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Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the ARGFX homeobox gene family. [provided by RefSeq, Jul 2008]
ARGFX (Arginine-Fifty Homeobox) is a Protein Coding gene. Among its related pathways are Preimplantation Embryo. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is OTP.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH03J121591 | Promoter/Enhancer | 1.5 | EPDnew Ensembl ENCODE dbSUPER | 0.3 | +25.3 | 25270 | 2.6 | TEAD4 POLR2A CEBPA ZNF316 MAFF ATF3 MAFK YY1 MYC MAFG | FBXO40 SNODB1644 IQCB1 ARGFX | |
GH03J121574 | Enhancer | 0.9 | Ensembl ENCODE | 0.4 | +6.8 | 6751 | 0.6 | JUND FOXA1 PKNOX1 REST DPF2 HDAC1 SOX6 TCF12 EP300 TAF9B | POLQ CSTA IQCB1 lnc-POLQ-1 ARGFX FBXO40 | |
GH03J121548 | Enhancer | 0.6 | ENCODE | 0.4 | -19.0 | -19001 | 1.2 | ARID3A RUNX3 ELF1 NBN HDGF JUNB BATF TBX21 ATF7 MTA2 | STXBP5L POLQ ARGFX | |
GH03J121561 | Enhancer | 0.3 | Ensembl | 0.4 | -6.0 | -6049 | 1 | ZNF384 | ARGFX POLQ | |
GH03J121570 | Enhancer | 0.2 | Ensembl | 0.7 | +2.7 | 2652 | 0.8 | ARGFX lnc-POLQ-1 FBXO40 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
GO:0003677 | DNA binding | IEA | -- |
GO:0043565 | sequence-specific DNA binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | ISA | -- |
GO:0005634 | nucleus | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Preimplantation Embryo |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ARGFX 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ARGFX 30 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 03 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs9813391 | - | p.Arg145Gln |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv8524n54 | CNV | gain | 21841781 |
esv2759172 | CNV | gain | 17122850 |
esv33473 | CNV | loss | 17666407 |
esv3451038 | OTHER | inversion | 20981092 |
esv3568985 | CNV | loss | 25503493 |
esv3575598 | CNV | gain | 25503493 |
esv3575599 | CNV | gain | 25503493 |
esv3597587 | CNV | gain | 21293372 |
esv3597593 | CNV | gain | 21293372 |
nsv1007522 | CNV | gain | 25217958 |
nsv1141890 | OTHER | inversion | 24896259 |
nsv591400 | CNV | gain | 21841781 |
nsv963357 | CNV | duplication | 23825009 |
nsv998740 | CNV | gain | 25217958 |
nsv999335 | CNV | gain | 25217958 |
nsv999349 | CNV | gain | 25217958 |
No disorders were found for ARGFX Gene.