Aliases for ARGFX Gene
External Ids for ARGFX Gene
- HGNC: 30146
- Entrez Gene: 503582
- Ensembl: ENSG00000186103
- OMIM: 611164
- UniProtKB: A6NJG6
Previous GeneCards Identifiers for ARGFX Gene
- GC03U900585
- GC03P122787
- GC03P121286
- GC03P118660
Summaries for ARGFX Gene
-
Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the ARGFX homeobox gene family. [provided by RefSeq, Jul 2008]
GeneCards Summary for ARGFX Gene
ARGFX (Arginine-Fifty Homeobox) is a Protein Coding gene. Among its related pathways are Preimplantation Embryo. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding.
UniProtKB/Swiss-Prot for ARGFX Gene
-
Putative transcription factor.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARGFX Gene
Genomics for ARGFX Gene
GeneHancer (GH) Regulatory Elements for ARGFX Gene
Promoters and enhancers for ARGFX Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH03I121548 | Enhancer | 0.8 | Ensembl ENCODE | 0.4 | -13.4 | -13355 | 1.2 | HDGF ZNF687 JUNB ELF1 BATF ZNF217 IKZF1 NBN ZBTB33 ATF7 | STXBP5L POLQ ARGFX GC03M121324 | |
| GH03I121574 | Enhancer | 0.8 | ENCODE | 0.4 | +12.3 | 12326 | 0.1 | HDAC1 PKNOX1 TAF9B ZBTB40 TCF12 GATA2 FOS SP5 REST ZEB2 | POLQ CSTA ARGFX FBXO40 GC03M121324 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ARGFX on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ARGFX gene promoter:
Regulatory Element Products
Genomic Locations for ARGFX Gene
Genomic Locations for ARGFX Gene
- chr3:121,562,303-121,590,622
- (GRCh38/hg38)
- Size:
- 28,320 bases
- Orientation:
- Plus strand
- chr3:121,286,778-121,309,469
- (GRCh37/hg19)
Genomic View for ARGFX Gene
Genes around ARGFX on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q13.33 by Ensembl
- 3q13.33 by Entrez Gene
- 3q13.33 by HGNC
ARGFX Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ARGFX Gene
Proteins for ARGFX Gene
-
Protein details for ARGFX Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- A6NJG6-ARGFX_HUMAN
- Recommended name:
- Arginine-fifty homeobox
- Protein Accession:
- A6NJG6
Protein attributes for ARGFX Gene
- Size:
- 315 amino acids
- Molecular mass:
- 35617 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for ARGFX Gene
Other Protein References for ARGFX Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ARGFX
- Invitrogen Antibodies for ARGFX
- GeneTex ARGFX antibody for ARGFX
Protein Products
-
OriGene Purified Proteins for ARGFX
- Search Origene for MassSpec and Protein Over-expression Lysates for ARGFX
- Origene Custom Protein Services for ARGFX
- antibodies-online: Search results for 2 available ARGFX Proteins ranked by validation data
- Compare Top ARGFX Proteins
-
Quality Products:
- Search GeneTex for Proteins for ARGFX
-
Abcam proteins for ARGFX
Assay Products
No data available for DME Specific Peptides for ARGFX Gene
Domains & Families for ARGFX Gene
Gene Families for ARGFX Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for ARGFX Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ARGFX Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
A6NJG6- Family:
-
- Belongs to the paired homeobox family.
Function for ARGFX Gene
Molecular function for ARGFX Gene
- UniProtKB/Swiss-Prot Function:
- Putative transcription factor.
