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This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein contains a SRC homology 3 domain and interacts with Bcl-2-associated protein family members. [provided by RefSeq, Aug 2012] See more...
Aliases for ARHGAP1 Gene
Aliases for ARHGAP1 Gene
External Ids for ARHGAP1 Gene
- HGNC: 673
- NCBI Entrez Gene: 392
- Ensembl: ENSG00000175220
- OMIM®: 602732
- UniProtKB/Swiss-Prot: Q07960
Previous GeneCards Identifiers for ARHGAP1 Gene
- GC11M048679
- GC11M047576
- GC11M046730
- GC11M046662
- GC11M046655
- GC11M046404
- GC11M046698
- GC11M047080
- GC11M047925
- GC11M055794
- GC11M056007
- GC11M056154
- GC11M059676
- GC11M050781
- GC11M051576
- GC11M052238
- GC11M052898
- GC11M053566
- GC11M054232
- GC11M054898
- GC11M055596
- GC11M061106
- GC11M063589
Summaries for ARHGAP1 Gene
-
This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein contains a SRC homology 3 domain and interacts with Bcl-2-associated protein family members. [provided by RefSeq, Aug 2012]
GeneCards Summary for ARHGAP1 Gene
ARHGAP1 (Rho GTPase Activating Protein 1) is a Protein Coding gene. Diseases associated with ARHGAP1 include Noma and Lowe Oculocerebrorenal Syndrome. Among its related pathways are p75 NTR receptor-mediated signalling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and SH3/SH2 adaptor activity. An important paralog of this gene is ARHGAP8.
UniProtKB/Swiss-Prot Summary for ARHGAP1 Gene
-
GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate.
Additional gene information for ARHGAP1 Gene
- HGNC (673)
- NCBI Entrez Gene (392)
- Ensembl (ENSG00000175220)
- OMIM® (602732)
- UniProtKB/Swiss-Prot (Q07960)
- Open Targets Platform(ENSG00000175220)
- Alliance of Genome Resources
- Search for ARHGAP1 at DataMed
- Search for ARHGAP1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARHGAP1 Gene
Genomics for ARHGAP1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ARHGAP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ARHGAP1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ARHGAP1
- Top Transcription factor binding sites by QIAGEN in the ARHGAP1 gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- CREB
- deltaCREB
- PPAR-gamma1
- PPAR-gamma2
Genomic Locations for ARHGAP1 Gene
Latest Assembly
- chr11:46,677,077-46,700,660
- (GRCh38/hg38)
- Size:
- 23,584 bases
- Orientation:
- Minus strand
Previous Assembly
- chr11:46,698,630-46,722,169
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 23,540 bases
- Orientation:
- Minus strand
Genomic View for ARHGAP1 Gene
Genes around ARHGAP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p11.2 by HGNC
- 11p11.2 by Entrez Gene
- 11p11.2 by Ensembl
ARHGAP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ARHGAP1 Gene
Proteins for ARHGAP1 Gene
-
Protein details for ARHGAP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q07960-RHG01_HUMAN
- Recommended name:
- Rho GTPase-activating protein 1
- Protein Accession:
- Q07960
- D3DQQ6
Protein attributes for ARHGAP1 Gene
- Size:
- 439 amino acids
- Molecular mass:
- 50436 Da
- Quaternary structure:
-
- Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with BNIPL.
- SequenceCaution:
-
- Sequence=AAA16142.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for ARHGAP1 Gene
Post-translational modifications for ARHGAP1 Gene
Other Protein References for ARHGAP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences ARHGAP1 / CDC42GAP Antibody
- G Biosciences Immunotag™ ARHGAP1 Antibody
-
Custom Antibody ServicesOriGene Antibodies for ARHGAP1
- Novus Biologicals Antibodies for ARHGAP1
-
Abcam antibodies for ARHGAP1
- Invitrogen Antibodies for ARHGAP1 (AFLGC-ARHGAP1)
-
Biorbyt antibodies for ARHGAP1
-
Custom Antibody ServicesProSci Antibodies for ARHGAP1
-
Santa Cruz Biotechnology (SCBT) Antibodies for ARHGAP1
- Sino Biological Antibodies for ARHGAP1
Protein products for research
-
OriGene Purified Proteins for ARHGAP1
- Search Origene for MassSpec and Protein Over-expression Lysates for ARHGAP1
- Origene Custom Protein Services for ARHGAP1
- antibodies-online: Show 4 available ARHGAP1 Proteins ranked by validation data
- Compare Top ARHGAP1 Proteins
-
Quality Products:
-
Abcam proteins for ARHGAP1
Assay products for research
No data available for DME Specific Peptides for ARHGAP1 Gene
Domains & Families for ARHGAP1 Gene
Gene Families for ARHGAP1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for ARHGAP1 Gene
- InterPro:
- Blocks:
-
- RhoGAP domain
- Cellular retinaldehyde-binding (CRAL)/Triple function domain (TRIO)
Suggested Antigen Peptide Sequences for ARHGAP1 Gene
- GenScript: Design optimal peptide antigens:
-
- p50-RhoGAP (RHG01_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ARHGAP1 Gene
Function for ARHGAP1 Gene
Molecular function for ARHGAP1 Gene
- UniProtKB/Swiss-Prot Function:
- GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate.
- GENATLAS Biochemistry:
- Rho/CDC42 GTPase activating protein 1,ubiquitously expressed
Phenotypes From GWAS Catalog for ARHGAP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005096 | GTPase activator activity | IDA | 8253717 |
| GO:0005515 | protein binding | IPI | 9262406 |
| GO:0017124 | SH3 domain binding | IEA | -- |
| GO:0031267 | small GTPase binding | IPI | 16380373 |
| GO:0045296 | cadherin binding | HDA | 25468996 |
Phenotypes for ARHGAP1 Gene
- MGI mutant phenotypes for ARHGAP1:
-
inferred from 1 alleles
- nervous system phenotype
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- cellular phenotype
- immune system phenotype
- mortality/aging
- renal/urinary system phenotype
- liver/biliary system phenotype
- hematopoietic system phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- skeleton phenotype
- integument phenotype
- embryo phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for ARHGAP1:
-
- Increased G1 DNA content
- Decreased viability
- no effect
- Decreased viability ratio
- Decreased viability after Maraba virus infection
- Decreased vaccinia virus (VACV) infection
- Increased IL-8 secretion
- Increased shRNA abundance (Z-score > 2)
- Decreased transferrin (TF) endocytosis, decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
- Decreased viability in ovarian lineage
- Increased gamma-H2AX phosphorylation
- Decreased shRNA abundance (Z-score < -2)
- Decreased Sindbis virus (SINV) infection
- G0/1 arrest
- Increased cell migration
Animal Models for ARHGAP1 Gene
- MGI Knock Outs for ARHGAP1:
-
- Arhgap1 Arhgap1<tm1Yizh>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ARHGAP1 - Starting at $85 >
- * ARHGAP1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ARHGAP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ARHGAP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for ARHGAP1
miRNA for ARHGAP1 Gene
- miRTarBase miRNAs that target ARHGAP1
-
- mmu-let-7b-5p (MIRT012227)
- mmu-miR-34b-5p (MIRT012921)
- hsa-miR-130b-3p (MIRT020316)
- hsa-miR-34a-5p (MIRT025280)
- hsa-miR-93-5p (MIRT028087)
- hsa-miR-19b-3p (MIRT031242)
- hsa-miR-20a-5p (MIRT441201)
- hsa-miR-106b-5p (MIRT441203)
- hsa-miR-433-5p (MIRT481597)
- hsa-miR-519c-3p (MIRT481598)
- hsa-miR-519b-3p (MIRT481599)
- hsa-miR-519a-3p (MIRT481600)
- hsa-miR-553 (MIRT481601)
- hsa-miR-548t-5p (MIRT481602)
- hsa-miR-548az-5p (MIRT481603)
- hsa-miR-106a-5p (MIRT481604)
- hsa-miR-17-5p (MIRT481605)
- hsa-miR-519d-3p (MIRT481606)
- hsa-miR-20b-5p (MIRT481607)
- hsa-miR-526b-3p (MIRT481608)
- hsa-miR-301b-3p (MIRT481609)
- hsa-miR-301a-3p (MIRT481610)
- hsa-miR-130a-3p (MIRT481611)
- hsa-miR-454-3p (MIRT481612)
- hsa-miR-4295 (MIRT481613)
- hsa-miR-3666 (MIRT481614)
- hsa-miR-19a-3p (MIRT481615)
- hsa-miR-1273e (MIRT481616)
- hsa-miR-25-5p (MIRT481617)
- hsa-miR-658 (MIRT481618)
- hsa-miR-1827 (MIRT481619)
- hsa-miR-219b-3p (MIRT481620)
- hsa-miR-4649-3p (MIRT481621)
- hsa-miR-4768-3p (MIRT481622)
- hsa-miR-940 (MIRT481623)
- hsa-miR-6893-5p (MIRT481624)
- hsa-miR-6808-5p (MIRT481625)
- hsa-miR-1912 (MIRT481626)
- hsa-miR-1295b-5p (MIRT481627)
- hsa-miR-302f (MIRT481628)
- hsa-miR-525-5p (MIRT494725)
- hsa-miR-520a-5p (MIRT494726)
- hsa-miR-506-3p (MIRT494727)
- hsa-miR-124-3p (MIRT494728)
- hsa-miR-198 (MIRT494729)
- hsa-miR-6770-5p (MIRT494730)
- hsa-miR-1253 (MIRT494731)
- hsa-miR-3919 (MIRT494732)
- hsa-miR-449c-5p (MIRT494733)
- hsa-miR-34b-5p (MIRT494734)
- hsa-miR-2682-5p (MIRT494735)
- hsa-miR-6511a-5p (MIRT494736)
- hsa-miR-1910-3p (MIRT494737)
- hsa-miR-6856-5p (MIRT494738)
- hsa-miR-6758-5p (MIRT494739)
- hsa-miR-3910 (MIRT494740)
- hsa-miR-3714 (MIRT494741)
- hsa-miR-424-3p (MIRT494742)
- hsa-miR-449b-5p (MIRT494743)
- hsa-miR-449a (MIRT494744)
- hsa-miR-34c-5p (MIRT494745)
- hsa-miR-6765-5p (MIRT530329)
- hsa-miR-4316 (MIRT530330)
- hsa-miR-3197 (MIRT530331)
- hsa-miR-6087 (MIRT530332)
- hsa-miR-6089 (MIRT530333)
- hsa-miR-4685-5p (MIRT530334)
- hsa-miR-6837-5p (MIRT530335)
- hsa-miR-3918 (MIRT530336)
- hsa-miR-4722-5p (MIRT559537)
- mmu-miR-1199-5p (MIRT594000)
- hsa-miR-3680-3p (MIRT630603)
- hsa-miR-557 (MIRT630604)
- hsa-miR-507 (MIRT630605)
- hsa-miR-450b-5p (MIRT630606)
- hsa-miR-19b-2-5p (MIRT630607)
- hsa-miR-19b-1-5p (MIRT630608)
- hsa-miR-19a-5p (MIRT630609)
- hsa-miR-4711-5p (MIRT630610)
- hsa-miR-7112-3p (MIRT630611)
- hsa-miR-153-5p (MIRT630612)
- hsa-miR-4328 (MIRT630613)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ARHGAP1
- Browse OriGene Inhibitory RNA Products For ARHGAP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARHGAP1
Clone products for research
- Applied Biological Materials (abm): Clones for ARHGAP1 - Starting at $45 >
- * ARHGAP1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for ARHGAP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ARHGAP1
Cell Lines for research
-
Horizon Cell Lines for ARHGAP1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARHGAP1 Gene
Localization for ARHGAP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP1 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| extracellular | 4 |
| endosome | 4 |
| nucleus | 3 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| golgi apparatus | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA,IDA | 25468996 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0010008 | endosome membrane | IDA | 16380373 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for ARHGAP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Actin Nucleation by ARP-WASP Complex |
CDC42 Pathway
.41
|
RhoA Pathway
.35
|
| 2 | G12-G13 in Cellular Signaling |
G12-G13 in Cellular Signaling
-
|
|
| 3 | RhoGDI Pathway |
RhoGDI Pathway
.33
|
|
| 4 | p75 NTR receptor-mediated signalling |
.36
|
|
| 5 | Signaling by GPCR | ||
Pathways by source for ARHGAP1 Gene
2 BioSystems pathways for ARHGAP1 Gene
3 Reactome pathways for ARHGAP1 Gene
3 GeneGo (Thomson Reuters) pathways for ARHGAP1 Gene
- G-protein signaling_Regulation of CDC42 activity
- G-protein signaling_Regulation of RAC1 activity
- G-protein signaling_RhoA regulation pathway
4 Qiagen pathways for ARHGAP1 Gene
- CDC42 Pathway
- G12-G13 in Cellular Signaling
- RhoA Pathway
- RhoGDI Pathway
1 GeneTex pathway for ARHGAP1 Gene
Interacting Proteins for ARHGAP1 Gene
Selected Interacting proteins:
Q07960-RHG01_HUMAN
ENSP00000310491
for ARHGAP1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for ARHGAP1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007264 | small GTPase mediated signal transduction | IDA | 8253717 |
| GO:0007266 | Rho protein signal transduction | TAS | 8253717 |
| GO:0016197 | endosomal transport | IMP | 16380373 |
| GO:0033572 | transferrin transport | IMP | 16380373 |
Drugs & Compounds for ARHGAP1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| HJC 0350 | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(1) ApexBio Compounds for ARHGAP1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| HJC 0350 | 885434-70-8 |
Transcripts for ARHGAP1 Gene
mRNA/cDNA for ARHGAP1 Gene
- 1 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000311956 3395 nts (view in UCSC)
- ENST00000524594 920 nts (view in UCSC)
- ENST00000525488 890 nts (view in UCSC)
- ENST00000526423 1377 nts (view in UCSC)
- ENST00000527588 2344 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ARHGAP1 - Starting at $85 >
- * ARHGAP1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ARHGAP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ARHGAP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for ARHGAP1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ARHGAP1
- Browse OriGene Inhibitory RNA Products For ARHGAP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARHGAP1
Clone products for research
- Applied Biological Materials (abm): Clones for ARHGAP1 - Starting at $45 >
- * ARHGAP1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for ARHGAP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ARHGAP1
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: |
| ExUns: | 14b |
|---|---|
| SP1: | |
| SP2: | |
| SP3: | |
| SP4: | |
| SP5: | |
| SP6: | |
| SP7: | |
| SP8: | |
| SP9: |
Relevant External Links for ARHGAP1 Gene
- GeneLoc Exon Structure for
- ARHGAP1
Expression for ARHGAP1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Placenta (Extraembryonic Tissues)
-
Gall Bladder (Hepatobiliary System)
-
Esophagus (Gastrointestinal Tract)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARHGAP1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ARHGAP1
SOURCE GeneReport for Unigene cluster for ARHGAP1 Gene:
Hs.138860mRNA Expression by UniProt/SwissProt for ARHGAP1 Gene:
Q07960-RHG01_HUMAN
Tissue specificity:
Ubiquitous.
