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP19 Gene

Proteins for ARHGAP19 Gene

  • Protein details for ARHGAP19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho GTPase-activating protein 19
    Protein Accession:
    Secondary Accessions:
    • A1XCP1
    • B4DZR1
    • Q14CF2
    • Q5J8M2
    • Q5T460
    • Q5T462
    • Q68DG6
    • Q8N9X1
    • Q8NF34
    • Q8TEK1

    Protein attributes for ARHGAP19 Gene

    494 amino acids
    Molecular mass:
    55756 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB84948.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04165.1; Type=Frameshift; Positions=280; Evidence={ECO:0000305};

    Alternative splice isoforms for ARHGAP19 Gene

neXtProt entry for ARHGAP19 Gene

Post-translational modifications for ARHGAP19 Gene

  • Ubiquitination at Lys48
  • Modification sites at PhosphoSitePlus

Other Protein References for ARHGAP19 Gene

No data available for DME Specific Peptides for ARHGAP19 Gene

Domains & Families for ARHGAP19 Gene

Gene Families for ARHGAP19 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ARHGAP19 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARHGAP19: view

No data available for UniProtKB/Swiss-Prot for ARHGAP19 Gene

Function for ARHGAP19 Gene

Molecular function for ARHGAP19 Gene

UniProtKB/Swiss-Prot Function:
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Phenotypes From GWAS Catalog for ARHGAP19 Gene

Gene Ontology (GO) - Molecular Function for ARHGAP19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS --
genes like me logo Genes that share ontologies with ARHGAP19: view
genes like me logo Genes that share phenotypes with ARHGAP19: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARHGAP19 Gene

Localization for ARHGAP19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP19 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGAP19 gene
Compartment Confidence
cytosol 5
nucleus 4
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARHGAP19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with ARHGAP19: view

Pathways & Interactions for ARHGAP19 Gene

genes like me logo Genes that share pathways with ARHGAP19: view

Pathways by source for ARHGAP19 Gene

1 GeneTex pathway for ARHGAP19 Gene
3 Reactome pathways for ARHGAP19 Gene

Interacting Proteins for ARHGAP19 Gene

Gene Ontology (GO) - Biological Process for ARHGAP19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP19: view

No data available for SIGNOR curated interactions for ARHGAP19 Gene

Drugs & Compounds for ARHGAP19 Gene

No Compound Related Data Available

Transcripts for ARHGAP19 Gene

mRNA/cDNA for ARHGAP19 Gene

Unigene Clusters for ARHGAP19 Gene

Rho GTPase activating protein 19:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP19 Gene

No ASD Table

Relevant External Links for ARHGAP19 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARHGAP19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARHGAP19 Gene

mRNA differential expression in normal tissues according to GTEx for ARHGAP19 Gene

This gene is overexpressed in Nerve - Tibial (x6.7).

Protein differential expression in normal tissues from HIPED for ARHGAP19 Gene

This gene is overexpressed in Bone (63.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARHGAP19 Gene

Protein tissue co-expression partners for ARHGAP19 Gene

NURSA nuclear receptor signaling pathways regulating expression of ARHGAP19 Gene:


SOURCE GeneReport for Unigene cluster for ARHGAP19 Gene:


mRNA Expression by UniProt/SwissProt for ARHGAP19 Gene:

Tissue specificity: Strong expression in fetal heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Weak expression in adult pancreas, spleen, thymus, and ovary.

Evidence on tissue expression from TISSUES for ARHGAP19 Gene

  • Nervous system(4.3)
  • Bone marrow(4.2)
  • Spleen(4.2)
genes like me logo Genes that share expression patterns with ARHGAP19: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGAP19 Gene

Orthologs for ARHGAP19 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGAP19 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARHGAP19 33
  • 99.32 (n)
-- 34
  • 95 (a)
(Canis familiaris)
Mammalia -- 34
  • 92 (a)
  • 91.97 (n)
(Bos Taurus)
Mammalia ARHGAP19 33
  • 90.24 (n)
-- 34
  • 90 (a)
(Mus musculus)
Mammalia Arhgap19 16 34 33
  • 86.1 (n)
(Rattus norvegicus)
Mammalia Arhgap19 33
  • 85.96 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 81 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 78 (a)
(Gallus gallus)
Aves ARHGAP19 34 33
  • 72.9 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap19 33
  • 65.82 (n)
Str.635 33
(Danio rerio)
Actinopterygii arhgap19 34 33
  • 62.8 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001687 33
  • 44.5 (n)
fruit fly
(Drosophila melanogaster)
Insecta RhoGAP54D 34 33
  • 44.03 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RGA1 34
  • 5 (a)
RGA2 34
  • 5 (a)
Species where no ortholog for ARHGAP19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARHGAP19 Gene

Gene Tree for ARHGAP19 (if available)
Gene Tree for ARHGAP19 (if available)
Evolutionary constrained regions (ECRs) for ARHGAP19: view image

Paralogs for ARHGAP19 Gene

Paralogs for ARHGAP19 Gene

(5) SIMAP similar genes for ARHGAP19 Gene using alignment to 4 proteins:

  • H7C5Z9_HUMAN
genes like me logo Genes that share paralogs with ARHGAP19: view

Variants for ARHGAP19 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP19 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000062182 -- 97,256,984(-) G/A intron_variant
rs1000124263 -- 97,273,895(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000143399 -- 97,252,618(-) A/G intron_variant
rs1000180040 -- 97,250,705(-) A/G intron_variant
rs1000215740 -- 97,225,062(-) G/A 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP19 Gene

Variant ID Type Subtype PubMed ID
dgv503n106 CNV deletion 24896259
esv1001501 CNV deletion 20482838
esv1003170 CNV deletion 20482838
esv1315028 CNV deletion 17803354
esv2304672 CNV deletion 18987734
esv2429720 CNV deletion 19546169
esv2739851 CNV deletion 23290073
esv2739862 CNV deletion 23290073
esv3261163 CNV deletion 24192839
esv3546724 CNV deletion 23714750
esv3624311 CNV loss 21293372
esv5077 CNV loss 18987735
esv6307 CNV loss 19470904
nsv1040903 CNV gain 25217958
nsv1069066 CNV deletion 25765185
nsv1069067 CNV deletion 25765185
nsv1070883 CNV deletion 25765185
nsv1110852 OTHER inversion 24896259
nsv1127135 CNV deletion 24896259
nsv1150585 CNV deletion 26484159
nsv473431 CNV novel sequence insertion 20440878
nsv512179 CNV loss 21212237
nsv7507 CNV deletion 18451855
nsv831952 CNV loss 17160897
nsv950999 CNV deletion 24416366
nsv955563 CNV deletion 24416366

Variation tolerance for ARHGAP19 Gene

Residual Variation Intolerance Score: 45.4% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARHGAP19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP19 Gene

Disorders for ARHGAP19 Gene

Additional Disease Information for ARHGAP19

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ARHGAP19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGAP19 Gene

Publications for ARHGAP19 Gene

  1. Sequence analysis of a human RhoGAP domain-containing gene and characterization of its expression in human multiple tissues. (PMID: 17454002) Lv L … Mao Y (DNA sequence : the journal of DNA sequencing and mapping 2007) 3 4 58
  2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for ARHGAP19 Gene

Sources for ARHGAP19 Gene

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