Phenotypes From GWAS Catalog for ARGFX Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0043565 | sequence-specific DNA binding | IEA | -- |
Phenotypes for ARGFX Gene
- GenomeRNAi human phenotypes for ARGFX:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for ARGFX gene
-
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- Search ViGene Biosciences for ARGFX
CRISPR Products
-
OriGene CRISPR knockouts for ARGFX
- genomics-online: gRNA clones - Search results for available ARGFX gene related products
- Applied Biological Materials CRISPR for ARGFX
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ARGFX
- GenScript: Design CRISPR guide RNA sequences for ARGFX
miRNA for ARGFX Gene
- miRTarBase miRNAs that target ARGFX
-
- hsa-mir-3163 (MIRT446650)
- hsa-mir-4668-3p (MIRT446651)
- hsa-mir-6848-5p (MIRT529820)
- hsa-mir-6846-5p (MIRT529821)
- hsa-mir-4697-5p (MIRT529822)
- hsa-mir-4488 (MIRT529823)
- hsa-mir-1237-5p (MIRT529824)
- hsa-mir-4283 (MIRT529825)
- hsa-mir-1256 (MIRT529826)
- hsa-mir-5197-5p (MIRT529827)
- hsa-mir-1231 (MIRT529828)
- hsa-mir-4776-5p (MIRT529829)
- hsa-mir-4795-3p (MIRT529830)
- hsa-mir-3619-3p (MIRT529831)
- hsa-mir-422a (MIRT529832)
- hsa-mir-378i (MIRT529833)
- hsa-mir-378h (MIRT529834)
- hsa-mir-378f (MIRT529835)
- hsa-mir-378e (MIRT529836)
- hsa-mir-378d (MIRT529837)
- hsa-mir-378c (MIRT529838)
- hsa-mir-378b (MIRT529839)
- hsa-mir-378a-3p (MIRT529840)
- hsa-mir-4638-3p (MIRT529841)
- hsa-mir-654-3p (MIRT529842)
- hsa-mir-6807-5p (MIRT647171)
- hsa-mir-938 (MIRT647172)
- hsa-mir-361-3p (MIRT647173)
- hsa-mir-129-2-3p (MIRT647174)
- hsa-mir-4438 (MIRT647175)
- hsa-mir-129-1-3p (MIRT647176)
- hsa-mir-5089-5p (MIRT684834)
- hsa-mir-7151-3p (MIRT684835)
- hsa-mir-5095 (MIRT684836)
- hsa-mir-6506-5p (MIRT684837)
- hsa-mir-619-5p (MIRT684838)
- hsa-mir-6504-3p (MIRT684839)
- hsa-mir-1180-5p (MIRT761188)
- hsa-mir-25-3p (MIRT764159)
- hsa-mir-25-5p (MIRT764203)
- hsa-mir-32-5p (MIRT765573)
- hsa-mir-363-3p (MIRT766178)
- hsa-mir-367-3p (MIRT766617)
- hsa-mir-377-5p (MIRT767355)
- hsa-mir-4459 (MIRT769232)
- hsa-mir-4537 (MIRT770120)
- hsa-mir-455-3p (MIRT770264)
- hsa-mir-4695-5p (MIRT771164)
- hsa-mir-5186 (MIRT773478)
- hsa-mir-6086 (MIRT775486)
- hsa-mir-6087 (MIRT775643)
- hsa-mir-6499-3p (MIRT776193)
- hsa-mir-6516-5p (MIRT777058)
- hsa-mir-658 (MIRT777324)
- hsa-mir-665 (MIRT777523)
- hsa-mir-6840-3p (MIRT780106)
- hsa-mir-7114-3p (MIRT781477)
- hsa-mir-760 (MIRT781779)
- hsa-mir-92a-3p (MIRT782670)
- hsa-mir-92b-3p (MIRT782709)
- hsa-mir-129-5p (MIRT783448)
- hsa-mir-197-3p (MIRT784064)
- hsa-mir-3149 (MIRT784661)
- hsa-mir-3167 (MIRT784722)
- hsa-mir-411-5p (MIRT785504)
- hsa-mir-483-5p (MIRT786864)
- hsa-mir-5096 (MIRT787091)
- hsa-mir-6832-5p (MIRT788993)
- hsa-mir-876-5p (MIRT789885)
miRNA Products
- Search ViGene Biosciences for ARGFX
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for ARGFX
- Browse OriGene Inhibitory RNA Products For ARGFX
- genomics-online: shRNA clones - Search results for available ARGFX gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ARGFX gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for ARGFX
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ARGFX
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available ARGFX gene related products
- orf clones - Search results for available ARGFX gene related products
- Applied Biological Materials Clones for ARGFX
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ARGFX
-
ViGene Biosciences adenoviral particle packaged cDNA for ARGFX gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ARGFX gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ARGFX gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARGFX Gene
Localization for ARGFX Gene
Subcellular locations from UniProtKB/Swiss-Prot for ARGFX Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ARGFX Gene
Pathways & Interactions for ARGFX Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Preimplantation Embryo | ||
Pathways by source for ARGFX Gene
1 BioSystems pathway for ARGFX Gene
Interacting Proteins for ARGFX Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
No data available for SIGNOR curated interactions for ARGFX Gene
Transcripts for ARGFX Gene
mRNA/cDNA for ARGFX Gene
- (1) REFSEQ mRNAs :
- (0) Additional mRNA sequences :
- -
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ARGFX Gene
- Arginine-fifty homeobox:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for ARGFX
- genomics-online: gRNA clones - Search results for available ARGFX gene related products
- Applied Biological Materials CRISPR for ARGFX
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ARGFX
- GenScript: Design CRISPR guide RNA sequences for ARGFX
miRNA Products
- Search ViGene Biosciences for ARGFX
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for ARGFX
- Browse OriGene Inhibitory RNA Products For ARGFX
- genomics-online: shRNA clones - Search results for available ARGFX gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ARGFX gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for ARGFX
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ARGFX
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available ARGFX gene related products
- orf clones - Search results for available ARGFX gene related products
- Applied Biological Materials Clones for ARGFX
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for ARGFX Gene
mRNA differential expression in normal tissues according to GTEx for ARGFX Gene
This gene is overexpressed in Testis (x26.1) and Heart - Left Ventricle (x4.6).
NURSA nuclear receptor signaling pathways regulating expression of ARGFX Gene:
ARGFXSOURCE GeneReport for Unigene cluster for ARGFX Gene:
Hs.224976mRNA Expression by UniProt/SwissProt for ARGFX Gene:
A6NJG6-ARGFX_HUMAN
Tissue specificity:
Expressed at low level in testis and undifferentiated embryonic stem cells.
Primer Products
-
OriGene qPCR primer pairs for ARGFX
- genomics-online: primer clones - Search results for available ARGFX gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARGFX Gene
Orthologs for ARGFX Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ARGFX 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ARGFX 34 33 |
|
OneToOne |
- Species where no ortholog for ARGFX was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for ARGFX Gene
(6) SIMAP similar genes for ARGFX Gene using alignment to 1 proteins:
Pseudogenes.org Pseudogenes for ARGFX Gene
No data available for Paralogs for ARGFX Gene
Variants for ARGFX Gene
| SNP ID | Clin | Chr 03 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000122614 | -- | 121,574,094(+) | T/C | intron_variant | |
| rs1000223165 | -- | 121,571,716(+) | A/C | intron_variant | |
| rs1000389820 | -- | 121,577,455(+) | T/C | intron_variant | |
| rs1000413149 | -- | 121,584,156(+) | C/T | intron_variant | |
| rs1000502538 | -- | 121,571,645(+) | A/G | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv8524n54 | CNV | gain | 21841781 |
| esv2759172 | CNV | gain | 17122850 |
| esv33473 | CNV | loss | 17666407 |
| esv3451038 | OTHER | inversion | 20981092 |
| esv3568985 | CNV | loss | 25503493 |
| esv3575598 | CNV | gain | 25503493 |
| esv3575599 | CNV | gain | 25503493 |
| esv3597587 | CNV | gain | 21293372 |
| esv3597593 | CNV | gain | 21293372 |
| nsv1007522 | CNV | gain | 25217958 |
| nsv1141890 | OTHER | inversion | 24896259 |
| nsv591400 | CNV | gain | 21841781 |
| nsv963357 | CNV | duplication | 23825009 |
| nsv998740 | CNV | gain | 25217958 |
| nsv999335 | CNV | gain | 25217958 |
| nsv999349 | CNV | gain | 25217958 |
Residual Variation Intolerance Score:
68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.31;
53.37% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ARGFX Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ARGFX
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARGFX Gene
Disorders for ARGFX Gene
Additional Disease Information for ARGFX
No disorders were found for ARGFX Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARGFX Gene
Publications for ARGFX Gene
- Annotation, nomenclature and evolution of four novel homeobox genes expressed in the human germ line. (PMID: 17005330) Booth HA … Holland PW (Gene 2007) 2 3 4 58
- The origin and evolution of ARGFX homeobox loci in mammalian radiation. (PMID: 20565723) Li G … Holland PW (BMC evolutionary biology 2010) 2 3 58
- The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 4 58
- A census of human transcription factors: function, expression and evolution. (PMID: 19274049) Vaquerizas JM … Luscombe NM (Nature reviews. Genetics 2009) 3
Products for ARGFX Gene
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- Cyagen custom Knockout/knockin (KOKI) mouse models for ARGFX
- VectorBuilder custom plasmid, inducible vectors for ARGFX
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ARGFX
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 37 available ARGFX Antibodies ranked by validation data
- Compare Top ARGFX Antibodies
- antibodies-online: Search results for available ARGFX related products ranked by validation data
- antibodies-online: Search results for 2 available ARGFX Proteins ranked by validation data
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- Quality Products:
- GeneTex ARGFX antibody for ARGFX
- Search GeneTex for Proteins for ARGFX
- ViGene Biosciences adenoviral particle packaged cDNA for ARGFX gene
- ViGene Biosciences lentiviral particle packaged cDNA for ARGFX gene
- ViGene Biosciences ready-to-package AAV shRNAs for ARGFX gene
- Search ViGene Biosciences for ARGFX
- Horizon Cell Lines for ARGFX
- genomics-online: cdna clones - Search results for available ARGFX gene related products
- orf clones - Search results for available ARGFX gene related products
- genomics-online: gRNA clones - Search results for available ARGFX gene related products
- genomics-online: primer clones - Search results for available ARGFX gene related products
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Sources for ARGFX Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
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