Evidence on tissue expression from TISSUES for ARHGAP1 Gene
- Pancreas(4.6)
- Blood(4.5)
- Liver(4.5)
- Spleen(4.4)
- Nervous system(3.9)
- Kidney(2.7)
- Muscle(2.7)
- Heart(2.7)
- Intestine(2.6)
- Skin(2.6)
- Lung(2)
- Bone marrow(2)
- Lymph node(2)
- Eye(2)
Primer products for research
-
OriGene qPCR primer pairs for ARHGAP1
-
OriGene qPCR primer pairs and template standards for ARHGAP1
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGAP1 Gene
Orthologs for ARHGAP1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ARHGAP1 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ARHGAP1 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ARHGAP1 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Arhgap1 29 16 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | ARHGAP1 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Arhgap1 29 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ARHGAP1 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ARHGAP1 29 |
|
||
| Lizard (Anolis carolinensis) |
Reptilia | ARHGAP1 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | arhgap1 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | arhgap1 29 30 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | RhoGAP68F 29 30 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | rga-1 29 30 |
|
OneToMany | |
| W02B12.8 31 |
|
|
|||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 30 |
|
OneToMany | |
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC1565.02c 29 |
|
- Species where no ortholog for ARHGAP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for ARHGAP1 Gene
- ENSEMBL:
- Gene Tree for ARHGAP1 (if available)
- TreeFam:
- Gene Tree for ARHGAP1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ARHGAP1: view image
- Alliance of Genome Resources:
- Additional Orthologs for ARHGAP1
Paralogs for ARHGAP1 Gene
Paralogs for ARHGAP1 Gene
(14) SIMAP similar genes for ARHGAP1 Gene using alignment to 3 proteins:
- RHG01_HUMAN
- E9PNR6_HUMAN
- H0YE29_HUMAN
Variants for ARHGAP1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ARHGAP1 Gene
| SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 932503 | Likely Benign: not provided | 46,680,539(-) |
C/T NM_004308.5(ARHGAP1):c.768G>A (p.Gln256=) |
SYNONYMOUS | |
| rs11822837 | Likely Benign: not provided | 46,679,391(-) |
G/Ap.Arg369Cys NM_004308.5(ARHGAP1):c.1105C>T (p.Arg369Cys) |
MISSENSE | |
| rs144522434 | Benign: not provided | 46,680,675(-) |
G/T NM_004308.5(ARHGAP1):c.708C>A (p.Pro236=) |
SYNONYMOUS | |
| rs144801476 | Benign: not provided | 46,680,520(-) |
G/A NM_004308.5(ARHGAP1):c.787C>T (p.Leu263Phe) |
MISSENSE | |
| rs554016754 | Benign: not provided | 46,695,733(-) |
C/T NM_004308.5(ARHGAP1):c.156G>A (p.Pro52=) |
SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3626191 | CNV | gain | 21293372 |
| esv3626192 | CNV | loss | 21293372 |
Residual Variation Intolerance Score:
46.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.92;
35.79% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ARHGAP1 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP1 Gene
Disorders for ARHGAP1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| noma |
|
|
| lowe oculocerebrorenal syndrome |
|
|
| dent disease 1 |
|
|
| microphthalmia |
|
|
| non-syndromic x-linked intellectual disability |
|
|
Search ARHGAP1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ARHGAP1
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for ARHGAP1 Gene
Publications for ARHGAP1 Gene
- Characterization of rhoGAP. A GTPase-activating protein for rho-related small GTPases. (PMID: 8288572) Lancaster CA … Hall A (The Journal of biological chemistry 1994) 2 3 4 22
- BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis. (PMID: 12901880) Qin W … Gu J (Biochemical and biophysical research communications 2003) 3 4 22
- The structure of the GTPase-activating domain from p50rhoGAP. (PMID: 9009196) Barrett T … Eccleston JF (Nature 1997) 3 4 22
- Mutation of ARHGAP9 in patients with coronary spastic angina. (PMID: 19911011) Takefuji M … Kaibuchi K (Journal of human genetics 2010) 3 40
- Rho-kinase contributes to sustained RhoA activation through phosphorylation of p190A RhoGAP. (PMID: 19103606) Mori K … Kaibuchi K (The Journal of biological chemistry 2009) 3 22
ExternalLinks
Products for ARHGAP1 Gene
- Custom Antibody ServicesOriGene Antibodies for ARHGAP1
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- VectorBuilder Viral vectors for ARHGAP1 (ie. lentivirus, AAV, adenovirus)
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- VectorBuilder Virus packaging for ARHGAP1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for ARHGAP1
- antibodies-online: Show 23 available ARHGAP1 Antibodies ranked by validation data
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- antibodies-online: Search results for available ARHGAP1 related products ranked by validation data
- antibodies-online: Show 4 available ARHGAP1 Proteins ranked by validation data
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- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for ARHGAP1
- Search Santa Cruz Biotechnology (SCBT) for ARHGAP1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ARHGAP1
- Horizon Cell Lines for ARHGAP1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ARHGAP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ARHGAP1
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- Biorbyt antibodies for ARHGAP1
Sources for ARHGAP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
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- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
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