Aliases for ARHGAP18 Gene
External Ids for ARHGAP18 Gene
Previous GeneCards Identifiers for ARHGAP18 Gene
ARHGAP18 belongs to a family of Rho (see MIM 165390) GTPase-activating proteins that modulate cell signaling (Potkin et al., 2009 [PubMed 19065146]).[supplied by OMIM, Apr 2010]
GeneCards Summary for ARHGAP18 Gene
ARHGAP18 (Rho GTPase Activating Protein 18) is a Protein Coding gene. Diseases associated with ARHGAP18 include Pthirus Pubis Infestation and Lice Infestation. Among its related pathways are Signaling by GPCR and p75 NTR receptor-mediated signalling. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP40.
UniProtKB/Swiss-Prot Summary for ARHGAP18 Gene
Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state (PubMed:21865595). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1 (PubMed:25778702). Regulates cell shape, spreading, and migration (PubMed:21865595).