Aliases for ARHGAP1 Gene
Aliases for ARHGAP1 Gene
External Ids for ARHGAP1 Gene
- HGNC: 673
- Entrez Gene: 392
- Ensembl: ENSG00000175220
- OMIM: 602732
- UniProtKB: Q07960
Previous GeneCards Identifiers for ARHGAP1 Gene
- GC11M048679
- GC11M047576
- GC11M046730
- GC11M046662
- GC11M046655
- GC11M046404
- GC11M046698
- GC11M047080
- GC11M047925
- GC11M050781
- GC11M051576
- GC11M052238
- GC11M052898
- GC11M053566
Summaries for ARHGAP1 Gene
-
This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein contains a SRC homology 3 domain and interacts with Bcl-2-associated protein family members. [provided by RefSeq, Aug 2012]
GeneCards Summary for ARHGAP1 Gene
ARHGAP1 (Rho GTPase Activating Protein 1) is a Protein Coding gene. Diseases associated with ARHGAP1 include Noma. Among its related pathways are Actin Nucleation by ARP-WASP Complex and Regulation of CDC42 activity. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and SH3/SH2 adaptor activity. An important paralog of this gene is PRR5-ARHGAP8.
UniProtKB/Swiss-Prot for ARHGAP1 Gene
-
GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate.
Additional gene information for ARHGAP1 Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP1 Gene
Genomics for ARHGAP1 Gene
GeneHancer (GH) Regulatory Elements for ARHGAP1 Gene
Promoters and enhancers for ARHGAP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ARHGAP1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ARHGAP1 gene promoter:
Regulatory Element Products
Genomic Locations for ARHGAP1 Gene
Genomic Locations for ARHGAP1 Gene
- chr11:46,677,075-46,700,665
- (GRCh38/hg38)
- Size:
- 23,591 bases
- Orientation:
- Minus strand
- chr11:46,698,630-46,722,165
- (GRCh37/hg19)
Genomic View for ARHGAP1 Gene
Genes around ARHGAP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p11.2 by Ensembl
- 11p11.2 by Entrez Gene
- 11p11.2 by HGNC
ARHGAP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ARHGAP1 Gene
Proteins for ARHGAP1 Gene
-
Protein details for ARHGAP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q07960-RHG01_HUMAN
- Recommended name:
- Rho GTPase-activating protein 1
- Protein Accession:
- Q07960
- D3DQQ6
Protein attributes for ARHGAP1 Gene
- Size:
- 439 amino acids
- Molecular mass:
- 50436 Da
- Quaternary structure:
-
- Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with BNIPL.
- SequenceCaution:
-
- Sequence=AAA16142.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for ARHGAP1 Gene
Post-translational modifications for ARHGAP1 Gene
- Ubiquitination at Lys212
Other Protein References for ARHGAP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for ARHGAP1 (ARHGAP1)
-
Custom Antibody ServicesOriGene Antibodies for ARHGAP1
- Novus Biologicals Antibodies for ARHGAP1
-
Abcam antibodies for ARHGAP1
- Invitrogen Antibodies for ARHGAP1
- GeneTex ARHGAP1 antibody for ARHGAP1
-
Santa Cruz Biotechnology (SCBT) Antibodies for ARHGAP1
Protein Products
-
OriGene Purified Proteins for ARHGAP1
- Search Origene for MassSpec and Protein Over-expression Lysates for ARHGAP1
- Origene Custom Protein Services for ARHGAP1
- antibodies-online: Search results for 4 available ARHGAP1 Proteins ranked by validation data
- Compare Top ARHGAP1 Proteins
-
Quality Products:
- Search GeneTex for Proteins for ARHGAP1
-
Abcam proteins for ARHGAP1
Assay Products
No data available for DME Specific Peptides for ARHGAP1 Gene
Domains & Families for ARHGAP1 Gene
Gene Families for ARHGAP1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for ARHGAP1 Gene
Suggested Antigen Peptide Sequences for ARHGAP1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for ARHGAP1 Gene
Function for ARHGAP1 Gene
Molecular function for ARHGAP1 Gene
- GENATLAS Biochemistry:
- Rho/CDC42 GTPase activating protein 1,ubiquitously expressed
- UniProtKB/Swiss-Prot Function:
- GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate.
Phenotypes From GWAS Catalog for ARHGAP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005070 | SH3/SH2 adaptor activity | TAS | 8253717 |
| GO:0005096 | GTPase activator activity | IDA,TAS | -- |
| GO:0005515 | protein binding | IPI | 9262406 |
| GO:0017124 | SH3 domain binding | IEA | -- |
| GO:0017137 | Rab GTPase binding | IPI | 16380373 |
Phenotypes for ARHGAP1 Gene
- MGI mutant phenotypes for ARHGAP1:
-
inferred from 1 alleles
- nervous system phenotype
- homeostasis/metabolism phenotype
- muscle phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- growth/size/body region phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- integument phenotype
- embryo phenotype
- hematopoietic system phenotype
- skeleton phenotype
- renal/urinary system phenotype
- liver/biliary system phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for ARHGAP1:
-
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased viability
- Decreased viability in esophageal squamous lineage
- Decreased viability ratio
- Increased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Decreased viability after Maraba virus infection
- Increased G1 DNA content
- G0/1 arrest
- Decreased IL-8 secretion
- Decreased cell migration
- Decreased shRNA abundance (Z-score < -2)
- Increased Sindbis virus (SINV) infection
- Increased cell migration
Animal Models for ARHGAP1 Gene
- MGI Knock Outs for ARHGAP1:
-
- Arhgap1 tm1Yizh
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ARHGAP1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ARHGAP1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ARHGAP1 gene
- Search ViGene Biosciences for ARHGAP1
CRISPR Products
-
OriGene CRISPR knockouts for ARHGAP1
- genomics-online: gRNA clones - Search results for 129 available ARHGAP1 gene related products
- Overview of 129 available ARHGAP1 gene related products
- Applied Biological Materials CRISPR for ARHGAP1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ARHGAP1
- GenScript: Design CRISPR guide RNA sequences for ARHGAP1
miRNA for ARHGAP1 Gene
- miRTarBase miRNAs that target ARHGAP1
-
- hsa-mir-130b-3p (MIRT020316)
- hsa-mir-34a-5p (MIRT025280)
- hsa-mir-93-5p (MIRT028087)
- hsa-mir-19b-3p (MIRT031242)
- hsa-mir-20a-5p (MIRT441201)
- hsa-mir-106b-5p (MIRT441203)
- hsa-mir-433-5p (MIRT481597)
- hsa-mir-519c-3p (MIRT481598)
- hsa-mir-519b-3p (MIRT481599)
- hsa-mir-519a-3p (MIRT481600)
- hsa-mir-553 (MIRT481601)
- hsa-mir-548t-5p (MIRT481602)
- hsa-mir-548az-5p (MIRT481603)
- hsa-mir-106a-5p (MIRT481604)
- hsa-mir-17-5p (MIRT481605)
- hsa-mir-519d-3p (MIRT481606)
- hsa-mir-20b-5p (MIRT481607)
- hsa-mir-526b-3p (MIRT481608)
- hsa-mir-301b-3p (MIRT481609)
- hsa-mir-301a-3p (MIRT481610)
- hsa-mir-130a-3p (MIRT481611)
- hsa-mir-454-3p (MIRT481612)
- hsa-mir-4295 (MIRT481613)
- hsa-mir-3666 (MIRT481614)
- hsa-mir-19a-3p (MIRT481615)
- hsa-mir-1273e (MIRT481616)
- hsa-mir-25-5p (MIRT481617)
- hsa-mir-658 (MIRT481618)
- hsa-mir-1827 (MIRT481619)
- hsa-mir-219b-3p (MIRT481620)
- hsa-mir-4649-3p (MIRT481621)
- hsa-mir-4768-3p (MIRT481622)
- hsa-mir-940 (MIRT481623)
- hsa-mir-6893-5p (MIRT481624)
- hsa-mir-6808-5p (MIRT481625)
- hsa-mir-1912 (MIRT481626)
- hsa-mir-1295b-5p (MIRT481627)
- hsa-mir-302f (MIRT481628)
- hsa-mir-525-5p (MIRT494725)
- hsa-mir-520a-5p (MIRT494726)
- hsa-mir-506-3p (MIRT494727)
- hsa-mir-124-3p (MIRT494728)
- hsa-mir-198 (MIRT494729)
- hsa-mir-6770-5p (MIRT494730)
- hsa-mir-1253 (MIRT494731)
- hsa-mir-3919 (MIRT494732)
- hsa-mir-449c-5p (MIRT494733)
- hsa-mir-34b-5p (MIRT494734)
- hsa-mir-2682-5p (MIRT494735)
- hsa-mir-6511a-5p (MIRT494736)
- hsa-mir-1910-3p (MIRT494737)
- hsa-mir-6856-5p (MIRT494738)
- hsa-mir-6758-5p (MIRT494739)
- hsa-mir-3910 (MIRT494740)
- hsa-mir-3714 (MIRT494741)
- hsa-mir-424-3p (MIRT494742)
- hsa-mir-449b-5p (MIRT494743)
- hsa-mir-449a (MIRT494744)
- hsa-mir-34c-5p (MIRT494745)
- hsa-mir-6765-5p (MIRT530329)
- hsa-mir-4316 (MIRT530330)
- hsa-mir-3197 (MIRT530331)
- hsa-mir-6087 (MIRT530332)
- hsa-mir-6089 (MIRT530333)
- hsa-mir-4685-5p (MIRT530334)
- hsa-mir-6837-5p (MIRT530335)
- hsa-mir-3918 (MIRT530336)
- hsa-mir-4722-5p (MIRT559537)
- hsa-mir-3680-3p (MIRT630603)
- hsa-mir-557 (MIRT630604)
- hsa-mir-507 (MIRT630605)
- hsa-mir-450b-5p (MIRT630606)
- hsa-mir-19b-2-5p (MIRT630607)
- hsa-mir-19b-1-5p (MIRT630608)
- hsa-mir-19a-5p (MIRT630609)
- hsa-mir-4711-5p (MIRT630610)
- hsa-mir-7112-3p (MIRT630611)
- hsa-mir-153-5p (MIRT630612)
