Aliases for ARHGAP15 Gene
External Ids for ARHGAP15 Gene
Previous GeneCards Identifiers for ARHGAP15 Gene
RHO GTPases (see ARHA; MIM 165390) regulate diverse biologic processes, and their activity is regulated by RHO GTPase-activating proteins (GAPs), such as ARHGAP15 (Seoh et al., 2003 [PubMed 12650940]).[supplied by OMIM, Mar 2008]
GeneCards Summary for ARHGAP15 Gene
ARHGAP15 (Rho GTPase Activating Protein 15) is a Protein Coding gene. Diseases associated with ARHGAP15 include Diverticulitis. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP12.
UniProtKB/Swiss-Prot Summary for ARHGAP15 Gene
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction.