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Aliases for ARHGAP11B Gene

Aliases for ARHGAP11B Gene

  • Rho GTPase Activating Protein 11B 2 3 5
  • Family With Sequence Similarity 7, Member B1 2 3
  • Rho-Type GTPase-Activating Protein 11B 3 4
  • GAP (1-8) 2 3
  • FAM7B1 3 4
  • Rho GTPase-Activating Protein 11B 3
  • Protein FAM7B1 4
  • B-T 3

External Ids for ARHGAP11B Gene

Previous HGNC Symbols for ARHGAP11B Gene

  • FAM7B1

Previous GeneCards Identifiers for ARHGAP11B Gene

  • GC00U917803
  • GC15P028707
  • GC15P030918
  • GC15P008099
  • GC15P030921

Summaries for ARHGAP11B Gene

GeneCards Summary for ARHGAP11B Gene

ARHGAP11B (Rho GTPase Activating Protein 11B) is a Protein Coding gene. Diseases associated with ARHGAP11B include Chromosome 15Q13.3 Deletion Syndrome. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP11A.

UniProtKB/Swiss-Prot for ARHGAP11B Gene

  • Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex. Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis (PubMed:25721503). Does not possess GTPase activator activity (PubMed:25721503).

Additional gene information for ARHGAP11B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP11B Gene

Genomics for ARHGAP11B Gene

GeneHancer (GH) Regulatory Elements for ARHGAP11B Gene

Promoters and enhancers for ARHGAP11B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I030624 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.4 1407 3.8 HDGF PKNOX1 ATF1 ARNT ARID4B SIN3A FEZF1 DMAP1 NCOA2 POLR2B ARHGAP11B DNM1P50 ENSG00000247728 GOLGA8Q HMGN2P5 ENSG00000260382 ULK4P3 LOC100288637
GH15I030953 Enhancer 1.1 Ensembl ENCODE dbSUPER 4.2 +329.5 329503 1.7 MAX SIN3A FOSL1 CTBP1 ZNF316 VEZF1 ZNF143 TRIM24 FOSL2 NFE2 MTMR10 ARHGAP11B RNU6-466P ENSG00000270015
GH15I030941 Enhancer 0.3 dbSUPER 10.3 +318.5 318548 3.2 CTCF MTMR10 FAN1 ARHGAP11B ENSG00000260382 RNU6-466P ENSG00000270015
GH15I029996 Enhancer 0.4 dbSUPER 4.8 -626.6 -626568 2.3 ZNF133 PRDM1 ARHGAP11B NCAPGP2 TJP1
GH15I030000 Enhancer 0.4 dbSUPER 4.5 -621.3 -621320 5.9 ZNF366 REST ZBTB20 ARHGAP11B NCAPGP2 TJP1 ENSG00000259647
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ARHGAP11B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARHGAP11B gene promoter:

Genomic Locations for ARHGAP11B Gene

Genomic Locations for ARHGAP11B Gene
148,500 bases
Plus strand

Genomic View for ARHGAP11B Gene

Genes around ARHGAP11B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP11B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP11B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP11B Gene

Proteins for ARHGAP11B Gene

  • Protein details for ARHGAP11B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho GTPase-activating protein 11B
    Protein Accession:

    Protein attributes for ARHGAP11B Gene

    267 amino acids
    Molecular mass:
    30251 Da
    Quaternary structure:
    No Data Available
    • ARHGAP11B arose from partial duplication of ARHGAP11A on the human lineage after separation from the chimpanzee lineage, but before the divergence from Neandertals.
    • When expressed in embryonic mouse neocortex, promotes basal progenitor generation and self-renewal, and can increase cortical plate area and induce gyrification.

neXtProt entry for ARHGAP11B Gene

Post-translational modifications for ARHGAP11B Gene

No Post-translational modifications

Other Protein References for ARHGAP11B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARHGAP11B Gene

Domains & Families for ARHGAP11B Gene

Gene Families for ARHGAP11B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ARHGAP11B Gene

Suggested Antigen Peptide Sequences for ARHGAP11B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARHGAP11B: view

No data available for UniProtKB/Swiss-Prot for ARHGAP11B Gene

Function for ARHGAP11B Gene

Molecular function for ARHGAP11B Gene

UniProtKB/Swiss-Prot Function:
Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex. Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis (PubMed:25721503). Does not possess GTPase activator activity (PubMed:25721503).

Phenotypes From GWAS Catalog for ARHGAP11B Gene

Gene Ontology (GO) - Molecular Function for ARHGAP11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS --
genes like me logo Genes that share ontologies with ARHGAP11B: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ARHGAP11B Gene

Localization for ARHGAP11B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGAP11B gene
Compartment Confidence
cytosol 5
plasma membrane 1
mitochondrion 1
peroxisome 1
nucleus 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ARHGAP11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ARHGAP11B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP11B Gene

Pathways & Interactions for ARHGAP11B Gene

genes like me logo Genes that share pathways with ARHGAP11B: view

Pathways by source for ARHGAP11B Gene

3 Reactome pathways for ARHGAP11B Gene

Interacting Proteins for ARHGAP11B Gene

Gene Ontology (GO) - Biological Process for ARHGAP11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0021987 cerebral cortex development IDA 25721503
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP11B: view

No data available for SIGNOR curated interactions for ARHGAP11B Gene

Drugs & Compounds for ARHGAP11B Gene

No Compound Related Data Available

Transcripts for ARHGAP11B Gene

mRNA/cDNA for ARHGAP11B Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARHGAP11B Gene

Rho GTPase activating protein 11B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP11B Gene

No ASD Table

Relevant External Links for ARHGAP11B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARHGAP11B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARHGAP11B Gene

NURSA nuclear receptor signaling pathways regulating expression of ARHGAP11B Gene:


SOURCE GeneReport for Unigene cluster for ARHGAP11B Gene:

genes like me logo Genes that share expression patterns with ARHGAP11B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGAP11B Gene

Orthologs for ARHGAP11B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGAP11B Gene

Organism Taxonomy Gene Similarity Type Details
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 54 (a)
(Bos Taurus)
Mammalia ARHGAP11B 34
  • 21 (a)
(Canis familiaris)
Mammalia ARHGAP11B 34
  • 20 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 14 (a)
-- 34
  • 2 (a)
(Gallus gallus)
Aves ARHGAP11A 34
  • 7 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 15 (a)
(Danio rerio)
Actinopterygii arhgap11a 34
  • 15 (a)
fruit fly
(Drosophila melanogaster)
Insecta cv-c 34
  • 2 (a)
(Caenorhabditis elegans)
Secernentea gei-1 34
  • 3 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LRG1 34
  • 6 (a)
Species where no ortholog for ARHGAP11B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ARHGAP11B Gene

Gene Tree for ARHGAP11B (if available)
Gene Tree for ARHGAP11B (if available)

Paralogs for ARHGAP11B Gene

(1) SIMAP similar genes for ARHGAP11B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARHGAP11B: view

Variants for ARHGAP11B Gene

Sequence variations from dbSNP and Humsavar for ARHGAP11B Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000467266 -- 30,634,573(+) G/T intron_variant
rs1000750308 -- 30,632,924(+) A/G intron_variant
rs1000819585 -- 30,634,965(+) A/G intron_variant
rs1000867529 -- 30,637,322(+) T/C intron_variant
rs1001158834 -- 30,629,805(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP11B Gene

Variant ID Type Subtype PubMed ID
dgv106n111 OTHER complex 26073780
dgv20e213 CNV loss 24956385
dgv2495n100 CNV loss 25217958
dgv2496n100 CNV gain 25217958
dgv2500n100 CNV gain+loss 25217958
dgv2503n100 CNV loss 25217958
dgv2504n100 CNV gain 25217958
dgv2505n100 CNV loss 25217958
dgv2514n100 CNV loss 25217958
dgv2517n100 CNV loss 25217958
dgv2518n100 CNV gain 25217958
dgv2520n100 CNV loss 25217958
dgv2523n100 CNV gain 25217958
dgv2524n100 CNV loss 25217958
dgv2525n100 CNV loss 25217958
dgv2526n100 CNV loss 25217958
dgv2527n100 CNV loss 25217958
dgv2528n100 CNV loss 25217958
dgv2529n100 CNV gain+loss 25217958
dgv2530n100 CNV gain 25217958
dgv2531n100 CNV loss 25217958
dgv2532n100 CNV gain 25217958
dgv2533n100 CNV loss 25217958
dgv2538n100 CNV loss 25217958
dgv2544n100 CNV gain+loss 25217958
dgv2547n100 CNV loss 25217958
dgv42e203 CNV gain+loss 21179565
dgv431n67 CNV loss 20364138
dgv4425n54 CNV gain 21841781
dgv4426n54 CNV loss 21841781
dgv4456n54 CNV gain 21841781
dgv4457n54 CNV loss 21841781
esv1523587 CNV insertion 17803354
esv21965 CNV gain+loss 19812545
esv24159 CNV gain+loss 19812545
esv2421741 CNV deletion 20811451
esv2422296 CNV duplication 17116639
esv2751526 CNV loss 17911159
esv2760022 CNV gain+loss 17122850
esv2760023 CNV gain+loss 17122850
esv2760365 CNV gain+loss 21179565
esv33337 CNV gain+loss 17666407
esv3584688 CNV loss 24956385
esv3636025 CNV loss 21293372
esv3636026 CNV gain 21293372
esv3892646 CNV loss 25118596
esv3892661 CNV gain 25118596
nsv1049195 CNV gain 25217958
nsv1049639 CNV gain+loss 25217958
nsv1052620 CNV gain 25217958
nsv1148560 OTHER inversion 26484159
nsv1160272 CNV duplication 26073780
nsv428300 CNV loss 18775914
nsv428302 CNV gain+loss 18775914
nsv469587 CNV loss 16826518
nsv483039 CNV gain 15286789
nsv517740 CNV gain+loss 19592680
nsv518720 CNV gain 19592680
nsv568748 CNV loss 21841781
nsv568752 CNV loss 21841781
nsv832949 CNV gain 17160897
nsv9232 CNV gain+loss 18304495
nsv9239 CNV loss 18304495
nsv974547 CNV duplication 23825009
nsv977696 CNV duplication 23825009

Variation tolerance for ARHGAP11B Gene

Residual Variation Intolerance Score: 77% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.20; 24.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARHGAP11B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP11B Gene

Disorders for ARHGAP11B Gene

MalaCards: The human disease database

(1) MalaCards diseases for ARHGAP11B Gene - From: DISEASES

Disorder Aliases PubMed IDs
chromosome 15q13.3 deletion syndrome
  • chromosome 15q13.3 microdeletion syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ARHGAP11B

genes like me logo Genes that share disorders with ARHGAP11B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARHGAP11B Gene

Publications for ARHGAP11B Gene

  1. Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion. (PMID: 25721503) Florio M … Huttner WB (Science (New York, N.Y.) 2015) 2 3 4 58
  2. A 3-Mb map of a large Segmental duplication overlapping the alpha7-nicotinic acetylcholine receptor gene (CHRNA7) at human 15q13-q14. (PMID: 11829490) Riley B … Makoff A (Genomics 2002) 2 3 58
  3. A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy. (PMID: 23962720) Speed D … Johnson MR (Human molecular genetics 2014) 3 58
  4. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody MC … Nusbaum C (Nature 2006) 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for ARHGAP11B Gene

Sources for ARHGAP11B Gene

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