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Aliases for ARGFX Gene

Aliases for ARGFX Gene

  • Arginine-Fifty Homeobox 2 3 5

External Ids for ARGFX Gene

Previous GeneCards Identifiers for ARGFX Gene

  • GC03U900585
  • GC03P122787
  • GC03P121286
  • GC03P118660

Summaries for ARGFX Gene

Entrez Gene Summary for ARGFX Gene

  • Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the ARGFX homeobox gene family. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARGFX Gene

ARGFX (Arginine-Fifty Homeobox) is a Protein Coding gene. Among its related pathways are Preimplantation Embryo. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding.

UniProtKB/Swiss-Prot for ARGFX Gene

  • Putative transcription factor.

Additional gene information for ARGFX Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARGFX Gene

Genomics for ARGFX Gene

GeneHancer (GH) Regulatory Elements for ARGFX Gene

Promoters and enhancers for ARGFX Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I121548 Enhancer 0.8 Ensembl ENCODE 0.4 -13.4 -13355 1.2 HDGF ZNF687 JUNB ELF1 BATF ZNF217 IKZF1 NBN ZBTB33 ATF7 STXBP5L POLQ ARGFX GC03M121324
GH03I121574 Enhancer 0.8 ENCODE 0.4 +12.3 12326 0.1 HDAC1 PKNOX1 TAF9B ZBTB40 TCF12 GATA2 FOS SP5 REST ZEB2 POLQ CSTA ARGFX FBXO40 GC03M121324
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ARGFX on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARGFX gene promoter:

Genomic Locations for ARGFX Gene

Genomic Locations for ARGFX Gene
28,320 bases
Plus strand

Genomic View for ARGFX Gene

Genes around ARGFX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARGFX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARGFX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARGFX Gene

Proteins for ARGFX Gene

  • Protein details for ARGFX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Arginine-fifty homeobox
    Protein Accession:

    Protein attributes for ARGFX Gene

    315 amino acids
    Molecular mass:
    35617 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARGFX Gene

Post-translational modifications for ARGFX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARGFX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARGFX Gene

Domains & Families for ARGFX Gene

Gene Families for ARGFX Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ARGFX Gene

Suggested Antigen Peptide Sequences for ARGFX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the paired homeobox family.
  • Belongs to the paired homeobox family.
genes like me logo Genes that share domains with ARGFX: view

Function for ARGFX Gene

Molecular function for ARGFX Gene

UniProtKB/Swiss-Prot Function:
Putative transcription factor.

Phenotypes From GWAS Catalog for ARGFX Gene

Gene Ontology (GO) - Molecular Function for ARGFX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with ARGFX: view
genes like me logo Genes that share phenotypes with ARGFX: view

Animal Model Products

CRISPR Products

miRNA for ARGFX Gene

miRTarBase miRNAs that target ARGFX

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARGFX Gene

Localization for ARGFX Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARGFX Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARGFX gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ARGFX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ARGFX: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ARGFX Gene

Pathways & Interactions for ARGFX Gene

SuperPathways for ARGFX Gene

SuperPathway Contained pathways
1 Preimplantation Embryo
genes like me logo Genes that share pathways with ARGFX: view

Pathways by source for ARGFX Gene

1 BioSystems pathway for ARGFX Gene

Gene Ontology (GO) - Biological Process for ARGFX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ARGFX: view

No data available for SIGNOR curated interactions for ARGFX Gene

Drugs & Compounds for ARGFX Gene

No Compound Related Data Available

Transcripts for ARGFX Gene

mRNA/cDNA for ARGFX Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARGFX Gene

Arginine-fifty homeobox:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARGFX Gene

No ASD Table

Relevant External Links for ARGFX Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARGFX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARGFX Gene

mRNA differential expression in normal tissues according to GTEx for ARGFX Gene

This gene is overexpressed in Testis (x26.1) and Heart - Left Ventricle (x4.6).

NURSA nuclear receptor signaling pathways regulating expression of ARGFX Gene:


SOURCE GeneReport for Unigene cluster for ARGFX Gene:


mRNA Expression by UniProt/SwissProt for ARGFX Gene:

Tissue specificity: Expressed at low level in testis and undifferentiated embryonic stem cells.
genes like me logo Genes that share expression patterns with ARGFX: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARGFX Gene

Orthologs for ARGFX Gene

This gene was present in the common ancestor of mammals.

Orthologs for ARGFX Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARGFX 34 33
  • 99.04 (n)
(Bos Taurus)
Mammalia ARGFX 34 33
  • 77.07 (n)
Species where no ortholog for ARGFX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ARGFX Gene

Gene Tree for ARGFX (if available)
Gene Tree for ARGFX (if available)

Paralogs for ARGFX Gene

(6) SIMAP similar genes for ARGFX Gene using alignment to 1 proteins: Pseudogenes for ARGFX Gene

genes like me logo Genes that share paralogs with ARGFX: view

No data available for Paralogs for ARGFX Gene

Variants for ARGFX Gene

Sequence variations from dbSNP and Humsavar for ARGFX Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000122614 -- 121,574,094(+) T/C intron_variant
rs1000223165 -- 121,571,716(+) A/C intron_variant
rs1000389820 -- 121,577,455(+) T/C intron_variant
rs1000413149 -- 121,584,156(+) C/T intron_variant
rs1000502538 -- 121,571,645(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ARGFX Gene

Variant ID Type Subtype PubMed ID
dgv8524n54 CNV gain 21841781
esv2759172 CNV gain 17122850
esv33473 CNV loss 17666407
esv3451038 OTHER inversion 20981092
esv3568985 CNV loss 25503493
esv3575598 CNV gain 25503493
esv3575599 CNV gain 25503493
esv3597587 CNV gain 21293372
esv3597593 CNV gain 21293372
nsv1007522 CNV gain 25217958
nsv1141890 OTHER inversion 24896259
nsv591400 CNV gain 21841781
nsv963357 CNV duplication 23825009
nsv998740 CNV gain 25217958
nsv999335 CNV gain 25217958
nsv999349 CNV gain 25217958

Variation tolerance for ARGFX Gene

Residual Variation Intolerance Score: 68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.31; 53.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARGFX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARGFX Gene

Disorders for ARGFX Gene

Additional Disease Information for ARGFX

No disorders were found for ARGFX Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARGFX Gene

Publications for ARGFX Gene

  1. Annotation, nomenclature and evolution of four novel homeobox genes expressed in the human germ line. (PMID: 17005330) Booth HA … Holland PW (Gene 2007) 2 3 4 58
  2. The origin and evolution of ARGFX homeobox loci in mammalian radiation. (PMID: 20565723) Li G … Holland PW (BMC evolutionary biology 2010) 2 3 58
  3. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 4 58
  4. A census of human transcription factors: function, expression and evolution. (PMID: 19274049) Vaquerizas JM … Luscombe NM (Nature reviews. Genetics 2009) 3

Products for ARGFX Gene

Sources for ARGFX Gene

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