Aliases for ARHGAP17 Gene
External Ids for ARHGAP17 Gene
Previous GeneCards Identifiers for ARHGAP17 Gene
RICH1 is a GTPase-activating protein (GAP). GAPs stimulate the intrinsic GTP hydrolysis of small G proteins, such as RHOA (MIM 165390), RAC1 (MIM 602048), and CDC42 (MIM 116952).[supplied by OMIM, Apr 2004]
GeneCards Summary for ARHGAP17 Gene
ARHGAP17 (Rho GTPase Activating Protein 17) is a Protein Coding gene. Diseases associated with ARHGAP17 include Spinal Canal Intradural Extramedullary Neoplasm and Deafness, Autosomal Recessive 25. Among its related pathways are Regulation of CDC42 activity and Tight junction. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and SH3 domain binding. An important paralog of this gene is ARHGAP44.
UniProtKB/Swiss-Prot Summary for ARHGAP17 Gene
Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1.