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Aliases for ARHGAP10 Gene

Aliases for ARHGAP10 Gene

  • Rho GTPase Activating Protein 10 2 3 5
  • GTPase Regulator Associated With Focal Adhesion Kinase 2 3 4
  • Rho-Type GTPase-Activating Protein 10 3 4
  • Graf-Related Protein 2 3 4
  • GRAF2 3 4
  • Rho GTPase-Activating Protein 10 3
  • PS-GAP 3
  • PSGAP 3

External Ids for ARHGAP10 Gene

Previous GeneCards Identifiers for ARHGAP10 Gene

  • GC10M024607
  • GC10M025022
  • GC04P149232
  • GC04P149011
  • GC04P148872
  • GC04P148653
  • GC04P144380

Summaries for ARHGAP10 Gene

GeneCards Summary for ARHGAP10 Gene

ARHGAP10 (Rho GTPase Activating Protein 10) is a Protein Coding gene. Among its related pathways are Ectoderm Differentiation and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARHGAP26.

UniProtKB/Swiss-Prot for ARHGAP10 Gene

  • GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity).

Additional gene information for ARHGAP10 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP10 Gene

Genomics for ARHGAP10 Gene

GeneHancer (GH) Regulatory Elements for ARHGAP10 Gene

Promoters and enhancers for ARHGAP10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I147730 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 550.8 +0.8 778 3.7 HDGF SIN3A ZNF2 ZNF121 GLIS2 ZNF143 KLF7 FOS RUNX3 SP3 ARHGAP10 PRMT9 RNA5SP165
GH04I147827 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 19.6 +98.3 98259 6.6 JUN FOSL1 ZFHX2 CTBP1 GATA3 FOSL2 RCOR1 FOS SMARCE1 SMARCC1 ARHGAP10 PRMT9 GC04P147826 RFPL4AP4
GH04I148059 Enhancer 1.2 FANTOM5 Ensembl ENCODE 12.4 +328.8 328840 2.2 CTCF MEIS2 KLF1 PKNOX1 ZBTB6 KLF17 FEZF1 ZFHX2 CTBP1 GLIS2 ARHGAP10 NR3C2 PRMT9 GC04P148078 GC04M148018
GH04I147799 Enhancer 1.2 Ensembl ENCODE dbSUPER 12.3 +68.0 68032 1.4 HDGF PKNOX1 RB1 BMI1 BATF KLF5 IRF4 ZNF143 ATF7 ETV6 GC04P147800 PRMT9 ARHGAP10 MIR4799
GH04I147753 Enhancer 1.1 Ensembl ENCODE dbSUPER 12.6 +23.5 23510 4.9 HDGF KLF1 BATF ZFHX2 ATF7 FOS RUNX3 EGR2 SRF JUNB ARHGAP10 RNA5SP165 GC04P147773
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ARHGAP10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARHGAP10 gene promoter:

Genomic Locations for ARHGAP10 Gene

Genomic Locations for ARHGAP10 Gene
chr4:147,732,063-148,072,780
(GRCh38/hg38)
Size:
340,718 bases
Orientation:
Plus strand
chr4:148,653,214-148,993,931
(GRCh37/hg19)

Genomic View for ARHGAP10 Gene

Genes around ARHGAP10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGAP10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGAP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP10 Gene

Proteins for ARHGAP10 Gene

  • Protein details for ARHGAP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A1A4S6-RHG10_HUMAN
    Recommended name:
    Rho GTPase-activating protein 10
    Protein Accession:
    A1A4S6
    Secondary Accessions:
    • A1L0S5
    • Q2VPC4
    • Q2VPC5
    • Q96EV3
    • Q96S75

    Protein attributes for ARHGAP10 Gene

    Size:
    786 amino acids
    Molecular mass:
    89375 Da
    Quaternary structure:
    • Interacts with PKN3. Interacts with caspase-activated PAK2 proteolytic fragment PAK-2p34; the interaction does not affect ARHGAP10 GTPase activation activity towards RHOA and CDC42. Interacts via its SH3 domain with PTK2/FAK1. Interacts with PTK2B/PYK2; the interaction negatively regulates ARHGAP10 GTPase-activating activity (By similarity).
    SequenceCaution:
    • Sequence=AAI26900.1; Type=Frameshift; Positions=785; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARHGAP10 Gene

neXtProt entry for ARHGAP10 Gene

Post-translational modifications for ARHGAP10 Gene

  • Phosphorylated. Phosphorylated in vitro by constitutive active PKN3.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGAP10 Gene

No data available for DME Specific Peptides for ARHGAP10 Gene

Domains & Families for ARHGAP10 Gene

Gene Families for ARHGAP10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ARHGAP10 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARHGAP10: view

No data available for UniProtKB/Swiss-Prot for ARHGAP10 Gene

Function for ARHGAP10 Gene

Molecular function for ARHGAP10 Gene

UniProtKB/Swiss-Prot Function:
GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity).

