Aliases for ARHGAP1 Gene
External Ids for ARHGAP1 Gene
Previous GeneCards Identifiers for ARHGAP1 Gene
This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein contains a SRC homology 3 domain and interacts with Bcl-2-associated protein family members. [provided by RefSeq, Aug 2012]
GeneCards Summary for ARHGAP1 Gene
ARHGAP1 (Rho GTPase Activating Protein 1) is a Protein Coding gene. Diseases associated with ARHGAP1 include Noma and Lowe Oculocerebrorenal Syndrome. Among its related pathways are Signaling by GPCR and Actin Nucleation by ARP-WASP Complex. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and SH3/SH2 adaptor activity. An important paralog of this gene is PRR5-ARHGAP8.
UniProtKB/Swiss-Prot Summary for ARHGAP1 Gene
GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate.