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Aliases for ARHGAP15 Gene

Aliases for ARHGAP15 Gene

  • Rho GTPase Activating Protein 15 2 3 5
  • Rho-Type GTPase-Activating Protein 15 3 4
  • Rho GTPase-Activating Protein 15 3
  • ArhGAP15 4
  • BM046 3

External Ids for ARHGAP15 Gene

Previous GeneCards Identifiers for ARHGAP15 Gene

  • GC02P142204
  • GC02P143909
  • GC02P144097
  • GC02P143720
  • GC02P143603
  • GC02P143565
  • GC02P143848
  • GC02P135878
  • GC02P143091

Summaries for ARHGAP15 Gene

Entrez Gene Summary for ARHGAP15 Gene

  • RHO GTPases (see ARHA; MIM 165390) regulate diverse biologic processes, and their activity is regulated by RHO GTPase-activating proteins (GAPs), such as ARHGAP15 (Seoh et al., 2003 [PubMed 12650940]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ARHGAP15 Gene

ARHGAP15 (Rho GTPase Activating Protein 15) is a Protein Coding gene. Among its related pathways are p75 NTR receptor-mediated signalling and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP12.

UniProtKB/Swiss-Prot for ARHGAP15 Gene

  • GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction.

Additional gene information for ARHGAP15 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP15 Gene

Genomics for ARHGAP15 Gene

GeneHancer (GH) Regulatory Elements for ARHGAP15 Gene

Promoters and enhancers for ARHGAP15 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J143127 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 650.2 +59.5 59485 5.7 HDGF STAT5A BMI1 BATF IRF4 ZNF207 ATF7 ETV6 BCLAF1 IKZF2 GC02P143132 ARHGAP15 MTCO3P5 ENSG00000231758 MTCO2P5 GC02P143090
GH02J143070 Promoter 0.5 EPDnew 650.7 0.0 -19 0.1 ARHGAP15 MTND3P9 GC02P143062
GH02J143261 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 6.3 +191.5 191473 2.9 PKNOX1 INSM2 FEZF1 KLF14 ZNF2 RAD21 ZEB1 ZNF366 ATF7 ZNF362 KYNU ARHGAP15 GC02P143346 ENSG00000257284
GH02J143148 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 6.9 +80.1 80079 5.1 PKNOX1 MNT MEF2B ELF1 ATF4 BCL11A TARDBP IKZF1 ATF7 ZNF24 ARHGAP15 GC02P143132 ENSG00000257284 GC02P143090
GH02J143544 Enhancer 0.7 UCNEbase ENCODE 11.7 +474.8 474759 1.9 ATF2 ARHGAP15 ENSG00000257640 ENSG00000258268 ENSG00000228655
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARHGAP15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARHGAP15 gene promoter:
  • LHX3b
  • Lhx3a
  • IRF-7A
  • CUTL1
  • FOXO3b
  • FOXO3a
  • FOXO3
  • AML1a
  • Evi-1
  • STAT3

Genomic Locations for ARHGAP15 Gene

Genomic Locations for ARHGAP15 Gene
697,385 bases
Plus strand
676,991 bases
Plus strand

Genomic View for ARHGAP15 Gene

Genes around ARHGAP15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP15 Gene

Proteins for ARHGAP15 Gene

  • Protein details for ARHGAP15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho GTPase-activating protein 15
    Protein Accession:
    Secondary Accessions:
    • Q53R36
    • Q53RD7
    • Q53RT6
    • Q53SX9
    • Q584N9
    • Q6PJE6
    • Q86WP1
    • Q8IXX1
    • Q9NRL8
    • Q9NZ77
    • Q9NZ91

    Protein attributes for ARHGAP15 Gene

    475 amino acids
    Molecular mass:
    54544 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF67618.1; Type=Frameshift; Positions=140, 185, 195, 202, 260, 265, 268, 311, 316, 323, 332; Evidence={ECO:0000305}; Sequence=AAF67633.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAF87324.1; Type=Frameshift; Positions=202, 233, 255, 259, 265, 268, 311, 314, 316, 320, 322, 326, 332, 338, 340, 418; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARHGAP15 Gene

neXtProt entry for ARHGAP15 Gene

Post-translational modifications for ARHGAP15 Gene

  • Ubiquitination at posLast=327327 and Lys206
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ARHGAP15 Gene

Domains & Families for ARHGAP15 Gene

Gene Families for ARHGAP15 Gene

Protein Domains for ARHGAP15 Gene

Suggested Antigen Peptide Sequences for ARHGAP15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The PH domain is required for localization to the membrane.
  • The PH domain is required for localization to the membrane.
genes like me logo Genes that share domains with ARHGAP15: view

Function for ARHGAP15 Gene

Molecular function for ARHGAP15 Gene

UniProtKB/Swiss-Prot Function:
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction.

Phenotypes From GWAS Catalog for ARHGAP15 Gene

Gene Ontology (GO) - Molecular Function for ARHGAP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS --
GO:0005515 protein binding IPI 12650940
genes like me logo Genes that share ontologies with ARHGAP15: view
genes like me logo Genes that share phenotypes with ARHGAP15: view

Animal Models for ARHGAP15 Gene

MGI Knock Outs for ARHGAP15:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARHGAP15 Gene

Localization for ARHGAP15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP15 Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGAP15 gene
Compartment Confidence
cytosol 5
nucleus 3
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (1)
  • Nucleoplasm (1)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARHGAP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ARHGAP15: view

Pathways & Interactions for ARHGAP15 Gene

genes like me logo Genes that share pathways with ARHGAP15: view

Pathways by source for ARHGAP15 Gene

1 BioSystems pathway for ARHGAP15 Gene
3 Reactome pathways for ARHGAP15 Gene

Gene Ontology (GO) - Biological Process for ARHGAP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0008360 regulation of cell shape IDA 12650940
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP15: view

No data available for SIGNOR curated interactions for ARHGAP15 Gene

Drugs & Compounds for ARHGAP15 Gene

No Compound Related Data Available

Transcripts for ARHGAP15 Gene

Unigene Clusters for ARHGAP15 Gene

Rho GTPase activating protein 15:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP15 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - -

Relevant External Links for ARHGAP15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARHGAP15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARHGAP15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGAP15 Gene

This gene is overexpressed in Whole Blood (x21.8) and Spleen (x4.1).

Protein differential expression in normal tissues from HIPED for ARHGAP15 Gene

This gene is overexpressed in Lymph node (15.9), Peripheral blood mononuclear cells (15.3), CD8 Tcells (10.6), and Blymphocyte (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARHGAP15 Gene

Protein tissue co-expression partners for ARHGAP15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARHGAP15 Gene:


SOURCE GeneReport for Unigene cluster for ARHGAP15 Gene:


mRNA Expression by UniProt/SwissProt for ARHGAP15 Gene:

Tissue specificity: Expressed in lung, liver and lymphoid cells.

Evidence on tissue expression from TISSUES for ARHGAP15 Gene

  • Bone marrow(4.4)
  • Liver(4.2)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with ARHGAP15: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGAP15 Gene

Orthologs for ARHGAP15 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP15 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARHGAP15 34 33
  • 99.72 (n)
(Canis familiaris)
Mammalia ARHGAP15 34 33
  • 94.18 (n)
(Bos Taurus)
Mammalia ARHGAP15 34 33
  • 92.98 (n)
(Monodelphis domestica)
Mammalia ARHGAP15 34
  • 91 (a)
(Mus musculus)
Mammalia Arhgap15 16 34 33
  • 88.37 (n)
(Rattus norvegicus)
Mammalia Arhgap15 33
  • 86.75 (n)
(Gallus gallus)
Aves ARHGAP15 34 33
  • 80.48 (n)
(Anolis carolinensis)
Reptilia ARHGAP15 34
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485536 33
  • 68.08 (n)
(Danio rerio)
Actinopterygii arhgap15 34 33
  • 64.27 (n)
(Caenorhabditis elegans)
Secernentea tag-325 34 33
  • 46.13 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 42 (a)
Species where no ortholog for ARHGAP15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP15 Gene

Gene Tree for ARHGAP15 (if available)
Gene Tree for ARHGAP15 (if available)
Evolutionary constrained regions (ECRs) for ARHGAP15: view image

Paralogs for ARHGAP15 Gene

(6) SIMAP similar genes for ARHGAP15 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ARHGAP15: view

Variants for ARHGAP15 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP15 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000000613 -- 143,352,815(+) A/C intron_variant
rs1000002339 -- 143,418,317(+) C/G intron_variant
rs1000004467 -- 143,393,496(+) G/A intron_variant
rs1000005137 -- 143,664,439(+) G/C genic_downstream_transcript_variant, intron_variant
rs1000015005 -- 143,460,699(+) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP15 Gene

Variant ID Type Subtype PubMed ID
dgv4086n100 CNV gain 25217958
esv26609 CNV gain 19812545
esv2667585 CNV deletion 23128226
esv2670420 CNV deletion 23128226
esv2672231 CNV deletion 23128226
esv2720910 CNV deletion 23290073
esv2720911 CNV deletion 23290073
esv2720912 CNV deletion 23290073
esv2720913 CNV deletion 23290073
esv2720914 CNV deletion 23290073
esv3303333 CNV mobile element insertion 20981092
esv3309422 CNV mobile element insertion 20981092
esv3328174 CNV insertion 20981092
esv3397923 CNV insertion 20981092
esv3560275 CNV deletion 23714750
esv3560276 CNV deletion 23714750
esv3560278 CNV deletion 23714750
esv3575308 CNV gain 25503493
esv3584098 CNV loss 25503493
esv3592749 CNV loss 21293372
esv3592750 CNV loss 21293372
esv3592751 CNV loss 21293372
esv3592753 CNV loss 21293372
esv3592756 CNV gain 21293372
esv3592757 CNV loss 21293372
esv994769 CNV insertion 20482838
nsv1001991 CNV loss 25217958
nsv1114140 CNV deletion 24896259
nsv1117261 CNV tandem duplication 24896259
nsv1127769 CNV deletion 24896259
nsv1139740 CNV duplication 24896259
nsv1150405 CNV duplication 26484159
nsv213976 CNV deletion 16902084
nsv2955 CNV insertion 18451855
nsv2956 CNV insertion 18451855
nsv459707 CNV loss 19166990
nsv477328 CNV novel sequence insertion 20440878
nsv515703 CNV loss 19592680
nsv519096 CNV loss 19592680
nsv523591 CNV loss 19592680
nsv524638 CNV loss 19592680
nsv583244 CNV loss 21841781
nsv583245 CNV loss 21841781
nsv821742 CNV gain 20364138
nsv821744 CNV gain 20364138
nsv821745 CNV loss 20364138
nsv955259 CNV duplication 24416366

Variation tolerance for ARHGAP15 Gene

Residual Variation Intolerance Score: 9.52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.39; 71.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARHGAP15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP15 Gene

Disorders for ARHGAP15 Gene

Additional Disease Information for ARHGAP15

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ARHGAP15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGAP15 Gene

Publications for ARHGAP15 Gene

  1. ArhGAP15, a novel human RacGAP protein with GTPase binding property. (PMID: 12650940) Seoh ML … Leung T (FEBS letters 2003) 2 3 4 58
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts. (PMID: 20468071) Dick DM … Bierut L (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 44 58
  5. Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. (PMID: 19197348) Lowe JK … Friedman JM (PLoS genetics 2009) 3 44 58

Products for ARHGAP15 Gene

Sources for ARHGAP15 Gene

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