Aliases for ARGLU1 Gene

Aliases for ARGLU1 Gene

  • Arginine And Glutamate Rich 1 2 3 5
  • Arginine And Glutamate-Rich Protein 1 3 4

External Ids for ARGLU1 Gene

Previous GeneCards Identifiers for ARGLU1 Gene

  • GC13M105992
  • GC13M107194
  • GC13M087787

Summaries for ARGLU1 Gene

GeneCards Summary for ARGLU1 Gene

ARGLU1 (Arginine And Glutamate Rich 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for ARGLU1 Gene

  • Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1.

Additional gene information for ARGLU1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARGLU1 Gene

Genomics for ARGLU1 Gene

GeneHancer (GH) Regulatory Elements for ARGLU1 Gene

Promoters and enhancers for ARGLU1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J106564 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 511.9 +0.2 225 6.3 EP300 NRF1 MYC POLR2G PHF8 ZFX ZNF639 POLR2A CLOCK ZBTB26 ARGLU1 LINC00551 LOC105370348 LINC00443 lnc-EFNB2-6
GH13J106561 Promoter/Enhancer 1 Ensembl ENCODE 12.2 +6.3 6340 1.6 RELA MEF2C POLR2A MEF2B RBM22 ZFHX2 BATF EBF1 IKZF1 RB1 lnc-EFNB2-6 ARGLU1 DQ866757
GH13J106033 Enhancer 0.5 ENCODE 11.6 +534.3 534279 0.2 CTCF SCRT1 RAD21 GATA3 ZBTB49 ZNF660 CEBPB PRDM1 CEBPG ARGLU1 ENSG00000287923 HSALNG0099148
GH13J106573 Enhancer 0.7 FANTOM5 Ensembl ENCODE 7.3 -5.2 -5163 0.7 FOS STAT3 ARGLU1 LOC105370348 LINC00551 lnc-ARGLU1-1
GH13J106548 Enhancer 0.4 Ensembl 10.7 +19.5 19504 0.7 FOS POLR2A FOSL2 FOXA1 CEBPB DQ866757 ARGLU1 lnc-EFNB2-6 EFNB2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARGLU1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ARGLU1

Top Transcription factor binding sites by QIAGEN in the ARGLU1 gene promoter:
  • AREB6
  • Chx10
  • E2F
  • E2F-1
  • FOXL1
  • FOXO4
  • Ik-1
  • MAZR
  • POU3F2 (N-Oct-5b)
  • ZID

Genomic Locations for ARGLU1 Gene

Genomic Locations for ARGLU1 Gene
26,494 bases
Minus strand
26,494 bases
Minus strand

Genomic View for ARGLU1 Gene

Genes around ARGLU1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARGLU1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARGLU1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARGLU1 Gene

Proteins for ARGLU1 Gene

  • Protein details for ARGLU1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Arginine and glutamate-rich protein 1
    Protein Accession:
    Secondary Accessions:
    • B4E0Y3
    • Q5T257
    • Q6IQ34

    Protein attributes for ARGLU1 Gene

    273 amino acids
    Molecular mass:
    33216 Da
    Quaternary structure:
    • Directly interacts with MED1.

    Alternative splice isoforms for ARGLU1 Gene


neXtProt entry for ARGLU1 Gene

Post-translational modifications for ARGLU1 Gene

  • Ubiquitination at Lys270
  • Modification sites at PhosphoSitePlus

Other Protein References for ARGLU1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARGLU1 Gene

Domains & Families for ARGLU1 Gene

Gene Families for ARGLU1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ARGLU1 Gene


Suggested Antigen Peptide Sequences for ARGLU1 Gene

GenScript: Design optimal peptide antigens:
  • Arginine and glutamate-rich protein 1 (ARGL1_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0430 family.
  • Belongs to the UPF0430 family.
genes like me logo Genes that share domains with ARGLU1: view

Function for ARGLU1 Gene

Molecular function for ARGLU1 Gene

UniProtKB/Swiss-Prot Function:
Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1.

Phenotypes From GWAS Catalog for ARGLU1 Gene

Gene Ontology (GO) - Molecular Function for ARGLU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22365833
GO:0045296 cadherin binding HDA 25468996
genes like me logo Genes that share ontologies with ARGLU1: view
genes like me logo Genes that share phenotypes with ARGLU1: view

Animal Models for ARGLU1 Gene

MGI Knock Outs for ARGLU1:
  • Arglu1 Arglu1<tm1a(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARGLU1 Gene

Localization for ARGLU1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARGLU1 Gene

Nucleus. Note=Recruited, in an estrogen-dependent manner, to ESR1 target gene promoters. Colocalizes with MED1.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARGLU1 gene
Compartment Confidence
nucleus 5
mitochondrion 4
cytosol 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
  • Cytosol (1)
  • Mitochondria (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARGLU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA --
GO:0005654 nucleoplasm IBA,IDA --
GO:0005739 mitochondrion IDA,IBA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with ARGLU1: view

Pathways & Interactions for ARGLU1 Gene

PathCards logo

SuperPathways for ARGLU1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARGLU1 Gene


No data available for Pathways by source and SIGNOR curated interactions for ARGLU1 Gene

Drugs & Compounds for ARGLU1 Gene

No Compound Related Data Available

Transcripts for ARGLU1 Gene

mRNA/cDNA for ARGLU1 Gene

11 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARGLU1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d
SP1: - - - - -
SP2: - - - - - -
SP3: -
SP5: -

Relevant External Links for ARGLU1 Gene

GeneLoc Exon Structure for

Expression for ARGLU1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARGLU1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARGLU1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.5) and Spleen (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARGLU1 Gene

Protein tissue co-expression partners for ARGLU1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ARGLU1

SOURCE GeneReport for Unigene cluster for ARGLU1 Gene:


Evidence on tissue expression from TISSUES for ARGLU1 Gene

  • Liver(4.4)
  • Nervous system(4)
  • Lung(3.3)
  • Pancreas(2.2)
  • Intestine(2.1)
  • Lymph node(2.1)
  • Spleen(2.1)
  • Stomach(2)
genes like me logo Genes that share expression patterns with ARGLU1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARGLU1 Gene

Orthologs for ARGLU1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARGLU1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARGLU1 31 30
  • 99.76 (n)
(Monodelphis domestica)
Mammalia ARGLU1 31
  • 97 (a)
(Bos Taurus)
Mammalia ARGLU1 31 30
  • 95.85 (n)
(Canis familiaris)
Mammalia ARGLU1 31 30
  • 94.63 (n)
(Mus musculus)
Mammalia Arglu1 17 31 30
  • 93.6 (n)
(Rattus norvegicus)
Mammalia Arglu1 30
  • 93.6 (n)
(Gallus gallus)
Aves ARGLU1 31 30
  • 86.15 (n)
(Anolis carolinensis)
Reptilia ARGLU1 31
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arglu1 30
  • 82.77 (n)
MGC76303 30
(Danio rerio)
Actinopterygii arglu1a 31
  • 82 (a)
arglu1b 31 30
  • 74.47 (n)
zgc55548 30
fruit fly
(Drosophila melanogaster)
Insecta CG31712 31
  • 46 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8765 31
  • 52 (a)
Species where no ortholog for ARGLU1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARGLU1 Gene

Gene Tree for ARGLU1 (if available)
Gene Tree for ARGLU1 (if available)
Evolutionary constrained regions (ECRs) for ARGLU1: view image

Paralogs for ARGLU1 Gene

No data available for Paralogs for ARGLU1 Gene

Variants for ARGLU1 Gene

Additional dbSNP identifiers (rs#s) for ARGLU1 Gene

Structural Variations from Database of Genomic Variants (DGV) for ARGLU1 Gene

Variant ID Type Subtype PubMed ID
esv3633468 CNV gain 21293372
nsv1039628 CNV gain 25217958
nsv1172 CNV insertion 18451855
nsv475169 CNV novel sequence insertion 20440878

Variation tolerance for ARGLU1 Gene

Residual Variation Intolerance Score: 36.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.07; 1.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARGLU1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ARGLU1 Gene

Disorders for ARGLU1 Gene

Additional Disease Information for ARGLU1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ARGLU1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARGLU1 Gene

Publications for ARGLU1 Gene

  1. Arginine and glutamate-rich 1 (ARGLU1) interacts with mediator subunit 1 (MED1) and is required for estrogen receptor-mediated gene transcription and breast cancer cell growth. (PMID: 21454576) Zhang D … Zhang X (The Journal of biological chemistry 2011) 2 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. ARGLU1 is a transcriptional coactivator and splicing regulator important for stress hormone signaling and development. (PMID: 30698747) Magomedova L … Cummins CL (Nucleic acids research 2019) 3 54
  4. Insights into the ubiquitin-proteasome system of human embryonic stem cells. (PMID: 29511261) Saez I … Vilchez D (Scientific reports 2018) 3 54
  5. BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression. (PMID: 30463901) Yu L … Engel JD (Genes & development 2018) 3 54

Products for ARGLU1 Gene

Sources for ARGLU1 Gene