Aliases for ARHGAP12 Gene
External Ids for ARHGAP12 Gene
Previous GeneCards Identifiers for ARHGAP12 Gene
This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may be involved in suppressing tumor formation by regulating cell invasion and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
GeneCards Summary for ARHGAP12 Gene
ARHGAP12 (Rho GTPase Activating Protein 12) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and G-protein signaling_Regulation of RAC1 activity. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP27.
UniProtKB/Swiss-Prot Summary for ARHGAP12 Gene
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.