- hsa-mir-4328 (MIRT630613)
miRNA Products
- Search ViGene Biosciences for ARHGAP1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for ARHGAP1
- Browse OriGene Inhibitory RNA Products For ARHGAP1
- genomics-online: shRNA clones - Search results for 129 available ARHGAP1 gene related products
- Overview of 129 available ARHGAP1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ARHGAP1 gene
Clone Products
- Sino Biological Human cDNA Clone for ARHGAP1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ARHGAP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ARHGAP1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for ARHGAP1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ARHGAP1
-
ViGene Biosciences adenoviral particle packaged cDNA for ARHGAP1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ARHGAP1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ARHGAP1 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARHGAP1 Gene
Localization for ARHGAP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP1 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 5 |
| endosome | 5 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| nucleus | 2 |
| mitochondrion | 1 |
| golgi apparatus | 1 |
- Vesicles (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IDA,IEA | 25468996 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0010008 | endosome membrane | IDA | 16380373 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for ARHGAP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Actin Nucleation by ARP-WASP Complex |
.41
|
.35
|
| 2 | G12-G13 in Cellular Signaling | ||
| 3 | RhoGDI Pathway |
.33
|
|
| 4 | p75 NTR receptor-mediated signalling |
.36
|
|
| 5 | Signaling by GPCR | ||
Pathways by source for ARHGAP1 Gene
1 GeneTex pathway for ARHGAP1 Gene
2 BioSystems pathways for ARHGAP1 Gene
3 Reactome pathways for ARHGAP1 Gene
3 GeneGo (Thomson Reuters) pathways for ARHGAP1 Gene
4 Qiagen pathways for ARHGAP1 Gene
Interacting Proteins for ARHGAP1 Gene
Selected Interacting proteins:
ENSP00000310491
Q07960-RHG01_HUMAN
for ARHGAP1 Gene via
STRING
IID
MINT
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007264 | small GTPase mediated signal transduction | IDA | 8253717 |
| GO:0007266 | Rho protein signal transduction | TAS | 8253717 |
| GO:0009967 | positive regulation of signal transduction | IEA | -- |
| GO:0032439 | endosome localization | IMP | 16380373 |
No data available for SIGNOR curated interactions for ARHGAP1 Gene
Drugs & Compounds for ARHGAP1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| HJC 0350 | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(1) ApexBio Compounds for ARHGAP1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| HJC 0350 | 885434-70-8 |
Transcripts for ARHGAP1 Gene
mRNA/cDNA for ARHGAP1 Gene
- (3) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (291) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ARHGAP1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ARHGAP1
- genomics-online: gRNA clones - Search results for 129 available ARHGAP1 gene related products
- Overview of 129 available ARHGAP1 gene related products
- Applied Biological Materials CRISPR for ARHGAP1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ARHGAP1
- GenScript: Design CRISPR guide RNA sequences for ARHGAP1
miRNA Products
- Search ViGene Biosciences for ARHGAP1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for ARHGAP1
- Browse OriGene Inhibitory RNA Products For ARHGAP1
- genomics-online: shRNA clones - Search results for 129 available ARHGAP1 gene related products
- Overview of 129 available ARHGAP1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ARHGAP1 gene
Clone Products
- Sino Biological Human cDNA Clone for ARHGAP1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ARHGAP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ARHGAP1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for ARHGAP1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: |
| ExUns: | 14b |
|---|---|
| SP1: | |
| SP2: | |
| SP3: | |
| SP4: | |
| SP5: | |
| SP6: | |
| SP7: | |
| SP8: | |
| SP9: |
Expression for ARHGAP1 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARHGAP1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ARHGAP1 Gene:
ARHGAP1SOURCE GeneReport for Unigene cluster for ARHGAP1 Gene:
Hs.138860mRNA Expression by UniProt/SwissProt for ARHGAP1 Gene:
Q07960-RHG01_HUMAN
Tissue specificity:
Ubiquitous.