Phenotypes From GWAS Catalog for ARHGAP10 Gene

Gene Ontology (GO) - Molecular Function for ARHGAP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS --
GO:0005515 protein binding IPI 11432776
genes like me logo Genes that share ontologies with ARHGAP10: view

Phenotypes for ARHGAP10 Gene

genes like me logo Genes that share phenotypes with ARHGAP10: view

Animal Model Products

miRNA for ARHGAP10 Gene

miRTarBase miRNAs that target ARHGAP10

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARHGAP10 Gene

Localization for ARHGAP10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP10 Gene

Cytoplasm. Cytoplasm, perinuclear region. Cell membrane. Note=Association to cell membrane is dependent on PH domain. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGAP10 gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear membrane (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARHGAP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS,IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with ARHGAP10: view

Pathways & Interactions for ARHGAP10 Gene

genes like me logo Genes that share pathways with ARHGAP10: view

Pathways by source for ARHGAP10 Gene

Gene Ontology (GO) - Biological Process for ARHGAP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IEA --
GO:0007165 signal transduction IEA --
GO:0043066 negative regulation of apoptotic process IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGAP10: view

No data available for SIGNOR curated interactions for ARHGAP10 Gene

Drugs & Compounds for ARHGAP10 Gene

No Compound Related Data Available

Transcripts for ARHGAP10 Gene

Unigene Clusters for ARHGAP10 Gene

Rho GTPase activating protein 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP10 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18
SP1: - -
SP2: - -
SP3: - - - -
SP4: -
SP5:

Relevant External Links for ARHGAP10 Gene

GeneLoc Exon Structure for
ARHGAP10
ECgene alternative splicing isoforms for
ARHGAP10

Expression for ARHGAP10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARHGAP10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGAP10 Gene

This gene is overexpressed in Esophagus - Gastroesophageal Junction (x4.5) and Esophagus - Muscularis (x4.2).

Protein differential expression in normal tissues from HIPED for ARHGAP10 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (28.2), Islet of Langerhans (7.4), Monocytes (6.8), and Urinary Bladder (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARHGAP10 Gene



NURSA nuclear receptor signaling pathways regulating expression of ARHGAP10 Gene:

ARHGAP10

SOURCE GeneReport for Unigene cluster for ARHGAP10 Gene:

Hs.368631

mRNA Expression by UniProt/SwissProt for ARHGAP10 Gene:

A1A4S6-RHG10_HUMAN
Tissue specificity: High levels of expression in heart and skeletal muscle.

Evidence on tissue expression from TISSUES for ARHGAP10 Gene

  • Kidney(4.3)
genes like me logo Genes that share expression patterns with ARHGAP10: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGAP10 Gene

Orthologs for ARHGAP10 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGAP10 33 34
  • 98.85 (n)
dog
(Canis familiaris)
Mammalia ARHGAP10 33 34
  • 91.43 (n)
cow
(Bos Taurus)
Mammalia ARHGAP10 33 34
  • 89.81 (n)
oppossum
(Monodelphis domestica)
Mammalia ARHGAP10 34
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgap10 33 16 34
  • 86.9 (n)
rat
(Rattus norvegicus)
Mammalia Arhgap10 33
  • 86.6 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGAP10 34
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARHGAP10 33 34
  • 77.55 (n)
lizard
(Anolis carolinensis)
Reptilia ARHGAP10 34
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap10 33
  • 71.74 (n)
Str.18454 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.18359 33
zebrafish
(Danio rerio)
Actinopterygii arhgap10 33 34
  • 63.44 (n)
fruit fly
(Drosophila melanogaster)
Insecta RhoGAP19D 35
  • 44 (a)
Graf 34
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C04D8.1 35
  • 47 (a)
T04C9.1 34
  • 33 (a)
OneToMany
Species where no ortholog for ARHGAP10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP10 Gene

ENSEMBL:
Gene Tree for ARHGAP10 (if available)
TreeFam:
Gene Tree for ARHGAP10 (if available)

Paralogs for ARHGAP10 Gene

genes like me logo Genes that share paralogs with ARHGAP10: view

Variants for ARHGAP10 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP10 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs483352827 not-provided, not provided 147,875,034(+) T/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs483352828 not-provided, not provided 147,965,041(+) T/C coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs483352829 not-provided, not provided 148,064,463(+) A/G coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs483352830 not-provided, not provided 147,875,140(+) C/T coding_sequence_variant, non_coding_transcript_variant, synonymous_variant
rs483352831 not-provided, not provided 147,906,740(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP10 Gene

Variant ID Type Subtype PubMed ID
dgv5435n100 CNV gain 25217958
esv274865 CNV gain+loss 21479260
esv3302900 CNV tandem duplication 20981092
esv3398182 CNV duplication 20981092
esv3569743 CNV loss 25503493
esv3569744 CNV loss 25503493
esv3569745 CNV loss 25503493
esv3602608 CNV loss 21293372
esv3602610 CNV loss 21293372
esv3602611 CNV loss 21293372
esv3602612 CNV loss 21293372
nsv1017904 CNV loss 25217958
nsv1024596 CNV loss 25217958
nsv1126045 CNV deletion 24896259
nsv1136910 CNV deletion 24896259
nsv1139314 CNV deletion 24896259
nsv292987 CNV insertion 16902084
nsv478903 CNV novel sequence insertion 20440878

Variation tolerance for ARHGAP10 Gene

Residual Variation Intolerance Score: 79.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.23; 52.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARHGAP10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARHGAP10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP10 Gene

Disorders for ARHGAP10 Gene

Additional Disease Information for ARHGAP10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ARHGAP10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGAP10 Gene

Publications for ARHGAP10 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. A genome-wide association study of prognosis in breast cancer. (PMID: 20332263) Azzato EM … Kraft P (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 44 58
  3. Mutation of ARHGAP9 in patients with coronary spastic angina. (PMID: 19911011) Takefuji M … Kaibuchi K (Journal of human genetics 2010) 3 44 58
  4. A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project. (PMID: 20031603) Marroni F … EUROSPAN Consortium (Circulation. Cardiovascular genetics 2009) 3 44 58
  5. PKNbeta interacts with the SH3 domains of Graf and a novel Graf related protein, Graf2, which are GTPase activating proteins for Rho family. (PMID: 11432776) Shibata H … Ono Y (Journal of biochemistry 2001) 3 4 58

Products for ARHGAP10 Gene

Sources for ARHGAP10 Gene

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