Evidence on tissue expression from TISSUES for ARHGAP1 Gene
- Pancreas(4.5)
- Blood(4.4)
- Liver(4.4)
- Spleen(4.3)
- Nervous system(3.7)
- Kidney(2.4)
- Heart(2.3)
- Muscle(2.3)
Primer Products
-
OriGene qPCR primer pairs for ARHGAP1
-
OriGene qPCR primer pairs and template standards for ARHGAP1
- genomics-online: primer clones - Search results for 129 available ARHGAP1 gene related products
- Overview of 129 available ARHGAP1 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGAP1 Gene
Orthologs for ARHGAP1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ARHGAP1 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | ARHGAP1 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | ARHGAP1 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Arhgap1 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ARHGAP1 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Arhgap1 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ARHGAP1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ARHGAP1 33 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ARHGAP1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | arhgap1 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | arhgap1 33 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | RhoGAP68F 35 33 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | rga-1 33 34 |
|
||
| W02B12.8 35 |
|
|
|||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany | |
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC1565.02c 33 |
|
- Species where no ortholog for ARHGAP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ARHGAP1 Gene
Paralogs for ARHGAP1 Gene
(14) SIMAP similar genes for ARHGAP1 Gene using alignment to 3 proteins:
Variants for ARHGAP1 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs796065313 | uncertain-significance, Exudative vitreoretinopathy 1 | 46,700,832(-) | TCGAATC/TC | upstream_transcript_variant | |
| rs796065314 | uncertain-significance, Exudative vitreoretinopathy 1 | 46,700,937(-) | C/A | upstream_transcript_variant | |
| rs796065315 | uncertain-significance, Exudative vitreoretinopathy 1 | 46,701,476(-) | C/T | upstream_transcript_variant | |
| rs1000133654 | -- | 46,691,698(-) | C/T | intron_variant | |
| rs1000254810 | -- | 46,691,373(-) | C/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3626192 | CNV | loss | 21293372 |
| esv3626191 | CNV | gain | 21293372 |
Residual Variation Intolerance Score:
46.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.92;
35.79% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ARHGAP1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ARHGAP1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP1 Gene
Disorders for ARHGAP1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| noma |
|
|
Search ARHGAP1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ARHGAP1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ARHGAP1 Gene
Publications for ARHGAP1 Gene
- Characterization of rhoGAP. A GTPase-activating protein for rho-related small GTPases. (PMID: 8288572) Lancaster CA … Hall A (The Journal of biological chemistry 1994) 2 3 4 22 58
- BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis. (PMID: 12901880) Qin W … Gu J (Biochemical and biophysical research communications 2003) 3 4 22 58
- The structure of the GTPase-activating domain from p50rhoGAP. (PMID: 9009196) Barrett T … Eccleston JF (Nature 1997) 3 4 22 58
- Mutation of ARHGAP9 in patients with coronary spastic angina. (PMID: 19911011) Takefuji M … Kaibuchi K (Journal of human genetics 2010) 3 44 58
- Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. (PMID: 19801982) Rivadeneira F … Genetic Factors for Osteoporosis (GEFOS) Consortium (Nature genetics 2009) 3 44 58
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Sources for ARHGAP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
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- (114) diseasecard
- (115) NIH Rare Diseases
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- (133) ENCODE
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- (135) Horizon
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- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
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- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew